A Personal Retrospective: Elevating Anandamide (AEA) by Targeting Fatty Acid Amide Hydrolase (FAAH) and the Fatty Acid Binding Proteins (FABPs)

Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain

(2016) Emma Leishman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

New report on drug trial disaster in France

(2016) Barbara Casassus   LANCET

Fatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias

(2016) Friedhelm Schroeder et al.   LIPIDS

Fatty acid amide hydrolase inhibitors: a patent review (2009 – 2014)

(2015) Alessio Lodola et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Fatty Acid-binding Proteins (FABPs) Are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)

(2015) Matthew W. Elmes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Targets of Cannabidiol in Neurological Disorders

(2015) Clementino Ibeas Bih et al.   Neurotherapeutics

Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice

(2014) Simon Nicolussi et al.   PHARMACOLOGICAL RESEARCH

New players in the fatty acyl ethanolamide metabolism

(2014) Iffat Ara Sonia Rahman et al.   PHARMACOLOGICAL RESEARCH

Involvement of Fatty Acid Amide Hydrolase and Fatty Acid Binding Protein 5 in the Uptake of Anandamide by Cell Lines with Different Levels of Fatty Acid Amide Hydrolase Expression: A Pharmacological Study

(2014) Emmelie Björklund et al.   PLoS One

Has FLAT fallen flat?

(2014) Christopher J. Fowler   TRENDS IN PHARMACOLOGICAL SCIENCES

Crystallographic study of FABP5 as an intracellular endocannabinoid transporter

(2014) Benoît Sanson et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Transport of endocannabinoids across the plasma membrane and within the cell

(2013) Christopher J. Fowler   FEBS Journal

Role of FAAH-Like Anandamide Transporter in Anandamide Inactivation

(2013) KwanNok Leung et al.   PLoS One

Anandamide Externally Added to Lipid Vesicles Containing-Trapped Fatty Acid Amide Hydrolase (FAAH) Is Readily Hydrolyzed in a Sterol-Modulated Fashion

(2012) Martin Kaczocha et al.   ACS Chemical Neuroscience

Fatty Acid Amide Hydrolase Inhibitors – Progress and Potential

(2012) Ish K. Khanna et al.   CNS & Neurological Disorders-Drug Targets

Inhibitory properties of ibuprofen and its amide analogues towards the hydrolysis and cyclooxygenation of the endocannabinoid anandamide

(2012) Christopher J. Fowler et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee

(2012) John P. Huggins et al.   PAIN

Targeting Fatty Acid Binding Protein (FABP) Anandamide Transporters – A Novel Strategy for Development of Anti-Inflammatory and Anti-Nociceptive Drugs

(2012) William T. Berger et al.   PLoS One

Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia

(2012) F M Leweke et al.   Translational Psychiatry

Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways

(2011) Kazuhito Tsuboi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Endocannabinoid tone versus constitutive activity of cannabinoid receptors

(2011) Allyn C. Howlett et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fatty Acid-binding Proteins TransportN-Acylethanolamines to Nuclear Receptors and Are Targets of Endocannabinoid Transport Inhibitors

(2011) Martin Kaczocha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A catalytically silent FAAH-1 variant drives anandamide transport in neurons

(2011) Jin Fu et al.   NATURE NEUROSCIENCE

Unique pathway for anandamide synthesis and liver regeneration

(2011) A. A. Izzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver

(2011) B. Mukhopadhyay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo

(2010) Gabriel M. Simon et al.   Molecular BioSystems

Exploiting Nanotechnologies and TRPV1 Channels to Investigate the Putative Anandamide Membrane Transporter

(2010) Alessia Ligresti et al.   PLoS One

The Insertion and Transport of Anandamide in Synthetic Lipid Membranes Are Both Cholesterol-Dependent

(2009) Eric Di Pasquale et al.   PLoS One

Identification of intracellular carriers for the endocannabinoid anandamide

(2009) M. Kaczocha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

(2008) Masato Furuhashi et al.   NATURE REVIEWS DRUG DISCOVERY

Structure-guided inhibitor design for human FAAH by interspecies active site conversion

(2008) M. Mileni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple pathways involved in the biosynthesis of anandamide

(2007) Jie Liu et al.   NEUROPHARMACOLOGY