Article
Cardiac & Cardiovascular Systems
Karrie F. Downing, Wendy N. Nembhard, Charles E. Rose, Jennifer G. Andrews, Anthony Goudie, Scott E. Klewer, Matthew E. Oster, Sherry L. Farr
Summary: Between 1980 and 1997, 8 out of 10 individuals with congenital heart defects (CHDs) in the US survived until 35 years of age, with survival rates varying based on the severity of CHDs, presence of noncardiac anomalies, birth weight, and maternal race and ethnicity. Among individuals without noncardiac anomalies, those with nonsevere CHDs had similar mortality rates between 1 and 35 years of age as the general population, and those with any CHD had similar mortality rates between 10 and 35 years of age as the general population.
Article
Obstetrics & Gynecology
Matheus Sarabion Vilela Pereira, Daniela Koeller Rodrigues Vieira, Maria de Fatima M. P. Leite, Maria Auxiliadora Monteiro Villar, Carla Verona Barreto Farias
Summary: Most patients with omphalocele have other malformations, especially congenital heart disease. The presence of concurrent defects has a significant impact on prognosis. An effective perinatal plan should be developed to minimize maternal morbidity and improve care for the newborn.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Pediatrics
Rachel K. Hopper, Steven H. Abman, Eleni G. Elia, Catherine M. Avitabile, Delphine Yung, Mary P. Mullen, Eric D. Austin, Angela Bates, Stephanie S. Handler, Jeffrey A. Feinstein, D. Dunbar Ivy, John P. Kinsella, Kenneth D. Mandl, J. Usha Raj, Lynn A. Sleeper
Summary: This study characterized comorbidities, outcomes, and treatment patterns in children with Down syndrome and pulmonary hypertension. The results showed that despite the presence of cardiac and respiratory comorbidities, children with Down syndrome-associated pulmonary hypertension have a similar survival rate to those with non-Down syndrome-associated pulmonary hypertension.
JOURNAL OF PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Fred H. Rodriguez, Cheryl L. Raskind-Hood, Trenton Hoffman, Sherry L. Farr, Jill Glidewell, Jennifer S. Li, Alfred D'Ottavio, Lorenzo Botto, Matthew R. Reeder, Daphne Hsu, George K. Lui, Anaclare M. Sullivan, Wendy M. Book
Summary: CDC's Surveillance of Congenital Heart Defects Across the Lifespan project aims to understand the epidemiology and outcomes of congenital heart defects (CHD) using large databases. The study found acceptable positive predictive values (PPV) for CHD identification based on ICD-9-CM codes, but further evaluation and algorithm development are needed for accurate identification.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Kimberley G. Miles, Dora Kormendine Farkas, Kristina Laugesen, Henrik Toft Sorensen, Nadine A. Kasparian, Nicolas Madsen
Summary: The incidence of mental health conditions among children with congenital heart disease (CHD) is higher than the general population, particularly among males and those with severe or single-ventricle CHD. Early intervention and mental health support may be especially important for these at-risk populations.
Article
Pediatrics
Abeer A. Hasan, Naser Aldain A. Abu Lehyah, Moath K. Al Tarawneh, Mahmoud Y. Abbad, Areen G. Fraijat, Razan A. Al-Jammal, Dania M. Moamar, Qasem A. Shersheer, Scott O. Guthrie, Joseph R. Starnes
Summary: This study investigated the epidemiology and identification methods of CHD in Jordan. The results showed a high incidence of CHD in Jordan, and prenatal and perinatal screening could facilitate early detection.
FRONTIERS IN PEDIATRICS
(2023)
Article
Public, Environmental & Occupational Health
Xingdi Yang, Jianjuan Zeng, Yiping Gu, Yiming Fang, Caiyun Wei, Shengkui Tan, Xiaoying Zhang
Summary: This hospital-based study in Guilin, China, aimed to determine the prevalence of birth defects in the region and classify them based on clinical presentation and causation. Of the 147,817 births recorded, 2,003 infants were diagnosed with BDs, with a total prevalence rate of 13.55 per 1,000 births. The study found that congenital heart defects, polydactyly, syndactyly, malformations of the external ear, and talipes equinovarus were the most common BD types.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Graziella Eshuis, Julia Hock, Gideon Marchie du Sarvaas, Hiske van Duinen, Rhoia Neidenbach, Freek van den Heuvel, Hans Hillege, Rolf M. F. Berger, Alfred Hager
Summary: This study aimed to provide a perspective for the interpretation of exercise capacity in patients with repaired Tetralogy of Fallot by describing the course of peakVO(2) from patients aged 6-63 years. The peakVO(2) of patients with rTOF was reduced at all ages, originating from childhood and declining over time. Sex differences in patients with rTOF were similar to natural existing sex differences.
