Review
Engineering, Biomedical
Duoyi Zhao, Tongtong Zhu, Jie Li, Liguo Cui, Zhiyu Zhang, Xiuli Zhuang, Jianxun Ding
Summary: This article comprehensively reviews the research and applications of artificial bone-substitute materials based on PLGA and its composites, discussing their potential and challenges in bone regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Polymer Science
Adriana Cristina Motta, Moema Hausen, Talita Stessuk, Elaine Conceicao de Oliveira, Anna Maria G. Melero, Eliana Aparecida de Rezende Duek
Summary: The study synthesized PDLGA (67:23) membranes and verified its degradation properties through cell culture, showing early degradation characteristics. Adipose-derived mesenchymal stem cells seeded in PDLGA membranes remained undifferentiated, providing data support for further research.
Article
Materials Science, Multidisciplinary
Ying Mao, Robert Guidoin, Yan Li, Gaetan Brochu, Ze Zhang, Lu Wang
Summary: Blending L-alpha-phosphatidylcholine (PC) with PLGA to yield hybrid scaffolds alters the physical properties and wettability, affecting biodegradability and biocompatibility. The addition of PC decreases fiber diameter and increases porosity and hydrophilicity, although it also reduces mechanical strength of the scaffolds.
MATERIALS & DESIGN
(2021)
Article
Polymer Science
Maria Herrero-Herrero, Jose Antonio Gomez-Tejedor, Ana Valles-Lluch
Summary: Tailored membranes with a fiber diameter of 1.8 μm were electrospun from PLGA and PCLGA solutions by adjusting electrospinning and polymer solution parameters. PCLGA, with its amorphous morphology, required the addition of a salt to increase conductivity for successful electrospinning, presenting notable difficulties due to its structure. Interestingly, PCLGA, with a higher glycolic acid molar fraction, could be successfully electrospun, a feat not previously reported.
Article
Materials Science, Composites
Azin Paydayesh, Seyed Rasoul Mousavi, Sara Estaji, Hossein Ali Khonakdar, Mohammad Amin Nozarinya
Summary: The addition of 3 phr FGNP to the PLA/CS blend resulted in a nanocomposite with superior properties, including significantly improved tensile strength and thermal stability, as well as a fine morphology and size distribution. The weight loss rate increased over time due to the decrease in degradable functional groups, while the electrical and thermal conductivity showed significant enhancements.
POLYMER COMPOSITES
(2022)
Article
Materials Science, Multidisciplinary
Xiaohui Yang, Xixia Liu, Fangshen Xu, Shunxian Ji, Yuchao Sun, Zhaojun Song, Jie Song, Yulian Wu, Jun Yin
Summary: In this study, degradable poly(lactic-co-glycolic acid) nerve guide conduits with microgroove or smooth inner surface were fabricated using a phase inversion-based dry-jet wet spinning method for the regeneration of recurrent laryngeal nerve (RLN). The results showed that the conduit with microgroove structure exhibited better cellular behavior and the ability to promote RLN regeneration in an animal model. This study contributes to the design and application of nerve guide conduits and tissue engineering in RLN injury repair.
MATERIALS & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Rong Wang, Xiaojie Sun, Lanlan Chen, Wenbin Liang
Summary: In this study, biodegradable blends of PGA and PBAT with in situ compatibilization using MDI were prepared. The addition of PBAT was found to increase the complex viscosity and storage modulus of the blends, leading to improved compatibility and impact strength. The morphology of the dispersed phase evolved from spherical structure to in situ microfiber, enhancing interfacial adhesion and improving toughness.
Article
Polymer Science
Yi-Hsun Yu, Shih-Jyun Shen, Yung-Heng Hsu, Ying-Chao Chou, Ping-Chun Yu, Shih-Jung Liu
Summary: In this study, a novel nanofibrous scaffold was developed for repairing ruptured Achilles tendons. It integrated multiple biomolecules layer by layer and achieved sustained release to enhance tendon healing. The experimental results demonstrated that the scaffold significantly improved the load-to-failure of the repaired tendons.
Article
Engineering, Biomedical
Lizhe Wang, Yaxin Li, Shuai Jiang, Zhihao Zhang, Sinan Zhao, Yuru Song, Jie Liu, Fei Tan
Summary: In order to improve the characteristics of alginate as a bone scaffold, a novel injectable tissue engineering scaffold containing poly(lactic-co-glycolic acid) (PLGA) microspheres and alginate was fabricated. PLGA microspheres containing magnesium (PMg) were developed by loading MgCO3 and MgO into PLGA microspheres. The addition of PMg effectively regulated the physicochemical properties of alginate hydrogels and improved cell attachment, proliferation, and osteogenesis.
BIOMEDICAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Atiah H. H. Almalki, Amany Belal, Ahmed A. A. Farghali, Rehab Mahmoud, F. M. Mustafa, H. R. Abd El-Mageed
Summary: This study investigated the interaction between Poly lactic-co-glycolic acid (PLGA), Chitosan (CH), and Zirconium dioxide (ZrO2) nanotube using density functional theory (DFT). The results showed that both CH and PLGA monomers chemically bonded with ZrO2, with PLGA having a stronger interaction. Molecular dynamics simulations demonstrated enhanced mechanical properties of PLGA and CH upon interaction with ZrO2. Additionally, the elastic modulus of PLGA and CH nanocomposites decreased with increasing temperature. Consequently, these PLGA-ZrO2 nanocomposites exhibit promising mechanical and thermal properties for applications in bone tissue engineering and drug delivery.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Arian Ehterami, Masoomeh Masoomikarimi, Farshid Bastami, Moslem Jafarisani, Morteza Alizadeh, Mohsen Mehrabi, Majid Salehi
Summary: The study developed a highly porous scaffold by PLLA/chitosan blend using LLPS method for nerve tissue engineering, showing good structural properties, hydrophilicity, and mechanical properties. Polymeric concentration in blend fabrication influences scaffold characteristics and cell responses.
MOLECULAR BIOTECHNOLOGY
(2021)
Article
Polymer Science
Yongxuan Chen, Kefeng Xie, Yucheng He, Wenbing Hu
Summary: The study reports the isothermal crystallization kinetics of poly(glycolic acid) (PGA) and compares it to poly((L)-lactic acid) (PLLA). It was found that PGA generally crystallizes more quickly than PLLA, which is attributed to the smaller hydrogen side group of PGA and the differences in molecular mobility and packing between the two polymers.
Article
Materials Science, Multidisciplinary
Eva M. M. Eger, Seema Agarwal
Summary: This study focuses on the characterization and reprocessing ability of PLGA in the form of dynamic covalent networks. The synthesized networks with dynamic bonding and debonding have enhanced thermomechanical properties and maintain the potential for thermal reprocessing and recycling like thermoplastics.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Kostas Tsachouridis, Evi Christodoulou, Alexandra Zamboulis, Anna Michopoulou, Panagiotis Barmpalexis, Dimitrios N. Bikiaris
Summary: The present study evaluates the use of novel copolymers for the preparation of paclitaxel loaded nanoparticles. The copolymers showed good enzymatic hydrolysis and low cytotoxicity, making them suitable drug matrix/carriers. The prepared nanoparticles exhibited small size, good drug loading and encapsulation efficiency. In vitro dissolution analysis showed biphasic drug dissolution profiles.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Han-Seung Ko, Sangwoon Lee, Doyoung Lee, Jae Young Jho
Summary: By introducing PGA fibers and HA into PLA composites and modifying HA, the tensile and flexural strength of PLA/HA-g-PLA composites were improved, along with enhancing the interfacial adhesion between HA and the PLA matrix.
Article
Materials Science, Biomaterials
Seyed Ahmad Ayati Najafabadi, Abbas Mohammadi, Anousheh Zargar Kharazi
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Polymer Science
Jaleh Varshosaz, Zahra Choopannejad, Mohsen Minaiyan, Anousheh Zargar Kharazi
Summary: Porous nanofibers loaded with TA were prepared using electrospinning method, with the optimal formulation containing 20% PGS and 10% TA in proportion to the total polymer quantity. These nanofibers showed good biocompatibility and excellent hemostatic effect in a rat tail-cut model.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Metallurgy & Metallurgical Engineering
Hossein Ahmadzadeh, Taghi Isfahani, Anoosheh Zargar Kharazi
PROTECTION OF METALS AND PHYSICAL CHEMISTRY OF SURFACES
(2020)
Review
Biochemistry & Molecular Biology
Shokoh Parham, Anousheh Zargar Kharazi, Hamid Reza Bakhsheshi-Rad, Hadi Nur, Ahmad Fauzi Ismail, Safian Sharif, Seeram RamaKrishna, Filippo Berto
Article
Polymer Science
Maryam Tayebi, Shokoh Parham, Hossein Abbastabbar Ahangar, Anousheh Zargar Kharazi
Summary: Periodontal tissue engineering has been revolutionized with the development of a composite membrane that shows high bioactivity, hydrophilicity, suitable mechanical properties, ideal morphology, and appropriate porosity for enhanced bone growth and effective treatment of periodontal disease.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Engineering, Biomedical
Parisa Heydari, Zargar Anosheh Kharazi, Seddigheh Asgary, Shokoh Parham
