Article
Endocrinology & Metabolism
Benjamin C. Cossins, Inge van den Munckhof, Joost H. W. Rutten, Marinette van der Graaf, Rinke Stienstra, Leo A. B. Joosten, Mihai G. Netea, Yang Li, Niels P. Riksen
Summary: This study examined the association between adipocyte size, adipose tissue inflammation, systemic inflammation, and metabolic and atherosclerotic complications of obesity in a sex-specific manner. The results showed that inflammation in abdominal subcutaneous adipose tissue is more related to metabolic complications than atherosclerotic complications, and there are significant sex-specific differences in this association.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Shuzo Kobayashi, Yasuhiro Mochida, Kunihiro Ishioka, Machiko Oka, Kyoko Maesato, Hidekazu Moriya, Sumi Hidaka, Takayasu Ohtake
Summary: The prevalence of metabolic syndrome (Mets) was investigated in hemodialysis (HD) patients, along with the validation of waist circumference (WC) criteria using computed tomography (CT) measurement of visceral fatty area (VFA). The study found that Mets was more prevalent in male HD patients (31.9%) compared to female HD patients (13.6%), despite a low proportion of patients with a body mass index over 25 (11.2%). The VFA measured by CT showed a strong positive correlation with WC, and factors such as shorter duration of HD, higher high-sensitive C-reactive protein, and higher Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) were associated with Mets in HD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Alieh Alipour, Vafa Baradaran Rahimi, Vahid Reza Askari
Summary: This study reviewed and discussed the significant impacts of 6-gingerol, a derivative of ginger, on metabolic syndrome, suggesting its potential as a treatment agent. More pre-clinical and clinical investigations are needed.
Article
Biochemistry & Molecular Biology
Fayaz Ahmad Mir, Ehsan Ullah, Raghvendra Mall, Ahmad Iskandarani, Tareq A. Samra, Farhan Cyprian, Aijaz Parray, Meis Alkasem, Ibrahem Abdalhakam, Faisal Farooq, Abdul-Badi Abou-Samra
Summary: This study found differential expression of serum metabolites and pathways between Arabic subjects with obesity and metabolic syndrome compared to subjects with obesity only. Lipids, including sphingomyelin, were significantly decreased in the group with metabolic syndrome. Non-lipid metabolites, such as quinolinate, kynurenine, and tryptophan, were also decreased in the group with metabolic syndrome. Metabolites and pathways associated with chronic inflammation were found to be dysregulated in subjects with metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Da Hea Seo, Yongin Cho, Seongha Seo, Seong Hee Ahn, Seongbin Hong, Kyung Hwa Ha, Jee-Seon Shim, Hyeon Chang Kim, Dae Jung Kim, So Hun Kim
Summary: We found no significant association between metabolically healthy obesity and subclinical atherosclerosis in patients without previous cardiovascular disease, suggesting that metabolic health may not play a role in the development of early stage atherosclerosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Hyun-Bum Kim, Geun-Jeon Kim, Kyung-do Han, Young-Hoon Joo
Summary: The study found that changes in MetS status were associated with the risk of laryngeal cancer. The group that developed MetS had a higher risk of laryngeal cancer compared to the MetS-free group, with abdominal obesity posing the highest risk among MetS components.
Review
Biochemistry & Molecular Biology
Lucia La Sala, Maurizio Crestani, Silvia Garavelli, Paola de Candia, Antonio E. Pontiroli
Summary: miRNAs play a crucial role in the development of diseases, particularly in the interaction between metabolic disorders and cardiovascular diseases. Studying the associations of miRNAs with cardiovascular risk factors and their mechanisms in inter-organ communication is essential for the development of new therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anna Bartosiewicz, Edyta Luszczki, Malgorzata Nagorska, Lukasz Oleksy, Artur Stolarczyk, Katarzyna Deren
Summary: Metabolic syndrome is prevalent among nurses in Poland, with overweight and obesity being significant factors influencing its development. Preventive and supportive measures are necessary to address this issue.
Review
Biochemistry & Molecular Biology
Kelly Warmink, Prateeksha Vinod, Nicoline M. Korthagen, Harrie Weinans, Jaqueline L. Rios
Summary: Obesity is associated with osteoarthritis, as it alters adipokine release, increases pro-inflammatory macrophage activity, and affects joint immune regulation. Studying inflammatory macrophage expression and inhibiting inflammatory macrophage phenotype polarization may provide insights into disease pathogenesis and therapy. Imaging techniques and blood-based biomarker analysis can enable early detection of osteoarthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Reyna Rodriguez-Mortera, Russell Caccavello, Ricardo Hermo, Maria Eugenia Garay-Sevilla, Alejandro Gugliucci
Summary: In a study comparing obese adolescents to lean controls, it was found that obese participants exhibited higher levels of hepcidin, ferritin, and IL-6. Differences in iron metabolism markers were not significant between the two groups except for ferritin. Hepcidin levels in obese adolescents were more correlated with inflammation and metabolic alterations than with iron metabolism.
