Article
Cell Biology
Ming Li, Da-Ming Xu, Shu-Bin Lin, Zheng-Liang Yang, Teng-Yu Xu, Jin-Huan Yang, Ze-Xin Lin, Ze-Kai Huang, Jun Yin
Summary: This study identified potential prognostic and therapeutic targets, such as PDCD6, GNG5, PHF6, and MAL2, in BLCA patients. Their high transcriptional expressions were significantly associated with favorable overall survival and may play important roles in BLCA treatment.
Article
Oncology
Gorka Larrinaga, Julio Calvete-Candenas, Jon Danel Solano-Iturri, Ana M. Martin, Angel Pueyo, Caroline E. Nunes-Xavier, Rafael Pulido, Juan F. Dorado, Jose I. Lopez, Javier C. Angulo
Summary: This study provides a novel description of the (Pro)renin receptor (PRR) protein and its prognostic role in invasive urothelial cancer of the bladder. It demonstrates that PRR expression is an independent prognostic marker and may be a potential target in urothelial carcinoma. The study suggests that PRR activates pathogenic pathways contributing to cell proliferation, immunosuppressive microenvironments, and aggressive neoplastic phenotypes.
Article
Oncology
Yu Li, Keying Zhang, Fa Yang, Dian Jiao, Mingyang Li, Xiaolong Zhao, Chao Xu, Shaojie Liu, Hongji Li, Shengjia Shi, Bo Yang, Lijun Yang, Donghui Han, Weihong Wen, Weijun Qin
Summary: The study confirmed the expression of PSMA and CD248 in the tumor-associated vessels of UCB patients, with high levels significantly associated with deteriorated clinicopathological features and poor prognosis. Both PSMA and CD248 expression serve as good risk factors for predicting prognosis, and combining them with other clinical risk factors can enhance predictive performance. Bioinformatic analysis suggests that PSMA and CD248 may promote angiogenesis and the progression of UCB.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Huan Feng, Zhiyao Deng, Yibao Huang, Zhuo Liu, Yajun Ruan, Tao Wang, Jihong Liu
Summary: This study reveals the comprehensive impact of cuproptosis on the tumor immune microenvironment, clinicopathological characteristics, and prognosis of patients with urothelial carcinoma of the bladder (UCB). A cuproptosis scoring system is developed to effectively predict the prognosis of UCB patients and their response to chemotherapy and immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Thomas van Doeveren, Jose A. Nakauma-Gonzalez, Andrew S. Mason, Geert J. L. H. van Leenders, Tahlita C. M. Zuiverloon, Ellen C. Zwarthoff, Isabelle C. Meijssen, Angelique C. van der Made, Antoine G. van Der Heijden, Kees Hendricksen, Bas W. G. van Rhijn, Charlotte S. Voskuilen, Job van Riet, Winand N. M. Dinjens, Hendrikus J. Dubbink, Harmen J. G. van de Werken, Joost L. Boormans
Summary: By sequencing genes in 15 UTUC patients treated by RNU, it was found that the majority of patients had a clonal relationship between UTUC and subsequent UCB, supporting the idea that UCBs following UTUC surgery are primarily clonally derived recurrences.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Immunology
Mulin Liu, Qin Zheng, Siyi Chen, Jiwei Liu, Shijun Li
Summary: In this study, it was found that FUT7 expression is increased in BLCA and is associated with prognosis and immune infiltration levels. Upregulation of FUT7 promotes proliferation and invasion of bladder cancer cells and decreases survival rates, while downregulation has the opposite effects.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Cell Biology
Ti-Chun Chan, Chung-Hsi Hsing, Yow-Ling Shiue, Steven K. Huang, Kun-Lin Hsieh, Yu-Hsuan Kuo, Chien-Feng Li
Summary: This study uncovers the biological significance of the CEBPD/hsa-miR-429/VEGFA axis in angiogenesis and tumor growth in urothelial carcinoma (UC). By inhibiting hsa-miR-429, CEBPD stabilizes the expression of VEGFA, leading to the progression of UC.
