Article
Geriatrics & Gerontology
Kazuki Hyodo, Kazuya Suwabe, Daisuke Yamaguchi, Hideaki Soya, Takashi Arao
Summary: This study compared the acute effects of intermittent and continuous light-intensity aerobic dance exercise (LADE) on mood and executive functions in older adults. Findings showed that intermittent exercise was more enjoyable and fun during exercise compared to continuous exercise, but there were similar effects on mood and executive function after both types of exercise.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Physiology
Brian R. MacIntosh, Juan M. Murias, Daniel A. Keir, Jamie M. Weir
Summary: The health benefits of physical activity depend on the frequency, intensity, duration, and type of exercise. Intensity is a crucial element and should be prescribed based on individual boundaries. Regular reassessment and adjustment are necessary to maintain physical activity in the moderate to vigorous intensity domains.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Serafin Murillo, Laura Brugnara, Joan-Marc Servitja, Anna Novials
Summary: This study compared the effects of High Intensity Interval Training (HIIT) and traditional moderate Intensity Continuous Training (MICT) on glycemic control and fitness capacity. The results showed that HIIT training improves glycemic stability and reduces the frequency of hypoglycemic episodes.
DIABETES & METABOLISM
(2022)
Article
Nutrition & Dietetics
Aristides Myrkos, Ilias Smilios, Andreas Zafeiridis, Maria-Eleni Kokkinou, Apostolos Tzoumanis, Helen Douda
Summary: This study compared the aerobic adaptations following two iso-effort, ratings of perceived exertion (RPE)-based training programs, an intense continuous (CON) and a high-intensity interval (INT). Results showed that there was no significant difference in aerobic adaptations between the two training methods when matched for effort.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Review
Medical Laboratory Technology
Yudong Wu, Qian Li, Renshuai Zhang, Xiaoli Dai, Wujun Chen, Dongming Xing
Summary: MicroRNAs, approximately 20-24 nucleotides in length, are considered reliable diagnostic and prognostic biomarkers for various diseases due to their reflection of disease progression and drug resistance. They play a crucial role in the diagnosis, prognosis, and treatment response prediction of diseases, potentially improving cure rates.
CLINICA CHIMICA ACTA
(2021)
Article
Psychology, Biological
Leonard H. Epstein, Sara O'Donnell, Mathew J. Biondolillo, David Hostler, James N. Roemmich
Summary: Exercise is a strong reinforcer for both animals and humans, with HIIT being shown to have a higher reinforcing value compared to MIAE. Inactive individuals may find HIIT more rewarding and may be more likely to adopt and maintain an exercise program involving HIIT rather than MIAE. Further research is needed to understand how to enhance the reinforcing value of exercise to encourage sedentary individuals to be more active.
PHYSIOLOGY & BEHAVIOR
(2021)
Review
Endocrinology & Metabolism
Mousa Khalafi, Shima Mojtahedi, Alireza Ostovar, Sara K. Rosenkranz, Mallikarjuna Korivi
Summary: This meta-analysis investigated the effects of high-intensity interval exercise (HIIE) compared to moderate-intensity exercise (MIE) and a control condition (CON) on postprandial glucose (PPG) and insulin (PPI) responses. The results showed that HIIE reduced PPG and PPI compared to the control condition. Subgroup analyses revealed significant reductions in PPG and PPI for both children and adults, as well as for healthy participants and those with metabolic disorders, with larger effects observed in individuals with metabolic disorders. There were no significant differences between HIIE and MIE for PPG or PPI, but when studies matched for total work performed, HIIE was more effective for decreasing PPG. HIIE is effective for reducing PPG and PPI in both children and adults, particularly in those with metabolic disorders.
Review
Multidisciplinary Sciences
Haohan Yu, Xudong Zhao, Xiaoxia Wu, Jing Yang, Jun Wang, Lijuan Hou
Summary: This systematic review and meta-analysis compared the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the quality of life (QOL) and mental health (MH) of patients with cardiovascular disease (CVDs). The study found that both HIIT and MICT had similar effects on QOL and MH in CVD patients. However, HIIT showed significant improvements in physical component summary (PCS) for coronary artery disease (CAD) patients and performed better in physical role, vitality, and social function compared to MICT.
