Article
Plant Sciences
David Banji, Otilia J. F. Banji, Shaik Rashida, Saeed Alshahrani, Saad S. Alqahtani
Summary: The study aimed to evaluate the bioavailability, anti-inflammatory, and anti-arthritic effects of Boswellia extract rich in Acetyl Keto Boswellic Acid (AKBA). The results showed that 10% AKBA had significant inhibition of paw edema and combination therapy with MTX reduced hepatotoxicity caused by MTX.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Jiawei Shi, Ye Gu, Yong Wang, Jiaxiang Bai, Longbin Xiong, Yunxia Tao, Yi Xue, Yaozeng Xu, Huilin Yang, Hongwei Ye, Dechun Geng
Summary: AKBA exerts an inhibitory effect on titanium particle-induced bone erosion, reducing osteoclast formation and resorptive function. It inhibits RANKL-induced osteoclastogenesis and osteoclast marker gene expression through the ERK signaling pathway, providing protection against periprosthetic osteolysis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tianke Yang, Xiaolei Lin, Hongzhe Li, Xiyue Zhou, Fan Fan, Jianing Yang, Yi Luo, Xin Liu
Summary: In this study, AKBA showed promising effects in alleviating oxidative injury and cataract formation by activating the Keap1/Nrf2/HO-1 cascade. AKBA increased cell viability, reduced ROS levels, and decreased apoptosis rate in vitro. It also modulated the expression of apoptosis-related proteins and activated Nrf2 both in vivo and in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Najeeb Ur Rehman, Saeed Ullah, Tanveer Alam, Sobia Ahsan Halim, Tapan Kumar Mohanta, Ajmal Khan, Muhammad U. Anwar, Rene Csuk, Satya Kumar Avula, Ahmed Al-Harrasi
Summary: A series of 24 new 1H-1,2,3-triazole hybrids of 3-O-acetyl-11-keto-beta-boswellic acid and 11-keto-beta-boswellic acid were synthesized using click chemistry. These compounds exhibited potent α-glucosidase inhibitory activity and showed interactions with amino acids in the active site.
Article
Medicine, Research & Experimental
Ajmal Khan, Imran Khan, Sobia Ahsan Halim, Najeeb Ur Rehman, Nasiara Karim, Waqar Ahmad, Majid Khan, Rene Csuk, Ahmed Al-Harrasi
Summary: fl-Boswellic acid (fl-BA) and 11-keto-fl-boswellic acid (fl-KBA) have potent anti-diabetic, antioxidant, and anti-hyperlipidemic effects. They improve body weight loss, water consumption, and blood glucose levels in diabetic animals. The inhibition of DPP-4 is the probable mechanism of action for their anti-diabetic activities.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Physiology
Muhammed Majeed, Kalyanam Nagabhushanam, Lincy Lawrence, Rameshprabu Nallathambi, Varadharajan Thiyagarajan, Lakshmi Mundkur
Summary: Boswellia serrata extracts, particularly Boswellin Super(R), have shown significant anti-inflammatory effects by inhibiting inflammatory proteins and gene expression, as well as reducing oxidative stress. The extract mediates its activity by blocking the NF-kappa B signaling pathway. In addition, BSE demonstrated reduced enzyme activity and improved arthritis symptoms in a collagen-induced arthritis model.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Alberto Asteggiano, Loris Curatolo, Valentina Schiavo, Andrea Occhipinti, Claudio Medana
Summary: This article introduces an HPLC method for the quantification of boswellic acids, which can be used for the analysis of food-grade resin extracts of Boswellia plant species. The method can be applied for quality control and studying the differences in regional origin, years of harvesting, and species-related differences.
