Article
Developmental Biology
Ramin Khanabdali, Shixuan Zheng, Phillip E. Melton, Harry M. Georgiou, Eric Moses, Shaun P. Brennecke, Bill Kalionis
Summary: The study revealed that DMSCs from the late/post-term period showed decreased cell proliferation and increased cell apoptosis compared to early term DMSCs. Late/post-term DMSCs also exhibited lower resistance to oxidative stress and decreased antioxidant capacity.
Review
Cell Biology
Vadim I. Chechekhin, Konstantin Yu. Kulebyakin, Romesh I. Kokaev, Pyotr A. Tyurin-Kuzmin
Summary: Adipose tissue relies on the regulation of multipotent mesenchymal stromal cells (MSCs), which serve as both precursors for new adipocytes and key paracrine regulators of adipose tissue homeostasis. The activity of MSCs is tightly controlled, regulating aspects such as proliferation, differentiation, and signal molecule production through modulation of hormonal sensitivity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Yun-Feng Zhou, Di Zhang, Wan-Ting Yan, Kai Lian, Zheng-Zheng Zhang
Summary: This article reviews the therapeutic potential of multipotent stromal cells (MSCs) in repairing meniscal injuries and discusses the avenues for utilizing these cells. The current progress on biomaterial implants is also reviewed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biology
Gina D. Kusuma, Harry M. Georgiou, Anthony Perkins, Mohamed H. Abumaree, Shaun P. Brennecke, Bill Kalionis
Summary: Preeclampsia is a serious disorder of pregnancy that can lead to hypertension and proteinuria. Abnormal placental growth and perfusion cause oxidative stress and secretion of abnormal levels of pro-angiogenic and anti-angiogenic factors by the placenta, resulting in damage to the maternal vascular endothelium and the clinical features of preeclampsia. Current treatments for preeclampsia are limited. The decidua is a major source of reactive oxygen species, and the role of decidua-derived MSC in normal and pathological placental development is poorly understood. MSC have the ability to respond to oxidative stress, but this response is compromised in preeclampsia.
YALE JOURNAL OF BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Janina Burk, Michaela Melzer, Alina Hagen, Katrin Susanne Lips, Katja Trinkaus, Ariane Nimptsch, Jenny Leopold
Summary: This study investigated the applicability of lipid phenotyping for MSC characterization and discrimination, finding differences in phospholipid species diversity between MSC from different species, and identified potentially suitable lipid markers across culture conditions. Phospholipid profiling could be a promising approach for MSC characterization, allowing for some heterogeneity within MSC while still achieving clear discrimination from fibroblasts.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Serena Martire, Francesca Montarolo, Michela Spadaro, Simona Perga, Maria Ludovica Sforza, Luca Marozio, Federica Frezet, Stefania Bruno, Giulia Chiabotto, Maria Chiara Deregibus, Giovanni Camussi, Giovanni Botta, Chiara Benedetto, Antonio Bertolotto
Summary: This study provides the first phenotypic and functional characterization of extracellular vesicles (EVs) from placental cells of women with Multiple Sclerosis (MS), showing their immunomodulatory potential in reducing inflammation and T cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell & Tissue Engineering
Hesham Soliman, Marine Theret, Wilder Scott, Lesley Hill, Tully Michael Underhill, Boris Hinz, Fabio M. Rossi
Summary: MSCs are essential for the development, maintenance, function, and regeneration of most tissues. They play a crucial role in responding to injury, promoting regeneration through secretion of trophic factors and ECM molecules, and contributing to fibrotic reparative processes. Through fate mapping and single cell omics, tissue-specific MSC identities and functions are being elucidated, providing unprecedented insights into the secret lives of tissue-resident MSCs.
Article
Neurosciences
Kaichuang Yang, Ruijie Lu, Jianan Lu, Shucai Fan, Qiang Zhang, Zijian Lou, Yuyuan Ma, Gang Lu, Ruolang Pan, Jianmin Zhang
Summary: This study isolated and purified MSCs from human cranial bone marrow (CB-MSCs) and characterized their differentiation capacity and immunomodulatory functions. The results showed that CB-MSCs exhibited neural-like cell differentiation potential and had regulatory effects on the immune system. These findings suggest that CB-MSCs may be promising candidates for the treatment of neurodegenerative diseases.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Immunology
Daniel Pitz Jacobsen, Heidi Elisabeth Fjeldstad, Guro Mork Johnsen, Ingrid Knutsdotter Fosheim, Kjartan Moe, Patji Alnaes-Katjavivi, Ralf Dechend, Meryam Sugulle, Anne Cathrine Staff
Summary: Decidua basalis, the endometrium of pregnancy, plays a crucial role in maternal-fetal interface with acute atherosis being a common lesion, particularly in conditions like preeclampsia. The causal factors and effects of acute atherosis are still uncertain, potentially involving various pathways such as inflammation and arterial lesions. Further research is needed to determine if the presence of acute atherosis can identify women at higher risk for premature cardiovascular disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Frederic Mourcin, Lea Verdiere, David Roulois, Rada Amin, Claire Lamaison, Vonick Sibut, Brice Thamphya, Celine Pangault, Celine Monvoisin, Sarah Huet, Marine Seffals, Sylvain Baulande, Fatima Mechta-Grigoriou, Patricia Legoix, Delphine Rossille, Marion Guirriec, Simon Leonard, Guillaume Cartron, Gilles Salles, Thierry Fest, Karin Tarte
Summary: The study identified three distinct human lymphoid stromal cell (LSC) subsets with different functions in healthy tissue. In lymphoma, LSCs can be reprogrammed in response to cytokines like tumor necrosis factor and transforming growth factor beta, leading to increased expression of chemokines. This bidirectional crosstalk between LSCs and malignant B cells may be a targetable axis in lymphoma.
