期刊
MICROMACHINES
卷 7, 期 4, 页码 -出版社
MDPI AG
DOI: 10.3390/mi7040063
关键词
lab-on-a-chip; all-glass; microfluidic; on-chip valve and pump; surface tension; glass microchip
类别
资金
- National Natural Science Foundation of China [40776082, 31371444]
A micro surface tension pump is a new type of low-cost, built-in, all-glass, microfluidic pump on a glass microchip fabricated by one-step glass etching. However, geometric minimization and optimization for practical use are challenging. Here, we report a one-square-millimeter, built-in, all-glass pump controlled by two-way digital gas pressure. The pump consists simply of two joint chambers and a piston between two gas control channels. It does not require pre-perfusion for initialization, and can immediately begin to run when a liquid enters its inlet channel. It is also more reliable than conventional micro pumps for practical use due to its ability to restart after the formation of a blocking bubble, which can serve as a valuable troubleshooting procedure. Its volumetric pump output was 0.5-0.7 nL . s(-1) under a pump head pressure of 300 Pa.
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