Review
Immunology
Ilari Kuitunen, Johanna Jaaskelainen, Matti Korppi, Marjo Renko
Summary: Based on a meta-analysis of 4 randomized controlled studies, it was found that short antibiotic treatment (3-5 days) was as effective and safe as longer treatment (7-10 days) for community-acquired pneumonia in children in high-income countries.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Infectious Diseases
Aurelien Dinh, Anne-Claude Cremieux, Didier Guillemot
Summary: Lower respiratory tract infections are a common reason for antibiotic use. Current guidelines recommend 5-7 days of antibiotic treatment for adults with community-acquired pneumonia (CAP), but physicians often prescribe longer durations. Shortening antibiotic treatment is a safe and acceptable strategy to reduce antibiotic use and prevent bacterial resistance. This review aims to evaluate the efficacy of short antibiotic duration in adult CAP and identify criteria to guide clinicians in reducing treatment duration.
CURRENT OPINION IN INFECTIOUS DISEASES
(2023)
Article
Immunology
Valerie M. Vaughn, Tejal N. Gandhi, Timothy P. Hofer, Lindsay A. Petty, Anurag N. Malani, Danielle Osterholzer, Lisa E. Dumkow, David Ratz, Jennifer K. Horowitz, Elizabeth S. McLaughlin, Tawny Czilok, Scott A. Flanders
Summary: In a 3-year quality improvement initiative, it was found that the appropriate use of 5-day antibiotic treatment for uncomplicated community-acquired pneumonia increased to 43.9% over time, resulting in a decrease in adverse events.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Critical Care Medicine
Christopher H. Goss, Sonya L. Heltshe, Natalie E. West, Michelle Skalland, Don B. Sanders, Raksha Jain, Tara L. Barto, Barbra Fogarty, Bruce C. Marshall, Donald R. VanDevanter, Patrick A. Flume
Summary: This study investigated different durations of intravenous antimicrobial treatment for CF exacerbations, revealing that for patients with early improvement, 10 days is as effective as 14 days, while for those with slower progress, 21 days does not show superiority over 14 days.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Respiratory System
Thomas M. File, Elizabeth Alexander, Lisa Goldberg, Anita F. Das, Christian Sandrock, Susanne Paukner, Gregory J. Moran
Summary: The research demonstrates that Lefamulin is noninferior to moxifloxacin in treating community-acquired bacterial pneumonia in adults, showing high efficacy in various patient subgroups without any new safety concerns identified.
BMC PULMONARY MEDICINE
(2021)
Article
Oncology
Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li
Summary: The rationale for antibiotic treatment of viral community-acquired pneumonia in adults was analyzed, revealing a high rate of unreasonable antibiotic use, highlighting the need for clinicians to reduce unnecessary antibiotic use.
FRONTIERS OF MEDICINE
(2021)
Article
Infectious Diseases
Dmitri Guz, Maayan Bracha, Yotam Steinberg, Dror Kozlovsky, Anat Gafter-Gvili, Tomer Avni
Summary: This study compared the efficacy of ceftriaxone and ampicillin in the treatment of hospitalized adults with community-acquired pneumonia (CAP). The results showed no significant difference in 30-day all-cause mortality between the two treatment groups, but the ampicillin group had a significantly lower rate of Clostridioides difficile infection (CDI). Further research is needed to confirm these results.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Medicine, General & Internal
Julia A. Bielicki, Wolfgang Stohr, Sam Barratt, David Dunn, Nishdha Naufal, Damian Roland, Kate Sturgeon, Adam Finn, Juan Pablo Rodriguez-Ruiz, Surbhi Malhotra-Kumar, Colin Powell, Saul N. Faust, Anastasia E. Alcock, Dani Hall, Gisela Robinson, Daniel B. Hawcutt, Mark D. Lyttle, Diana M. Gibb, Mike Sharland
Summary: In a clinical trial involving 814 children with community-acquired pneumonia, it was found that lower-dose oral amoxicillin (35-50 mg/kg/day) was noninferior to higher dose (70-90 mg/kg/day), and a 3-day regimen was noninferior to 7 days in terms of the need for antibiotic re-treatment. However, various factors such as disease severity, treatment setting, prior antibiotics received, and acceptability of the noninferiority margin need to be considered when interpreting the findings.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Immunology
Leigh M. Howard, Kathryn M. Edwards, Yuwei Zhu, Carlos G. Grijalva, Wesley H. Self, Seema Jain, Krow Ampofo, Andrew T. Pavia, Sandra R. Arnold, Jonathan A. McCullers, Evan J. Anderson, Richard G. Wunderink, Derek J. Williams
Summary: Clinical features did not reliably distinguish HMPV-associated pneumonia from other pathogens. HMPV-associated pneumonia was less severe than bacterial and adult RSV pneumonia, but was otherwise as or more severe than other common pathogens.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Manjunath P. Pai, Mark Wilcox, Surya Chitra, Paul McGovern
Summary: The fixed-dosing strategy of omadacycline demonstrated consistent safety and efficacy in patients with CABP of different body sizes, with similar clinical success rates across ascending BMI groups and diabetes status. Patients who had clinical success or clinical stability at ECR generally showed continued clinical success at PTE. Safety profiles for omadacycline and moxifloxacin were largely similar across BMI subgroups and by diabetes history.
