期刊
FRONTIERS IN PHYSIOLOGY
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2016.00076
关键词
passive tension; connection; striated muscle; posttranslational modification; hypertrophic signaling
类别
资金
- German Research Foundation (DIG) [KR 3409/5-1, SIB 1116 TPA2]
- grant of the research commission of the University of Dusseldorf
Titin is a giant scaffold protein with multiple functions in striated muscle physiology. Due to the elastic I-band domains and the filament-like integration in the half-sarcomere titin is an important factor for sarcomere assembly and serves as an adaptable molecular spring that determines myofilament distensibility. Protein-interactions e.g., with muscle ankyrin repeat proteins or muscle LIM-protein link titin to hypertrophic signaling and via p62 and Muscle Ring Finger proteins to mechanisms that control protein quality control. This review summarizes our current knowledge on titin as a central node for exercise induced mechanosignaling and remodeling and further highlights the pathophysiological implications.
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