Article
Cardiac & Cardiovascular Systems
Xuelian Yuan, Fengchao Liang, Jun Zhu, Keyong Huang, Li Dai, Xiaohong Li, Yanping Wang, Qi Li, Xiangfeng Lu, Jianfeng Huang, Lihui Liao, Yang Liu, Dongfeng Gu, Hanmin Liu, Fangchao Liu
Summary: This study investigated the association between maternal exposure to fine particulate matter (PM2.5) and fetal congenital heart defects (CHDs) in China. The results showed that higher maternal PM2.5 exposure, especially during the preconception period, increased the risk of certain types of CHDs in offspring. The findings highlight the importance of improving air quality in China and other highly polluted regions for CHD prevention.
Article
Pediatrics
Thomas Aldersley, John Lawrenson, Paul Human, Gasnat Shaboodien, Blanche Cupido, George Comitis, Rik De Decker, Barend Fourie, Lenise Swanson, Alexia Joachim, Phaphama Magadla, Malebogo Ngoepe, Liam Swanson, Alistair Revell, Raj Ramesar, Andre Brooks, Nicole Saacks, Bianca De Koning, Karen Sliwa, John Anthony, Ayesha Osman, Bernard Keavney, Liesl Zuhlke
Summary: The PROTEA project aims to establish a cohort for congenital heart disease research in Southern Africa, with initial findings indicating lower prevalence of mild CHD subtypes compared to international estimates and higher prevalence of severe subtypes.
FRONTIERS IN PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Markus Schwerzmann, Francisco Javier Ruperti-Repilado, Helmut Baumgartner, Berto Bouma, Judith Bouchardy, Werner Budts, Laurence Campens, Massimo Chessa, Maria Jesus del Cerro Marin, Harald Gabriel, Pastora Gallego, Rocio Garcia-Orta, Ana Elvira Gonzalez, Annette Schophuus Jensen, Magalie Ladouceur, Berta Miranda-Barrio, Marielle Morissens, Agnes Pasquet, Joaquin Rueda, Annemien E. van den Bosch, Heleen Berdina van der Zwaan, Daniel Tobler, Matthias Greutmann
Summary: This study aimed to collect clinical outcome data and identify risk factors for a complicated course of COVID-19 in patients with adult congenital heart disease (ACHD). Risk factors such as age, obesity, and multiple comorbidities were associated with an increased risk of a complicated COVID-19 course in ACHD patients. Cyanotic heart disease, including unrepaired cyanotic defects or Eisenmenger syndrome, were identified as particularly high-risk congenital cardiac defects in ACHD patients.
Article
Cardiac & Cardiovascular Systems
Jack R. Griffiths, Udi Nussinovitch, Jackson J. Liang, Richard Sims, Zachary T. Yoneda, Hannah M. Bernstein, Mohan N. Viswanathan, Paul Khairy, Uma N. Srivatsa, David S. Frankel, Francis E. Marchlinski, Amneet Sandhu, M. Benjamin Shoemaker, Sanghamitra Mohanty, John D. Burkhardt, Andrea Natale, Dhanunjaya Lakireddy, Natasja M. S. De Groot, Edward P. Gerstenfeld, Jeremy P. Moore, Pablo Avila, Sabine Ernst, Duy T. Nguyen
Summary: This study retrospectively analyzed the characteristics and outcomes of AF ablation in patients with CHD. The results showed that AF ablation was safe and resulted in effective AF control in CHD patients. There was no significant difference in the one-year success rate of ablation among patients with different complexities of CHD. Further research is needed to identify the most appropriate ablation targets in this challenging population.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Review
Cell Biology
Yuwen Chen, Deyong Xiao, Lu Zhang, Chen-Leng Cai, Bai-Yan Li, Ying Liu
Summary: Tbx20, a member of the T-box gene family, plays crucial roles in cardiovascular development and homeostasis, as well as cardiac remodeling in response to pathophysiological stresses. Mutations and genetic variants in TBX20 are associated with a wide spectrum of congenital heart defects and heart diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Joan Carles Trullas, Juan Ignacio Perez-Calvo, Alicia Conde-Martel, Pau Llacer Iborra, Ivan Suarez Pedreira, Gabriela Ormaechea, Llanos Soler Rangel, Alvaro Gonzalez Franco, Jose Maria Cepeda, Manuel Montero-Perez-Barquer
Summary: This study aimed to characterize patients with heart failure with preserved ejection fraction (HF-PEF) by determining their prevalence, progression over time, and describing their clinical and epidemiological characteristics. Results showed that HF-PEF patients are older, more likely to be female, and have higher prevalence of certain comorbidities compared to HF patients with reduced ejection fraction. Despite a lower mortality rate, a substantial proportion of HF-PEF patients still required disease-modifying treatment.
Article
Cardiac & Cardiovascular Systems
Danielle S. Burstein, Joseph W. Rossano, Heather Griffis, Xuemei Zhang, Rachel Fowler, Benjamin Frischertz, Yuli Y. Kim, JoAnn Lindenfield, Jeremy A. Mazurek, Jonathan B. Edelson, Jonathan N. Menachem
Summary: Limited contemporary data exist regarding outcomes and resource use among adults with congenital heart disease and heart failure. This study compared outcomes and resource use between adults with congenital heart disease and heart failure (ACHD-HF) and non-ACHD with heart failure (HF-non-ACHD). The study found that ACHD-HF patients have increased emergency department and hospital resource use over the past 10 years, but are less likely to receive advanced heart failure therapies such as ventricular assist device (VAD) or transplant compared with non-ACHD heart failure patients.