RESPIRATORY MEDICINE
(2021)
Article
Medicine, General & Internal
George D. Rodriguez, Nathan Warren, Roman Yashayev, Surya Chitra, Maria Amodio-Groton, Kelly Wright
Summary: The 2019 guidelines recommend respiratory fluoroquinolones for treating community-acquired bacterial pneumonia in adults with comorbidities. However, fluoroquinolone use has decreased due to safety warnings. This study assessed the safety and efficacy of omadacycline compared to moxifloxacin for treating adult pneumonia patients with comorbidities. The results showed that omadacycline and moxifloxacin had similar efficacy in patients with comorbidities.
FRONTIERS IN MEDICINE
(2023)
Correction
Respiratory System
Ane Uranga, Amaia Artaraz, Amaia Bilbao, Jose Maria Quintana, Ignacio Arriaga, Maider Intxausti, Jose Luis Lobo, Julia Amaranta Garcia, Jesus Camino, Pedro Pablo Espana
Summary: An amendment to this paper has been published and can be accessed via the original article.
BMC PULMONARY MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Yujiao Zheng, Changren Shi, Yaowei Han, Xinmin Li, Lijing Dong, Yan Li, Hui Chen, Yushui Wang, Jinsong Li, Geli Liu, Rong Ma, Fengmei Lian, Xiaolin Tong
Summary: The study shows that Maxing Ganshi Decoction (MGD) can improve the clinical symptoms of children with community-acquired pneumonia (CAP) and shorten the time to fever resolution.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Cristina Avendano-Sola, Antonio Ramos-Martinez, Elena Munez-Rubio, Belen Ruiz-Antoran, Rosa Malo de Molina, Ferran Torres, Ana Fernandez-Cruz, Jorge Calderon-Parra, Concepcion Payares-Herrera, Alberto Diaz de Santiago, Irene Romera-Martinez, Ilduara Pintos, Jaime Lora-Tamayo, Mikel Mancheno-Losa, Maria L. Paciello, A. L. Martinez-Gonzalez, Julia Vidan-Estevez, Maria J. Nunez-Orantos, Maria Isabel Saez-Serrano, Maria L. Porras-Leal, Maria C. Jarilla-Fernandez, Paula Villares, Jaime Perez de Oteyza, Ascension Ramos-Garrido, Lydia Blanco, Maria E. Madrigal-Sanchez, Martin Rubio-Batlles, Ana Velasco-Iglesias, Jose R. Pano-Pardo, J. A. Moreno-Chulilla, Eduardo Muniz-Diaz, Inmaculada Casas-Flecha, Mayte Perez-Olmeda, Javier Garcia-Perez, Jose Alcami, Jose L. Bueno, Rafael F. Duarte
Summary: The study conducted in Spain involving 27 hospitals showed that convalescent plasma (CP) can significantly reduce the risk of progression to invasive mechanical ventilation or ECMO treatment, or death within 28 days for COVID-19 patients. However, the difference was not significant at 14 days and there was no significant improvement in overall survival.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Pediatrics
Jeffrey M. Pernica, Stuart Harman, April J. Kam, Redjana Carciumaru, Thuva Vanniyasingam, Tyrus Crawford, Dale Dalgleish, Sarah Khan, Robert S. Slinger, Martha Fulford, Cheryl Main, Marek Smieja, Lehana Thabane, Mark Loeb
Summary: In previously healthy children with community-acquired pneumonia not requiring hospitalization, short-course antibiotic therapy appeared to be comparable to standard care.