Article
Cardiac & Cardiovascular Systems
Lars Lind, Hanna Markstad, Hakan Ahlstrom, Oskar Angeras, John Brandberg, Mattias Brunstrom, Gunnar Engstrom, Jan E. Engvall, Maria J. Eriksson, Mats Eriksson, Anders Gottsater, Emil Hagstrom, Benno Krachler, Erik Lampa, Maria Mannila, Peter M. Nilsson, Fredrik H. Nystrom, Anders Persson, Bjorn Redfors, Anette Sandstro, Raquel Themudo, Sebastian Volz, Johan Arnlov, Carl Johan Ostgren, Goran Bergstrom
Summary: This study investigated whether individuals who are obese but do not have metabolic syndrome (MetS) are associated with increased coronary artery calcium and carotid plaques. The results showed that individuals who are obese but do not have MetS had increased severity of coronary artery stenosis, but no increased occurrence of carotid plaques, further emphasizing that obesity is not a benign condition even in the absence of MetS.
Article
Biochemistry & Molecular Biology
Delia-Maria Nicoara, Andrei-Ioan Munteanu, Alexandra-Cristina Scutca, Niculina Mang, Iulius Juganaru, Giorgiana-Flavia Brad, Otilia Marginean
Summary: Childhood obesity is a global concern due to its increasing incidence and potential long-term cardiovascular implications. This study investigated the diagnostic utility of various inflammatory indices in obese children with metabolic syndrome (MetS) and their relationship with cardiometabolic risk biomarkers. The results showed that the systemic immune-inflammation index (SII) had diagnostic value in distinguishing MetS patients among obese children and was positively associated with cardiometabolic risk biomarkers, indicating its potential role as an additional measure of cardiometabolic instability in obese children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Wurong Du, Kaibo Guo, Huimin Jin, Leitao Sun, Shanming Ruan, Qiaoling Song
Summary: This meta-analysis suggests that metabolic syndrome is independently associated with an increased risk of renal cell cancer in adults. The association is consistent across different genders, ethnicities, and population sources.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Athanasia Tragomalou, George Paltoglou, Maria Manou, Ioannis V. Kostopoulos, Sofia Loukopoulou, Maria Binou, Ourania E. Tsitsilonis, Flora Bacopoulou, Penio Kassari, Marina Papadopoulou, George Mastorakos, Evangelia Charmandari
Summary: Obesity in adolescence is linked to cardiovascular disease. Non-traditional risk factors can be used as biomarkers to predict future CVD. Lifestyle intervention programs can improve these risk factors.
Review
Nutrition & Dietetics
In-Seon Lee, Seok-Jae Ko, Yu Na Lee, Gahyun Lee, Hasanur Rahman, Bonglee Kim
Summary: Metabolic syndrome is a medical condition characterized by abdominal obesity, insulin resistance, high blood pressure, and hyperlipidemia. The brown seaweed Laminaria japonica may have therapeutic effects on metabolic syndrome due to its anti-inflammatory and antioxidant properties.
Letter
Cardiac & Cardiovascular Systems
Martijn H. van der Ree, Rianne H. A. de Bruin-Bon, Brian V. Balgobind, Wiert F. Hoeksema, Jorrit Visser, Hanneke W. M. van Laarhoven, Nadia Haj Mohammad, Edith M. T. Dieleman, Maarten C. C. M. Hulshof, Matthijs Boekholdt, Pieter G. Postema
Article
Clinical Neurology
Leon A. Rinkel, Chiel F. P. Beemsterboer, Nina-Suzanne Groeneveld, Nick H. J. Lobe, S. Matthijs Boekholdt, Berto J. Bouma, Fenna F. Muller, Ludo F. M. Beenen, Henk A. Marquering, Charles B. L. M. Majoie, Yvo B. W. E. M. Roos, Adrienne van Randen, R. Nils Planken, Jonathan M. Coutinho
Summary: Cardiac CT can detect cardiac thrombi in patients with acute ischemic stroke, and these patients have more severe symptoms and the thrombi are usually located in the left atrial appendage, which significantly affects the functional outcome.
