Article
Biochemistry & Molecular Biology
Yabin Li, Xirui Wang, Zhihuang Zhao, Jinxing Shang, Gang Li, Ruijian Zhang
Summary: NEAT1 plays an oncogenic role in glioma progression by promoting cell proliferation and interacting with miR-98-5p and BZW1. Inhibition of NEAT1 through the miR-98-5p/BZW1 pathway suppresses glioma cell proliferation in vivo. Targeting NEAT1/miR-98-5p/BZW1 may provide a novel therapeutic approach for glioma patients.
BIOSCIENCE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Meiya Mao, Xiaojiao Zheng, Yuehua Sheng, Jinghan Chai, Huiqing Ding
Summary: This study investigates the mechanism of action of Evodiamine (EVO) and miR-152-3p in ovarian cancer. EVO inhibits the expression of NEAT1 and CDK19, increases the level of miR-152-3p, and attenuates the progression of ovarian cancer cells.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Cell Biology
Yangwei Xu, Yanyan Li, Yue Qiu, Fei Sun, Guifang Zhu, Jingbo Sun, Guixing Cai, Wanmei Lin, Yun Fu, Hongmei Wu, Shanshan Jiang, Zhihui Wen, Feiyan Feng, Junjie Luo, Yuqin Yang, Qingling Zhang
Summary: NEAT1 is upregulated in most GC samples and is associated with poor prognosis. It promotes GC angiogenesis by competitively sponging miR-17-5p to activate the TGF beta/Smad pathway and upregulate proangiogenic factors like VEGF.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Shirin Azizidoost, Farhoodeh Ghaedrahmati, Omid Anbiyaee, Riyadh Ahmad Ali, Maryam Cheraghzadeh, Maryam Farzaneh
Summary: Colorectal cancer is the third leading cause of cancer death in the world. Recent studies have shown that long non-coding RNAs play important roles in colorectal cancer cells, and NEAT1 is a key factor involved in the development and progression of colorectal cancer.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Yu-xi Liu, Yan Ke, Pin Qiu, Jie Gao, Gao-pi Deng
Summary: Anomalies in long non-coding RNA (lncRNA) cause early ovarian failure. The down-regulation of lncRNA nuclear enriched abundant transcript 1 (NEAT1) is connected to premature ovarian failure (POF) mice, but the mechanism is unclear. NEAT1 reduced apoptosis and autophagy in cyclophosphamide-treated ovarian granulosa cells (OGCs) by suppressing the expression of miR-654. Inhibition of NEAT1 overexpression on apoptosis and autophagy in OGCs was reversed by miR-654 mimics. NEAT1 modulated the STC2/MAPK pathway to decrease apoptosis and autophagy in POF.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jingjing Cui, Jian Wang, Yeke Lv, Dong Xu
Summary: The study found that the expression of lncRNA NEAT1 was up-regulated in the serum of infantile pneumonia patients, while miR-146b was down-regulated. Knocking down lncRNA NEAT1 promoted cell growth and reduced apoptosis, while over-expressing miR-146b enhanced cell viability. This study demonstrated that lncRNA NEAT1 regulates infantile pneumonia by sponging miR-146b.
MOLECULAR BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Li Dong, Yumin Zheng, Xiaoguang Luo
Summary: This study focused on exploring the role of NEAT1 in Parkinson's disease (PD) and its effects on PD and related molecular mechanisms. The results showed that NEAT1 was involved in the development of PD, regulating cellular proliferation, apoptosis, and autophagy. Interfering with NEAT1 had potential therapeutic effects on PD by increasing the level of miR-107-5p.
Article
Biochemistry & Molecular Biology
Xiang Wei, Shan Xu, Liang Chen
Summary: Sevoflurane exacerbates neurotoxicity by inhibiting cell viability and promoting cell apoptosis, neuroinflammation, and ROS production. Neat1 is up-regulated in sevoflurane-treated cells, and its knockdown can improve sevoflurane-induced neurotoxicity. Through a ceRNA mechanism, it was found that Neat1 interacts with miR-298-5p to up-regulate Srpk1, ultimately contributing to sevoflurane-stimulated neurotoxicity.
