Article
Medicine, General & Internal
Briana K. Clifford, Nadeem O. Kaakoush, Nicodemus Tedla, David Goldstein, David Simar
Summary: This study aimed to compare the effects of high-intensity and low-intensity aerobic exercise on the inflammatory profile of cancer survivors. It found that both low-intensity and high-intensity exercise can positively modulate inflammatory markers. Scaling up low-intensity exercise over time may be more applicable and achievable for cancer survivor cohorts while still eliciting beneficial effects on systemic inflammation.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Luciele Guerra Minuzzi, Fabio Santos Lira, Rodrigo Araujo Bonetti de Poli, Vithor Hugo Fialho Lopes, Alessandro Moura Zagatto, Katsuhiko Suzuki, Barbara M. Antunes
Summary: This study aimed to investigate the cytokine responses to high-intensity intermittent exercise (HIIE) during the follicular and luteal phases of the menstrual cycle. The results showed that the concentrations of TNF-alpha and IL-10 before exercise were significantly higher in the luteal phase compared to the follicular phase, and the concentration of IL-10 decreased after exercise, indicating an altered inflammatory status.
Article
Sport Sciences
Fatma Rhibi, Hassane Zouhal, Fabio Santos Lira, Nejmeddine Ouerghi, Jacques Prioux, Sophia Besbes, Jed M. Tijani, Anthony C. Hackney, Abderraouf Ben Abderrahman
Summary: This study examined the effects of high-intensity intermittent training (HIIT) programs with varying intensities on metabolic, hormonal, and inflammatory markers in young men. The results showed that training at 110% of maximal aerobic velocity (MAV) was more effective in improving markers such as glucose, cortisol, and IL-6 at rest, at the end of exercise, and during recovery compared to training at 100% MAV.
Article
Nutrition & Dietetics
Francisco Jesus Llorente-Cantarero, Concepcion M. Aguilera, Juan Luis Perez-Navero, Angel Gil, Juan de Dios Benitez-Sillero, Mercedes Gil-Campos
Summary: The study aimed to assess the relationship between fitness levels with plasma adipokines and inflammatory biomarkers in prepubertal children. The results showed that an adequate level of fitness is inversely associated with risk factors related to low-grade inflammation and obesity.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Bruna Cunha Mendes, Candice Lais Knoner Copetti, Vilma Simoes Pereiea Panza, Lucas B. R. Orssatto, Julia Salvan da Rosa, Fernando Diefenthaeler, Eduardo Monguilhott Dalmarco, Patricia Faria Di Pietro, Debora Kurrle Rieger
Summary: The study found that consuming ju, cara fruit juice may help alleviate the inflammatory response to high-intensity intermittent exercise, possibly due to reducing muscle stress. Compared to water, the impact of ju, cara fruit juice on tumor necrosis factor-alpha and IL-10 was more pronounced. Additionally, individuals who consumed ju, cara fruit juice performed better during sprints.
Article
Nutrition & Dietetics
Debora Romualdo Lacerda, Albena Nunes-Silva, Ana Leticia Malheiros Silveira, Katia Anunciacao Costa, Debora Fernandes Rodrigues, Michele Macedo Moraes, Vanessa Pinho, Gustavo Batista Menezes, Mauro Martins Teixeira, Samuel Penna Wanner, Danusa Dias Soares, Adaliene Versiani Matos Ferreira
Summary: This study investigated the effect of acute exercise on the inflammatory response in adipose tissue of lean and obese mice. Acute exercise enhanced the levels of IL-6 and tumor necrosis factor-a in the adipose tissue of lean mice, while no changes were observed in proinflammatory cytokines in obese mice. However, the levels of IL-13, IL-4, and IL-10 were increased in obese mice after exercise. These findings suggest that acute exercise promotes an inflammatory response in adipose tissue of lean mice, but elicits an anti-inflammatory response in adipose tissue of obese mice.
