Article
Multidisciplinary Sciences
Suhayl Mulla, Adele R. Ludlam, Aiman Elragig, Cathy Slack, Zita Balklava, Michael Stich, Alex Cheong
Summary: Ageing research aims to identify factors that affect lifespan and understand their effects. This study introduces a bilogistic model to describe the shape of lifespan curves in Caenorhabditis elegans. The model provides a better fit to experimental data than other models, and can identify and confirm biphasic lifespan data.
ROYAL SOCIETY OPEN SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Shiling Feng, Chunyan Zhang, Tao Chen, Lijun Zhou, Yan Huang, Ming Yuan, Tian Li, Chunbang Ding
Summary: The study found that OLE significantly prolongs the lifespan of Caenorhabditis elegans and increases their resistance to lethal heat shock and oxidative stress. OLE regulates stress resistance and lifespan extension in nematodes through the activation of the IIS and SKN-1/Nrf2 signaling pathways.
Article
Biochemistry & Molecular Biology
Jeroen Dobbelaere, Tiffany Y. Su, Balazs Erdi, Alexander Schleiffer, Alexander Dammermann
Summary: Cilia are cellular projections that perform sensory and motile functions in eukaryotic cells. In this study, a set of 386 human genes associated with cilium assembly or motility were identified by analyzing the presence and absence pattern in the genomes of diverse eukaryotes. The novel genes were further characterized and found to be related to cilium defects in fruit flies and nematodes. This dataset defines the core set of genes required for cilium assembly and motility across eukaryotes and provides a valuable resource for future studies.
Article
Biochemistry & Molecular Biology
Nattapong Wongchum, Ananya Dechakhamphu
Summary: The study found that XN supplementation can extend the lifespan of fruit flies, increase their antioxidant enzyme activities, improve their survival rates against hydrogen peroxide and paraquat, and enhance their resistance to cold and heat shock as well as starvation stress.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Review
Cell Biology
Aleksandra Dabrowska, Juhi Kumar, Charalampos Rallis
Summary: Cellular and animal models have played a crucial role in understanding the relationship between diet, nutrient-response signaling pathways, and lifespan regulation. Recent advancements in drug treatments, mutagenesis, and high-throughput screens have provided valuable insights into cellular metabolism, development, and aging. Scientists are now focusing on characterizing growth and stress pathways to identify interventions for healthy aging and age-related diseases.
Article
Geriatrics & Gerontology
Caglar Berkel, Ercan Cacan
Summary: The research focused on aging and lifespan-extending compounds across different model organisms such as yeast, worms, flies and mice. The study identified aspirin as the compound with the highest percent increase in average lifespan when data from all organisms studied were combined, followed by minocycline, N-acetyl cysteine, nordihydroguaiaretic acid and rapamycin. Additionally, it was found that minocycline led to the highest percent increase in average lifespan among other compounds in fruit flies and nematodes.
Article
Multidisciplinary Sciences
Masaharu Uno, Yuri Tani, Masanori Nono, Emiko Okabe, Saya Kishimoto, Chika Takahashi, Ryoji Abe, Takuya Kurihara, Eisuke Nishida
Summary: The study highlights the importance of communication between neuronal DAF-16 and intestinal DAF-16 in regulating organismal lifespan.