SCIENTIFIC REPORTS
(2023)
Article
Psychiatry
Chia-Liang Tsai, Tsu-Kung Lin
Summary: Cognitive impairments in individuals with Parkinson's disease can be improved by high-intensity interval exercise (HIIE) and continuous moderate-intensity exercise (CMIE), but their effects on peripheral dopamine levels differ.
MENTAL HEALTH AND PHYSICAL ACTIVITY
(2023)
Review
Endocrinology & Metabolism
Josie L. Fullerton, Josephine M. Thomas, Laura Gonzalez-Trueba, Cara Trivett, Josie C. van Kralingen, Stuart M. Allan, Terence J. Quinn, Lorraine M. Work
Summary: This systematic review aimed to assess the range and quality of clinical and preclinical evidence supporting the association of individual microRNAs and their use in the diagnosis and prognosis of ischaemic or haemorrhagic stroke. The findings highlighted specific microRNAs that consistently showed differential expression in both clinical and preclinical samples following stroke. However, further studies with larger populations and consistent methodologies are needed to confirm the clinical value of circulating microRNAs as biomarkers for stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Endocrinology & Metabolism
Stella V. V. Philbois, Victor B. B. Ribeiro, Jens Tank, Rosana Maria dos Reis, Darius A. A. Gerlach, Hugo C. D. Souza
Summary: This study aimed to compare the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on cardiovascular autonomic control in women with polycystic ovarian syndrome (PCOS). The results showed that both training protocols had similar effects on the evaluated parameters, suggesting that both HIIT and MICT can be recommended for the treatment of PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Chia-Liang Tsai, Yu-Chuan Chang, Chien-Yu Pan, Tsai-Chiao Wang, Jozef Ukropec, Barbara Ukropcova
Summary: The study found that both high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) have positive effects on executive function and oculomotor performance in late middle-aged and older adults. Both exercise modes were able to reduce reaction times in performance tasks, while HIIE showed a more significant improvement in oculomotor control compared to MICE.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Sport Sciences
Manuel Fernandez-Sanjurjo, Angel E. Diaz-Martinez, Sergio Diez-Robles, Felipe Gonzalez-Gonzalez, David De Gonzalo-Calvo, Manuel Rabadan, Alberto Davalos, Benjamin Fernandez-Garcia, Eduardo Iglesias-Gutierrez
Summary: This study analyzed the response of circulating miRNA to a maximal incremental exercise test and identified specific functional subsignatures of miRNA related to different exercise markers. The findings provide novel evidence about the potential regulatory role of miRNA in exercise response and adaptation.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2021)
Article
Medicine, Research & Experimental
Allyne Baia Leite, Hernando Nascimento Lima, Caleb de Oliveira Flores, Caroline Assuncao Oliveira, Larissa Esterfanne Cavalcante Cunha, Jonas Luz Neves, Thiago Macedo Lopes Correia, Fabricio Freire de Melo, Marcio Vasconcelos Oliveira, Amelia Cristina Mendes de Magalhaes, Telma de Jesus Soares, Liliany Souza de Brito Amaral
Summary: This study compared the effects of preconditioning with high-intensity interval training and continuous training of different intensities on innate immunity markers in female rats with cisplatin-induced acute kidney injury. The results showed that all training protocols promoted renal protection, but high-intensity interval training was more effective in mitigating acute kidney injury induced by cisplatin.
Article
Rehabilitation
Srijit Banerjee, Kelly Semper, Katy Skarparis, Jenni Naisby, Liane Lewis, Gabriel Cucato, Robert Mills, Mark Rochester, John Saxton
Summary: This study investigated patient perspectives on preoperative high intensity aerobic interval exercise before radical cystectomy, finding that social support, previous exercise experience, and objective measures of progression were key motivational factors for engaging in exercise prehabilitation. Patients also highlighted the need for clear information from healthcare providers.
