Article
Pediatrics
Francoise Lazarini, Sarah Levivien, Yoann Madec, Fabien Taieb, Estelle Mottez, Tan-Phuc Buivan, Audrey Maudoux, Sylvette Wiener-Vacher, Jerome Nevoux, Thierry Van den Abbeele, Pierre Gressens, Pierre-Marie Lledo, Natacha Teissier
Summary: Congenital cytomegalovirus infection is associated with reduced olfactory performance in children with infection symptoms at birth, which may lead to difficulties in olfactory discrimination for these children.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Chemistry, Analytical
Tomasz Wasilewski, Nathalia F. Brito, Bartosz Szulczynski, Marek Wojciechowski, Natalia Buda, Ana Claudia A. Melo, Wojciech Kamysz, Jacek Gebicki
Summary: The detection of biomarkers is crucial for non-invasive medical diagnosis and screening. Reliable disease-specific volatile organic compounds can be identified through analysis of trace level gaseous analytes in breath samples. Biosensors utilizing micro- and nanotechnology advancements show promise in improving the accuracy of diagnosis, but their translation from scientific laboratories to actual clinical diagnostics is still challenging.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ping Zhu, Shuge Liu, Yulan Tian, Yating Chen, Wei Chen, Ping Wang, Liping Du, Chunsheng Wu
Summary: This study developed an in vivo bioelectronic nose based on a bioengineered rat to detect specific odorants. By recording electrophysiological-responsive signals from the olfactory bulb, different odorants could be successfully classified and detected. The detection limit was low and the method showed promising application potential.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Divesh Thaploo, Stefanie Zelder, Thomas Hummel
Summary: The study concludes that CNV is a useful electrophysiological measure of cognition, but odors of different hedonic tones have only minor effects on CNV in the present context.
Article
Nanoscience & Nanotechnology
Sangjun Noh, Francesco Tombola, Peter Burke
Summary: This article describes the concept and roadmap of an engineered electronic nose with the ability to detect analytes that differ by as little as one carbon atom. The strategy involves genetically engineering a fused olfactory odorant receptor (OR) to an ion channel protein, which can electrically detect the binding of a single ligand to a single OR protein domain. The combination of these technological advances and the evolution of OR proteins over millions of years would enable the goal of single molecule sensing with specificity towards analytes that differ by as little as one carbon atom.
Article
Biophysics
Jungyun Park, Jong-Min Lee, Hoje Chun, Yujin Lee, Sung Jun Hong, Hyunwook Jung, Ye-Ji Kim, Won-Geun Kim, Vasanthan Devaraj, Eun Jung Choi, Jin-Woo Oh, Byungchan Han
Summary: This paper demonstrates a highly selective and responsive optical biosensor using genetically engineered phages with optimized peptide sequences interacting with volatile organic compounds. The sensor shows significant improvement in sensing resolution and classification success rate for explosive VOCs, achieved through a systematic approach combining computational prediction and experimental validation.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Otorhinolaryngology
Anna Kristina Hernandez, Dorothea Woosch, Antje Haehner, Thomas Hummel
Summary: This study examined the effects of omega-3 supplementation on olfactory recovery in patients with postviral olfactory dysfunction. The results showed that the improvement in odor thresholds was more pronounced in the group receiving omega-3 supplementation compared to the control group. Age, sex, and duration of symptoms did not have an effect on olfactory scores in both groups.
Article
Engineering, Electrical & Electronic
Ryan Joseph Ward, Fred Paul Mark Jjunju, Elias J. Griffith, Sophie M. Wuerger, Alan Marshall
Summary: The phenomenology of synaesthesia can provide cognitive benefits and enhance interactive experiences through transforming odours into the visual domain using a low-cost augmented reality/virtual reality system. The artificial form of synesthesia created in this study has the potential to increase human odour discrimination, highlighting the prospects for augmenting human-machine interfaces.
