Article
Dermatology
Bo Joergensen, Sophie Blaise, Ann-Sofie Svensson
Summary: This study compared the performance and safety of Exufiber (R) gelling fibre and Aquacel (R) Extra (TM) Hydrofiber (R) wound dressings in managing chronic, exuding leg ulcers. The findings demonstrated that both dressings were effective in reducing wound area and were well tolerated, with clinicians expressing higher satisfaction with Exufiber (R).
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Dermatology
Joachim Dissemond, Kristina Aare, Kerem Ozer, Divay Gandhi, Jessica L. Ryan, Mitch DeKoven
Summary: This study compared the clinical performance and outcomes of Aquacel Ag+ and Sorbact dressings for patients with venous leg ulcers, diabetes foot ulcers, and pressure injuries in Germany and the US. The results showed that in Germany, Aquacel Ag+ users required less surgery, while in the US, there were significantly higher odds of complete wound healing with Aquacel Ag+ dressings compared to Sorbact.
JOURNAL OF WOUND CARE
(2023)
Article
Microbiology
Justyna Paleczny, Adam Junka, Malwina Brozyna, Karolina Dydak, Monika Oleksy-Wawrzyniak, Daria Ciecholewska-Jusko, Ewelina Dziedzic, Marzenna Bartoszewicz
Summary: This study demonstrates how changing a single variable (medium composition) in the standard in vitro model not only affects the characteristics of staphylococcal biofilms, but also may alter the efficacy of clinically applied wound antimicrobials.
Article
Engineering, Environmental
Junyao Song, Haoyu Chen, Yaqian Lv, Wanqun Yang, Fenglang Zhang, Tianyi Wang, Danping Liu, Yingshan Qu, Lei Han, Jun Fu, Xiaoying Kong
Summary: This study developed a hybrid single atom nanozyme material composed of Zn single-atom catalysts and copper peroxide, which exhibited superior antibacterial properties and therapeutic effects for the treatment of biofilm-infected wounds.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Beatriz G. Bernardes, Pasquale Del Gaudio, Paulo Alves, Raquel Costa, Carlos A. Garcia-Gonzalez, Ana Leite Oliveira
Summary: Wounds should be managed based on the healing phase and condition, with excessive exudate production posing challenges. Aerogels, especially bio-based ones, offer potential in promoting wound healing and regeneration through their unique properties and nanostructure.
Article
Nanoscience & Nanotechnology
Bo Yuan, Xin Zhou, Yingke Li, Yin Zhao, Mintao Xue, Qunfeng Guo, Gang Zheng, Xiongsheng Chen, Han Lin, Xiang Guo
Summary: This study demonstrates the excellent performance of a BPs@HA composite coating in eliminating bacterial biofilms and accelerating bone fracture healing. Through in vitro and in vivo studies on bacterial biofilms and bone fracture healing, the BPs@HA coating was shown to regulate the expression of core markers related to bone mesenchymal stem cell differentiation and bone formation through metabolism-related pathways.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Tara Pourseif, Robabehbeygom Ghafelehbashi, Mohammadreza Abdihaji, Niloufar Radan, Ehsan Kaffash, Maryam Heydari, Maryam Naseroleslami, Neda Mousavi-Niri, Iman Akbarzadeh, Qun Ren
Summary: This study aims to develop a niosomal platform for the delivery of TCH to treat bacterial infections in wounds. Chitosan was used to obtain controlled drug release and antibacterial activity. The optimized TCH-Nio showed a controlled release rate, and TCH-Nio@CS, with chitosan coating, exhibited 2-fold higher antibacterial activity compared to TCH-Nio. The formulated niosomes showed no in vitro toxicity towards human cells and down-regulated biofilm genes in tested bacteria.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Wenhui Chu, Pan Wang, Zhe Ma, Lin Peng, Chenyuan Guo, Yongqian Fu, Lingzhi Ding
Summary: Ag+-modified chitosan nanoparticles were used to deliver lupeol, forming CS-Ag-L-NPs, which were then encapsulated in a self-assembled sericin hydrogel. The nanoparticles showed good antibacterial activity and low hemolysis ratio. The CS-Ag-L-NPs sericin gel exhibited multiple beneficial effects for wound healing and bacterial infection suppression.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Xinyu Ren, Zhiming Hou, Bo Pang, Cen Gao, Rongbing Tang
Summary: This study presents a biohybrid dressing combining the natural abilities of a Bromeliad leaf with the therapeutic effects of artificial materials for diabetic wound therapy. The dressing consists of an outer layer using photosynthesis to generate oxygen and reduce hyperglycemia, and an inner layer containing catalase to decrease oxidative stress and inflammation. This biohybrid dressing shows promise in enhancing wound healing by promoting angiogenesis, re-epithelialization, alleviating chronic inflammation, and suppressing bacterial infection.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Hanif Haidari, Richard Bright, Sanjay Garg, Krasimir Vasilev, Allison J. Cowin, Zlatko Kopecki
Summary: The development of highly potent ultrasmall AgNPs combined with a biocompatible hydrogel has shown promising results in eliminating mature biofilm infections in vivo and promoting wound healing. The treatment exhibited superior antibacterial efficacy and improved wound closure, re-epithelization, and collagen deposition compared to conventional silver-based treatments.
