Article
Biochemistry & Molecular Biology
Dai-Ting Lin, Ning-Juo Kao, Tzu-Wen Liu Cross, Wei-Ju Lee, Shyh-Hsiang Lin
Summary: This study investigated the effects of a ketogenic diet (medium chain triglyceride, MCT) on cognitive performance after long-term consumption of a high-fat-high-cholesterol diet. The results showed that the MCT diet improved spatial learning and memory performance, reduced expression of inflammatory proteins, and increased expression of neurotrophic factors compared to the high-fat-high-cholesterol diet. This suggests that the MCT diet may help slow down neurodegeneration.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Manju Sharma, Virendra Tiwari, Swati Chaturvedi, Muhammad Wahajuddin, Shubha Shukla, Jiban Jyoti Panda
Summary: This study developed self-fluorescent nanoparticles as a therapeutic system for Alzheimer's disease (AD), showing the ability to inhibit and disrupt the amyloid fibrils associated with AD. These nanoparticles were nontoxic to neural cells and protected neurons from cytotoxicity. Animal model experiments demonstrated that the nanoparticles improved memory in AD model rats. Overall, the nanoparticles showed promising potential as nanotheranostic agents for AD therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cardiac & Cardiovascular Systems
Fabian Eichelmann, Laury Sellem, Clemens Wittenbecher, Susanne Jaeger, Olga Kuxhaus, Marcela Prada, Rafael Cuadrat, Kim G. Jackson, Julie A. Lovegrove, Matthias B. Schulze
Summary: This study assessed the associations between plasma lipids and cardiometabolic diseases and found several lipids associated with disease risk. The study also tested the effect of dietary fat modification on these lipids and found that unsaturated fatty acids may have a beneficial effect on long-term cardiometabolic risk prevention.
Article
Neurosciences
Natalia Yanguas-Casas, Cristina Torres, Andrea Crespo-Castrillo, Sonia Diaz-Pacheco, Kiera Healy, Catherine Stanton, Julie A. Chowen, Luis M. Garcia-Segura, Maria Angeles Arevalo, John F. Cryan, Maria L. de Ceballos
Summary: Long-term high-fat diet can lead to obesity and inflammation, affecting gut microbiota. The effects of diet vary between sexes and genotypes of mice, with female TgAPP mice showing some resistance to diet-induced effects.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Geriatrics & Gerontology
Xiaorui Fan, Bin Liu, Junyi Zhou, Xinru Gu, Yanyan Zhou, Yifei Yang, Feifei Guo, Xiaolu Wei, Hongjie Wang, Nan Si, Jian Yang, Baolin Bian, Haiyu Zhao
Summary: The study investigated the impact of a high-fat diet on Alzheimer's disease, revealing no significant effect on A beta levels or contextual memory but moderating neuroinflammation. Additionally, Huanglian Jiedu decoction shows potential as an AD drug by globally suppressing inflammation and lipid accumulation to alleviate cognitive impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Gianni Mancini, Candida Dias, Catia F. Lourenco, Joao Laranjinha, Andreza de Bem, Ana Ledo
Summary: The study found that a high fat/cholesterol diet may lead to mitochondrial dysfunction and significantly decreased nitric oxide production in a mouse model of Alzheimer's disease, exacerbating brain tissue damage. In normal mice, the diet only caused moderate hypercholesterolemia but resulted in significant decline in spatial memory.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Jianing Cao, Min Wang, Congcong Gong, William Kwame Amakye, Xiaoyu Sun, Jiaoyan Ren
Summary: The study revealed a decrease in microbial diversity and an increase in bacteria abundance within A beta plaques in the brains of APP/PS1 mice, along with an observed increase in blood-brain barrier permeability. This suggests a potential link between brain microbes and Alzheimer's disease progression, warranting further investigation into the migration route of microbiota into the brain and their role in AD pathology.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Kaja Falkenhain, Sean R. Locke, Dylan A. Lowe, Nicholas J. Reitsma, Terry Lee, Joel Singer, Ethan J. Weiss, Jonathan P. Little
Summary: This study found that among adults with overweight/obesity, a Mediterranean-style ketogenic diet app with breath acetone biofeedback was more effective in promoting weight loss compared to a calorie-restricted, low-fat diet app. Additionally, markers such as hemoglobin A1c and liver enzymes showed greater improvement in the ketogenic diet group.