NEUROCHEMICAL RESEARCH
(2021)
Article
Neurosciences
Jiakai Chen, Handong Wang, Junjun Wang, Wenhao Niu, Chulei Deng, Mengliang Zhou
Summary: Accumulated evidence suggests that NEAT1 promotes glioma progression by acting as a sponge for miR-128-3p. The NEAT1/miR-128-3p/ITGA5 axis is involved in glioma initiation and progression, offering a potential novel strategy for treatment. NEAT1 competitively binds to miR-128-3p to enhance ITGA5 expression, activating the FAK signaling pathway and promoting cell growth in glioma.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Li Li, Yan Ma, Kamalibaike Maerkeya, Davuti Reyanguly, Lili Han
Summary: The up-regulation of lncRNA OIP5-AS1 in cervical cancer tissues promotes cell proliferation and enhances the Warburg effect of tumor cells under hypoxic conditions through the miR-124-5p/IDH2/HIF-1α pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hai-rong Zhang, Shi-yong Wu, Zhong-xue Fu
Summary: The study demonstrated that lncRNA-cCSC1 promotes cell proliferation in colorectal cancer by interacting with miR-124-3p and upregulating the expression of CD44.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Xia Lv, Xiang-Yan Zhang, Qian Zhang, Ying-Jie Nie, Guang-Heng Luo, Xia Fan, Song Yang, Qing-Hua Zhao, Jian-Quan Li
Summary: The study reveals that NEAT1 plays a role in the inflammation and cell cycle progression of ARDS via the NEAT1/miR-27a/PTEN regulatory network, providing new insight into the pathologic mechanism behind ARDS.
LABORATORY INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Lin Zhu, Fengchun Wang, Wenhui Fan, Zhi Jin, Chao Teng, Jianxin Zhang
Summary: NEAT1 is upregulated in breast tumors and cell lines, and silencing NEAT1 sensitizes breast cancer cells to Taxol. miR-23a-3p is downregulated in breast cancer and acts as a tumor suppressor. In Taxol-resistant MDA-MB-231 breast cancer cells, NEAT1 is significantly increased and miR-23a-3p is downregulated, with FOXA1 identified as a target of miR-23a-3p.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Genetics & Heredity
Xinyu Wei, Shuang Tao, Huilan Mao, Haitao Zhu, Lingyu Mao, Wenhao Pei, Xiuru Shi, Yingxiang Shi, Shiwen Zhang, Yulun Wu, Ke Wei, Jing Wang, Siyan Pang, Wenrui Wang, Changjie Chen, Qingling Yang
Summary: This study found that lncRNA NEAT1 is highly expressed in BC cells and exosomes. NEAT1 promotes migration and paclitaxel resistance in BC cells, while downregulation of NEAT1 reduces drug resistance. In addition, downregulation of NEAT1 decreases migration and proliferation of BC cells by inhibiting CXCL12 expression and reducing miR-133b adsorption. This study reveals that exosomal lncRNA NEAT1 derived from SKBR3/PR cells in the tumor microenvironment can induce paclitaxel resistance, cell migration, and growth, and may serve as a new target for clinical treatment of BC.
Article
Oncology
Hanquan Wu, Dengwen Dong, Jiwei Wang, Shiwen Yin, Yuanxiang Gong, Chao Yang, Yihan Bai, Junyi Wang, Yanhong Du
Summary: The study demonstrated that long noncoding RNA nuclear paraspeckle assembly transcript 1 is up-regulated in colorectal cancer tissues and cells, promoting proliferation and invasion of colorectal cancer by targeting miR-448 to promote the expression of ZEB1, which may play a significant role in the tumorigenesis of colorectal cancer.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)