Review
Immunology
Samira Rastgoo, Ghazaleh Shimi, Farideh Shiraseb, Ashkan Karbasi, Damoon Ashtary-Larky, Mohsen Yousefi, Elnaz Golalipour, Omid Asbaghi, Mohammad Zamani
Summary: This systematic review and meta-analysis examined the effects of conjugated linoleic acid (CLA) supplementation on inflammatory cytokines and adipokines. The results showed that CLA supplementation significantly decreased IL-6 and TNF-alpha levels, slightly increased CRP levels, and had no effect on adiponectin and leptin levels. Subgroup analysis revealed that CLA supplementation reduced adiponectin and leptin in women.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Virginia Camacho, Valeriya Kuznetsova, Robert S. Welner
Summary: The immune microenvironment plays a crucial role in regulating hematopoiesis and immune cell dysfunction significantly contributes to neoplastic disease. Leukemic inflammatory cytokines can alter immune cells, and targeting the immune landscape may have therapeutic value in limiting leukemia growth. Further research is needed to understand how leukemic cytokines impact immune cells and potential immunotherapeutic approaches for patients with hematological myeloid malignancies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Orthopedics
Emanuele Chisari, Laura Rehak, Wasim S. Khan, Nicola Maffulli
Summary: There is a renewed interest in investigating the role of inflammation in tendinopathy pathogenesis, particularly during the initial phases. Understanding both early and late stages of tendon injury pathogenesis could lead to the development of new and effective treatments targeting inflammatory pathways.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Fisheries
Amro M. Soliman, Daniel R. Barreda
Summary: Acute inflammation plays a crucial role in the immune responses of fish, protecting the host from infection and promoting tissue repair. Inflammatory signals and mediators drive leukocyte recruitment, antimicrobial mechanisms, and resolution of inflammation. Understanding the kinetics and unique characteristics of fish inflammation is important for studying fish diseases and potential treatments.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Review
Cell Biology
Ariane R. de F. Rocha, Nubia de S. Morais, Silvia E. Priore, Sylvia do C. C. Franceschini
Summary: The study examines the association between inflammatory biomarkers and metabolic syndrome components in adolescents. Inflammation may precede the development of metabolic disorders in teenagers. Evaluating inflammatory biomarkers in the presence of metabolic alterations can help identify risk factors for progressing MetS in adolescents.
Article
Food Science & Technology
Hrvoje Urlic, Marko Kumric, Goran Dujic, Josip Vrdoljak, Daniela Supe-Domic, Zeljko Dujic, Josko Bozic
Summary: This study investigated the anti-inflammatory effects of CBD in hypertensive patients and found that oral CBD administration significantly reduced serum concentrations of IL-8, IL-10, and IL-18. Higher baseline levels of IL-8 and IL-10 predicted greater reduction in diastolic blood pressure, and the extent of reduction in IL-8 and IL-10 serum levels correlated with the extent of reduction in diastolic blood pressure.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Camila S. Stolf, Catharina M. Sacramento, Carolina A. P. G. Alvarenga, Jonathan R. Vieira, Cassia F. Araujo, Mabelle F. Monteiro, Helvis E. S. Paz, Mauro P. Santamaria, Karina G. S. Ruiz, Renato C. Casarin
Summary: This study aims to assess the local immune response of Perio4C patients by exposing primary gingival fibroblast cells (GFs) to Aggregatibacter actinomycetemcomitans protein extract (AaPE) and quantifying the secretion of inflammatory cytokines IL-4, IL-17, TNF-alpha, IL-1 beta, IFN-gamma, and IL-10 super-family members (IL-10, IL-19, and IL-24) by them. The results showed that Perio4C GFs had lower production of certain pro- and anti-inflammatory molecules, leading to a pro-inflammatory extracellular environment.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Victor M. Baiao, Vinicius A. Cunha, Marvery P. Duarte, Francini P. Andrade, Aparecido P. Ferreira, Otavio T. Nobrega, Joao L. Viana, Heitor S. Ribeiro
Summary: Individuals with chronic kidney disease (CKD) show systemic inflammation. Exercise interventions significantly reduce levels of inflammatory markers and increase levels of IL-10 in individuals with CKD. Resistance interventions have greater anti-inflammatory effects compared to aerobic interventions. Combined exercise interventions do not lead to significant changes in inflammatory markers.
Article
Biochemistry & Molecular Biology
Haruna Takeda, Shohei Murakami, Zun Liu, Tomohiro Sawa, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Hideyo Sato, Takaaki Akaike, Hiroki Sekine, Hozumi Motohashi
Summary: The excessive inflammatory response of macrophages is regulated by the metabolic alteration involving cysteine and its related metabolites. Activation of the cystine transporter xCT increases cysteine uptake by macrophages and contributes to the production of supersulfides, creating a negative feedback loop to limit excessive inflammation. Understanding the finely tuned regulation of macrophage inflammatory response by sulfur metabolism is important for disease pathogenesis and potential therapeutic strategies.
