Article
Oncology
Miran Jeong, Yi-Yue Wang, Ju-Yeon Choi, Myong Cheol Lim, Jung-Hye Choi
Summary: This study highlights the interaction between macrophages and ovarian cancer cells in metastasis. CCL7 in macrophages promotes ovarian cancer cell invasion, contributing to the development and metastasis of ovarian cancer. The CCL7/CCR3 axis may play a crucial role in the effect of tumor-associated macrophages on human ovarian cancer metastasis.
Article
Immunology
Liwei Zhang, Cong Zhang, Zhengwei Xing, Chunyang Lou, Jianbang Fang, Zhiwei Wang, Mingxing Li, Hao He, Hualong Bai
Summary: Through multi-omics analysis, this study found that intercellular communication in the tumor microenvironment can promote metastasis and alter transcriptome subtypes in hepatocellular carcinoma through the JUN-Hippo signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Chengmei Huang, Ruizhang Ou, Xiaoning Chen, Yaxin Zhang, Jiexi Li, Yihao Liang, Xiaohui Zhu, Lei Liu, Mingzhou Li, Dagui Lin, Junfeng Qiu, Guanglong Liu, Lingjie Zhang, Yuanyuan Wu, Huiyi Tang, Yanmin Liu, Li Liang, Yanqing Ding, Wenting Liao
Summary: SPON2 drives M2-TAM infiltration in the tumor microenvironment, playing an important role in colorectal cancer tumor growth and metastasis, suggesting its potential as a valuable biomarker guiding macrophage-targeting therapies.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Weiwei Shi, Ding Ma, Yin Cao, Lili Hu, Shuwen Liu, Dongliang Yan, Shan Zhang, Guang Zhang, Zhongxia Wang, Junhua Wu, Chunping Jiang
Summary: Sphingosine kinase 2/Sphingosine-1-phosphate promotes TNBC metastasis through the activation of the PAK1/LIMK1/Cofilin1 signaling pathway. ABC294640 inhibits TNBC metastasis in vivo and could be developed as a novel agent for the clinical treatment of TNBC.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Oncology
Yuting Li, Xiaofan Gao, Yibao Huang, Xiaoran Zhu, Yingying Chen, Liru Xue, Qingqing Zhu, Bo Wang, Mingfu Wu
Summary: Although previous studies have revealed the etiology of cervical cancer, metastasis still remains the main cause of poor prognosis and high cancer-related mortality. Close communication between cervical cancer cells and immune cells in the tumor microenvironment (TME) has been shown to promote metastatic dissemination. Understanding the mechanisms of tumor metastasis is crucial for the development of effective therapies. This review interprets various characteristics of the TME that contribute to lymphatic metastasis of cervical cancer, and summarizes the complex interactions between tumor cells and immune cells, as well as potential therapeutic strategies to target the TME.
FRONTIERS IN ONCOLOGY
(2023)
Article
Peripheral Vascular Disease
Anqi Li, Linyu Zhu, Ningjing Lei, Jiajia Wan, Xixi Duan, Shuangqing Liu, Yanru Cheng, Ming Wang, Zhuoyu Gu, Huilei Zhang, Yueyue Bai, Li Zhang, Fazhan Wang, Chen Ni, Zhihai Qin
Summary: The expression of S100A4 in lymphatic endothelial cells promotes lymphatic vessel sprouting in growing tumors by regulating glycolysis. S100A4 plays a crucial role in the position and motility of tip cells, and its expression is upregulated under hypoxic conditions. These findings suggest that S100A4 is a novel regulator of tumor-induced lymphangiogenesis.
Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biology
Sayaka Ueno, Tamotsu Sudo, Hideyuki Saya, Eiji Sugihara
Summary: This study reveals that pigment epithelium-derived factor (PEDF) promotes the dissemination of ovarian cancer by inducing IL-10 expression in macrophages. High PEDF gene expression is associated with poor prognosis in ovarian cancer patients, and elevated PEDF levels are correlated with early recurrence. BET inhibitors reduce PEDF expression and limit both cancer cell survival and macrophage induction.