DISABILITY AND REHABILITATION
(2021)
Article
Cell Biology
Qun Chen, Fan Zhang, Lei Dong, Huimin Wu, Jie Xu, Hanqin Li, Jin Wang, Zhen Zhou, Chunyan Liu, Yanbo Wang, Yuyan Liu, Liangsheng Lu, Chen Wang, Minghui Liu, Xi Chen, Cheng Wang, Chunni Zhang, Dangsheng Li, Ke Zen, Fangyu Wang, Qipeng Zhang, Chen-Yu Zhang
Summary: The study reveals that SIDT1 expressed on gastric pit cells is necessary for the absorption of dietary microRNAs, and deficiency in SIDT1 leads to reduced absorption. The stomach is identified as the primary site for dietary microRNA absorption, and the process relies on SIDT1 and low pH. Oral administration of plant-derived miR2911 can delay liver fibrosis, but this effect is nullified in SIDT1-deficient mice.
Article
Oncology
Yujie Zhong, Xiaoyu Ding, Yuying Bian, Jing Wang, Wanqing Zhou, Xiangdong Wang, Pumin Li, Yi Shen, Jun-Jun Wang, Jing Li, Chunni Zhang, Cheng Wang
Summary: miR-520c-3p and miR-1274b were found to be significantly increased in NSCLC patients and decreased after tumor resection, showing potential as biomarkers for early diagnosis of NSCLC with high AUCs in ROC curve analysis. Logistic regression analysis confirmed the two-miRNA panel as an independent risk factor for NSCLC.
MOLECULAR ONCOLOGY
(2021)
Article
Oncology
Zhiying Gao, Likun Zhou, Jing Bai, Meng Ding, Deshui Liu, Shaohai Zheng, Yuewen Li, Xiulan Li, Xiaojuan Wang, Ming Jin, Huizi Shangting, Changchun Qiu, Cheng Wang, Xiaojie Zhang, Chenyu Zhang, Xi Chen
Summary: This study identified three HCMV-encoded miRNAs that were significantly increased in the plasma of pregnant women with APOs, with hcmv-miR-US25-1-5p showing the highest sensitivity and specificity. These miRNAs could serve as potential noninvasive biomarkers for predicting and monitoring APOs during HCMV infection.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Pediatrics
Cheng Tan, Xiuying Yi, Ying Chen, Shuangshuang Wang, Qing Ji, Fang Li, Yuwen Wang, Runmei Zou, Cheng Wang
Summary: The study aims to explore the ECG changes of children with dilated cardiomyopathy (DCM) when their posture changes, and found that differences in T-wave amplitude and QT interval may have value in diagnosing and predicting the prognosis of DCM. Changes in these parameters before and after treatment could also potentially predict disease response and therapeutic efficacy.
FRONTIERS IN PEDIATRICS
(2021)
Article
Orthopedics
Yu Kang, Chao Liu, Ming Wang, Cheng Wang, Yi-Guo Yan, Wen-Jun Wang
Summary: In this study, a novel rat model of interbody fusion was developed based on anterior lumbar corpectomy and fusion, which more closely resembles clinical surgery. The surgeries were successfully completed with 3D-printed titanium cages, and Micro-CT results showed higher fusion rates, BV/TV, and Tb.N in group B compared to group A.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Physiology
Dandan Li, Pingping Wang, Wenyan Wei, Cheng Wang, Yong Zhong, Lei Lv, Junjun Wang
Summary: The dynamic changes of circulating miRNAs during a 5-km run test at 51-52% maximum oxygen uptake contribute to the adaptive regulation of cardiovascular function. Some specific miRNAs showed significant increases post-exercise and correlated with traditional cardiovascular-related indicators, highlighting their potential role in cardiovascular adaptation during exercise.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ping Liu, Jin Huang, Wanzhen Mei, Xingfang Zeng, Cheng Wang, Chuan Wen, Jing Xu
Summary: The study investigated the protective effect of EGCG on H/R-stimulated cardiomyocytes, showing that EGCG can alleviate cell damage by increasing ATG4C expression. Moreover, overexpression of ATG4C can further enhance the protective effect of EGCG and reduce cell autophagy induced by H/R stimulation.