Review
Biochemistry & Molecular Biology
Amer E. Alkhalifa, Nour F. Al-Ghraiybah, Julia Odum, John G. Shunnarah, Nataleigh Austin, Amal Kaddoumi
Summary: The review explores the role of the blood-brain barrier in the pathogenesis and therapy of Alzheimer's Disease (AD). Molecular and genetic changes, as well as receptors and transporters, are implicated in BBB dysfunction and AD pathology. Preserving and restoring BBB function is considered a potential strategy for mitigating the progression and severity of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Liuyi Zheng, Guangyao Lin, Ruyue Li, Haining Gan, Xuejun Huang, Nan Yao, Dake Cai, Ziming Zhao, Zixuan Hu, Minyi Li, Huazhen Xu, Leyi Li, Sha Peng, Xinxin Zhao, Yijing Lai, Yuxing Chen, Dane Huang
Summary: ICAC promotes reverse cholesterol transport (RCT) and lowers lipid levels in both serum and liver without causing liver steatosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biophysics
Ben R. Dickie, Herve Boutin, Geoff J. M. Parker, Laura M. Parkes
Summary: The study revealed that Alzheimer's disease pathology and ageing can affect blood-brain barrier water permeability, with changes occurring earlier in the presence of AD pathology.
NMR IN BIOMEDICINE
(2021)
Article
Nutrition & Dietetics
In Young Cho, Kyung Min Lee, Yoojin Lee, Chuel Min Paek, Ha Jin Kim, Ju Young Kim, Kiheon Lee, Jong Soo Han, Woo Kyung Bae
Summary: This study evaluated the dietary habits of CCVD patients using the Diet Quality Index-International and found that the quality of dietary habits of CCVD patients was lower than non-CCVD subjects. Evaluation and education of adequate dietary habits are needed in the management of CCVD patients.
Article
Cell Biology
Martin Gabay, Abraham Weizman, Nidal Zeineh, Meygal Kahana, Fadi Obeid, Nahum Allon, Moshe Gavish
Summary: The main obstacle in treating brain tumors is the lack of effective therapeutic strategies capable of penetrating the blood-brain barrier.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Eunkyung Clare Ko, Sarah Spitz, Francesca Michela Pramotton, Olivia M. Barr, Ciana Xu, Georgios Pavlou, Shun Zhang, Alice Tsai, Anna Maaser-Hecker, Mehdi Jorfi, Se Hoon Choi, Rudolph E. Tanzi, Roger D. Kamm
Summary: A three-dimensional Alzheimer's disease model was developed using a compartmentalized microfluidic device that combines a microvascular network of the human blood-brain barrier with pre-differentiated neurospheres. This model has the potential to replicate key neurovascular phenotypes of Alzheimer's disease in vitro.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Shuo Yang, Xincen Wang, He Li, Xiaoxu Wang, Yu Song, Peixu Cong, Jie Xu, Changhu Xue
Summary: The study aimed to investigate the effects and mechanism of sea cucumber phospholipids on cholesterol metabolism in atherosclerosis. The results showed that sea cucumber phospholipids significantly inhibited the generation of arterial plaque. PE-P reduced the contents of SFA-CE and MUFA-CE in mice liver, while PC-O specifically upregulated the levels of CE20:5 and CE22:6 in the serum of mice. Furthermore, PC-O and PE-P inhibited cholesterol synthesis pathway and promoted cholesterol catabolism by regulating gene expressions of bile acid synthesis and lysosomal activity. In conclusion, sea cucumber phospholipids can ameliorate the symptoms of atherosclerosis by regulating cholesterol metabolism.