Article
Oncology
Chaojie Xu, Dongchen Pei, Yi Liu, Yang Yu, Jinhua Guo, Nan Liu, Zhengjun Kang
Summary: This study investigated the prognostic role of tumor microenvironment-related genes in bladder urothelial carcinoma and developed a prediction model, providing guidance for immunotherapy strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Jiwei Cheng, Haibo Ma, Ming Yan, Wenqun Xing
Summary: THAP9-AS1 is overexpressed in esophageal squamous cell carcinoma (ESCC) and is positively correlated with tumor size, TNM stage, lymph node metastasis, and prognosis. It functions as a competing endogenous RNA (ceRNA) for miR-133b, leading to the upregulation of SOX4 and promoting ESCC progression.
CELL DEATH & DISEASE
(2021)
Article
Pathology
Christina M. Gutierrez, Bradley C. Carthon, Shreyas Joshi, Adeboye O. Osunkoya
Summary: Primary urothelial carcinoma of the ureter is a relatively rare type of urinary tract tumor, often found in association with other urinary tract tumors. Our understanding of this type of cancer is limited due to the lack of comprehensive studies, highlighting the need for further research to explore its clinical characteristics.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Keisuke Shigeta, Kazuhiro Matsumoto, Nobuyuki Tanaka, Shuji Mikami, Takeo Kosaka, Yota Yasumizu, Toshikazu Takeda, Ryuichi Mizuno, Eiji Kikuchi, Mototsugu Oya
Summary: This study evaluates the biological characteristics and transitions of upper tract urothelial carcinoma (UTUC) to metachronous bladder tumors. The results show that UTUC tumor origin has different molecular expression patterns compared to subsequent non-muscle-invasive bladder cancer (NMIBC) after radical nephroureterectomy (RNU) and bladder primary MIBC. FGFR3 expression from UTUC origin may have a favorable prognosis compared to primary MIBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Hong-Lin He, Hong-Yue Lai, Ti-Chun Chan, Chung-Hsi Hsing, Steven K. Huang, Kun-Lin Hsieh, Tzu-Ju Chen, Wan-Shan Li, Yu-Hsuan Kuo, Yow-Ling Shiue, Chien-Feng Li
Summary: Zinc finger and SCAN domain containing 4 (ZSCAN4) is downregulated in muscle-invasive bladder cancer and its low expression is significantly correlated with tumor progression, metastasis, and vascular invasion in both upper urinary tract urothelial carcinoma (UTUC) and urinary bladder urothelial carcinoma (UBUC). Furthermore, low expression of ZSCAN4 serves as an independent negative prognostic factor for both diseases. Gene ontology analysis reveals that ZSCAN4 and its co-downregulated genes are associated with the mitotic cell cycle.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Yi Jiang, Chao Zhu, Haoxuan Huang, Gaomin Huang, Bin Fu, Xiaoqing Xi
Summary: This study found that overexpression of TUBA1C in bladder cancer is associated with a poor prognosis and is related to immune cell infiltration, immune checkpoint gene expression levels, and drug sensitivity levels. Functional assays showed that inhibiting TUBA1C could suppress bladder cancer cell proliferation, migration, and invasion, and induce apoptosis and cell cycle arrest.
