A Hypothesis for Using Pathway Genetic Load Analysis for Understanding Complex Outcomes in Bilirubin Encephalopathy

Pre- or post-ischemic bilirubin ditaurate treatment reduces oxidative tissue damage and improves cardiac function

(2016) Bhavisha Bakrania et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Unbound Bilirubin and Auditory Neuropathy Spectrum Disorder in Late Preterm and Term Infants with Severe Jaundice

(2016) Sanjiv B. Amin et al.   JOURNAL OF PEDIATRICS

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Neonatal Jaundice in Low- and Middle-Income Countries: Lessons and Future Directions from the 2015 Don Ostrow Trieste Yellow Retreat

(2016) Chiara Greco et al.   Neonatology

Serum unbound bilirubin as a predictor for clinical kernicterus in extremely low birth weight infants at a late age in the neonatal intensive care unit

(2015) Ichiro Morioka et al.   BRAIN & DEVELOPMENT

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

(2015) Sue Richards et al.   GENETICS IN MEDICINE

A Randomized Trial of Phototherapy with Filtered Sunlight in African Neonates

(2015) Tina M. Slusher et al.   NEW ENGLAND JOURNAL OF MEDICINE

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

The clinical syndrome of bilirubin-induced neurologic dysfunction

(2015) Vinod K. Bhutani et al.   Seminars in Fetal & Neonatal Medicine

Why is kernicterus still a major cause of death and disability in low-income and middle-income countries?

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Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

A general framework for estimating the relative pathogenicity of human genetic variants

(2014) Martin Kircher et al.   NATURE GENETICS

Serum Bilirubin and Bilirubin/Albumin Ratio as Predictors of Bilirubin Encephalopathy

(2014) I. Iskander et al.   PEDIATRICS

The Natural History of Jaundice in Predominantly Breastfed Infants

(2014) M. J. Maisels et al.   PEDIATRICS

The Bilirubin Albumin Ratio in the Management of Hyperbilirubinemia in Preterm Infants to Improve Neurodevelopmental Outcome: A Randomized Controlled Trial – BARTrial

(2014) Christian V. Hulzebos et al.   PLoS One

Hyperbilirubinemia, hemolysis, and increased bilirubin neurotoxicity

(2014) Michael Kaplan et al.   SEMINARS IN PERINATOLOGY

Bilirubin–albumin binding, bilirubin/albumin ratios, and free bilirubin levels: Where do we stand?

(2014) Christian V. Hulzebos et al.   SEMINARS IN PERINATOLOGY

Gene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data

(2013) Yu Liu et al.   BMC Systems Biology

Post-GWAS: where next? More samples, more SNPs or more biology?

(2013) P Marjoram et al.   HEREDITY

Genetics and Pediatric Unconjugated Hyperbilirubinemia

(2013) Jon F. Watchko   JOURNAL OF PEDIATRICS

Rat Cerebellar Slice Cultures Exposed to Bilirubin Evidence Reactive Gliosis, Excitotoxicity and Impaired Myelinogenesis that Is Prevented by AMPA and TNF-α Inhibitors

(2013) Andreia Barateiro et al.   MOLECULAR NEUROBIOLOGY

Bilirubin-Induced Neurologic Damage — Mechanisms and Management Approaches

(2013) Jon F. Watchko et al.   NEW ENGLAND JOURNAL OF MEDICINE

Predischarge Screening for Severe Neonatal Hyperbilirubinemia Identifies Infants Who Need Phototherapy

(2012) Vinod K. Bhutani et al.   JOURNAL OF PEDIATRICS

Unconjugated Bilirubin Restricts Oligodendrocyte Differentiation and Axonal Myelination

(2012) Andreia Barateiro et al.   MOLECULAR NEUROBIOLOGY

An anatomically comprehensive atlas of the adult human brain transcriptome

(2012) Michael J. Hawrylycz et al.   NATURE

ER Stress, Mitochondrial Dysfunction and Calpain/JNK Activation are Involved in Oligodendrocyte Precursor Cell Death by Unconjugated Bilirubin

(2012) Andreia Barateiro et al.   NEUROMOLECULAR MEDICINE

Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10

(2012) Sandra L. Silva et al.   NEUROPHARMACOLOGY

Bilirubin accumulation and Cyp mRNA expression in selected brain regions of jaundiced Gunn rat pups

(2012) Silvia Gazzin et al.   PEDIATRIC RESEARCH

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Evolving Landscape of Neurotoxicity by Unconjugated Bilirubin: Role of Glial Cells and Inflammation

(2012) Dora Brites   Frontiers in Pharmacology

Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin

(2011) Ana R. Vaz et al.   EXPERIMENTAL NEUROLOGY

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(2011) Jurg Ott et al.   NATURE REVIEWS GENETICS

Risk Factors for Neurotoxicity in Newborns With Severe Neonatal Hyperbilirubinemia

(2011) R. Gamaleldin et al.   PEDIATRICS

Bilirubin Injury to Neurons and Glial Cells: New Players, Novel Targets, and Newer Insights

(2011) Dora Brites   SEMINARS IN PERINATOLOGY

Auditory Impairment in Infants at Risk for Bilirubin-Induced Neurologic Dysfunction

(2011) Steven M. Shapiro et al.   SEMINARS IN PERINATOLOGY

Pathway genetic load allows simultaneous evaluation of multiple genetic associations

(2010) Ryan M. Huebinger et al.   BURNS

Features of bilirubin-induced reactive microglia: From phagocytosis to inflammation

(2010) Sandra L. Silva et al.   NEUROBIOLOGY OF DISEASE

Genomewide Association Studies and Assessment of the Risk of Disease

(2010) Teri A. Manolio   NEW ENGLAND JOURNAL OF MEDICINE

Chronic bilirubin encephalopathy: diagnosis and outcome

(2010) Steven M. Shapiro   Seminars in Fetal & Neonatal Medicine

Visual assessment of jaundice in term and late preterm infants

(2009) R Keren et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

A transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells

(2009) Raffaella Calligaris et al.   BMC GENOMICS

Unbound (Free) Bilirubin: Improving the Paradigm for Evaluating Neonatal Jaundice

(2009) C. E. Ahlfors et al.   CLINICAL CHEMISTRY

Genome-wide association meta-analysis for total serum bilirubin levels

(2009) A. D. Johnson et al.   HUMAN MOLECULAR GENETICS

Bilirubin selectively inhibits cytochromecoxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid

(2009) Ana Rita Vaz et al.   JOURNAL OF NEUROCHEMISTRY

Exploring the genetic architecture of neonatal hyperbilirubinemia

(2009) Jon F. Watchko et al.   Seminars in Fetal & Neonatal Medicine

Surveillance of extreme hyperbilirubinaemia in Denmark. A method to identify the newborn infants

(2008) Jesper Vandborg Bjerre et al.   ACTA PAEDIATRICA

Genetic Predisposition, Nongenetic Risk Factors, and Coronary Infarct

(2008) Antonia Trichopoulou et al.   ARCHIVES OF INTERNAL MEDICINE