IEEE SENSORS JOURNAL
(2021)
Review
Cell Biology
Smija M. Kurian, Rafaella G. Naressi, Diogo Manoel, Ann-Sophie Barwich, Bettina Malnic, Luis R. Saraiva
Summary: Odor detection starts with the activation of odorant receptors in mature olfactory sensory neurons, and different odorants activate unique receptors, providing an explanation for perceiving different odors. Recent studies have found that antagonist interactions play an important role in the formation of combinatorial receptor code.
CELL AND TISSUE RESEARCH
(2021)
Article
Nutrition & Dietetics
Giorgia Sollai, Melania Melis, Mariano Mastinu, Danilo Paduano, Fabio Chicco, Salvatore Magri, Paolo Usai, Thomas Hummel, Iole Tomassini Barbarossa, Roberto Crnjar
Summary: This study found that patients with inflammatory bowel disease (IBD), such as Crohn's disease (CD) and ulcerative colitis (UC), showed different body weight situations, possibly related to olfactory function and genotype. Lower olfactory function may delay satiety sensation, increasing meal duration and body weight.
Article
Health Care Sciences & Services
Fabrice Denis, Anne-Lise Septans, Lea Periers, Jean-Michel Maillard, Florian Legoff, Hirac Gurden, Sylvain Moriniere
Summary: This study found that olfactory training and visual stimulation assisted by a dedicated web application significantly improved olfaction in patients, especially after at least 28 days of olfactory training.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Review
Psychology, Clinical
David E. Vance, Victor A. Del Bene, Vidyulata Kamath, Jennifer Sandson Frank, Rebecca Billings, Do-Yeon Cho, Jun Y. Byun, Alexandra Jacob, Joseph N. Anderson, Kristina Visscher, Kristen Triebel, Karli M. Martin, Wei Li, Frank Puga, Pariya L. Fazeli
Summary: Olfactory training (OT), involving repeated exposure to odorants, has shown potential to improve olfactory functioning. This systematic review found emerging evidence that OT is associated with improved global cognition, specifically in verbal fluency and learning/memory. Additionally, OT is linked to increased volume of olfactory-related brain regions and altered functional connectivity. These benefits were observed not only in patients with smell loss, but also in individuals with normal smell ability. Implications for practice and further research are discussed.
NEUROPSYCHOLOGY REVIEW
(2023)
Article
Behavioral Sciences
Daniel Kowatschew, Sigrun Korsching
Summary: The sense of smell relies on large gene families to detect and differentiate various odors. Four major olfactory receptor families have been discovered, with only three already present in lamprey, a jawless vertebrate. However, a fourth family was believed to have originated in jawed vertebrates. This study examined the complete vomeronasal receptor repertoire in three lamprey species and found evidence of v1r and v2r genes, indicating an early origin of the V2R family in the shared ancestor of jawed and jawless vertebrates. Despite the presence of v2r genes, lampreys have not yet acquired an olfactory function for this family, suggesting a disconnect between the evolutionary origin and functional onset of the V2R family as olfactory receptors.
Review
Surgery
Francisco Alves de Sousa, Mariline Santos, Joao Tavares Correia, Ana Nobrega Pinto, Luis Meireles, Miguel Ferreira
Summary: The study aimed to assess the impact of septorhinoplasty on olfactory function in late postoperative period. A comprehensive review and meta-analysis showed that there was no significant alteration in olfactory function after septorhinoplasty. Some studies observed a temporary decline in olfactory function shortly after surgery, followed by improvement.
FACIAL PLASTIC SURGERY
(2023)
Article
Otorhinolaryngology
T. Hummel, N. Power Guerra, N. Gunder, A. Haehner, S. Menzel
Summary: The sense of smell is crucial for human beings, as it warns us of danger and enhances our quality of life through perceiving flavors. Olfactory disorders have diverse causes and require thorough diagnosis and treatment options. Olfactory training and drug therapies are effective, and communication with patients is paramount.
LARYNGO-RHINO-OTOLOGIE
(2023)