Article
Pharmacology & Pharmacy
Georges Jourdi, Imane Boukhatem, Pablo F. Barcelona, Samuel Fleury, Melanie Welman, H. Uri Saragovi, Samuela Pasquali, Marie Lordkipanidze
Summary: Recent research has shown that brain-derived neurotrophic factor (BDNF) has activating effects on isolated platelets. However, since BDNF circulates in plasma, it is necessary to find a mechanism to prevent constant activation of platelets. In this study, α2M was identified as a physiological regulator of BDNF bioavailability and an inhibitor of BDNF-induced platelet activation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
David Azoulay, Mira Naamad, Dafna Frydman, Ellen Broide, Ari Zimran, Galia Stemer, Shoshana Revel-Vilk
Summary: This study investigated the relationship between BDNF levels and platelet activity and bleeding tendency in patients with Gaucher disease. The results showed that serum BDNF levels were positively correlated with platelet count and moderately correlated with platelet P-selectin expression. Patients with multiple bleeding manifestations had lower serum BDNF levels. Splenectomized patients had significantly elevated plasma BDNF levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Michael Robert Jaskolski, Anna Katharina Diedrich, Alexandru Odainic, Susanne Viktoria Schmidt, Marie-Therese Schmitz, Brigitte Strizek, Ulrich Gembruch, Waltraut Maria Merz, Anne Floeck
Summary: The objective of this study was to investigate the influence of dietary and insulin-dependent gestational diabetes on BDNF blood levels in maternal-neonatal pairs. The results showed that neonates of mothers with gestational diabetes had significantly lower BDNF levels, while maternal BDNF levels also decreased but did not reach significance.
Article
Biochemistry & Molecular Biology
Narges Marefati, Farimah Beheshti, Farzaneh Vafaee, Moslem Barabadi, Mahmoud Hosseini
Summary: The study showed that IA could improve LPS-induced learning and memory impairments by reducing neuro-inflammation and brain tissue oxidative damage while increasing BDNF levels.
NEUROCHEMICAL RESEARCH
(2021)
Article
Clinical Neurology
Leo Sher, Linda M. Bierer, Janine Flory, Iouri Makotkine, Rachel Yehuda
Summary: This study found that plasma BDNF levels were higher among combat veterans who made suicide attempts post-deployment compared to those who did not. BDNF may be involved in the pathophysiology of suicidal behavior in this population.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biology
Andonia Petkova-Tuffy, Nina Goedecke, Julio Viotti, Martin Korte, Thomas Dresbach
Summary: The study reveals that NL1 and BDNF act together to play a crucial role in synaptic maturation, including increasing the stability of active zones and recycling of synaptic vesicles, a process that relies on a transsynaptic pathway between them. Using BDNF can mimic the effects of NL1 overexpression on structural and functional maturation, while blocking BDNF signaling can prevent the effects of NL1 on presynaptic maturation.
Article
Geriatrics & Gerontology
Jia Liu, Wei Yang, Hongyu Luo, Yixin Ma, Huan Zhao, Xiaojuan Dan
Summary: The study indicated that the BDNFVal66Met polymorphism is associated with mild cognitive impairment (MCI) in elderly patients with type 2 diabetes mellitus, especially those with low educational levels.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Review
Materials Science, Biomaterials
Chenlu Yao, Chao Wang
Summary: Platelet-derived extracellular vesicles (PEVs) are released from platelets and play a critical role in hemostasis and thrombosis. Recent research has shown that PEVs have important functions in inflammation, angiogenesis, and cancer. PEVs have been utilized as drug delivery platforms, targeting inflammatory sites both passively and actively. This review summarizes the biological function of PEVs, recent applications in targeted drug delivery, and future development prospects.
BIOMATERIALS SCIENCE
(2023)
Article
Multidisciplinary Sciences
Carlos Berlanga-Macias, Mairena Sanchez-Lopez, Montserrat Solera-Martinez, Ana Diez-Fernandez, Inmaculada Ballesteros-Yanez, Carlos A. Castillo-Sarmiento, Isabel A. Martinez-Ortega, Vicente Martinez-Vizcaino
Summary: This study found no significant positive association between exclusive breastfeeding and BDNF serum levels in Spanish schoolchildren aged eight to 11 years. Regardless of breastfeeding duration, age group, or sexual maturation, BDNF levels did not show significant differences, indicating that exclusive breastfeeding may not have a significant impact on BDNF levels in this age group.