Article
Biotechnology & Applied Microbiology
Takashi Taguchi, Wei Duan, Wendy Wolfson, Brandy Duhon, Emily G. Halphen, Mandi J. Lopez
Summary: This study explores the generation of functional insulin producing cell clusters from feline adipose-derived multipotent stromal cells, offering a new approach for treating feline diabetes mellitus. Results show that cluster functionality is enhanced through dynamic culture.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Clinical Neurology
Amara Larpthaveesarp, Praneeti Pathipati, Samuel Ostrin, Anthony Rajah, Donna Ferriero, Fernando F. Gonzalez
Summary: The study found that both single-dose MSC/EPO and multidose systemic EPO can improve long-term neurobehavioral outcomes even when administered after a delay, with EPO showing the most overall effectiveness.
Article
Cell Biology
Manijeh Khanmohammadi, Shayanti Mukherjee, Saeedeh Darzi, Kallyanashis Paul, Jerome A. Werkmeister, Fiona L. Cousins, Caroline E. Gargett
Summary: SUSD2 marker can enrich maternal pMSCs, originating potentially from eMSCs. SUSD2(+) pMSCs exhibit higher CFU-F activity and express more perivascular markers CD146, CD140b, and SUSD2 compared to SUSD2(-) pSFs. Placental decidua basalis can serve as an alternative MSC source for clinical translation when endometrial tissue is inaccessible.
CELL AND TISSUE RESEARCH
(2021)
Article
Cell & Tissue Engineering
Gertraud Eylert, Reinhard Dolp, Alexandra Parousis, Richard Cheng, Christopher Auger, Magdalena Holter, Ingrid Lang-Olip, Viola Reiner, Lars-Peter Kamolz, Marc G. Jeschke
Summary: This study suggests that for full-thickness burn excised wound regeneration, the optimal cell dosage range is the low dose range of 200 to 40,000 cells/cm(2), rather than the traditional belief that more cells lead to better healing outcomes.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Shiqi Xiang, Zixuan Lin, Meagan J. J. Makarcyzk, Kanyakorn Riewruja, Yiqian Zhang, Xiurui Zhang, Zhong Li, Karen L. Clark, Eileen Li, Silvia Liu, Tingjun Hao, Madalyn R. R. Fritch, Peter G. G. Alexander, Hang Lin
Summary: This study elucidates the difference between hiMPCs and hMSCs in response to TGF beta and presents a robust method for obtaining low hypertrophy hiMPCs-derived cartilage. The results also indicate the importance of activating both Smad2/3 and Smad1/5 in the initiation of chondrogenesis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Letter
Biophysics
Moussab Damlaj, Khadega A. Abuelgasim, Ayman Alhejazi, Bader Alahmari, Ahmed Alaskar, Mohsen Alzahrani
BONE MARROW TRANSPLANTATION
(2020)
Editorial Material
Cell Biology
Dunia Jawdat, Yasser Almutairi, Hana A. Fakhoury, Ahmed S. Alaskar, Ali H. Hajeer
Editorial Material
Cell Biology
Dunia Jawdat, Hana A. Fakhoury, Nezih Cereb, Ahmed S. Alaskar, Ali H. Hajeer
Editorial Material
Cell Biology
Dunia Jawdat, Riyadh Algharib, Abdullah Almusa, Ahmed S. Alaskar, Ali H. Hajeer
Editorial Material
Cell Biology
Dunia Jawdat, Yasser Almutairi, Qamariyyah Alnafie, Ahmed S. Alaskar, Ali H. Hajeer
Editorial Material
Cell Biology
Dunia Jawdat, Mahammad Mohammadi, Loay Haneef, Ahmed S. Alaskar, Ali H. Hajeer
Article
Cell Biology
Dunia Jawdat, Walid Almashaqbeh, Abdulrahman Sumaily, Nada Albaloushi, Sami Jammah, Abdulrahman Alsultan
CELL AND TISSUE BANKING
(2020)
Article
Public, Environmental & Occupational Health
Ahmed Alaskar, Naila A. Shaheen, Mohammed Bosaeed, Hina Rehan, Mushtaq Rather, Hind Salama, Khadega A. Abuelgasim, Giamal Gmati, Moussab Damlaj, Bader Alahmari, Mohsen Alzahrani, Adel Othman, May Anne Mendoza, Ayman Alhejazi
Summary: In this small cohort of hematology or oncology patients, MERS-CoV infection has a 100% mortality rate, regardless of the status of the underlying disease. Further studies are needed to validate these findings.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Letter
