Article
Environmental Sciences
Melanie Blanc-Legendre, Sacha Sire, Armelle Christophe, Francois Brion, Marie-Laure Begout, Xavier Cousin
Summary: This study found that exposure to various estrogenic endocrine disruptors (EDs) can cause behavioral alterations in zebrafish during the embryonic period, including three previously unknown bisphenol substitutes. However, there is currently no consensus on the effects of these substances. Although these behavioral changes are unrelated to the specificity or structure of substances that regulate brain aromatase (aroB), the behavioral effects of estrogenic EDs should not be neglected in the context of environmental safety.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Akira Kubota, Masashi Hirano, Yuka Yoshinouchi, Xing Chen, Michiko Nakamura, Yumi Wakayama, Jae Seung Lee, Haruhiko Nakata, Hisato Iwata, Yusuke K. Kawai
Summary: This study evaluated the estrogen-like effects of bisphenol A (BPA) and its analogs (BPs) using zebrafish. Most BPs concentration-dependently induced the expression of CYP19A1b, which was suppressed by a nonselective estrogen receptor antagonist. The EC50 values and relative potencies of BPs in inducing CYP19A1b expression were estimated, and some BPs showed greater estrogenic potency than BPA. Molecular docking simulations revealed lower interaction energies of certain BPs with zebrafish estrogen receptor subtypes compared to BPA, which correlated with their in vivo potencies.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Manuel S. Vidal, Ramkumar Menon, Gracia Fe B. Yu, Melissa D. Amosco
Summary: This article summarizes the possible mechanisms of action of bisphenols on preterm birth by conducting an integrative literature search. The results suggest that bisphenols may have adverse effects on the placenta, decidua, and fetal membranes, leading to failure of pregnancy maintenance and preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Karolina Nowak, Ziga Jakopin
Summary: Due to concerns about endocrine disruption, bisphenol A (BPA) is being phased out and replaced with other substances. This study aimed to evaluate the endocrine-disrupting potential of 18 BPA analogues and their halogenated derivatives. The results showed that some BPA analogues displayed higher endocrine disruption potential than BPA itself. Halogenation was predicted to increase the binding affinity of bisphenols for certain nuclear receptors. Further in vitro experiments are needed to confirm these findings and evaluate the safety of BPA substitutes and their halogenated transformation products.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biology
Jieyi Yuan, Jingwen Yang, Xiuwen Xu, Zexianghua Wang, Zhijing Jiang, Zhiqing Ye, Yucheng Ren, Qing Wang, Tianming Wang
Summary: This study investigated the effects of Bisphenol A (BPA) on the reproduction of sea cucumbers and found that BPA can cause reproductive toxicity by interfering with the endocrine system. They also identified the role of G protein-coupled estrogen receptor 1 (GPER1) in sea cucumber reproduction.
Article
Neurosciences
Jessica M. Rosin, Nikol Tretiakov, Emily Hanniman, Kiana Hampton, Deborah M. Kurrasch
Summary: This study found that gestational exposure to BPA can impact the number and morphology of embryonic hypothalamic microglia, but does not significantly affect their activation level and cytokine secretion.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Marine & Freshwater Biology
Maria A. Risalde, Ana Ma Molina, Antonio J. Lora, Nahum Ayala, Jose C. Gomez-Villamandos, Ma Rosario Moyano
Summary: This study evaluated the expression of cyp19a aromatase in zebrafish after exposure to different concentrations of BPA, finding that these aromatases are overexpressed and could be good biomarkers for identifying early effects of low BPA concentrations. The study is the first to localize and quantify the expression of cyp19a1a and cyp19a1b in the cells of brain and ovary after fish exposure to BPA.
AQUATIC TOXICOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Siemon De Nys, Eveline Putzeys, Radu Corneliu Duca, Philippe Vervliet, Adrian Covaci, Imke Boonen, Marc Elskens, Jeroen Vanoirbeek, Lode Godderis, Bart Van Meerbeek, Kirsten L. Van Landuyt
Summary: The study successfully quantified the one-year release of BPA from four commercial materials using an optimized analytical method. Results showed that BPA continuously eluted from all tested composites over a year when ethanol was used as the extraction solvent, while in water, BPA release could be detected for up to a year but levels could not be accurately quantified after several weeks.
Review
Toxicology
Henrique Eloi Costa, Elisa Cairrao
Summary: Bisphenol A (BPA) is a widely produced synthetic compound that can disrupt the endocrine system and have detrimental effects on the neurological system. Exposure to BPA can lead to oxidative stress, changes in gene and protein expression, neuronal damage, and increased risk of neurologic diseases such as stroke, Alzheimer's, and Parkinson's. Epidemiological studies have also shown that BPA exposure during neurodevelopment can contribute to the emergence of disorders such as ADHD, ASD, depression, and cognitive disorders.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Food Science & Technology
Iris Reina-Perez, Alicia Olivas-Martinez, Vicente Mustieles, Francisco Javier Ruiz-Ojeda, Jose Manuel Molina-Molina, Nicolas Olea, Mariana F. Fernandez
Summary: BPF and BPS were found to increase intracellular lipid accumulation and affect gene expression related to adipogenesis in human adipose-derived stem cells; their obesogenic effects may involve multiple pathways. This study reveals for the first time the obesogenic potential of BPF in human adipose-derived stem cells.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
David A. Geier, Mark R. Geier
Summary: A study using NHANES data found that 82% of the tested individuals in the United States had detectable concentrations of glyphosate in their urine. There was a significant inverse correlation between glyphosate concentrations and total testosterone and total estradiol concentrations, but no correlation with sex hormone binding globulin concentrations.