Article
Obstetrics & Gynecology
Melike Geyik Bayman, Zeynep Ozturk Inal, Fatih Hayiroglu, Elif Nur Yildirim Ozturk, Kazim Gezginc
Summary: The aim of this study was to investigate the impact of gestational diabetes mellitus (GDM) on brain-derived neurotrophic factor (BDNF) levels in foetal umbilical cord blood. The study found that GDM had no effect on cord blood BDNF levels, but cord blood BDNF values were higher in female infants and in patients using insulin for GDM.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Letter
Psychiatry
Angelo Emilio Claro, Clelia Palanza, Marianna Mazza, Alessandro Rizzi, Linda Tartaglione, Giuseppe Marano, Giovanna Muti-Schuenemann, Marta Rigoni, Paola Muti, Alfredo Pontecorvi, Luigi Janiri, Gabriele Sani, Dario Pitocco
Summary: The aim of this paper is to discuss the relationship between stress, depression, increased inflammation, and reduced BDNF levels. It is hypothesized that severe or prolonged stress may be a driving factor for the onset of depression. Both stress and depression can activate the production of pro-inflammatory genes, leading to chronic inflammation and reduced BDNF levels. The paper also explores possible reasons for the increased risk of type 2 diabetes in individuals with depression.
WORLD JOURNAL OF PSYCHIATRY
(2022)
Review
Medicine, General & Internal
Xian-Qiong Xie, Dong-Gui Cai, Quan Yang
Summary: The meta-analysis study found no significant association between BDNF rs6265 polymorphism and the risk of type 2 diabetes mellitus (T2DM), with no observed subgroup effects.
Review
Behavioral Sciences
Ya-Hai Wang, Huan-Huan Zhou, Qiang Luo, Sidong Cui
Summary: This study investigated the effects of physical exercise on brain-derived neurotrophic factor (BDNF) in healthy individuals. The findings showed that both acute and long-term exercise had significant positive effects on circulating BDNF levels. Subgroup analysis revealed that long-term aerobic exercise, female participants, participants older than 60 years, and aerobic exercise contributed to a more pronounced improvement in BDNF levels.
BRAIN AND BEHAVIOR
(2022)
Article
Nutrition & Dietetics
Safa Sefidgari-Abrasi, Leila Roshangar, Pouran Karimi, Mohammad Morshedi, Marziyeh Rahimiyan-Heravan, Maryam Saghafi-Asl
Summary: This study investigated the impacts of L. plantarum and inulin supplementation on diabetic cardiomyopathy, showing that these supplements can reduce cardiac apoptosis and fibrosis levels by modulating serotonin and BDNF as well as their cardiac receptors.
CLINICAL NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Li Song, Xiaoxiao Zhao, Runzhen Chen, Jiannan Li, Jinying Zhou, Chen Liu, Peng Zhou, Ying Wang, Yi Chen, Hanjun Zhao, Hongbing Yan
Summary: This study found that high PCSK9 levels were independently associated with major adverse cardiovascular events (MACEs) in ST-segment elevation myocardial infarction (STEMI) patients with diabetes undergoing primary percutaneous coronary intervention (PCI). This association may be due to the stronger correlations between PCSK9 and inflammation and platelet activation markers in diabetic patients.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Agata Tyminska, Krzysztof Ozieranski, Marek Wawrzacz, Pawel Balsam, Cezary Maciejewski, Magdalena Kleszczewska, Magdalena Zawadzka, Michal Marchel, Maria G. Crespo-Leiro, Aldo P. Maggioni, Jaroslaw Drozdz, Grzegorz Opolski, Marcin Grabowski, Agnieszka Kaplon-Cieslicka
Summary: Heart rate control in patients with heart failure after hospitalization is unsatisfactory, possibly due to inadequate doses of beta-blockers and neglect of other heart rate lowering drugs.
CARDIOLOGY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Szczepan Wiecha, Przemyslaw Seweryn Kasiak, Igor Cieslinski, Tim Takken, Tomasz Palka, Beat Knechtle, Pantelis T. Nikolaidis, Lukasz A. Malek, Marek Postula, Artur Mamcarz, Daniel Sliz
Summary: This study compared predicted VO2max (pVO2max) with directly measured VO2max and found that the accuracy of available prediction models has not been validated in endurance athletes. The models underestimated pVO2max in younger and higher trained athletes, and overestimated pVO2max in older and lower trained athletes. These models should only be used as a supplemental method for physicians and new models need to be developed for clinical practice and sports diagnostics.