Biophysics
Mohsen Alzahrani, Moussab Damlaj, Mohammed Essa, Bader Alahmari, Ahmed Alaskar, Ayman Hejazi, Enas Basher, Husam Alsadi, Mazin Ahmed, Rodaina Abujoub, Samer Ghazi, Heba Alshobaki, Khadega Abuelgasim, Hind Salama, Giamal Gmati, Abdulrahman Alsultan
BONE MARROW TRANSPLANTATION
(2022)
Letter
Biophysics
Moussab Damlaj, Bader Alahmari, Ahmed Alaskar, Ayman Alhejazi, Husam Alsadi, Inaam Shehab-Eddine, Abdulrahman Alghamdi, Walid Almashaqbeh, Heba Alshobaki, Isam Mahasneh, Ashwaq Alotaibi, Tahany Alanazi, Maybelle Balili, Mohammed Quarshi, Mazin Ahmed, Mohsen Alzahrani
BONE MARROW TRANSPLANTATION
(2022)
Review
Biophysics
Mohamad Mohty, Florent Malard, Ahmed S. Alaskar, Mahmoud Aljurf, Mutlu Arat, Peter Bader, Frederic Baron, Ali Bazarbachi, Didier Blaise, Eolia Brissot, Fabio Ciceri, Selim Corbacioglu, Jean-Hugues Dalle, Fiona Dignan, Anne Huynh, Michelle Kenyon, Arnon Nagler, Antonio Pagliuca, Zinaida Peric, Paul G. Richardson, Annalisa Ruggeri, Tapani Ruutu, Ibrahim Yakoub-Agha, Rafael F. Duarte, Enric Carreras
Summary: Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can occur after hematopoietic cell transplantation (HCT). The European Society for Blood and Marrow Transplantation (EBMT) has recently updated the definition and severity grading system for SOS/VOD in adult patients. The aim of this work is to provide an update on the diagnosis, severity assessment, pathophysiology, and treatment of SOS/VOD in adult patients.
BONE MARROW TRANSPLANTATION
(2023)
Article
Cell Biology
Walid Almashaqbeh, Husam Ardah, Amal Alasmari, Anadel Hakeem, Shahad Alsaigh, Amairah Aloushan, Dunia Jawdat
Summary: This study examined the impact of passive smoking and caffeine consumption on the quality of cord blood. The findings revealed that pregnant women who consume caffeine showed a reduction in the quantity and potency of stem cells in cord blood, while passive smoking had no significant effect.
CELL AND TISSUE BANKING
(2023)
Article
Public, Environmental & Occupational Health
Dunia Jawdat, Ali Hajeer, Salam Massadeh, Nora Aljawini, Malak S. Abedalthagafi, Manal Alaamery
Summary: This study reveals an association between ABO blood group phenotypes and susceptibility and severity of COVID-19 infection. Blood group phenotype O is found to be protective against COVID-19 infection, while blood group phenotype B is associated with an increased risk. However, further studies with larger sample sizes and different ethnic groups are needed to validate these findings.
JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH
(2022)
Article
Hematology
Dunia Jawdat, Yasser Almutairi, Zainab Almutairi, Abdullah Almusa, Ali Hajeer
Summary: Finding HLA-matched donors for patients in need of HSCT is more likely within their own ethnic group. Establishing local and international stem cell donor registries increases the chances of finding matched donors. While the top scoring registries varied, having a local registry like SSCDR can significantly impact the chances of finding matched donors for patients.
TRANSPLANTATION AND CELLULAR THERAPY
(2021)
Article
Health Care Sciences & Services
Mohammed Albalawi, Syed Ziauddin Ahmed Zaidi, Nawal AlShehry, Ahmed AlAskar, Abdul Rehman Zia Zaidi, Rania Nagib Mohammed Abdallah, Abdul Salam, Ahmed AlSagheir, Nour AlMozain, Ghada Elgohary, Khalid Batarfi, Alia Alfaraedi, Osamah Khojah, Rehab Al-Ansari, Mona Alfaraj, Afra Dayel, Ahmed Al Bahrani, Arwa Nabhan Abdelhameed, Hind Alhumaidan, Jawaher M. Al-Otaibi, Ghazala Radwi, Abdulrahman Raizah, Hind Shatry, Sara Alsaleh, Hazzaa AlZahrani, Hani Al-Hashmi
JMIR RESEARCH PROTOCOLS
(2020)