Article
Microbiology
Fang Zhang, Liying Wang, Jiayu Jin, Yulu Pang, Hao Shi, Ziyi Fang, Han Wang, Yujie Du, Yufan Hu, Yingchun Zhang, Xiaoyue Ding, Zuobin Zhu
Summary: This study investigated the impact of Escherichia coli mutant strains on fruit fly lifespan and found that feeding E. coli purE strain resulted in the longest lifespan in fruit flies, which was also validated in Caenorhabditis elegans. RNA sequencing and analysis revealed that E. coli mutant strains affect lifespan by regulating protein synthesis rate and ATP levels. This research provides new insights into the genetic influences of gut microbiota on host lifespan and offers a foundation for developing anti-aging probiotics and drugs.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiao-Shuai Zhang, Wen-Sheng Li, Wei-Hua Xu
Summary: Previous studies have shown that high levels of reactive oxygen species can induce diapause and extend lifespan in the moth Helicoverpa armigera. This occurs through the activation of c-Jun N-terminal kinase and subsequent upregulation of PRMT1 expression, which prevents Akt-mediated FoxO phosphorylation and promotes diapause initiation. This study provides insight into the complex regulatory mechanism of pupal diapause and lifespan extension in H. armigera.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Shengjie Fan, Yingxuan Yan, Ying Xia, Zhenyu Zhou, Lingling Luo, Mengnan Zhu, Yongli Han, Deqiang Yao, Lijun Zhang, Minglv Fang, Lina Peng, Jing Yu, Ying Liu, Xiaoyan Gao, Huida Guan, Hongli Li, Changhong Wang, Xiaojun Wu, Huanhu Zhu, Yu Cao, Cheng Huang
Summary: Using C. elegans as a model, researchers found that nomilin, a compound found in citrus fruit, significantly extended the lifespan, healthspan, and toxin resistance of the nematodes. This anti-aging effect was dependent on specific pathways and nuclear hormone receptors. Additionally, nomilin was identified to directly bind with the human pregnane X receptor (hPXR). In animal studies, dietary supplementation of nomilin improved healthspan and lifespan, and induced a gene signature associated with longevity.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Dario R. Gomez-Linton, Silvestre Alavez, Arturo Navarro-Ocana, Angelica Roman-Guerrero, Luis Pinzon-Lopez, Laura J. Perez-Flores
Summary: The study found that achiote seed extract and its main compounds have significant modulatory effects on the lifespan and stress responses of Caenorhabditis elegans, increasing lifespan, antioxidant activity, and thermal stress resistance without adverse effects on fertility. These effects are independent of caloric restriction but dependent on the insulin/insulin growth factor-1 pathway.
Article
Chemistry, Medicinal
Jing-Shan Wu, Chun-Guo Lin, Chang-Long Jin, Yan-Xia Zhou, Ying-Xiu Li
Summary: The marine bacterium Planococcus maritimu ML1206 was found to have antioxidant properties and could enhance the ability of nematodes to resist oxidative stress and extend their lifespan. These findings suggest that ML1206 has potential anti-aging and antioxidant functions and could be used in aquaculture and as a dietary supplement.
Article
Biochemistry & Molecular Biology
Monica Filaferro, Alessandro Codeluppi, Virginia Brighenti, Francesca Cimurri, Ana Maria Gonzalez-Paramas, Celestino Santos-Buelga, Davide Bertelli, Federica Pellati, Giovanni Vitale
Summary: In this study, an autochthonous variety of sweet cherry was processed to prepare polyphenol-rich extracts, which showed protective effects against Parkinson's disease and oxidative stress. The findings suggest that these extracts could be potential candidates for the formulation of nutraceutical products to prevent oxidative stress-induced disorders.
Article
Cell Biology
Nan Xin, Jenni Durieux, Chunxia Yang, Suzanne Wolff, Hyun-Eui Kim, Andrew Dillin
Summary: The mitochondrial unfolded protein response (UPRmt) maintains mitochondrial proteostasis by regulating the transcription factor ATFS-1. After UPRmt activation, ATFS-1 enters the nucleus to regulate UPRmt genes. The study found that despite reduced mitochondrial membrane potential, mitochondrial import increases during UPRmt activation, and an intact import machinery is essential for UPRmt-mediated lifespan extension.
JOURNAL OF CELL BIOLOGY
(2022)
Review
Nutrition & Dietetics
Xinlu Guo, Junjie Luo, Jingyi Qi, Xiya Zhao, Peng An, Yongting Luo, Guisheng Wang
Summary: The increasing elderly proportion of the population poses burdens on society, the economy, and the medical field. Polysaccharides have gained attention for their potential use in anti-aging therapies due to their natural and efficient biological properties, including antioxidant, anti-inflammatory, and immune regulatory activities.
Article
Geriatrics & Gerontology
Mikhail V. V. Shaposhnikov, Anastasia A. A. Gorbunova, Nadezhda V. V. Zemskaya, Natalia S. S. Ulyasheva, Natalya R. R. Pakshina, Daria V. V. Yakovleva, Alexey Moskalev
Summary: This study investigated the geroprotective effects of individual and simultaneous overexpression of genes encoding key enzymes of H2S biosynthesis on a Drosophila melanogaster model. Simultaneous overexpression of CBS and CSE showed additive effects in males and synergistic effects in females on median lifespan. Individual overexpression of CBS increased thermotolerance and decreased transcription levels of stress-responsive transcription factors HIF1 and Hsf, while individual overexpression of CSE increased paraquat resistance. Simultaneous overexpression of both genes increased resistance to hyperthermia in old females or paraquat in old males. The findings suggest a sex-specific epistatic interaction between CBS and CSE overexpression effects on longevity and stress resistance.
