Article
Psychiatry
Viola Hollestein, Geert Poelmans, Natalie J. Forde, Christian F. Beckmann, Christine Ecker, Caroline Mann, Tim Schaefer, Carolin Moessnang, Sarah Baumeister, Tobias Banaschewski, Thomas Bourgeron, Eva Loth, Flavio Dell'Acqua, Declan G. M. Murphy, Nicolaas A. Puts, Julian Tillmann, Tony Charman, Emily J. H. Jones, Luke Mason, Sara Ambrosino, Rosemary Holt, Sven Boelte, Jan K. Buitelaar, Jilly Naaijen
Summary: The E/I imbalance hypothesis suggests that the imbalance between excitatory and inhibitory mechanisms underlies the behavioral characteristics of autism. This study used innovative analysis methods to investigate the relationships between genetic variance, brain structure, and autism symptomatology. The results suggest complex relationships between E/I-related genetics and autism symptom profiles as well as brain structure alterations.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neurosciences
Evan C. Rosenberg, Simon Chamberland, Michael Bazelot, Erica R. Nebet, Xiaohan Wang, Sam McKenzie, Swati Jain, Stuart Greenhill, Max Wilson, Nicole Marley, Alejandro Salah, Shanice Bailey, Pabitra Hriday Patra, Rebecca Rose, Nicolas Chenouard, Simon(e) D. Sun, Drew Jones, Gyorgy Buzsaki, Orrin Devinsky, Gavin Woodhall, Helen E. Scharfman, Benjamin J. Whalley, Richard W. Tsien
Summary: CBD reduces seizures in pediatric epilepsies, possibly by blocking the effects of LPI at synapses and reducing hyperexcitability.
Article
Neurosciences
Kyungchul Noh, Woo-Hyun Cho, Byung Hun Lee, Dong Wook Kim, Yoo Sung Kim, Keebum Park, Minkyu Hwang, Ellane Barcelon, Yoon Kyung Cho, C. Justin Lee, Bo-Eun Yoon, Se-Young Choi, Hye Yoon Park, Sang Beom Jun, Sung Joong Lee
Summary: Dominance behavior can influence social hierarchy. Here the authors show that cortical astrocytes can enhance excitatory and reduce inhibitory transmission via release of glutamate and ATP, which modulate dominance behavior, affecting the establishment of social hierarchy, among adult male mice.
NATURE NEUROSCIENCE
(2023)
Article
Pediatrics
Vinod Sharma, Arushi Gahlot Saini, Prahbhjot Malhi, Pratibha Singhi
Summary: The study found that about one-fourth of children with autism spectrum disorders also have epilepsy, with female gender and adverse perinatal events being independent risk factors. Subclinical or isolated EEG abnormalities are associated with abnormal neurological examination.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Psychiatry
Laura Colomar, Antonia San Jose Caceres, Juan Alvarez-Linera, Javier Gonzalez-Penas, Abigail Huertas Paton, Daniel Martin de Blas, Ana Paloma Polo Arrondo, Andrea Solis, Emily Jones, Mara Parellada
Summary: This article presents a study protocol to explore the longitudinal role of E/I imbalance in ASD symptoms, combining different approaches to measure the E/I ratio and using the trajectories of symptom severity as a framework. The findings derived from this study could contribute to the ASD biomarkers research and might provide valuable evidence for the development of more personalized treatments in ASD.
Article
Neurosciences
Jianchen Fan, Xinyan Dong, Yejiao Tang, Xuehui Wang, Donghui Lin, Lifen Gong, Chen Chen, Jie Jiang, Weida Shen, Anyu Xu, Xiangnan Zhang, Yicheng Xie, Xin Huang, Linghui Zeng
Summary: The pathogenesis of temporal lobe epilepsy (TLE) is closely related to neural circuits in the brain, especially the synaptic excitation/inhibition balance. Through a TLE model, the study found an increase in excitatory synapses and a decrease in inhibitory synapses, as well as active synaptic phagocytosis by microglia after seizure formation. These findings provide new insights into the understanding of TLE and potential therapeutic targets for epilepsy treatment.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Peijuan Luo, Fan Yang, Jing Li, James E. Niemeyer, Fengrui Zhan, Joshua Estin, Mingrui Zhao, Dan Li, Weihong Lin, Jyun-You Liou, Hongtao Ma, Theodore H. Schwartz
Summary: This study reveals that epileptic discharges can spread through interconnected nodes in the brain and activate both excitatory and inhibitory neurons in specific regions. This finding has significant implications for understanding the mechanisms and propagation of epilepsy.