Article
Immunology
Chao Xia, Wei Huang, Yun-Liang Chen, Hai-Bin Fu, Ming Tang, Tao-Lan Zhang, Jing Li, Guo-Hua Lv, Yi-Guo Yan, Zhi-Hua Ouyang, Nvzhao Yao, Cheng Wang, Ming-Xiang Zou
Summary: This study investigated the expression of PD-L1, HHLA2, B7H3, IDO-1, and Galectin-9 in spinal chordoma and their association with tumor infiltrating lymphocytes, clinicopathological characteristics, and patient survival. The results showed that HHLA2 and PD-L1 were commonly expressed in spinal chordoma and their coexpression independently predicted worse local recurrence-free survival and overall survival. In contrast, stromal levels of PD-L1 and Galectin-9 were associated with better prognosis. This study provides insights into the immunosuppressive mechanism in chordoma and may contribute to the development of improved immunotherapy approaches.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xuemei Luo, Jie Xiong, Hong Cai, Runmei Zou, Fang Li, Yuwen Wang, Cheng Wang
Summary: This study evaluated the mechanism of VD deficiency on the function of cardiac autonomic nervous system (ANS) in rats. The results showed that VD deficiency leads to imbalance in heart rate variability, impaired release and secretion of neurotransmitters and local plasma hormones in the heart, and downregulation of potassium channel protein expression.
CARDIOVASCULAR THERAPEUTICS
(2022)
Article
Clinical Neurology
Ze-Peng Li, Lu-Lu Liu, Hao Liu, Jing-Hua Tan, Xue-Lin Li, Zhun Xu, Zhi-Hua Ouyang, Cheng Wang, Yi-Guo Yan, Jing-Bo Xue
Summary: This study aimed to analyze the factors influencing early recurrence after transforaminal endoscopy lumbar discectomy (TELD) in the treatment of lumbar disc herniation. The study found that postoperative annulus-fibrosus tear size, disc height index (DHI), and location of the herniation were associated with early recurrence. Increased base width of the herniation, severe disc degeneration, decreased cross-sectional area of the foramen (CSAF), and Modic change were identified as risk factors for early recurrence after TELD.
GLOBAL SPINE JOURNAL
(2022)
Article
Engineering, Biomedical
Yijia Liao, Yiguo Yan, Yu Kang, Wenjun Wang, Xizheng Song, Wen Peng, Haibin Fu, Huarong Chen, Cheng Wang
Summary: This study compared the biomechanical characteristics of external spinal fixation and internal fixation system for treating lumbar fracture through finite element analysis. The results showed that the external fixation system had a better stress distribution and overall mobility compared to the internal fixation system.
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2022)
Review
Cardiac & Cardiovascular Systems
Ting Zhao, Shuo Wang, Miao Wang, Hong Cai, Yuwen Wang, Yi Xu, Runmei Zou, Cheng Wang
Summary: This article reviews the value of electrocardiographic indicators in the diagnosis and prognosis of children with vasovagal syncope (VVS).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Cheng Wang, Cuiping Zhang, Quan Fu, Nan Zhang, Meng Ding, Zhen Zhou, Xi Chen, Fengmin Zhang, Chunni Zhang, Chen-Yu Zhang, Jun-Jun Wang
Summary: This study identified three piRNAs with significantly increased levels in the serum of patients with brucellosis. The combination of these three piRNAs could serve as a novel blood-based auxiliary tool for detecting brucellosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Clinical Neurology
Jiahuan Wu, Ying Meng, Fei Xu, Qian Wu, Cheng Wang
Summary: This study investigated the genome-wide biological significance of circulating miRNA markers in adult epileptic seizures patients. The results identified potential biomarkers for adult epilepsy and revealed their functions in cell regulating pathways.
FRONTIERS IN NEUROLOGY
(2022)
Article
Immunology
Cheng Wang, Yunhua Zhu, Penglu Chen, Chen Wang, Wanqing Zhou, Cuiping Zhang, Jing Wang, Xi Chen, Meng Ding, Chunni Zhang, Jun-Jun Wang, Chen-Yu Zhang
Summary: The majority of HCMV miRNAs were significantly upregulated in the serum of fever patients, suggesting their potential role in monitoring HCMV activation status in patients with immune disorders.
FRONTIERS IN IMMUNOLOGY
(2022)