Article
Engineering, Environmental
Pengyu Chen, Jing Yang, Bowen Xiao, Yanfeng Zhang, Shuai Liu, Lingyan Zhu
Summary: The research demonstrates that graphene oxide (GO) can alleviate the developmental toxicity induced by bisphenol A (BPA) and recover the affected gene pathways, improving the endocrine disruption effects caused by BPA.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Iris Reina-Perez, Alicia Olivas-Martinez, Vicente Mustieles, Elena Salamanca-Fernandez, Jose Manuel Molina-Molina, Nicolas Olea, Mariana F. Fernandez
Summary: This study investigated the combined effect of bisphenol A (BPA) and its substitutes, bisphenol F (BPF) and S (BPS), on the adipogenic differentiation of human adipose-derived stem cells (hASCs). The researchers found that the mixture of bisphenols promoted lipid accumulation in the cells in a dose-dependent manner, with a maximal response at 10 μM. The effect was mediated by the estrogen receptor, and the mixture also altered the expression of adipogenic markers in a non-monotonic dose-response pattern.
Article
Biochemistry & Molecular Biology
Aeman Zahra, Rachel Kerslake, Ioannis Kyrou, Harpal S. Randeva, Cristina Sisu, Emmanouil Karteris
Summary: This paper presents a detailed analysis of the changes in gene expression in normal human ovarian cells treated with the xenoestrogen BPA. The study reveals that BPA exposure affects the expression of several genes, including those related to oocyte maturation. Further research is needed to explore the effects of BPA in ovarian health and disease using validated in vitro and in vivo models, in order to fill knowledge gaps in basic biology, hazard characterization, and risk assessment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Ignacio Babiloni-Chust, Reinaldo S. dos Santos, Regla M. Medina-Gali, Atenea A. Perez-Serna, Jose-Antonio Encinar, Juan Martinez-Pinna, Jan-Ake Gustafsson, Laura Marroqui, Angel Nadal
Summary: 17 beta-estradiol protects pancreatic beta-cells from apoptosis via estrogen receptors ER alpha, ER beta, and GPER. Conversely, the endocrine disruptor bisphenol-A (BPA) increases basal apoptosis in the same cell type through the same estrogen receptors. The molecular events that trigger these opposite actions have not been identified yet.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Pascal Coumailleau, Elisabeth Pellegrini, Fatima Adrio, Nicolas Diotel, Joel Cano-Nicolau, Ahmed Nasri, Colette Vaillant, Olivier Kah
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2015)
Article
Developmental Biology
Nicolas Diotel, Colette Vaillant, Olivier Kah, Elisabeth Pellegrini
GENE EXPRESSION PATTERNS
(2016)
Article
Toxicology
Lina Chouchene, Elisabeth Pellegrini, Marie-Madeleine Gueguen, Nathalie Hinfray, Francois Brion, Benjamin Piccini, Olivier Kah, Khaled Said, Imed Messaoudi, Farzad Pakdel
JOURNAL OF APPLIED TOXICOLOGY
(2016)
Article
Pharmacology & Pharmacy
Joel Cano-Nicolau, Clementine Garoche, Nathalie Hinfray, Elisabeth Pellegrini, Noureddine Boujrad, Farzad Pakdel, Olivier Kah, Francois Brion
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2016)
Article
Neurosciences
Pietro Cacialli, Livia D'angelo, Olivier Kah, Pascal Coumailleau, Marie-Madeleine Gueguen, Elisabeth Pellegrini, Carla Lucini
JOURNAL OF COMPARATIVE NEUROLOGY
(2018)
Review
Cell Biology
Pietro Cacialli, Antonio Palladino, Carla Lucini
NEURAL REGENERATION RESEARCH
(2018)
Review
Neurosciences
Nicolas Diotel, Thierry D. Charlier, Christian Lefebvre d'Hellencourt, David Couret, Vance L. Trudeau, Joel C. Nicolau, Olivier Meilhac, Olivier Kah, Elisabeth Pellegrini
FRONTIERS IN NEUROSCIENCE
(2018)
Article
Neurosciences
Maria Rita Perez, Elisabeth Pellegrini, Joel Cano-Nicolau, Marie-Madeleine Gueguen, Dounia Menouer-Le Guillou, Yohann Merot, Colette Vaillant, Gustavo M. Somoza, Olivier Kah
EUROPEAN JOURNAL OF NEUROSCIENCE
(2013)
Review
Behavioral Sciences
Nicolas Diotel, Colette Vaillant, Cyril Gabbero, Svetlana Mironov, Alexis Fostier, Marie-Madeleine Gueguen, Isabelle Anglade, Olivier Kah, Elisabeth Pellegrini
HORMONES AND BEHAVIOR
(2013)
Article
Anatomy & Morphology
Livia D'Angelo, Paolo de Girolamo, Alessandro Cellerino, Eva Terzibasi Tozzini, Luciana Castaldo, Carla Lucini
MICROSCOPY RESEARCH AND TECHNIQUE
(2012)
Article
Multidisciplinary Sciences
Pietro Cacialli, Marie-Madeleine Gueguen, Pascal Coumailleau, Livia D'Angelo, Olivier Kah, Carla Lucini, Elisabeth Pellegrini
Review
Biochemistry & Molecular Biology
Carla Lucini, Livia D'Angelo, Pietro Cacialli, Antonio Palladino, Paolo de Girolamo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Anatomy & Morphology
Pietro Cacialli, Livia D'Angelo, Paolo de Girolamo, Luigi Avallone, Carla Lucini, Elisabeth Pellegrini, Luciana Castaldo
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2018)
Article
Endocrinology & Metabolism
Olivier Kah, Elisabeth Pellegrini, Colette Valliant, Francois Brion
CORRESPONDANCES EN METABOLISMES HORMONES DIABETES ET NUTRITION
(2014)