Article
Engineering, Biomedical
Maria Isabel Fuhro, Francini P. Andrade, Gilson P. Dorneles, Fabio S. Lira, Pedro R. T. Romao, Alessandra Peres, Mariane Monteiro
Summary: Intradialytic exercise had no significant impact on CCR5 expression in CKD patients, but could prevent excessive inflammatory response induced by hemodialysis in elderly patients with CKD.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2022)
Article
Nutrition & Dietetics
Priscila A. Q. Rossi, Fabio S. Lira, Vanessa R. Bezerra, Nicolas W. Clark, David H. Fukuda, Valeria L. G. Panissa
Summary: This study examined the effects of capsiate supplementation on energy intake, self-reported appetite sensations, and other parameters. Results showed limited impact of capsiate supplementation combined with aerobic exercise on the examined variables, but changes in autonomic nervous system function may have occurred in the absence of exercise.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2022)
Review
Physiology
Camila S. Padilha, Caique Figueiredo, Rafael Deminice, Karsten Kruger, Marilia Seelaender, Jose Cesar Rosa-Neto, Fabio S. Lira
Summary: The mechanisms underlying immunometabolic disturbances during muscle atrophy are still unknown, and physical exercise has the potential to mitigate and promote muscle recovery. However, there is no consensus on the optimal exercise intensity for improving muscle strength and function.
Article
Public, Environmental & Occupational Health
Thalysi M. Hisamatsu, Crystian B. Oliveira, Fabio S. Lira, Priscila K. Morelhao, Bruna R. Azevedo, Italo R. Lemes, Marcia R. Franco, Rafael Z. Pinto
Summary: This study found that higher levels of perceived occupational physical activity predicted higher levels of disability at 6-month follow-up in patients with chronic low back pain, while other physical activity measures were not associated with pain intensity or disability.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2022)
Review
Pharmacology & Pharmacy
Thiago Barros Estanislau, Karsten Kruger, Jose Cesar Rosa-Neto, Camila S. Padilha, Daniela Caetano Goncalves, Luciele Guerra Minuzzi, Fabio Santos Lira
Summary: Feeding pattern is closely related to health status, and timed eating can promote molecular synchronization and a healthy response. Disorganized feeding patterns may lead to non-synchronization of clock genes and chronic diseases. Time-restricted eating is an effective strategy for promoting health and treating chronic diseases.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Immunology
Pedro R. T. Romao, Paula C. Teixeira, Lucas Schipper, Igor da Silva, Paulo Santana Filho, Luiz Carlos Rodrigues Junior, Alessandra Peres, Simone Goncalves da Fonseca, Marta Chagas Monteiro, Fabio S. Lira, Marco Andrey Cipriani Frade, Juliana Comerlato, Carolina Comerlato, Fernando Hayashi Sant'Anna, Marina Bessel, Celina Monteiro Abreu, Eliana M. Wendland, Gilson P. Dorneles
Summary: Monocytes play a crucial role in the initial immune response to SARS-CoV-2, and high viral load can contribute to the severity of COVID-19. This study found that COVID-19 patients have altered monocyte phenotype and mitochondrial function, including changes in monocyte subsets, molecule expression, mitochondrial polarization, and reactive oxygen species generation. These findings provide insights into the pathological mechanisms involving viral load, monocyte activation, and mitochondrial dysfunction in severe COVID-19.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Patricia C. Garcia-Suarez, Jorge A. Aburto-Corona, Ivan Renteria, Luis M. Gomez-Miranda, Jose Moncada-Jimenez, Fabio Santos Lira, Barbara Moura Antunes, Alberto Jimenez-Maldonado
Summary: This study investigated the impact of short-term high-intensity circuit training on resting heart rate variability in adults during the COVID-19 pandemic. The results showed that 36 sessions of HICT did not induce cardio-vagal adaptations in adults. The exercise protocol did not modify the resting HRV in adults under social isolation elicited by the pandemic.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Cell Biology
Camila S. Padilha, Ana E. Von Ah Morano, Karsten Krueger, Jose C. Rosa-Neto, Fabio S. Lira
