Review
Biochemistry & Molecular Biology
Surendra Kumar Sagar
Summary: This review focuses on the function of miR-106b and its downstream targets in cancer, providing insights into how miR-106b regulates cancer cell proliferation, migration, invasion, and metastasis by modulating tumor suppressor genes. The potential of miR-106b as a candidate for detection, diagnosis, and prognosis assessment in different cancer types is highlighted.
Review
Medicine, Research & Experimental
Jianan Xu, Yuanyuan Sun, Weineng Fu, Shuang Fu
Summary: Myc target 1 (MYCT1), located at 6q25.2, is a crucial player in cancer development with widely distributed expression in cells and variable subcellular localization across different cancer types. It is regulated by multiple transcription factors and aberrant expression of MYCT1 impacts key biological processes and tumor immune responses in cancer cells. Despite some debated functions, MYCT1 holds undeniable significance in cancer development. This review aims to comprehensively examine the relationship between MYCT1 and cancer, providing valuable insights for cancer diagnosis and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Seyede Fatemeh Hosseini, Setareh Javanshir-giv, Hanieh Soleimani, Homa Mollaei, Farzad Sadri, Zohreh Rezaei
Summary: MicroRNA production in tumorigenesis is dysregulated by various processes, leading to dysfunctional and dysregulated miRNAs. These miRNAs have been identified as potential biomarkers for human cancer, although further evaluation is necessary. The miR-28 family, especially miR-28-5p and miR-28-3p, play essential roles in various cancers and can serve as diagnostic biomarkers for prognosis and early detection of cancers.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Arash Safarzadeh, Solmaz Hassani Fard Katiraei, Bashdar Mahmud Hussen, Mohammadreza Hajiesmaeili
Summary: This review article explores the functions of miR-328 in the development of human carcinogenesis and highlights the discrepancies in different studies, which may be attributed to different stages/grades of tumor tissues or other clinical characteristics.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Sujin Choi, Soonchul Lee, Young-Hoon Han, Junwon Choi, Isaac Kim, Jusung Lee, Hyun-Ju An
Summary: miR-31-3p is expressed at lower levels in prostate cancer tissues compared to adjacent normal tissues, and it plays a tumor-suppressive role by inducing apoptosis and decreasing cell proliferation, migration, invasiveness. GABBR2 is identified as a direct target of miR-31-3p.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Jennifer Sally Samson, Venkatachalam Deepa Parvathi
Summary: Lung cancer is the second most common cancer worldwide and the leading cause of cancer-related deaths. Non-small-cell lung carcinoma (NSCLC) accounts for more than 85% of lung cancer cases, and despite advancements in therapy, the survival rate for NSCLC patients remains low. miRNAs have been identified as molecules that play a crucial role in tumorigenesis and progression of various cancers, including NSCLC. Dysregulation of miRNAs has been recognized as a causative mechanism in NSCLC tumorigenesis. This review discusses the role of miRNAs in NSCLC tumor progression and their potential as therapeutic biomarkers, highlighting specific miRNAs that could be explored for NSCLC management.
Review
Biochemistry & Molecular Biology
Da Young Lee, Jung Nyeo Chun, Minsoo Cho, Insuk So, Ju-Hong Jeon
Summary: E2F8 is a multifaceted transcription factor that is involved in various aspects of cancer development and progression. It has the ability to promote cancer cell proliferation and survival while also exhibiting tumor-suppressing activity. This review highlights the recent progress in understanding the role of E2F8 in human cancers and its implications for developing therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Oncology
Maria Victoria Castro, Pablo Lopez-Bergami
Summary: ROR1 and ROR2 are Wnt receptors, and they are associated with tumor progression. While ROR1 always promotes tumorigenesis, ROR2 has a complex role in different tumor types, either promoting or inhibiting tumor progression.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Petra Korac, Mariastefania Antica, Maja Matulic
Summary: miR-7 is an ancient miRNA involved in cell signaling pathways, acting primarily as a tumor suppressor by inhibiting cell proliferation and promoting apoptosis. It also has additional roles in cell regulation and protection, with potential for use in biotherapeutics.
Review
Biology
Junaid Ali Shah, Saadullah Khattak, Mohd Ahmar Rauf, Yong Cai, Jingji Jin
Summary: miRNAs are small non-coding RNA transcripts that regulate gene expression in cells, including tumorigenesis. The miR-371-373 genes are found to be abnormally expressed in various cancers and may serve as molecular biomarkers for cancer diagnosis and prevention. Further studies linking miR-371-373 functions to tumorigenesis suggest their potential applications in cancer diagnosis and treatment.
Article
Gastroenterology & Hepatology
Shigeo Hisamori, Junko Mukohyama, Sanjay Koul, Takanori Hayashi, Michael Evan Rothenberg, Masao Maeda, Taichi Isobe, Luis Enrique Valencia Salazar, Xin Qian, Darius Michael Johnston, Dalong Qian, Kaiqin Lao, Naoya Asai, Yoshihiro Kakeji, Vincenzo Alessandro Gennarino, Debashis Sahoo, Piero Dalerba, Yohei Shimono
Summary: In this study, it was found that the coordinated upregulation of miR-200c and miR-203 in colon epithelial cells is associated with terminal differentiation and plays a role in controlling the expansion capacity and stem cell properties of epithelial cells by suppressing BMI1 expression.
JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Oncology
Juan Lu, Danhua Zhu, Lanjuan Li
Summary: miR-608 is decreased in cancer, especially in solid tumors, and acts as a tumor suppressor. It inhibits transmembrane proteins and multiple signaling pathways, participating in various biological processes in cancer cells, such as proliferation and migration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Asmaa M. Elfiky, Rania Hassan Mohamed, Fatma El-Zahraa Abd EL-Hakam, Mohamed A. Yassin, Mahmoud ElHefnawi
Summary: This study demonstrated the potential of LA-PAMAM carrier for targeted delivery of tumor suppressor miR-218 as a therapeutic candidate for HCC. The combination of hyperbranched polyamidoamine and lactobionic acid efficiently suppressed HepG2 cell proliferation and down-regulated the oncogenic HOXA1 target.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Cell Biology
Hanieh Shirvani, Jalaledin Ghanavi, Amin Aliabadi, Fatemehsadat Mousavinasab, Mehrdad Talebi, Jamal Majidpoor, Sajad Najafi, Seyyed Mohammad Miryounesi, Seyed Mohsen Aghaei Zarch
Summary: This review discusses the expression levels, target genes, and mechanisms of miR-211 in different cancers, revealing its oncogenic or tumor-suppressive impact on tumorigenesis and cancer development. Additionally, miR-211 may serve as a noninvasive biomarker and therapeutic factor for the diagnosis and treatment of cancer.
CELLULAR SIGNALLING
(2023)
Article
Medicine, Research & Experimental
Hyun Jeong Seok, Young Eun Choi, Jae Yeon Choi, Joo Mi Yi, Eun Joo Kim, Mi Young Choi, Su-Jae Lee, In Hwa Bae
Summary: Breast cancer is the most common female cancer worldwide, with difficulties in treatment due to unknown mechanisms. Research suggests that miRNA can serve as effective biomarkers for various diseases, including cancer. The study found that miR-5088-5p, promoted by Fyn, is involved in the malignancy of breast cancer.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