Summary: This study demonstrated the impact of SIM/CIP on long-term wound healing efficiency and CUR/CIP on short-term wound contraction through the preparation of biodegradable dressings containing different drugs. In vivo results also showed that the use of SIM/CIP dressing can promote collagen deposition and angiogenesis.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Engineering, Biomedical
Niloofar Mokhtari, Anousheh Zargar Kharazi
Summary: The study created a PGS/PLA composite scaffold with plasma surface modification, exhibiting mechanical properties close to natural vessels, superhydrophilic property, good blood compatibility, and enhanced cell growth, making it a suitable candidate for vascular tissue regeneration.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Materials Science, Multidisciplinary
Shokoh Parham, Anousheh Zargar Kharazi, Hamid Reza Bakhsheshi-Rad, Mahshid Kharaziha, Ahmad Fauzi Ismail, Safian Sharif, Mahmood Razzaghi, Seeram RamaKrishna, Filippo Berto
Summary: Wound dressings have evolved from using natural materials to customizable electrospun polymers that contain active compounds for wound healing and infection prevention. Electrospun polymeric nanofibers are considered promising for enhancing skin regeneration and controlling wound infection.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Biophysics
Shokoh Parham, Anousheh Zargar Kharazi
Summary: This study develops a flexible cellulosic textile nanocomposite with clove herbal medicine and demonstrates its potential applications in antimicrobial activity and wound healing. The nano emulsion containing clove herbal medicine was confirmed to contain eugenol and had a mean size between 100 and 300 nm. The wound dressing showed high antimicrobial activity and significant improvement in in vivo wound healing and in vitro cellular compatibility.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Materials Science, Textiles
Parisa Heydari, Shokoh Parham, Anousheh Zargar Kharazi, Shaghayegh Haghjooy Javanmard, Seddigheh Asgary
Summary: Plasma treatment improved the hemocompatibility and degradation rate of bilayer PGS/PCL and PGS/PLA scaffolds, mechanical tests showed suitability for vascular tissue engineering, with the elongation of PGS/PCL scaffolds being more suitable for vascular graft applications.
FIBERS AND POLYMERS
(2022)
Article
Engineering, Environmental
Paria Khaloo Kermani, Anousheh Zargar Kharazi
Summary: In this study, a novel wound dressing containing vitamin B5 and vitamin C was fabricated using electrospinning. The dressing showed good physical properties, antibacterial activity, and cytotoxicity, making it suitable for wound healing.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Dermatology
Darioush Khodabakhshi, Golnaz Vaseghi, Arezoo Mirzaee, Asghar Eskandarinia, Anousheh Zargar Kharazi
Summary: This study investigated the effect of an ointment based on ostrich oil containing honey, beeswax, and ethanolic extracts of Nigella sativa, propolis, and Cassia angustifolia on wound healing in diabetic rats. The ointment showed remarkable antibacterial activity and significantly accelerated wound healing in vivo.
JOURNAL OF WOUND CARE
(2023)
Article
Engineering, Environmental
Sepideh Ghadirian, Saeed Karbasi, Anousheh Zargar Kharazi, Mohsen Setayeshmehr
Summary: This study investigates the effect of halloysite nanotubes (HNT) on the physical, mechanical, and biological properties of polyhydroxy butyrate (PHB)-based scaffolds for cartilage regeneration. The results indicate that the incorporation of 5 wt% HNT positively enhances the properties of PHB-based electrospun scaffolds including decreased fiber diameter, improved mechanical properties, increased resistance to degradation, and enhanced cell growth.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Polymer Science
Mehdi Atari, Zahra Mohammadalizadeh, Anoushe Zargar Kharazi, Shaghayegh Haghjooy Javanmard
Summary: Solvent type and solution viscosity have significant effects on the characteristics of electrospun scaffolds. This study investigates the impact of different solvents on the physicomechanical properties of PGS/PCL blend electrospun scaffolds. The results show that PGS/PCL/CF-AC scaffolds have more uniform fiber diameter and smaller pore size. Moreover, CF-AC solvent has a greater influence on the mechanical parameters compared to DMF, due to better solution viscosity, spinnability, and fiber distribution uniformity.
POLYMER-PLASTICS TECHNOLOGY AND MATERIALS
(2022)
Article
Medicine, Research & Experimental
Mona Gorji, Anoosheh Zargar Kharazi, Mohsen Setayeshmehr, Nazem Ghasemi, Mitra Soleimani, Batool Hashemibeni
Summary: The study demonstrated that FNP/ASU loaded in PLGA scaffold has significant effects on chondrogenic differentiation of human adipose-derived stem cells and tissue engineering.
ADVANCED BIOMEDICAL RESEARCH
(2021)