Summary: This perspective review discusses the impact of physical exercise on immunometabolic responses. Physical exercise can stimulate the mobilization and migration of immune cells, as well as the production of anti-inflammatory cytokines, thereby enhancing immune regulatory function.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Fabricio Eduardo Rossi, Alberto Jimenez Maldonado, Jason Michael Cholewa, Sergio Luiz Galan Ribeiro, Clara Andressa de Araujo Barros, Caique Figueiredo, Thomas Reichel, Karsten Kruger, Fabio Santos Lira, Luciele Guerra Minuzzi
Summary: The aim of this study was to investigate the metabolic and inflammatory fluctuations in two seasonal phases of badminton training, and the ability of youth badminton athletes to respond to an inflammatory challenge given by acute exercise on these markers. The results showed a major responsivity of IL-10 and IL-1Ra to a maximal exercise even at the end of an entire season, suggesting a more effective acute inflammatory response in youth badminton athletes.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Bruna Spolador de Alencar Silva, Telmo Pereira, Luciele Guerra Minuzzi, Camila Souza Padilha, Caique Figueiredo, Tiago Olean-Oliveira, Ivete Vera Medeiros dos Santos, Ana Elisa von Ah Morano, Osmar Marchioto, Jose Procopio Jabur Ribeiro, Vanessa Ribeiro Dos Santos, Marilia Seelaender, Alexandre Abilio Teixeira, Ronaldo Vagner T. Dos Santos, Valdir de Aquino Lemos, Ana Paula Coelho Figueira Freire, Gilson Pires Dorneles, Bruna Marmett, Andre Olean-Oliveira, Marcos F. S. Teixeira, Patricia M. Seraphim, Armando Caseiro, Ricardo Aurino Pinho, Hashim Islam, Jonathan Peter Little, Karsten Krueger, Jose Cesar Rosa-Neto, Manuel-Joao Coelho-E-Silva, Fabio Santos Lira
Summary: This study aimed to evaluate the association between physical activity and immunometabolic responses in young adults after mild-to-moderate COVID-19 infection. The results showed that COVID-19 patients had lower physical activity levels and exhibited impacts on lung function, immune cell phenotype, and cytokine production.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Sport Sciences
Wondyefraw Mekonen, Guenther Schwaberger, Manfred Lamprecht, Peter Hofmann
Summary: This study investigated the effects of different exercise intensities and durations on blood protein changes and their association with carbohydrate and fat metabolism.
JOURNAL OF FUNCTIONAL MORPHOLOGY AND KINESIOLOGY
(2023)
Article
Sport Sciences
Matthias Schuetzenhoefer, Philipp Birnbaumer, Peter Hofmann
Summary: The aim of this study was to determine two intensity thresholds from accelerometer measures. The results showed that accelerometer thresholds from tibia placement during a maximal incremental running test can be comparable to standard ventilatory thresholds.
Review
Biochemistry & Molecular Biology
Matheus Santos de Sousa Fernandes, Tiago Ramos Lacerda, Debora Eduarda da Silva Fidelis, Gabriela Carvalho Jurema Santos, Tayrine Ordonio Filgueira, Raphael Fabricio de Souza, Claudia Jacques Lagranha, Fabio S. Lira, Angela Castoldi, Fabricio Oliveira Souto
Summary: This systematic review evaluates the impact of environmental enrichment (EE) on oncological factors in experimental studies on various cancer models. The findings demonstrate that different EE protocols effectively reduce tumor growth and development in terms of angiogenesis, volume, weight, and the number of mice with tumors. Additionally, EE enhances the rate of tumor inhibition. These findings emphasize the importance of EE as a valuable tool in cancer management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Daniel Schneditz, Peter Hofmann, Simon Krenn, Maximilian Waller, Sebastian Mussnig, Manfred Hecking
Summary: Short-term variability in body mass is common but data on this variability is limited. For individuals with impaired volume homeostasis, such as kidney failure patients, body mass variability should be taken into consideration during therapy. The study found that body mass relative differences remained constant over time.
Review
Immunology
Jose Cesar Rosa-Neto, Fabio Santos Lira, Jonathan Peter Little, Graham Landells, Hashim Islam, Benedicte Chazaud, David B. Pyne, Ana Maria Teixeira, Helena Batatinha, Barbara Moura Antunes, Luciele Guerra Minuzzi, Jana Palmowksi, Richard J. Simpson, Karsten Krueger
EXERCISE IMMUNOLOGY REVIEW
(2022)