JOURNAL OF NUTRITION
(2023)
Article
Multidisciplinary Sciences
Barbara Scherz, Roland Rabl, Stefanie Flunkert, Siegfried Rohler, Joerg Neddens, Nicole Taub, Magdalena Temmel, Ute Panzenboeck, Vera Niederkofler, Robert Zimmermann, Birgit Hutter-Paier
Article
Multidisciplinary Sciences
Victoria Schiffer, Estibaliz Santiago-Mujika, Stefanie Flunkert, Staffan Schmidt, Martina Farcher, Tina Loeffler, Irene Schilcher, Maria Posch, Joerg Neddens, Ying Sun, Jan Kehr, Birgit Hutter-Paier
Article
Radiology, Nuclear Medicine & Medical Imaging
Severin Mairinger, Thomas Filip, Michael Sauberer, Stefanie Flunkert, Thomas Wanek, Johann Stanek, Sara Furtner, Birgit Hutter-Paier, Nobuyuki Okamura, Claudia Kuntner
NUCLEAR MEDICINE AND BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Barbara Hinteregger, Tina Loeffler, Stefanie Flunkert, Joerg Neddens, Ruth Birner-Gruenberger, Thomas A. Bayer, Tobias Madl, Birgit Hutter-Paier
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Tina Loeffler, Irene Schilcher, Stefanie Flunkert, Birgit Hutter-Paier
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Behavioral Sciences
Arianna Novati, Giuseppe Manfre, Stefanie Flunkert, Johanneke E. Van der Harst, Judith R. Homberg, Robert Wronski, Huu Phuc Nguyen
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Neurosciences
Joerg Neddens, Magdalena Daurer, Tina Loeffler, Saioa Alzola Aldamizetxebarria, Stefanie Flunkert, Birgit Hutter-Paier
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2020)
Article
Neurosciences
Estibaliz Etxeberria-Rekalde, Saioa Alzola-Aldamizetxebarria, Stefanie Flunkert, Isabella Hable, Magdalena Daurer, Joerg Neddens, Birgit Hutter-Paier
Summary: Researchers conducted a comprehensive analysis of R6/2 mice, identifying Ctip2 and TSPO as new markers associated with the motor system and early neuroinflammation, providing a new direction for the study of HD.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Stephan Kurat, Petra Heinrich, Agnes Molnar-Kasza, Tina Loeffler, Stefanie Flunkert, Birgit Hutter-Paier
Summary: Researchers introduced the mutant huntingtin gene into a rodent model and found significant symptoms in female homozygous BACHD rats, while male homozygous BACHD rats showed mild symptoms similar to previously published studies.
Article
Neurosciences
Barbara Hinteregger, Tina Loeffler, Stefanie Flunkert, Joerg Neddens, Thomas A. Bayer, Tobias Madl, Birgit Hutter-Paier
Summary: The Tg4-42 mouse model is valuable for preclinical AD research, providing insights into pathological features of AD and revealing changes in metabolic biomarkers for future studies or drug development.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Agnes Molnar-Kasza, Barbara Hinteregger, Joerg Neddens, Roland Rabl, Stefanie Flunkert, Birgit Hutter-Paier
Summary: ALS remains an incurable and devastating disease, with drug development efforts mainly focused on SOD1-G93A mice. Testing drugs on SOD1-G93A/low mice may be a better way to evaluate the efficacy of new drugs against ALS.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Thomas Filip, Severin Mairinger, Joerg Neddens, Michael Sauberer, Stefanie Flunkert, Johann Stanek, Thomas Wanek, Nobuyuki Okamura, Oliver Langer, Birgit Hutter-Paier, Claudia Kuntner
Summary: A novel transgenic rat model was generated by cross-breeding APP and Tau rats, and was characterized using PET imaging and immunofluorescence analysis. An age-related increase in [C-11]PiB and [F-18]THK-5317 binding was observed in several brain regions in the APP/Tau group, but not in the control group. The study revealed low human tau and amyloid fibril expression levels in the model, questioning its utility for further studies.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Neurosciences
Shirin Sharghi, Stefanie Flunkert, Magdalena Daurer, Roland Rabl, Boris Philippe Chagnaud, Marcello Leopoldo, Enza Lacivita, Birgit Hutter-Paier, Manuela Prokesch
Summary: Autism spectrum disorder (ASD) is characterized by impaired social communication and repetitive behavior, and its causes are still unclear. In this study, the GABA(B) receptor agonist R-Baclofen and the selective agonist for the 5HT(7) serotonin receptor LP-211 were tested on mouse models of ASD. Results showed that both compounds improved social deficits and repetitive behaviors in the mice. However, further studies are needed to evaluate their effectiveness as potential ASD treatments.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Joshua Adekunle Babalola, Magdalena Lang, Meekha George, Anika Stracke, Carmen Tam-Amersdorfer, Izaskun Itxaso, Domjan Lucija, Jelena Tadic, Irene Schilcher, Tina Loeffler, Stefanie Flunkert, Manuela Prokesch, Gerd Leitinger, Achim Lass, Birgit Hutter-Paier, Ute Panzenboeck, Gerald Hoefler
Summary: In this study, astaxanthin was found to enhance the clearance of misfolded proteins in the brains of Alzheimer's disease patients, reduce inflammation, and alter the expression levels of transport proteins.
Article
Multidisciplinary Sciences
Estibaliz Santiago-Mujica, Stefanie Flunkert, Roland Rabl, Joerg Neddens, Tina Loeffler, Birgit Hutter-Paier