Article
Engineering, Biomedical
Jie Li, Sharon Shui Yee Leung, Yik Lok Chung, Simon Kwoon Ho Chow, Volker Alt, Markus Rupp, Christoph Brochhausen, Chun Sing Chui, Margaret Ip, Wing-Hoi Cheung, Ronald Man Yeung Wong
Summary: This study developed a hydrogel therapy with dual release of DNase I and Vancomycin to eliminate MRSA infection and prevent biofilm formation, promoting fracture healing.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Ling Li, Qian Zhao, Fan Feng, Chenglin Li, Tiantian Wang, Weichao Chen, Xiaochuan Ren, Yuesheng Huang, Jiwei Li
Summary: This study developed a Janus dressing (TPU/Cotton) by directly electrospinning thermoplastic polyurethane (TPU) nanofiber on cotton microfibers, which can drain excess exudate unidirectionally. Ag/Zn dot electrodes were deposited on the TPU layer to produce an electric field that penetrates the wound when activated by wound exudate. Hydro-activated Ag/Zn's electrical stimulation (ES) promotes fibroblast cell migration and exhibits strong antibacterial activity. In vivo experiments showed that exudate management coupled with ES accelerates wound healing by promoting re-epithelization, collagen deposition, and vascularization. Additionally, the Ag/Zn@TPU/Cotton dressing demonstrates excellent biocompatibility in vitro cytotoxicity experiments. This research provides insights for developing next-generation wound dressings with self-activated electrical stimulation and exudate management.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Physical
Wei Zhang, Xue Guan, Xiao Qiu, Tonghuan Gao, Wanying Yu, Mengyuan Zhang, Liru Song, Dan Liu, Jidong Dong, Zaixing Jiang, Dawei Zhang
Summary: In this study, skin-inspired multilayer Janus composite nanofibrous membranes were designed and prepared as wound dressings with superhydrophilicity and superhydrophobicity. The membranes were investigated for their wettability, morphology, in-vitro release, cytotoxicity, antimicrobial activity, and healing effect. Results from animal experiments and histological analysis demonstrated that the composite membranes were more effective in improving the healing of full-thickness defect wounds and promoting the growth of collagen fibers and collagen deposition. The composite membranes consisted of a drug-loading layer with a superhydrophilic surface for self-pumping and drugs backflow, a hydrophobic polyvinylidene fluoride layer for delaying exudates loss, and a superhydrophobic coating with self-cleaning properties for avoiding the adhesion of foreign microorganisms.
APPLIED SURFACE SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Takeshi Kogo, Kazufumi Sugi, Hideyuki Kanematsu, Hotaka Kai, Akiko Ogawa, Nobumitsu Hirai, Toshiyuki Takahashi, Takehito Kato
Summary: The evaluation of biofilm formation is important due to its widespread occurrence and problematic nature in various settings. The researchers propose a novel method that utilizes Ag+ reduction reaction to accurately quantify biofilm formation. This method overcomes the limitations of dye staining method and enables quantitative evaluation of biofilms on different substrates.