COMMUNICATIONS BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Xu Wang, Jie Mao, Tao Zhou, Xingyi Chen, Haoyang Tu, Jinyan Ma, Yixuan Li, Yushi Ding, Yong Yang, Hongxi Wu, Xinying Tang
Summary: The study found that MYDGF can promote the progression of HCC by enhancing the self-renewal of liver CSCs, promoting tumor angiogenesis, and inducing the release of inflammatory cytokines. The findings provide evidence that MYDGF can directly affect the self-renewal of liver CSCs and indirectly exacerbate the inflammatory microenvironment to accelerate HCC progression.
Review
Oncology
Saida Mebarek, Najwa Skafi, Leyre Brizuela
Summary: Prostate cancer is the second most common cancer in men worldwide, with the majority of patients being above 65. Sphingosine 1-phosphate (S1P) is a bioactive lipid that plays a crucial role in the oncogenesis of prostate cancer. S1P metabolism and its enzymes have been extensively studied in relation to prostate cancer development and potential therapeutic targets. This review summarizes the significant findings and the current progress in targeting S1P metabolism for prostate cancer treatment.
Article
Peripheral Vascular Disease
Xiao-Jing Chen, Wen-Fei Wei, Zi-Ci Wang, Nisha Wang, Chu-Hong Guo, Chen-Fei Zhou, Luo-Jiao Liang, Sha Wu, Li Liang, Wei Wang
Summary: A novel lymphatic pattern LVEM encapsulating lymphatic vessels by TAMs in the hypoxic TME promotes metastasis of CSCC. IL-10 derived from hypoxic TAMs induces Sp1 upregulation in LECs, facilitating LVEM formation and a positive feedback loop that strengthens LNM. Knockdown of Sp1 or blockage of CCL1 disrupts LVEM formation and attenuates LNM.
Review
Endocrinology & Metabolism
Monika Martiniakova, Vladimira Mondockova, Roman Biro, Veronika Kovacova, Martina Babikova, Nina Zemanova, Sona Ciernikova, Radoslav Omelka
Summary: The skeleton is a common site of metastatic disease, particularly in prostate and breast cancers, leading to bone complications and poor prognosis. The interaction between bone cells and tumor cells is crucial in the development of bone metastasis. Several bone-derived factors, including OC, ucOC, FGF23, SCL, and LCN2, have been identified as potential tumor biomarkers and therapeutic targets. Targeting these factors may offer new approaches in the prevention and treatment of bone metastasis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Mathilde Bied, William W. Ho, Florent Ginhoux, Camille Bleriot
Summary: Macrophages are both important regulators of tissue homeostasis and abundant in the tumor microenvironment (TME), where they seem to support tumor development. However, tumor-associated macrophages (TAMs) exhibit vast heterogeneity and their associated functions have only recently been uncovered. This review outlines the various TAM populations identified thus far and their specialized roles in different stages of cancer progression. The article also discusses how macrophages may prime the premetastatic niche to facilitate metastasis and how subsequent metastasis-associated macrophages can support secondary tumor growth. Finally, the challenges in TAM research are addressed.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qiaoyun Hou, Shuohua Chen, Qi An, Boya Li, Yan Fu, Yongzhang Luo
Summary: The study confirms plasma Hsp90 alpha as a biomarker for breast cancer, providing insights into its prognostic value across different clinical stages, and suggests that eHsp90 alpha plays a role in promoting lymphangiogenesis in breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Hongliang Zhang, Yiyang Yu, Jun Wang, Yu Han, Tingting Ren, Yi Huang, Chenglong Chen, Qingshan Huang, Wei Wang, Jianfang Niu, Jingbing Lou, Wei Guo
Summary: In this study, it was found that macrophage-derived exosomal lncRNA LIFR-AS1 can promote osteosarcoma cell proliferation, invasion, and restrain cell apoptosis via the miR-29a/NFIA axis. LIFR-AS1 acts as a potential novel therapeutic target for osteosarcoma therapy.