Letter
Gastroenterology & Hepatology
Daniil Rafaelevich Markaryan, Aleksandr Maksimovich Lukianov, Tatiana Nikolaevna Garmanova, Ekaterina Aleksandrovna Kazachenko, Aleksey Igorevich Moskalev, Bruno Roche
COLORECTAL DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Anastasiya Snezhkina, Maria Fedorova, Anastasiya Kobelyatskaya, Daria Markova, Margarita Lantsova, Anna Ikonnikova, Marina Emelyanova, Dmitry Kalinin, Elena Pudova, Nataliya Melnikova, Alexey Dmitriev, George Krasnov, Vladislav Pavlov, Anna Kudryavtseva
Summary: In this study, a high frequency missense variant p.H102R in the SDHD gene was found in an extended cohort of Russian HNPGL patients using whole-exome sequencing. The variant was associated with somatic loss of the gene wild-type allele and evident LOH at the 11p15.5 region and potential loss of the whole of chromosome 11. These findings help with understanding the mechanism of tumorigenesis and are important for the development of cost-effective genetic screening programs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Elena Yushkova, Alexey Moskalev
Summary: Transposable elements (TEs) play a crucial role in eukaryotic genomes, impacting aging, carcinogenesis, and other age-related diseases. This review explores the fundamental properties of TEs and their complex interactions with cellular processes, highlighting their diverse effects on genetics and epigenetics. The review discusses TEs' interactions with recombination, replication, repair, and chromosomal regulation, their ability to balance activity and repression, their involvement in gene creation and RNA expression, and their role in DNA damage and regulatory networks. The review also evaluates the contribution of derepressed TEs to age-related effects in individual cells and tissues. Conflicting information about TE activity under stress and theories related to aging mechanisms are addressed. Furthermore, the review examines the specific impact of TEs on aging processes in germline and soma, as well as the regulation of TEs in cells. Recent findings on somatic mutations in human and animal tissues are discussed, focusing on their potential functional consequences. Additionally, the review explores the correlation between somatic TE activation and age-related changes in heterochromatin maintenance and longevity regulation. Notably, the review also explores the differences between transposon- and retrotransposon-mediated structural genome changes and their association with aging and age-related pathologies. Finally, based on published data, the review proposes a hypothesis regarding the influence of species-specific features of TE number, composition, and distribution on aging dynamics in different animal genomes.
AGEING RESEARCH REVIEWS
(2023)
Article
Gastroenterology & Hepatology
Vladimir Ivashkin, Oleg Shifrin, Roman Maslennikov, Elena Poluektova, Alexander Korolev, Anna Kudryavtseva, George Krasnov, Nona Benuni, Giovanni Barbara
Summary: This study investigated the changes in the fecal microbiome of patients with symptomatic uncomplicated diverticular disease (SUDD) after repeated monthly treatment with rifaximin and found that rifaximin effectively decreased abdominal pain in these patients. The study also showed that rifaximin increased the abundance of beneficial microbial elements in the gut.
BMC GASTROENTEROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anastasiya Snezhkina, Vladislav Pavlov, Maria Fedorova, Dmitry Kalinin, Elena Pudova, Anastasiya Kobelyatskaya, Ildar Bakhtogarimov, George Krasnov, Anna Kudryavtseva
Summary: Malignant middle ear paraganglioma (MEPGL) is a rare neuroendocrine tumor. A case of malignant MEPGL was studied using comprehensive genetic analysis. A germline pathogenic mutation in the SDHB gene was identified, along with five novel somatic variants. The analysis showed the presence of specific mutation signatures and revealed the importance of SDHB mutation combined with loss of heterozygosity in tumor initiation and progression. These findings enhance our understanding of the molecular genetic mechanisms associated with this rare tumor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yulia S. Vershinina, George S. Krasnov, David G. Garbuz, Mikhail V. Shaposhnikov, Maria S. Fedorova, Elena A. Pudova, Irina V. Katunina, Alexey B. Kornev, Nadezhda V. Zemskaya, Alexander A. Kudryavtsev, Elizaveta V. Bulavkina, Anna A. Matveeva, Natalia S. Ulyasheva, Zulfiya G. Guvatova, Artemiy A. Anurov, Alexey A. Moskalev, Anna V. Kudryavtseva
Summary: Torin-2 is a highly selective inhibitor of TORC1 and TORC2 complexes, which can be used as an alternative to rapamycin. It has lower concentrations and fewer side effects than rapamycin. Our study evaluated the transcriptomic changes induced by Torin-2 in the heads of fruit flies and suggested possible neuroprotective mechanisms. Torin-2 had a slight positive effect on the lifespan of male flies but no positive effect on females.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Denis A. A. Golubev, Nadezhda V. V. Zemskaya, Anastasia A. A. Gorbunova, Daria V. V. Kukuman, Alexey Moskalev, Mikhail V. V. Shaposhnikov
Summary: Inhibition of YAP/TAZ with pharmacological inhibitors increases the lifespan of Drosophila melanogaster by decreasing the expression levels of wg and E2f1 genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Anastasiia V. Badaeva, Alexey B. Danilov, Paul Clayton, Alexey A. Moskalev, Alexander V. Karasev, Andrey F. Tarasevich, Yulia D. Vorobyeva, Viacheslav N. Novikov
Summary: Neuronutrition is a part of nutritional neuroscience that studies the effects of different dietary components on behavior and cognition. It also encompasses the use of various nutrients and diets to prevent and treat neurological disorders. This narrative review explores the current understanding of neuronutrition as a key concept for brain health and its potential application in the prevention and treatment of various disorders.