Article
Cardiac & Cardiovascular Systems
Aleksandra Gasecka, Oliwia Fidali, Aleksandra Klebukowska, Karolina Jasinska-Gniadzik, Piotr Szwed, Karolina Witkowska, Ceren Eyileten, Marek Postula, Marcin Grabowski, Krzysztof J. Filipiak, Marcin Ufnal
Summary: This study investigates the association between plasma concentrations of gut metabolites and major adverse cardiac and cerebrovascular events (MACCE) after acute myocardial infarction (AMI). The findings suggest that increased levels of trimethylamine-N-oxide (TMAO) may be an independent predictor of MACCE and contribute to post-AMI cardiac dysfunction.
POSTEPY W KARDIOLOGII INTERWENCYJNEJ
(2023)
Review
Biochemistry & Molecular Biology
Chiara Siracusa, Jolanda Sabatino, Isabella Leo, Ceren Eyileten, Marek Postula, Salvatore De Rosa
Summary: Lack of timely intervention strategies for acute ischemic stroke due to limited understanding of underlying mechanisms. Circular RNAs involved in pathophysiological processes of ischemic stroke, providing potential therapeutic targets and clinical biomarkers.
Review
Cardiac & Cardiovascular Systems
Karolina Gumiezna, Piotr Barus, Grazyna Sygitowicz, Agnieszka Wisniewska, Dorota Ochijewicz, Karolina Pasierb, Dominika Klimczak-Tomaniak, Ewa Kuca-Warnawin, Janusz Kochman, Marcin Grabowski, Grzegorz Opolski, Mariusz Tomaniak, Krzysztof J. Filipiak
Summary: Immature platelet fraction (IPF) has been found to play important roles in diagnosis, prognosis, and potential therapy in cardiovascular medicine. It serves as an independent predictor of cardiovascular death in patients with acute coronary syndromes, particularly ST-segment elevation myocardial infarction. Additionally, IPF can be used for monitoring antiplatelet therapy.
CARDIOLOGY JOURNAL
(2023)
Article
Clinical Neurology
A. Cudna, E. Bronisz, D. Mirowska-Guzel, I. Kurkowska-Jastrz Ebska
Summary: Damage to the blood-brain barrier (BBB) from neuroinflammation after epileptic seizures can disrupt brain homeostasis. This study examined the involvement of modulatory proteins in BBB integration. Serum analysis of 50 epilepsy patients showed slight increases in MMP-2 levels after seizures, along with decreases in TSP-1 and -2 levels and an increase in TIMP-2 expression. However, there were no significant changes in alpha 2-macroglobulin and MMP-7 levels. These findings suggest the initiation of repair processes and improved integrity of the BBB after seizures. Further studies correlating serum markers with brain expression are needed for potential identification of epileptic seizure biomarkers.
Article
Clinical Neurology
Agnieszka Piechal, Jan Bembenek, Anna Baranowska, Tomasz Litwin, Dagmara Mirowska-Guzel, Anna Czlonkowska
Summary: This study evaluated olfactory dysfunction in patients with Wilson's Disease (WD) and found that patients with WD had a weaker sense of smell compared to healthy controls. Older individuals and those with predominantly neurological symptoms were more likely to experience olfactory disorders.
NEUROLOGIA I NEUROCHIRURGIA POLSKA
(2023)
Article
Biochemistry & Molecular Biology
Gloria M. M. Gager, Ceren Eyileten, Marek Postula, Anna Nowak, Aleksandra Gasecka, Bernd Jilma, Jolanta M. M. Siller-Matula
Summary: This study investigated the relationship between blood-derived microRNAs (miRNAs) and long-term all-cause mortality in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). The expression of miR-223 was found to be associated with improved long-term survival in NSTE-ACS patients. This hypothesis-generating study suggests that miR-223 may be a suitable predictor for long-term all-cause mortality.