CANCER CELL INTERNATIONAL
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Ingrid Fleming
EUROPEAN HEART JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Andreas Weigert, Lina Herhaus
Summary: Autophagy is a mechanism of cellular homeostasis that degrades cellular constituents, but it can also actively communicate with neighboring cells through a process called secretory autophagy. Secretory autophagy utilizes extracellular vesicles to secrete cellular content, which can modulate the functional profile of recipient cells. The immune system can sense these secreted molecules, including extracellular vesicles, and initiate the restoration of tissue homeostasis.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Florestan J. Koll, Severine Banek, Luis Kluth, Jens Koellermann, Katrin Bankov, Felix K. -H. Chun, Peter J. Wild, Andreas Weigert, Henning Reis
Summary: We analyzed the immune cells in the tumor microenvironment of 101 patients with muscle-invasive urothelial bladder cancer using multiplex immunohistochemistry. We found that high concentrations of macrophages were associated with increased risk of death, while high concentrations of Tregs were associated with decreased risk of death. We also identified two clusters, one with a high concentration of macrophages and the other with a high concentration of Tregs, which were associated with the worst and best survival rates, respectively.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Veronika Lutz, Veronique M. Hellmund, Felix S. R. Picard, Hartmann Raifer, Teresa Ruckenbrod, Matthias Klein, Tobias Bopp, Rajkumar Savai, Peter Duewell, Corinna U. Keber, Andreas Weigert, Ho-Ryun Chung, Malte Buchholz, Andre Menke, Thomas M. Gress, Magdalena Huber, Christian Bauer
Summary: Signaling through IL18R induces exhaustion of CD8(+) T cells, characterized by expression of coinhibitory receptors and loss of effector function. This exhaustion is mediated by an NLRP3-expressing tumor microenvironment that releases IL18. These findings suggest that NLRP3-mediated IL18R signaling could be a potential target for immunotherapy in pancreatic carcinoma.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Physiology
Timothy Warwick, Giulia Karolin Buchmann, Beatrice Pflueger-Mueller, Manuela Spaeth, Christoph Schuermann, Wesley Abplanalp, Lukas Tombor, David John, Andreas Weigert, Martin Leo-Hansmann, Stefanie Dimmeler, Ralf P. Brandes
Summary: Treatment of vascular stenosis with angioplasty can cause acute vascular damage, leading to restenosis. Single-cell RNA sequencing analysis of mouse carotid tissue after wire injury revealed the presence of smooth muscle cells that are also associated with atherosclerosis and myocardial infarction. These cells, called SEM cells, show specific gene expression patterns that could be targeted therapeutically to combat restenosis development.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Immunology
Maximilian Haist, Justus Kaufmann, Ivan-Maximiliano Kur, Stefanie Zimmer, Stephan Grabbe, Heinz Schmidberger, Andreas Weigert, Arnulf Mayer
Summary: In this study, the infiltration of CD8 T cells and the expression of PD-L1 were found to be significantly associated with the efficacy and survival of chemoradiotherapy in patients with oropharyngeal cancer. However, tumor cell proliferation and the expression of stem cell markers showed no independent prognostic effect.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Verena Wilmes, Ivan M. Kur, Andreas Weigert, Marcel A. Verhoff, Elise Gradhand, Silke Kauferstein
Summary: This study examines the expression of iNOS and NT production in postmortem human myocardial infarction hearts. The results demonstrate that resident macrophages are the main source of iNOS expression in these hearts, and there is a correlation between iNOS and NT production, indicating the involvement of iNOS in oxidative stress.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Zhou Zhou, Min Zhang, Chengcheng Zhao, Xu Gao, Zheng Wen, Junfang Wu, Chen Chen, Ingrid Fleming, Jiong Hu, Dao Wen Wang
Summary: Myocarditis is a challenging inflammatory disease of the heart, and EETs and sEH inhibitors can prevent the progression of coxsackie B3 virus-induced myocarditis and promote viral resistance by increasing IFN production.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Annika Karger, Siavash Mansouri, Matthias S. Leisegang, Andreas Weigert, Stefan Guenther, Carsten Kuenne, Ilka Wittig, Sven Zukunft, Stephan Klatt, Blerina Aliraj, Laura Klotz, Hauke Winter, Poornima Mahavadi, Ingrid Fleming, Clemens Ruppert, Biruta Witte, Ibrahim Alkoudmani, Stefan Gattenloehner, Friedrich Grimminger, Werner Seeger, Soni Savai Pullamsetti, Rajkumar Savai
Summary: Long noncoding RNAs (lncRNAs) play a role in gene transcription in many cells, but their function in tumor-associated macrophages (TAMs) is not well understood. The lncRNA ADPGK-AS1 is upregulated in M2-like human macrophages, macrophages exposed to lung cancer cells, and TAMs from human lung cancer tissue. Overexpression of ADPGK-AS1 promotes an M2-like, tumor-promoting phenotype in macrophages, while its knockdown induces an M1-like, tumor-suppressive phenotype, inhibiting lung tumor growth.