Article
Andrology
Miao Mo, Xiheng Hu, Wei He, Xiongbing Zu, Long Wang, Yangle Li
Summary: This study investigated the relationship between genesets and histopathological stages of bladder cancer using GSEA, identifying that activating tumor immune microenvironment is a negative factor for outcomes of urothelial bladder carcinoma, which provides potential combination strategy for patients with bladder cancer.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Oncology
Yinghui Hong, Mingliang Ye, Fan Wang, Jun Fang, Chun Wang, Jie Luo, Jialiang Liu, Jing Liu, Lan Liu, Qiu Zhao, Ying Chang
Summary: This study reveals that miR-21-3p promotes migration and invasion of HCC cells and upregulates YAP1 expression by directly inhibiting SMAD7, highlighting a major epigenetic mechanism in HCC pathogenesis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Physical
Shuang Yang, Ji-Yu Zhu, Xiao-Nan Chen, Meng-Jie Huang, Sheng-Hao Cai, Ji-Yuan Han, Ji-Sen Li
Summary: In this study, a new catalyst Ni2P-Ru2P/NF was reported, which showed excellent electrocatalytic performance for the oxygen and hydrogen evolution reactions in alkaline media. Additionally, it demonstrated fast catalytic performance for full water splitting with a low cell voltage.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Review
Nanoscience & Nanotechnology
Feng Wang, Wenyao Zhang, Hao Li, Xiaonan Chen, Sining Feng, Ziqing Mei
Summary: Developing dressings that can accelerate the healing of diabetic wounds is of great clinical significance. Nanoparticles have significant advantages in promoting wound healing due to their antibacterial properties, low cytotoxicity, good biocompatibility, and drug delivery ability. Adding nanoparticles to dressings and using them to deliver drugs and cytokines has been proven to be effective.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Medicine, Research & Experimental
Mingyang Li, Zijia Tao, Yiqiao Zhao, Lei Li, Jianyi Zheng, Zeyu Li, Xiaonan Chen
Summary: In recent years, m(5)C RNA modification has been found to play a crucial role in regulating RNA metabolism and function, affecting cell proliferation, differentiation, apoptosis, and other biological processes. m(5)C modification is associated with the pathogenesis and progression of cancers, and abnormal expression of related genes can be used to predict patient prognosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Xiaonan Chen, Yiqing Zou, Shuqi Zhang, Pengchao Fang, Shuxuan Li, Pengyu Li, Yingying Sun, Gang Yuan, Haiyan Hu
Summary: This study developed a pharmaceutical vesicle RHL/Cl-Ch-cal that showed promising effects in combating Helicobacter pylori (H. pylori) infection. Through a combination of cholesterol-PEG, calcitriol, and clarithromycin, RHL/Cl-Ch-cal effectively disrupted the architecture of H. pylori biofilms, killed dispersed bacteria, and inhibited bacterial re-adhesion. Moreover, it activated the host immune response and killed intracellular H. pylori. The study provides a comprehensive attack strategy for H. pylori therapies.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Surgery
Shijie Li, Xiaonan Chen, Jianyi Zheng, Xuefeng Liu
Summary: Preoperative estimated glomerular filtration rate (eGFR) is associated with postoperative oncological outcomes in upper tract urothelial carcinoma (UTUC) patients treated with radical nephroureterectomy (RNU), and this association is affected by sex. Female patients have lower eGFR and worse oncological outcomes.
FRONTIERS IN SURGERY
(2022)
Article
Chemistry, Applied
Pengxiang Yuan, Xiaonan Chen, Soottawat Benjakul, Jipeng Sun, Bin Zhang
Summary: Chemical and proteomics analysis revealed significant changes in muscle tissues of pike eel during chilling and frozen storage, with a decrease in springiness and myofibrillar protein content. Cold stress induced alterations in muscle proteins, affecting membrane structural constituents, cytoskeleton, and binding functional proteins. The identified differentially abundant proteins were mainly associated with cytoskeleton function, impacting the physical structure and chemical performances of muscle tissues under cold conditions.
Article
Pharmacology & Pharmacy
Yiqin Rao, Yingying Sun, Pengyu Li, Mao Xu, Xiaonan Chen, Yalong Wang, Yan Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: The study proposes an antibiotic-adjuvant liposome called NANO@PS-LPs, which combines azithromycin, an adjuvant, and a biofilm dispersant to effectively eliminate Pseudomonas aeruginosa biofilms, kill dispersed bacteria, inhibit survivor metabolism, and prevent recurrent infections.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Yilun Ji, Xiaonan Chen, Shengqiu Lin, Milton Brian Traw, Dacheng Tian, Sihai Yang, Long Wang, Ju Huang
Summary: This study evaluated the accumulation of somatic mutations in Musa basjoo, a wild relative of banana, and found a higher mutation rate compared to other plants. Interestingly, these mutations were shared among different tissues, suggesting they arise early in development and are derived from a few stem cells.