Article
Multidisciplinary Sciences
Ryan N. Delgado, Denise E. Allen, Matthew G. Keefe, Walter R. Mancia Leon, Ryan S. Ziffra, Elizabeth E. Crouch, Arturo Alvarez-Buylla, Tomasz J. Nowakowski
Summary: Studies have shown that human cortical progenitors are capable of generating both excitatory neurons and cortical interneurons, expanding our understanding of the origins of neuronal diversity in the human cortex. By utilizing a new cellular barcoding tool called STICR, researchers were able to trace the clonal lineage of human cortical progenitors and identify transcriptional similarities between cortically born GABAergic neurons and cortical interneurons born from the ganglionic eminences.
Article
Food Science & Technology
Judit Biosca-Brull, Laia Guardia-Escote, Jordi Blanco, Pia Basaure, Maria Cabre, Fernando Sanchez-Santed, Jose L. Domingo, Maria Teresa Colomina
Summary: The balance of excitatory and inhibitory neurotransmitters is crucial for brain development. This study found that pesticide exposure, particularly to chlorpyrifos (CPF), is associated with neurodevelopmental disorders. Mouse experiments showed that prenatal CPF exposure affected social behavior in male mice, while the GABA system was activated in females. These findings suggest that prenatal CPF exposure has a stronger impact on males and may contribute to sex differences observed in autism spectrum disorder (ASD).
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biology
Owen Mackwood, Laura B. Naumann, Henning Sprekeler
Summary: Understanding the connectivity in the brain and how it is influenced by activity-dependent synaptic plasticity is a major challenge in neuroscience. Research in mice's V1 area suggests that connections between excitatory and inhibitory neurons contribute to a stimulus-specific competition among neurons, highlighting the importance of synaptic plasticity in shaping cortical computations.
Article
Multidisciplinary Sciences
Nerea Llamosas, Sheldon D. Michaelson, Thomas Vaissiere, Camilo Rojas, Courtney A. Miller, Gavin Rumbaugh
Summary: The Syngap1 gene promotes experience-dependent excitatory synapse strengthening in the mouse cortex, while synaptic depression and bouton elimination are unaffected. It enhances somatic neural activity in weakly active neurons within cortical networks, but has little impact on highly active neurons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Fu Hung Shiu, Jennifer C. Wong, Takahiro Yamamoto, Trisha Lala, Ryan H. Purcell, Sharon Owino, Dan Zhu, Erwin G. Van Meir, Randy A. Hall, Andrew Escayg
Summary: The adhesion G protein-coupled receptor BAI1/ADGRB1 plays a crucial role in angiogenesis suppression, phagocytosis mediation, and acting as a brain tumor suppressor. It is also involved in dendritic spine and excitatory synapse development and interacts with autism-relevant proteins. Reduced expression of full length Bai1 leads to social behavior deficits, increased seizure susceptibility, delayed growth, reduced brain weight, decreased neuron density, and increased apoptosis during brain development.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Frances St George-Hyslop, Moritz Haneklaus, Toomas Kivisild, Frederick J. Livesey
Summary: Loss-of-function mutations in the CNTNAP2 gene contribute to the pathogenesis of neurodevelopmental disorders by causing complex changes in human cerebral cortex excitatory neuron development, resulting in aberrant neural network formation and function.
