Review
Gastroenterology & Hepatology
Gareth J. Sanger, Paul L. R. Andrews
Summary: This study summarizes the drugs used to treat gastroparesis and explores the rationale behind blocking different pathways causing vomiting and increasing gastric emptying via different mechanisms. The results suggest that some drug classes lack scientific rationale for inhibiting vomiting. NK1 antagonism shows some rationale but limited efficacy against nausea. The efficacy of selective 5-HT4 agonists varies. Further research is needed to develop novel approaches targeting nausea and objective assessments of nausea.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Elisabeth K. Steinsvik, Dag A. Sangnes, Eirik Softeland, Martin Biermann, Jorg Assmus, Georg Dimcevski, Odd Helge Gilja, Trygve Hausken
Summary: The study showed that patients with diabetic gastroparesis have motility disturbances in the proximal stomach and antral distension. Ultrasound examination of the stomach provides valuable information about gastric motility in these patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Irene Sarosiek, Mark Van Natta, Henry P. Parkman, Thomas Abell, Kenneth L. Koch, Braden Kuo, Robert J. Shulman, Gianrico Farrugia, Madhusudan Grover, Frank A. Hamilton, Pankaj J. Pasricha, Katherine P. Yates, Laura Miriel, Laura Wilson, Goro Yamada, James Tonascia, Richard W. McCallum
Summary: This study aimed to evaluate the effectiveness of domperidone (DOM) in treating gastroparesis (GP) and found that DOM treatment can moderately but significantly improve the symptoms of GP.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Clinical Neurology
Karissa N. Arca, Jacqueline Cai, Fangfang Wang, Gassan Kassim, William L. Hasler, Mashal J. Batheja
Summary: This article reviews the recent literature on the pathophysiology and clinical manifestations of migraine and gastroparesis, highlighting the management considerations when these disorders coexist. There is increasing recognition of the overlap in the pathophysiology of migraine and gastroparesis, with a complex interplay between the central, autonomic, and enteric nervous systems. This has implications for treatment selection and optimizing outcomes.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Review
Gastroenterology & Hepatology
David Adams, Abigail Stocker, William Lancaster, Thomas Abell
Summary: This article reviews the use of bioelectric therapy of neuromodulation, via gastric electrical stimulation, for patients with drug refractory gastroparesis syndromes including surgical aspects of device placement and subsequent management. In addition to discussing newer concepts, the role of pyloric dysfunction in gastroparesis and the potential use of stimulation devices and pyloric therapies in concert are explored.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Review
Nutrition & Dietetics
Devanshi Gala, Hattie H. Wright, Bekhinkosi Zigori, Skye Marshall, Megan Crichton
Summary: The study suggests that CINV-specific nutrition education and support from health professionals can improve CINV. Non-restrictive dietary patterns, particularly those including adequate energy and macronutrient intakes, ginger, and Mediterranean diet concepts, may benefit CINV.
CLINICAL NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Connie Kang, Matt Shirley
Summary: IV amisulpride is efficacious in both prevention and treatment of post-operative nausea and vomiting, with a tolerable safety profile. It is a useful option for adults who have failed previous antiemetic prophylaxis.
Review
Gastroenterology & Hepatology
Brian E. Lacy, Jan Tack, C. Prakash Gyawali
Summary: This article outlines a strategy for defining, diagnosing, and managing refractory gastroparesis, including evaluating symptoms and physical examination findings, verifying the accuracy of gastric emptying studies, classifying patients based on symptoms and study results, and initiating treatment based on the predominant symptom.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Plant Sciences
Yuchan Shin, Bonglee Kim, Woojin Kim
Summary: This review summarizes the results of 14 studies on the effects of herbal extracts and ginger component on cisplatin-induced nausea and vomiting. Herbal medicine shows potential as a viable treatment option for cisplatin-induced neuropathic pain.
Article
Gastroenterology & Hepatology
Paul J. Silver, Michael J. Coles, Candrice R. Heath, Henry P. Parkman
Summary: This study investigated the prevalence of patient-reported hair loss in gastroparesis (Gp) patients, the association between hair loss and severity of Gp and nutritional deficiencies, and the effects of multivitamin treatment on hair loss. Hair loss was reported in 46% of Gp patients and was associated with more severe symptoms, weight loss, and multiple vitamin deficiencies. Treatment with multivitamins improved hair loss in 40% of patients.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Review
Medicine, General & Internal
June Tome, Amrit K. Kamboj, Seth Sweetser
Summary: Nausea and vomiting are common symptoms in both outpatient and inpatient settings, and they can significantly impact quality of life. Clinical evaluation and treatment of these symptoms can be complex due to various underlying causes and treatment options. This concise review presents a practical 5-step approach for clinical evaluation and treatment, suitable for primary care and subspecialty settings.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Pharmacology & Pharmacy
Estevao Luiz Carvalho Braga, Nubia Vercosa, Ismar Lima Cavalcanti
Summary: The single use of fosaprepitant is equally effective as the use of palonosetron in preventing vomiting in the first 48 hours after laparoscopic cholecystectomy in women.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Torri D. Metz, Amanda A. Allshouse, Gwendolyn A. McMillin, Robert M. Silver, Marcela C. Smid, David M. Haas, Hyagriv N. Simhan, George R. Saade, William A. Grobman, Samuel Parry, Judith H. Chung, Marian P. Jarlenski
Summary: The objective of this study was to evaluate the association between cannabis use and nausea and vomiting in early pregnancy. The results showed that higher THC-COOH levels were associated with greater odds of moderate-to-severe nausea.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jouko Levijoki, Lasse Saloranta, Johanna Tuunainen, Janne Kaskinoro, Sari Pappinen, Sandra Nourry, Anne-Marie Betat, Anne Maurin, Maarit Pakarinen, Sari Hakkinen, Johanna Tervapuro, Hertta Pihlasvaara, Christophe Drieu La Rochelle, Heikki Joensuu
Summary: Ocular administration of palonosetron as eye drops can effectively prevent and treat nausea and vomiting. This method provides a quick and convenient way to deliver the medication when intravenous administration is not possible.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Review
Pharmacology & Pharmacy
Le Yu Naing, Matthew Heckroth, Prateek Mathur, Thomas L. Abell
Summary: This article discusses the current treatments for gastroparesis and explores potential new medications. It emphasizes the importance of understanding the pathophysiology of gastroparesis in order to develop successful therapeutic agents.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)