Article
Biochemistry & Molecular Biology
Fedor I. I. Isaev, Arsenii R. R. Sadykov, Alexey Moskalev
Summary: Based on blood parameters, we investigated the influence of Kivach Clinic's special medical spa program on the biological age of patients. The results showed that the spa treatment has the potential to reduce biological age.
Article
Biochemistry & Molecular Biology
Anastasiya A. Kobelyatskaya, Elena A. Pudova, Irina V. Katunina, Anastasiya V. Snezhkina, Maria S. Fedorova, Vladislav S. Pavlov, Anastasiya O. Kotelnikova, Kirill M. Nyushko, Boris Y. Alekseev, George S. Krasnov, Anna V. Kudryavtseva
Summary: This study used RNA-Seq profiling to analyze localized and locally advanced prostate cancer tissue samples from Russian patients. The study identified different transcriptome profiles and affected biological processes within high-risk and intermediate risk groups, providing potential therapeutic targets and prognostic markers for the considered categories of prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
A. P. Karmanov, L. S. Kocheva, O. V. Raskosha, A. A. Moskalev
Summary: This paper presents studies on the chemical and topological structure of lignin macromolecules from various herbaceous plants. The composition and properties of the biopolymers were determined using 13C-NMR spectroscopy, electron paramagnetic resonance, FTIR spectroscopy, and Py-GC/MS spectrometry. The results show that lignin from Rhodiola rosea belongs to the class of star-shaped polymers, and it has geroprotective properties and improves the cognitive abilities of model animals.
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Elena A. Pudova, Anastasiya A. Kobelyatskaya, Irina V. Katunina, Anastasiya V. Snezhkina, Maria S. Fedorova, Vladislav S. Pavlov, Ildar R. Bakhtogarimov, Margarita S. Lantsova, Sergey P. Kokin, Kirill M. Nyushko, Boris Ya. Alekseev, Dmitry V. Kalinin, Nataliya V. Melnikova, Alexey A. Dmitriev, George S. Krasnov, Anna V. Kudryavtseva
Summary: Radical prostatectomy is the gold standard treatment for prostate cancer, but complete cure is not always achieved and recurrence is common. The current methods for assessing prognosis and choosing treatment strategies in PCa patients are not sufficient and new markers are needed. This study used RNA-Seq to identify potential prognostic markers at the gene expression and miRNA levels associated with cancer aggressiveness. The expression of candidate markers was validated and the predictive value of different marker combinations was analyzed using machine learning algorithms, with the CST2 + OCLN + pT model showing the highest potential (AUC = 0.863) based on CatBoost Classifier algorithm.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zulfiya G. Guvatova, Anastasiya A. Kobelyatskaya, Elena A. Pudova, Irina V. Tarasova, Anna V. Kudryavtseva, Olga N. Tkacheva, Irina D. Strazhesko, Alexey A. Moskalev
Summary: This study estimated the epigenetic age of long-lived individuals and found that their epigenetic age was significantly lower than their chronological age, indicating a slowing of aging. However, there were no significant differences in epigenetic age between healthy long-lived individuals and those with frailty, and no differences in epigenetic age were observed based on sex. The study emphasizes the need for further research on the epigenetic status of centenarians.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