APPLIED SCIENCES-BASEL
(2023)
Article
Plant Sciences
Chong Zhou, Yao Wang, Qiyuan Zhang, Guanghu Zhou, Xianglin Ma, Xiaowen Jiang, Wenhui Yu
Summary: Boswellic acid is a traditional medicine with antioxidant and antiapoptotic effects. It has been found to alleviate oxidative stress and apoptosis caused by sciatic nerve injury in rats by activating the NF-E2-related factor 2/heme oxygenase 1 signaling pathway. Boswellic acid promotes myelin regeneration and functional recovery, reduces lipid peroxidation levels, and enhances antioxidant enzyme activity. It is a promising therapeutic agent for sciatic nerve repair.
Article
Chemistry, Physical
Satya Kumar Avula, Najeeb Ur Rehman, Faizullah Khan, Obaid Ullah, Sobia Ahsan Halim, Ajmal Khan, Muhammad U. Anwar, Shaikh Mizanoor Rahman, Rene Csuk, Ahmed Al-Harrasi
Summary: A series of new analogues of 3-O-acetyl-11-keto-fi-boswellic acid and 3-O-acetyl-fi-boswellic acid were synthesized using Click chemistry reaction protocol. The synthesized compounds showed potent anti-proliferative activity against triple-negative breast cancer cell lines. Compounds 10j, 10f, and 10i exhibited exceptional inhibitory potency and were more potent than the parent compounds. The cheminformatics method identified CHK1 as the potential drug target for the most potent compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Applied
Asma Bini Araba, Najeeb Ur Rehman, Amna Al-Araimi, Sulaiman Al-Hashmi, Sulaiman Al-Shidhani, Rene Csuk, Hidayat Hussain, Ahmed Al-Harrasi, Fahad Zadjali
Summary: A series of new 11-keto-beta-boswellic acid analogs were synthesized by modifying the hydroxyl and carboxylic acid functional groups of ring A, showing potent anti-cancer activity against breast and prostate cancer cell lines. This study suggests that chemical modification of the functional groups in these analogs can effectively enhance their biological activity.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Yi-hui Yang, Wan Li, Li-wen Ren, Hong Yang, Yi-zhi Zhang, Sen Zhang, Yue Hao, Dong-ke Yu, Rong-sheng Tong, Guan-hua Du, Jian-you Shi, Jin-hua Wang
Summary: Glioblastoma (GBM) is a common malignant brain tumor with limited treatment options. This study showed that S670, a synthesized amide derivative of AKBA, inhibits GBM cell proliferation and induces cell death through the generation of ROS and modulation of ROS-mediated signaling pathways. Treatment with S670 also effectively inhibits tumor growth in a mouse model. These findings suggest that S670 may be a promising drug candidate for GBM treatment.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Genetics & Heredity
Shubham Upadhayay, Sidharth Mehan, Aradhana Prajapati, Pranshul Sethi, Manisha Suri, Ayat Zawawi, Majed N. Almashjary, Shams Tabrez
Summary: This study investigates the protective potential of AKBA on multiple sclerosis (MS) and found that AKBA can upregulate antioxidant proteins, restore neurochemical abnormalities, and potentially prevent pathological changes in MS.
Article
Cell Biology
Minghe Lv, Xibing Zhuang, Qi Zhang, Yunfeng Cheng, Duojiao Wu, Xiangdong Wang, Tiankui Qiao
Summary: The combination treatment of AKBA and cisplatin enhances the sensitivity of NSCLC cells to cisplatin by regulating cell cycle, inducing apoptosis, and suppressing autophagy.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Chemistry, Medicinal
Satya Kumar Avula, Najeeb Ur Rehman, Majid Khan, Sobia Ahsan Halim, Ajmal Khan, Kashif Rafiq, Rene Csuk, Biswanath Das, Ahmed Al-Harrasi
Summary: A series of new derivatives of boswellic acids were synthesized and evaluated for their inhibitory activity against carbonic anhydrase II, showing moderate to significant inhibition. The most active inhibitors were found to be non-competitive inhibitors with specific inhibition constants. Molecular docking studies revealed the compounds' accommodation in the allosteric site of carbonic anhydrase II.