Article
Oncology
Jose M. Quintana, Ane Anton-Ladislao, Santiago Lazaro, Nerea Gonzalez, Marisa Bare, Nerea Fernandez de Larrea, Maximino Redondo, Antonio Escobar, Cristina Sarasqueta, Susana Garcia-Gutierrez, Urko Aguirre, Eduardo Briones
Summary: According to this study, proper implementation of quality indicators in patients with colorectal cancer can reduce mortality but increase the risk of adverse outcomes.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Article
Cardiac & Cardiovascular Systems
Susana Garcia-Gutierrez, Ane Villanueva, Iratxe Lafuente, Ibon Rodriguez, Ainara Lozano-Bahamonde, Nekane Murga, Josefina Orus, Emilia Rosa Camacho, Jose Maria Quintana, Raul Quiros
Summary: This study conducted a nested case-control study to analyze the characteristics of patients who were readmitted to hospital within 1 month after an episode of acute decompensated heart failure (ADHF). The findings revealed that factors such as chronic decompensated heart failure, previous diagnosis of arrhythmia, worsening symptoms, and changes in quality of life and frailty were associated with readmission. The results provide insights for preventing readmissions in ADHF patients during the first month after discharge.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Health Care Sciences & Services
Carme Miret, Miren Orive, Maria Sala, Susana Garcia-Gutierrez, Cristina Sarasqueta, Maria Jose Legarreta, Maximino Redondo, Amado Rivero, Xavier Castells, Jose M. Quintana, Olatz Garin, Montse Ferrer
Summary: The purpose of this study is to obtain reference norms for EORTC QLQ-C30, EORTC QLQ-BR23, and EQ-5D-5L based on a population of Spanish non-metastatic breast cancer patients. The study found independent associations between age, comorbidity, and tumor stage with health-related quality of life (HRQoL). These reference norms can be useful for interpreting scores of non-metastatic breast cancer patients and comparing them with country-specific reference values.
QUALITY OF LIFE RESEARCH
(2023)
Article
Orthopedics
Marta Gonzalez-Saenz-de-Tejada, Jose M. Quintana, Juan C. Arenaza, Jesus R. Azcarate-Garitano, Pedro M. Esnaola-Guisasola, Isidoro Garcia-Sanchez, Alejandro Baguer-Antonio, Amaia Bilbao-Gonzalez
Summary: This study aimed to analyze the factors related to greater gains in Health Related Quality of Life (HRQOL) and a greater probability of exceeding their corresponding minimal clinically important differences (MCID) in patients with Osteoarthritis of the knee undergoing total knee arthroplasty (TKA) in the long term. The results showed that lower preoperative HRQOL scores, older age, higher BMI, certain comorbidities, and readmissions at 6 months were associated with lower gains in HRQOL. In addition, having peripheral vascular disease, complications, and readmissions within 6 months of discharge were associated with a lower probability of exceeding the MCID. The study also found that the changes in HRQOL from 6 months to 10 years were not significant for pain or stiffness, and only small for function.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Correction
Medicine, General & Internal
Jose Quintana, Ane Anton-Ladislao, Miren Orive, Amaia Aramburu, Milagros Iriberri, Raquel Sanchez, Alberto Jimenez-Puente, Javier de-Miguel-Diez, Cristobal Esteban
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Computer Science, Information Systems
Janire Portuondo-Jimenez, Irantzu Barrio, Pedro P. Espana, Julia Garcia, Ane Villanueva, Maria Gascon, Lander Rodriguez, Nere Larrea, Susana Garcia-Gutierrez, Jose M. Quintana
Summary: This study aims to identify factors associated with SARS-CoV-2 infection that are linked to hospitalization, ICU admission, and mortality, and develop clinical prediction rules. A retrospective cohort study of 380,081 patients with SARS-CoV-2 infection was conducted, with a subsample of 46,402 patients attending Emergency Departments. Predictive models were developed using multivariate logistic regression models with Lasso penalization. Age, gender, vaccination status, baseline comorbidities and treatments, vital signs, and other background data were found to be predictors of death and adverse disease progression.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2023)
Article
Multidisciplinary Sciences
Miren Hayet-Otero, Fernando Garcia-Garcia, Dae-Jin Lee, Joaquin Martinez-Minaya, Pedro Pablo Espana Yandiola, Isabel Urrutia Landa, Monica Nieves Ermecheo, Jose Maria Quintana, Rosario Menendez, Antoni Torres, Rafael Zalacain Jorge, Inmaculada Arostegui
Summary: A data-driven exploration using machine learning was conducted to predict the severity of SARS-CoV-2 pneumonia. Clinical and other factors such as C-reactive protein, pneumonia severity index, respiratory rate, and oxygen levels were found to be important predictors.