MOLECULAR GENETICS AND GENOMICS
(2023)
Article
Chemistry, Medicinal
Lishan Ouyang, Jiaqi Li, Xiaonan Chen, Huiming Huang, Yingying Tian, Xingxing Li, Daoran Pang, Xuejiao Wei, Jinxin Xie, Longyan Wang, Dongxiao Liu, Pengfei Tu, Jun Li, Zhongdong Hu
Summary: Chinese dragon's blood ethyl acetate extract (CDBEE) has demonstrated anti-gastric cancer effects by suppressing proliferation and metastasis, inhibiting epithelial-mesenchymal transition, inducing apoptotic and autophagic cell death, and showing no obvious toxicity or side effects. Therefore, CDBEE may be a promising candidate drug for the treatment of gastric cancer.
PHYTOTHERAPY RESEARCH
(2023)
Article
Oncology
Shijie Li, Zeyu Li, Jianyi Zheng, Xiaonan Chen
Summary: This study aimed to investigate risk factors for intraoperative hemodynamic instability (HDI) and construct a clinical model for predicting intraoperative HDI for large pheochromocytomas and paragangliomas (PPGLs) patients. Independent risk factors were identified and a predictive model was constructed, which showed good predictive power in the training and validation cohorts. This model can help in individualized pre-treatment decision-making.
Review
Biochemistry & Molecular Biology
Mingyang Li, Lei Li, Jianyi Zheng, Zeyu Li, Shijie Li, Kefeng Wang, Xiaonan Chen
Summary: Renal cell carcinoma (RCC) is a common type of kidney cancer with unremarkable symptoms in early stages and low sensitivity to radiotherapy and chemotherapy. Liquid biopsy, an emerging non-invasive test, can measure patient biomarkers for diagnosis, prognostic assessment, treatment monitoring, and response evaluation. With rapid development and iteration of extraction and analysis technologies, liquid biopsy has become a low cost, high efficiency, and high accuracy clinical detection method. In this review, we comprehensively discuss the components, clinical applications, limitations, and future prospects of liquid biopsy in the past 5 years.
Article
Medicine, General & Internal
Zeyu Li, Lei Li, Jianyi Zheng, Mingyang Li, Siyu Wu, Kerong Xin, Rong Li, Song Bai, Xiaonan Chen
Summary: This study aimed to investigate the relationship between kidney stone history and human bone health. Results showed a negative correlation between lumbar bone mineral density and kidney stone history, and an interaction between serum 25-hydroxyvitamin D and lumbar BMD regarding kidney stone formation. Therefore, maintaining high lumbar BMD and serum 25-hydroxyvitamin D levels may help prevent the occurrence of kidney stones.
Review
Medicine, Research & Experimental
Siyu Wu, Rong Li, Yuanhong Jiang, Jiazheng Yu, Jianyi Zheng, Zeyu Li, Mingyang Li, Kerong Xin, Yang Wang, Zhenqun Xu, Shijie Li, Xiaonan Chen
Summary: Liquid biopsy is an accurate method for determining molecular profiles in urothelial carcinoma (UC). It has the potential to play a crucial role in early diagnosis, treatment monitoring, and prognosis prediction, thereby contributing to precision medicine in UC management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Lei Li, Mingyang Li, Jianyi Zheng, Zeyu Li, Xiaonan Chen
Summary: This study reveals that NSUN5 is highly expressed in ccRCC and is associated with tumor immunity. The high-risk group responds poorly to immunosuppressive treatment and has lower stromal scores compared to the low-risk group. NSUN5 knockout reduces ccRCC cell proliferation and migration, while increasing apoptosis.
Review
Biochemistry & Molecular Biology
Shijie Li, Kerong Xin, Shen Pan, Yang Wang, Jianyi Zheng, Zeyu Li, Xuefeng Liu, Bitian Liu, Zhenqun Xu, Xiaonan Chen
Summary: Bladder cancer is a global clinical challenge characterized by late presentation, poor prognosis, and low survival rates. Traditional methods for diagnosis and monitoring, such as cystoscopy and tissue biopsy, have limitations and high costs. In recent years, liquid biopsies, specifically blood-based ones, have emerged as highly efficient methods for discovering biomarkers and monitoring tumor progression. Several liquid biopsy biomarkers have shown promising results in clinical applications, including early detection, residual disease detection, recurrence prediction, and therapy response.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