BIOLOGICAL PSYCHIATRY
(2023)
Editorial Material
Psychiatry
Kareen Heinze, Helen C. Barron, Emma K. Howes, Mani Ramaswami, Matthew R. Broome
Summary: In a healthy brain, maintaining balance between excitation and inhibition is crucial for neural stability. Reduced inhibition may be the underlying cause of shared symptoms in autism and psychosis, with altered levels of gamma-aminobutyric acid (GABA) potentially providing a therapeutic target for both disorders.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Pediatrics
Elizabeth Berry-Kravis, Robyn A. Filipink, Richard E. Frye, Sailaja Golla, Stephanie M. Morris, Howard Andrews, Tse-Hwei Choo, Walter E. Kaufmann, FORWARD Consortium
Summary: This study investigated the prevalence of seizures in individuals with Fragile X syndrome and found it to be 12%, with males having a significantly higher rate than females. Factors such as autism spectrum disorder, current sleep apnea, and severe intellectual disability were associated with seizures in FXS patients.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Fatma El-Zahraa A. El-Gamal, Mohammed M. Elmogy, Mohammed Ghazal, Ahmed Atwan, Manuel F. Casanova, Gregory N. Barnes, Ayman S. El-Baz, Hassan Hajjdiab
FRONTIERS IN BIOSCIENCE-LANDMARK
(2018)
Article
Neurosciences
Fatma E. A. El-Gamal, Mohammed M. Elmogy, Mohammed Ghazal, Ahmed Atwan, Manuel F. Casanova, Gregory N. Barnes, Robert Keynton, Ayman S. El-Baz, Ashraf Khalil
FRONTIERS IN HUMAN NEUROSCIENCE
(2018)
Article
Neurosciences
Jiannan Kang, Erjuan Cai, Junxia Han, Zhen Tong, Xin Li, Estate M. Sokhadze, Manuel F. Casanova, Gaoxiang Ouyang, Xiaoli Li
FRONTIERS IN NEUROSCIENCE
(2018)
Letter
Neurosciences
Eleanor J. Cole, Peter G. Enticott, Lindsay M. Oberman, M. Frampton Gwynette, Manuel F. Casanova, Scott L. J. Jackson, Ali Jannati, James C. McPartland, Adam J. Naples, Nicolaas A. J. Puts
BIOLOGICAL PSYCHIATRY
(2019)
Article
Anatomy & Morphology
Carlos Arturo Gonzalez-Acosta, Martha Isabel Escobar, Manuel Fernando Casanova, Hernan J. Pimienta, Efrain Buritica
FRONTIERS IN NEUROANATOMY
(2018)
Review
Neurosciences
Manuel F. Casanova, Emily L. Casanova
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Psychiatry
Emily L. Casanova, Zachary Gerstner, Julia L. Sharp, Manuel F. Casanova, Frank Alex Feltus
FRONTIERS IN PSYCHIATRY
(2018)
Article
Behavioral Sciences
Emily L. Casanova, Andrew E. Switala, Srini Dandamudi, Allison R. Hickman, Joshua Vandenbrink, Julia L. Sharp, Frank Alex Feltus, Manuel F. Casanova
Article
Psychology, Multidisciplinary
Emily L. Casanova, Julia L. Sharp, Stephen M. Edelson, Desmond P. Kelly, Manuel F. Casanova
BEHAVIORAL SCIENCES
(2018)
Article
Neurosciences
Estate M. Sokhadze, Eva V. Lamina, Emily L. Casanova, Desmond P. Kelly, Ioan Opris, Allan Tasman, Manuel F. Casanova
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2018)
Proceedings Paper
Imaging Science & Photographic Technology
Marwa Ismail, Gregory Barnes, Matthew Nitzken, Andrew Switala, Ahmed Shalaby, Ehsan Hosseini-Asl, Manuel Casanova, Robert Keynton, Ashraf Khalil, Ayman El-Baz
2017 24TH IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING (ICIP)
(2017)
Article
Neurosciences
Ioan Opris, Manuel F. Casanova, Mikhail A. Lebedev, Aurel I. Popescu
PHYSICS OF THE MIND AND BRAIN DISORDERS: INTEGRATED NEURAL CIRCUITS SUPPORTING THE EMERGENCE OF MIND
(2017)
Article
Neurosciences
Ioan Opris, Brian R. Noga, Liviu Bilteanu, Manuel F. Casanova
PHYSICS OF THE MIND AND BRAIN DISORDERS: INTEGRATED NEURAL CIRCUITS SUPPORTING THE EMERGENCE OF MIND
(2017)
Article
Neurosciences
Cosmin Sonea, Anca-Liliana Opris, Manuel F. Casanova, Ioan Opris, Marian Vladimir Constantinescu
PHYSICS OF THE MIND AND BRAIN DISORDERS: INTEGRATED NEURAL CIRCUITS SUPPORTING THE EMERGENCE OF MIND
(2017)
Proceedings Paper
Imaging Science & Photographic Technology
Fatma El-Zahraa A. El-Gamal, Mohammed M. Elmogy, Mohammed Ghazal, Ahmed Atwan, Gregory N. Barnes, Manuel F. Casanova, R. Keynton, Ayman S. El-Baz
2017 24TH IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING (ICIP)
(2017)