Article
Cardiac & Cardiovascular Systems
Xiaojing Chen, Erik Thunstrom, Per-Olof Hansson, Annika Rosengren, Zacharias Mandalenakis, You Zhong, Constantinos Ergatoudes, Kenneth Caidahl, Michael Fu
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Mikael Dellborg, Zacharias Mandalenakis
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Pigi Dikaiou, Lena Bjorck, Martin Adiels, Christina E. Lundberg, Zacharias Mandalenakis, Karin Manhem, Annika Rosengren
Summary: This study found a significant association between body mass index in young women and the risk for early cardiovascular disease and mortality, with overweight and obese women showing a markedly increased risk.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Neurosciences
Alexia Karagianni, Zacharias Mandalenakis, Mikael Dellborg, Naqibullah Mirzada, Magnus Carl Johansson, Peter Eriksson
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2020)
Article
Medicine, General & Internal
Xiaojing Chen, Salim Bary Barywani, Per-Olof Hansson, Annika Rosengren, Erik Thunstrom, You Zhong, Constantinos Ergatoudes, Zacharias Mandalenakis, Kenneth Caidahl, Michael Fu
Article
Cardiac & Cardiovascular Systems
Kristofer Skoglund, Joel Heimdahl, Zacharias Mandalenakis, Ulf Thilen, Bengt Johansson, Christina Christersson, Peder Sorensson, Mikael Dellborg
SCANDINAVIAN CARDIOVASCULAR JOURNAL
(2020)
Article
Public, Environmental & Occupational Health
Carina U. Persson, Anna-Clara Collen, Annika Rosengren, Zacharias Mandalenakis, Tatiana Zverkova Sandstrom, Michael Fu, Mikael Dellborg, Saga Johansson, Per-Olof Hansson
Article
Cardiac & Cardiovascular Systems
Xiaotong Cui, Zacharias Mandalenakis, Erik Thunstrom, Michael Fu, Kurt Svardsudd, Per-Olof Hansson
Summary: In this study involving middle-aged male cohort, it was found that an RHR of 60-70 bpm was associated with the lowest cardiovascular mortality. Time-updated RHR could potentially serve as a useful long-term prognostic index in the general population.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Fedchenko, Zacharias Mandalenakis, Kok Wai Giang, Annika Rosengren, Peter Eriksson, Mikael Dellborg
Summary: Patients with congenital heart disease have a higher risk of myocardial infarction compared to controls, and also a higher risk of developing new-onset heart failure, recurrent MI, or death after the index MI. Proper management of modifiable cardiovascular risk factors is crucial in reducing morbidity and mortality in these patients.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Zacharias Mandalenakis, Kok Wai Giang, Peter Eriksson, Hans Liden, Mats Synnergren, Hakan Wahlander, Maria Fedchenko, Annika Rosengren, Mikael Dellborg
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Immunology
Ulrika Snygg-Martin, Kok Wai Giang, Mikael Dellborg, Josefina Robertson, Zacharias Mandalenakis
Summary: Patients with congenital heart disease have a higher cumulative incidence of infective endocarditis compared to controls, and this incidence increases with age. The incidence of infective endocarditis varies by age but not by birth year.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Kok Wai Giang, Maria Fedchenko, Mikael Dellborg, Peter Eriksson, Zacharias Mandalenakis
Summary: Patients with congenital heart disease have a 5-fold higher risk of developing index ischemic stroke compared with controls, but they have a 34% lower risk of recurrent stroke and a 47% lower risk of all-cause mortality after index stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Mikael Dellborg, Kok Wai Giang, Peter Eriksson, Hans Liden, Maria Fedchenko, Anders Ahnfelt, Annika Rosengren, Zacharias Mandalenakis
Summary: In recent decades, the survival rate of children with congenital heart disease (CHD) has greatly increased. However, this study found that adult survivors with CHD have a higher risk of mortality compared to the general population, although at least 75% of patients can live past middle age and become sexagenerians.
Letter
Cardiac & Cardiovascular Systems
Niklas Bergh, Kristofer Skoglund, Maria Fedchenko, Entela Bollano, Peter Eriksson, Mikael Dellborg, Kok Wai Giang, Zacharias Mandalenakis
Article
Cardiac & Cardiovascular Systems
Filip Eckerstrom, Peter Eriksson, Mikael Dellborg, Georgios Lappas, Annika Rosengren, Vibeke Elisabeth Hjortdal, Zacharias Mandalenakis
Summary: The overall all-cause mortality for patients with EA declined dramatically from 64 times to 20 times that of controls without EA, from the 1970s to the early 1990s. Unoperated patients with EA had better survival than did operated patients, possibly reflecting the higher severity of disease or more severe associated cardiac defects in patients undergoing surgery.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2021)