Review
Health Care Sciences & Services
Chiara Siracusa, Niccolo Vono, Maria Benedetta Morano, Jolanda Sabatino, Isabella Leo, Ceren Eyileten, Eleonora Cianflone, Marek Postula, Daniele Torella, Salvatore De Rosa
Summary: Despite improvements in diagnosis and treatment, ischemic stroke remains a challenge with significant morbidity and mortality. The identification of high-risk individuals, timely diagnosis, recognition of different clinical forms, treatment response assessment, and prognostic evaluation are unmet clinical needs. This article provides an overview of circular RNAs as potential biomarkers in stroke, aiming to gather comprehensive information on this promising class of molecules.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Bela Merkely, Robert Hatala, Jerzy K. Wranicz, Gabor Duray, Csaba Foldesi, Zoltan Som, Marianna Nemeth, Kinga Goscinska-Bis, Laszlo Geller, Endre Zima, Istvan Osztheimer, Levente Molnar, Julia Karady, Gerhard Hindricks, Ilan Goldenberg, Helmut Klein, Matyas Szigeti, Scott D. Solomon, Valentina Kutyifa, Attila Kovacs, Annamaria Kosztin, BUDAPEST CRT Upgrade Invest
Summary: De novo implanted cardiac resynchronization therapy with defibrillator (CRT-D) reduces the risk of morbidity and mortality in patients with left bundle branch block, heart failure and reduced ejection fraction (HFrEF). However, among HFrEF patients with right ventricular pacing (RVP), the efficacy of CRT-D upgrade is uncertain.
EUROPEAN HEART JOURNAL
(2023)
Review
Primary Health Care
Dagmara Mirowska-Guzel, Aneta Nitsch-Osuch
Summary: Multiple sclerosis is a chronic demyelinating disease of the central nervous system with unclear aetiology, involving genetic and environmental factors, including infections. Preventing infections reduces the risk of MS relapse and improves quality of life outcome. Vaccinations should be an integral part of treatment for MS patients.
FAMILY MEDICINE AND PRIMARY CARE REVIEW
(2023)
Article
Biochemistry & Molecular Biology
Sonia Borodzicz-Jazdzyk, Agnieszka Kolodzinska, Katarzyna Czarzasta, Malgorzata Wojciechowska, Renata Glowczynska, Benedykt Szczepankiewicz, Liana Puchalska, Grzegorz Opolski, Agnieszka Cudnoch-Jedrzejewska
Summary: The aim of this study was to evaluate the presence and dynamics of necroptosis and pyroptosis in the rat model of TTS. The results showed higher plasma concentrations of interleukin-1β in TTS patients compared to controls. Protein expression associated with necroptosis and pyroptosis was observed in the myocardium after the injection of isoprenaline. These findings suggest that TTS is associated with inflammatory-associated programmed cell death and inflammation may occur simultaneously with cardiomyocyte death.
Review
Cardiac & Cardiovascular Systems
Michal Wasiak, Mateusz Tajstra, Dariusz Kosior, Mariusz Gasior
Summary: Recent data shows that there is no mortality benefit from implantable cardioverter-defibrillator (ICD) therapy compared to optimal medical treatment in patients with non-ischemic cardiomyopathy. Despite recommendations for ICD implantation remaining unchanged, these findings have significantly impacted the routine practice of ICD implantation in Europe.
CARDIOLOGY JOURNAL
(2023)
Review
Primary Health Care
Dagmara Mirowska-Guzel, Magdalena Niedzielko, Rafal Kulakowski
Summary: Nirmatrelvir/ritonavir (Paxlovid) is indicated for high-risk patients with severe COVID-19, with ritonavir acting as a pharmacokinetic booster. Ritonavir can affect plasma levels of other drugs, potentially leading to interactions and adverse reactions. Data on the clinical impact of Paxlovid DDIs is currently lacking, and there is uncertainty in managing the co-administration of various medications.
FAMILY MEDICINE AND PRIMARY CARE REVIEW
(2023)
Article
Cardiac & Cardiovascular Systems
Jakub Maksym, Agnieszka Kaplon-Cieslicka, Piotr Scislo, Zenon Huczek, Michal Marchel, Radoslaw Piatkowski, Janusz Kochman, Grzegorz Opolski, Marcin Grabowski, Tomasz Mazurek
Summary: This study investigated the safety and efficacy of LAAC procedure followed by antiplatelet therapy in a high-risk population. The results showed that this treatment strategy was safe and effective in high-risk patients. Peri-procedural complications and treatment endpoints were evaluated.
POSTEPY W KARDIOLOGII INTERWENCYJNEJ
(2023)