MEDICINAL CHEMISTRY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Liwen Han, Qing Xia, Lei Zhang, Xuanming Zhang, Xiaobin Li, Shanshan Zhang, Lizhen Wang, Changxiao Liu, Kechun Liu
Summary: This study found that AKBA, a compound found in Boswellia serrate, exhibits developmental and cardiotoxicity in zebrafish through oxidative stress mechanism.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Business
Sanjay Kumar Singh, Manlio Del Giudice, Charbel Jose Chiappetta Jabbour, Hengky Latan, Amrik Singh Sohal
Summary: Stakeholder pressure can influence green dynamic capabilities and green innovation, ultimately affecting firm performance. Furthermore, green dynamic capabilities mediate the relationship between stakeholder pressure and green innovation.
BUSINESS STRATEGY AND THE ENVIRONMENT
(2022)
Article
Business
Alberto Ferraris, William Y. Degbey, Sanjay Kumar Singh, Stefano Bresciani, Sylvaine Castellano, Fabio Fiano, Jerome Couturier
Summary: This study examines the individual-level microfoundations of subsidiary CEOs in emerging markets as antecedents of the strategic agility of multinational enterprises, and examines subsidiary embeddedness as a key organizational-level moderator of these relationships. The findings suggest that the tenure and overall experience of subsidiary CEOs in emerging markets, as well as their cognitive characteristics, positively affect MNE strategic agility. Additionally, subsidiary embeddedness moderates these relationships in different ways, providing opportunities for new managerial and theoretical considerations.
JOURNAL OF WORLD BUSINESS
(2022)
Article
Engineering, Multidisciplinary
Anurag Pathak, Manoj Kumar, Sanjay Kumar Singh, Umesh Singh, Manoj Kumar Tiwari, Sandeep Kumar
Summary: This article addresses the estimation problem in step-stress partially accelerated life test of Maxwell Boltzmann distribution, considering progressive type-II censoring with binomial removals. The maximum likelihood and Bayes estimators of the parameter are derived under symmetric and asymmetric loss functions. Furthermore, the performance of these estimators is compared based on risks. The proposed methodology is illustrated using the time to failure of Aluminium reduction cells and survival times of male rats exposed to high radiation levels in weeks.
INTERNATIONAL JOURNAL OF SYSTEM ASSURANCE ENGINEERING AND MANAGEMENT
(2022)
Review
Chemistry, Medicinal
Aiswarya Chaudhuri, Dulla Naveen Kumar, Deepa Dehari, Sanjay Singh, Pradeep Kumar, Pradeep Kumar Bolla, Dinesh Kumar, Ashish Kumar Agrawal
Summary: This article discusses the treatment strategies for triple-negative breast cancer, introduces the application of nanotechnology to enhance the efficacy of drug therapy, and overcome the limitations of conventional chemotherapy and targeted therapy.
Article
Business
Bader K. AlNuaimi, Sanjay Kumar Singh, Shuang Ren, Pawan Budhwar, Dmitriy Vorobyev
Summary: Drawing upon new institutional theory, this study examined the influence of digital transformational leadership and organizational agility on digital transformation, revealing their positive effects and the mediating role of organizational agility in the relationship between leadership and transformation. These findings contribute to a deeper understanding of the impact of transformational leadership and organizational agility on digital transformation, as well as the role of digital strategy in this process.
JOURNAL OF BUSINESS RESEARCH
(2022)
Article
Business
Madhusmita Panda, Rabindra Kumar Pradhan, Sanjay Kumar Singh
Summary: This study applied goal-setting theory to investigate the impact of organizational culture on the psychological empowerment and job performance of organizationally assigned expatriates. It also explored the moderating role of host country language ability in this relationship.
JOURNAL OF BUSINESS RESEARCH
(2022)
Article
Management
Ranya Saeed Alhumoudi, Sanjay Kumar Singh, Syed Zamberi Ahmad
Summary: Perceived corporate social responsibility has a positive impact on passionate attitudes towards work and mediates the relationship between perceived CSR and innovative work behavior. The study suggests mixed-method investigations for future research and emphasizes the importance of engaging in CSR activities for organizations. Passionate Gen Y nurses play a valuable role in improving patient care services through innovative work behavior.
