Article
Medicine, Research & Experimental
Zhihua Teng, Jie Yao, Ling Zhu, Lufeng Zhao, Gang Chen
Summary: This study revealed that ZNF655 is abundantly expressed in NSCLC, and its knockdown can inhibit the malignant behaviors of tumor cells, leading to decreased tumorigenesis. ZNF655 may regulate apoptosis of NSCLC cells through the PI3K/Akt and p53 signaling pathways.
Article
Oncology
Miao Li, Yan Rui, Wenjia Peng, Junfeng Hu, Anbang Jiang, Zeyu Yang, Linian Huang
Summary: This study investigated a novel molecular therapeutic target, FIGNL1, for lung cancer and found that its high expression was associated with decreased function and enhanced cell death in lung cancer cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Immunology
Lei Yang, You-Ling Shi, Yan Ma, Wei-Wei Ren, Guang-Ming Pang, Jiao Liu
Summary: The study revealed that the upregulation of KLF16 expression in OSCC cells, interfering with KLF16 resulted in cell cycle arrest, inhibited cell growth, and promoted cell apoptosis.
Article
Biochemistry & Molecular Biology
Min Yu, Xiaoyan Hu, Jingyu Yan, Ying Wang, Fei Lu, Junlei Chang
Summary: The study confirmed that NSC139021 effectively inhibited the proliferation of glioblastoma cells and induced apoptosis by regulating the p53 signaling pathway and cell cycle kinase pathway, suggesting a potential therapeutic role in glioblastoma treatment.
Article
Pharmacology & Pharmacy
Ming Li, Zhifeng Yang, Zhaoyuan Song, Cunxiang Bo, Shuo Wang, Qiang Jia
Summary: The aim of the study was to investigate the effects and potential mechanisms of ATM on the progression of liver fibrosis. The results showed that ATM deficiency exacerbated liver fibrosis development and was associated with the activation of the TGF-beta 1/Smad2 signaling pathway.
Article
Oncology
Jun Zhou, Wanpin Nie, Jiajia Yuan, Zeyu Zhang, Liangliang Mi, Changfa Wang, Ranglang Huang
Summary: GSG2 plays a crucial role in the progression of CCA and its overexpression predicts disease deterioration. Experimental results demonstrate that downregulation of GSG2 inhibits proliferation, promotes apoptosis, arrests cell cycle, and weakens migration in CCA cells.
Article
Biotechnology & Applied Microbiology
Tiangang Ma, Yanbing Hu, Yinxue Guo, Qinghua Zhang
Summary: The study demonstrates that miR-203 carried by extracellular vesicles from endothelial cells can inhibit the malignant phenotypes of NSCLC cells and delay tumor growth by targeting DTL and promoting p21 protein stability.
CANCER GENE THERAPY
(2022)
Article
Cell Biology
Tao Ma, Yan Chen, Zhi-Gang Yi, Jia Liu, Yan-Hong Li, Jun Bai, Wen-Ting Tie, Mei Huang, Xiao-Feng Zhu, Ji Wang, Juan Du, Xiu-Qin Zuo, Qin Li, Fan-Li Lin, Liu Tang, Jing Guo, Hong-Wen Xiao, Qian Lei, Xiao-Li Ma, Li-Juan Li, Lian-Sheng Zhang
Summary: This study reveals that NORAD acts as an oncogene in multiple myeloma and exerts its effects through the BMP6/P-ERK1/2 axis. Knockdown of NORAD promotes apoptosis and induces cell cycle arrest, while inhibiting cell proliferation in multiple myeloma.
CELLULAR SIGNALLING
(2022)
Article
Multidisciplinary Sciences
Jenny F. Nathans, James A. Cornwell, Marwa M. Afifi, Debasish Paul, Steven D. Cappell
Summary: The study reveals that the G(1)-S checkpoint does not effectively prevent cells with damaged DNA from entering S phase and replicating their DNA, leading to different cell fate outcomes. Cells triggering the DNA damage checkpoint in G(1) phase route back to quiescence, and most damaged cells actually fail to arrest and proceed through the G(1)-S transition.
Article
Oncology
Job-Joris Meijer, Alessandro Leonetti, Giulia Airo, Marcello Tiseo, Christian Rolfo, Elisa Giovannetti, Mahrou Vahabi
Summary: Despite poor prognosis for SCLC patients, immunotherapeutic approaches show potential. Targeting aberrant signaling pathways with new agents has shown promising results, while epigenetic alterations, gene amplifications, and mutations can act as potential biomarkers. Further research and clinical translational studies can help identify specific predictive biomarkers.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Xiaohua Zhang, Tianying Zhang, Xiaojuan Han, Zhongying Qiu, Jianghong Cheng, Xingchun Gao, Xingchun Gou
Summary: The study showed that CACUL1 overexpression in glioma tissues promoted cell proliferation, suppressed apoptosis, and induced cell cycle arrest. Knockdown of CACUL1 hindered cell proliferation and induced apoptosis in glioblastoma cells, suggesting a potential oncogenic role for CACUL1 in gliomas.
CURRENT CANCER DRUG TARGETS
(2021)
Article
Multidisciplinary Sciences
Marco D'Ario, Rafael Tavares, Katharina Schiessl, Benedicte Desvoyes, Crisanto Gutierrez, Martin Howard, Robert Sablowski
Summary: The study reveals that cell size variability in the Arabidopsis shoot stem cell niche is corrected by adjusting the growth period before DNA synthesis. KRP4 and FBL17 proteins play key roles in removing excess cell cycle regulators, ensuring daughter cells are born with comparable amounts of KRP4. This suggests a potential mechanism where a cell cycle regulator associated with mitotic chromosomes can read DNA content as a cell size-independent scale.
Article
Biology
Mohamed A. Elkady, Ahmed S. Doghish, Ahmed Elshafei, Mostafa M. Elshafey
Summary: miR-567 is downregulated in A549 NSCLC cells, but its upregulation can inhibit cell proliferation, promote apoptosis, induce cell cycle arrest, and act as a tumor suppressor by regulating CDK8 gene expression.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Jakub Rok, Justyna Kowalska, Zuzanna Rzepka, Dominika Stencel, Anna Skorek, Klaudia Banach, Dorota Wrzesniok
Summary: Melanoma is the most dangerous form of skin cancer due to its high mortality, aggressiveness, and low effectiveness of therapy. Previous studies have shown the therapeutic potential of minocycline, doxycycline, and chlortetracycline on melanoma cells. This study aimed to evaluate the cytotoxicity of tigecycline, a third-generation tetracycline, on melanotic and amelanotic melanoma cell lines. The results demonstrated that tigecycline efficiently inhibited the proliferation of both types of melanoma cells, accompanied by dysregulation of the cell cycle, depolarization of the mitochondrial membrane, and alterations in various molecular levels. However, the drug induced apoptosis only in melanotic melanoma cells, while amelanotic cells exhibited resistance and showed increased autophagy marker levels.
Article
Biochemistry & Molecular Biology
Laura Francesca Pisani, Gian Eugenio Tontini, Carmine Gentile, Beatrice Marinoni, Isabella Teani, Nicoletta Nandi, Pasquale Creo, Emanuele Asti, Luigi Bonavina, Maurizio Vecchi, Luca Pastorelli
Summary: IL-33 has antiproliferative and proapoptotic effects on gastric cancer cell lines, while it stimulates proliferation and reduces apoptosis in normal epithelial cell lines. These effects may be mediated through the regulation of cell cycle gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)