Article
Cardiac & Cardiovascular Systems
Charalambos Antoniades, Dimitris Tousoulis, Marija Vavlukis, Ingrid Fleming, Dirk J. Duncker, Etto Eringa, Olivia Manfrini, Alexios S. Antonopoulos, Evangelos Oikonomou, Teresa Padro, Danijela Trifunovic-Zamaklar, Giuseppe De Luca, Tomasz Guzik, Edina Cenko, Ana Djordjevic-Dikic, Filippo Crea
Summary: This article reviews the heterogeneity of adipose tissue depots in humans and emphasizes the interactions between perivascular adipose tissue (PVAT) and the vascular wall. It highlights the potential therapeutic target of PVAT in cardiovascular diseases and its role as a clinically important source of diagnostic and prognostic biomarkers of vascular function. It also discusses recent imaging technologies that visualize PVAT in clinical practice and the integration of PVAT information into prognostic models using artificial intelligence and machine learning technologies.
EUROPEAN HEART JOURNAL
(2023)
Article
Cell Biology
Sophia Walter, Christina Mertens, Martina U. Muckenthaler, Christiane Ott
Summary: Iron is an abundant trace element in the human body and plays essential roles in physiological processes. Aging disrupts iron balance and leads to iron accumulation and inflammation. Inflammation and proteolysis affect iron metabolism, aggravating iron imbalance.
MECHANISMS OF AGEING AND DEVELOPMENT
(2023)
Article
Cell Biology
Tobias F. Primke, Rebecca Ingelfinger, Mohammed A. F. Elewa, Igor Macinkovic, Andreas Weigert, Matthias P. Fabritius, Christoph A. Reichel, Angelika Ullrich, Uli Kazmaier, Luisa D. Burgers, Robert Fuerst
Summary: Research has found that depolymerizing microtubule-targeting agents can reduce inflammation by inhibiting the expression of pro-inflammatory molecules and decreasing leukocyte adhesion to endothelial cells. These agents not only affect leukocytes but also significantly decrease the inflammatory response of vascular endothelial cells. The study sets a baseline for further exploration of the anti-inflammatory effects of depolymerizing microtubule-targeting agents.
Meeting Abstract
Medicine, Research & Experimental
Florestan Koll, Jens Koellermann, Luis Kluth, Severine Banek, Felix Chun, Andreas Weigert, Peter Wild, Henning Reis
LABORATORY INVESTIGATION
(2023)
Article
Genetics & Heredity
Diego Morazan-Fernandez, Javier Mora, Jose Arturo Molina-Mora
Summary: Tumor-specific antigens expressed only in cancer cells have been extensively explored for immunotherapeutic strategies. In this study, a bioinformatic protocol was proposed to detect tumor-specific antigens associated with single nucleotide variants (SNVs) or mutations. The protocol successfully identified neoantigens and provided a complete pipeline for the design of cancer vaccines using DNA sequencing data.
Article
Biology
Pauline Hog, Silvia Kuntschar, Peter Rappl, Arnaud Huard, Andreas Weigert, Bernhard Bruene, Tobias Schmid
Summary: Macrophages are a versatile immune cell group involved in inflammatory reactions. This study reveals that prostaglandin E-2 (PGE(2)) may contribute to the regulation of Lyve1 expression and impact inflammatory responses. PGE(2) synergizes with dexamethasone to enhance Lyve1 expression, while CD44 expression remains unchanged. Lyve1-expressing macrophages integrate inflammatory stimuli with extracellular matrix-derived signals.