INTERNATIONAL JOURNAL OF ORGANIZATIONAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Sanjeev Meena, Radheshyam Sharma, Sanjay Kumar Singh, Ashish Kumar, R. Shiv Ramakrishnan, Stuti Sharma, G. K. Koutu, Lokesh Gaur
Summary: This study characterized the genetic diversity of farmers' varieties in central India using SSR markers and blast-linked markers. The results showed clear geographical discrimination among the varieties and the presence of multiple blast resistance genes, which could be utilized in future breeding programs.
JOURNAL OF PLANT BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Computer Science, Information Systems
Durgesh Singh, Sanjay K. Singh, Sandeep Sambhaji Udmale
Summary: In this paper, a self-embedding block-wise fragile image watermarking scheme is proposed for authentication, localization, and recovery with enhanced accuracy. The scheme splits the cover image into non-overlapping blocks and calculates restoration and authentication bits from the MSBs planes. The proposed scheme achieves high-quality restoration and significant authentication possibilities for each block, with high Peak Signal to Noise Ratio and Normalized Correlation Coefficient up to 50% tampering rate.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Medicine, General & Internal
Jeremy J. Hoffman, Reena Yadav, Sandip Das Sanyam, Pankaj Chaudhary, Abhishek Roshan, Sanjay K. Singh, Sailesh K. Mishra, Simon Arunga, Victor H. Hu, David Macleod, Astrid Leck, Matthew J. Burton
Summary: This study describes the health-seeking journey for patients with microbial keratitis in Nepal and identifies factors associated with delay.
FRONTIERS IN MEDICINE
(2022)
Article
Microbiology
Shiwali Rana, Sanjay Kumar Singh, Laurent Dufosse
Summary: This study reveals the correct identification of Indian Fusarium isolates and their potential for BEA production through multigene phylogeny. It also suggests their possible applications in medicine, agriculture, and industry.
Article
Green & Sustainable Science & Technology
Ashish Malik, Sanjay Kumar Singh
Summary: An experimental program was conducted to determine the dynamic properties of pond ash and the effects of additives such as crumb rubber and coir fiber. The results showed that crumb rubber improved the liquefaction resistance of pond ash, while coir fiber had no significant effect on it. The dynamic shear modulus of pond ash decreased when mixed with crumb rubber, but increased significantly when mixed with coir fiber.
JOURNAL OF RENEWABLE MATERIALS
(2023)
Article
Energy & Fuels
Ab Quyoom Seh, Dinesh C. Gupta
Summary: This study investigated the quaternary Heusler alloy CoZrMnAs using the Wein2k simulation code based on density functional theory. The results showed that CoZrMnAs has a stable structure and ferromagnetic nature, and exhibits half-metallic properties, making it suitable for waste heat recovery.
Review
Biotechnology & Applied Microbiology
Rana Shiwali, Singh Sanjay Kumar
Summary: This review provides comprehensive information on beauvercin, including its biosynthetic pathway and various bioactivities. Beauvercin shows antimicrobial, insecticidal, and anticancer properties, but its genotoxicity should also be taken into consideration. For researchers, this documentation serves as an important reference for optimizing and enhancing beauvericin production.
RESEARCH JOURNAL OF BIOTECHNOLOGY
(2022)
Proceedings Paper
Materials Science, Multidisciplinary
Deepak Kumar Sharma, Nikimoni Das, Sanjay Kumar Singh, Krishna Murari Pandey
Summary: The main objective of this research is to experimentally evaluate the performance of triple concentric tube heat exchangers under steady-state conditions. Water is used as the working fluid and is circulated at different temperatures. The study investigates the variation of fluid temperature along the length of the heat exchanger and the relationship between friction factor, Nusselt number, and Reynolds number. The experimental results show that the counter-current arrangement performs the best.
MATERIALS TODAY-PROCEEDINGS
(2022)