Article
Engineering, Biomedical
Haipeng Wang, Wu Duan, Zhongjing Ren, Xinxin Li, Wenjie Ma, Yingchun Guan, Fuqiang Liu, Li Chen, Peng Yan, Xinguo Hou
Summary: Proper management of exudate is clinically valuable for reducing wound infection and promoting wound healing. A novel sandwich-structured composite wound dressing (SCWD) is proposed, which effectively manages wound exudate and provides a favorable environment for wound healing. Experimental results show that SCWD significantly reduces wound infection, avoids tearing of wound tissues, and accelerates wound healing.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Dermatology
Keith G. Harding, Marek Szczepkowski, Jacek Mikosinski, Krystyna Twardowska-Saucha, Stephen Blair, Nicola M. Ivins, Wojciech Saucha, Jane Cains, Kim Peters, David Parsons, Philip Bowler
INTERNATIONAL WOUND JOURNAL
(2016)
Article
Dermatology
Daniel G. Metcalf, David Parsons, Philip G. Bowler
INTERNATIONAL WOUND JOURNAL
(2017)
Article
Biotechnology & Applied Microbiology
David Parsons, Kate Meredith, Victoria J. Rowlands, Darryl Short, Daniel G. Metcalf, Philip G. Bowler
BIOMED RESEARCH INTERNATIONAL
(2016)
Article
Dermatology
Stephen C. Davis, Jie Li, Joel Gil, Jose Valdes, Michael Solis, Alex Higa, Philip Bowler
INTERNATIONAL WOUND JOURNAL
(2018)
Article
Dermatology
Philip G. Bowler
JOURNAL OF WOUND CARE
(2018)
Article
Infectious Diseases
M. Haalboom, M. H. E. Blokhuis-Arkes, R. J. Beuk, R. Meerwaldt, R. Klont, M. J. Schijffelen, P. B. Bowler, M. Burnet, E. Sigl, J. A. M. van der Palen
CLINICAL MICROBIOLOGY AND INFECTION
(2019)
Article
Dermatology
Ruth Scully, Jennifer Hurlow, Mike Walker, Daniel Metcalf, David Parsons, Philip Bowler
JOURNAL OF WOUND CARE
(2018)
Letter
Dermatology
David Parsons, Philip Bowler
JOURNAL OF WOUND CARE
(2019)
Review
Public, Environmental & Occupational Health
Philip Bowler, Christine Murphy, Randall Wolcott
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2020)
Article
Medicine, General & Internal
Thomas E. Serena, Philip G. Bowler, Gregory S. Schultz, Anna D'souza, Monique Y. Rennie
Summary: Early awareness and management of bacterial burden and biofilm are crucial for wound healing. Semi-quantitative analysis is a relatively simple method for measuring wound microbial load, but other clinically relevant approaches are needed to determine wound bioburden and guide best management practices.
Article
Dermatology
Jenny Hurlow, Philip G. Bowler
Summary: Wound infection is a complex pathology, with significant differences between acute and chronic infections in terms of pathogens, immune responses, and clinical manifestations. Antibiotics are appropriate for acute wound infections, but overuse in chronic wound management contributes to antibiotic resistance.
JOURNAL OF WOUND CARE
(2022)
Review
Medicine, General & Internal
Michael Burnet, Daniel G. Metcalf, Scarlet Milo, Clemens Gamerith, Andrea Heinzle, Eva Sigl, Kornelia Eitel, Marieke Haalboom, Philip G. Bowler
Summary: Traditionally, wound infection is defined by clinical signs and microbiological analysis. However, these approaches have limitations, especially in early or complex wounds. Patient-derived biomarkers of immune activation may indicate wound infection earlier and more reliably. Detection of innate immune cell enzymes offers a new, simple, and effective approach to determine wound infection status, enhancing infection resolution and wound healing.
Article
Emergency Medicine
Daniel G. Metcalf, Philip G. Bowler
Article
Dermatology
Daniel G. Metcalf, Lawrence Tsai, Corrine Williams, David Pritchard, David Parsons, Philip G. Bowler
WOUND MANAGEMENT & PREVENTION
(2019)
Article
Dermatology
Daniel Metcalf, Philip G. Bowler
WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
(2019)