Article
Cardiac & Cardiovascular Systems
Cristobal Esteban, Ane Anton-Ladislao, Amaia Aramburu, Leyre Chasco, Miren Orive, Eva Tabernero, Monica Rayon, Jose Joaquin Cebrian, Jose Teran, Ignacio Garcia-Talavera, Jose M. Quintana
Summary: This study aimed to determine the impact of hospitalizations on levels of physical activity (PA) and whether other factors were associated with subsequent changes in PA. The results showed a significant difference in PA between patients readmitted up to 2 months after the index admission and those not readmitted. Predictors of the decrease in PA included admission for COPD exacerbation, readmission, baseline HAD depressive symptoms, worse CAT score, and patient-reported need for help.
RESPIRATORY MEDICINE
(2023)
Correction
Gastroenterology & Hepatology
Miren Orive, Irantzu Barrio, Santiago Lazaro, Nerea Gonzalez, Marisa Bare, Nerea Fernandez de Larrea, Maximino Redondo, Sarai Cortajarena, Amaia Bilbao, Urko Aguirre, Cristina Sarasqueta, Jose M. Quintana
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Geriatrics & Gerontology
Pedro P. Espana, Amaia Bilbao-Gonzalez, Nere Larrea, Idoia Castillo-Sintes, Susana Garcia-Gutierrez, Janire Portuondo, Ane Villanueva, Ane Uranga, Maria J. Legarreta, Maria Gascon, Jose M. Quintana
Summary: This study investigated the impact of COVID-19 vaccines and previous SARS-CoV-2 infections in preventing hospitalization and mortality in nursing home residents. The results showed a significant decrease in hospitalization and death rates after vaccination, and individuals with previous COVID-19 infections had even lower rates.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Health Care Sciences & Services
Janire Portuondo-Jimenez, Maria Gascon, Julia Garcia, Maria-Jose Legarreta, Ane Villanueva, Nere Larrea, Susana Garcia-Gutierrez, Endika Munitiz, Jose M. Quintana
Summary: The study aimed to examine the relationship between the population deprivation index and the utilization of health services, adverse outcomes, and mortality during the COVID-19 pandemic. A retrospective cohort study was conducted on patients with SARS-CoV-2 infection from March 1, 2020 to January 9, 2022. The results showed that individuals in the most deprived quintiles had a higher risk of death, poor outcome, hospital admission, and emergency room visits compared to those in the least deprived quintile. These differences were observed in different stages of the pandemic. Therefore, interventions are needed to minimize these inequalities.
Article
Gastroenterology & Hepatology
Miren Orive, Irantzu Barrio, Santiago Lazaro, Nerea Gonzalez, Marisa Bare, Nerea Fernandez de Larrea, Maximino Redondo, Sarai Cortajarena, Amaia Bilbao, Urko Aguirre, Cristina Sarasqueta, Jose M. Quintana
Summary: The study aims to identify prognostic variables for 5-year survival in colorectal cancer (CRC) patients and propose a survival prognostic score that considers changes in health-related quality of life (HRQoL) over time. Data was collected from CRC patients through a prospective observational cohort study, including diagnosis, intervention, and follow-up at 1, 2, 3, and 5 years. HRQoL data was assessed using EQ-5D-5L, EORTC-QLQ-C30, and HADS questionnaires. Multivariate Cox proportional models were used for analysis. The results identified several predictors of mortality over the 5-year follow-up period. These findings provide insights for establishing preventive and controlling measures for long-term follow-up of CRC patients based on easily measurable variables.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)