EUROPEAN STROKE JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Yannick Kaiser, Jeremy Labrecque, Erik S. G. Stroes, S. Matthijs Boekholdt, Daniel Bos
EUROPEAN HEART JOURNAL
(2023)
Article
Clinical Neurology
Johan Lim, Hannah A. W. Walter, Rianne A. C. M. de Bruin-Bon, Myrthe C. Jarings, R. Nils Planken, Wouter E. M. Kok, Joost Raaphorst, Yigal M. Pinto, Ahmad S. Amin, S. Matthijs Boekholdt, Anneke J. van der Kooi
Summary: This study explores the effectiveness of a multimodality screening approach in detecting potentially reversible myocarditis in newly diagnosed patients with idiopathic inflammatory myopathy. The screening includes cardiac evaluation using biomarkers, electrocardiography, echocardiography, and cardiac magnetic resonance imaging. The study suggests that a diagnostic algorithm combining high-sensitivity cardiac troponins and cardiac magnetic resonance imaging may be effective in detecting myocarditis in adult patients with idiopathic inflammatory myopathy.
JOURNAL OF NEUROMUSCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Frank Meijerink, Marja Holierook, Susanne Eberl, Danielle Robbers-Visser, S. Matthijs Boekholdt, Marcel A. M. Beijk, Karel T. Koch, Robbert J. de Winter, Berto J. Bouma, Jan Baan
Summary: This study aimed to determine whether low-dose dobutamine stress echocardiography (DSE) during transcatheter edge-to-edge mitral valve repair (TMVR) can predict residual mitral regurgitation (MR) at discharge. The results showed that an increase of MR during DSE can predict the presence of >moderate MR at discharge.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Martijn H. van der Ree, Edith M. T. Dieleman, Jorrit Visser, R. Nils Planken, S. Matthijs Boekholdt, Rianne H. A. de Bruin-Bon, Coen R. N. Rasch, Wiert F. Hoeksema, Rianne M. A. J. de Jong, Michiel J. B. Kemme, Jippe C. Balt, Arthur A. M. Wilde, Brian Balgobind, Pieter G. Postema
Summary: This study aims to evaluate the efficacy and safety of Stereotactic Arrhythmia Radiotherapy (STAR). It found that STAR can reduce the number of treated ventricular tachycardia episodes by more than 50% in 67% of patients with therapy-refractory VT. No decrease in cardiac and pulmonary function or treatment-related serious adverse events were observed during follow-up.
Article
Clinical Neurology
L. A. Rinkel, B. J. Bouma, S. M. Boekholdt, C. F. P. Beemsterboer, N. H. J. Lobe, L. F. M. Beenen, H. A. Marquering, C. B. L. M. Majoie, Y. B. W. E. M. Roos, A. van Randen, R. N. Planken, J. M. Coutinho
Summary: This study found that cardiac CT has low sensitivity in screening for PFO (patent foramen ovale) in patients with acute stroke, therefore it is not a suitable method for detecting PFO. For young patients with cryptogenic stroke, additional echocardiography is still needed after cardiac CT as a first-line screening method.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Bang Zheng, Bowen Su, Sara Ahmadi-Abhari, Dimitrios Kapogiannis, Ioanna Tzoulaki, Elio Riboli, Lefkos Middleton
Summary: A study conducted in the UK found that type 2 diabetes patients who were treated with metformin had a lower risk of dementia. The risk was even lower for patients who used metformin for a longer duration.
ALZHEIMERS & DEMENTIA
(2023)
Article
Urology & Nephrology
Sanne J. van der Veen, Mohamed el Sayed, Carla E. M. Hollak, Marion M. Brands, C. Khya S. Snelder, S. Matthijs Boekholdt, Liffert Vogt, Susan M. I. Goorden, Andre B. P. van Kuilenburg, Mirjam Langeveld
Summary: Fabry disease is a heterogeneous X-linked lysosomal storage disease with varying manifestations in the kidneys, heart, and brain even among patients of the same sex and classification. The study investigates the association between plasma lysoGb3 levels and disease manifestations in untreated patients with Fabry disease, and finds that higher levels of lysoGb3 are associated with disease progression in various organs.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tinka J. van Trier, Marjolein Snaterse, S. Matthijs Boekholdt, Wilma J. M. Scholte op Reimer, Steven H. J. Hageman, Frank L. J. Visseren, Jannick A. N. Dorresteijn, Ron J. G. Peters, Harald T. Jorstad
Summary: This study aims to assess the discrimination, calibration, and clinical utility of low-risk SCORE2 and SCORE2-OP models for cardiovascular disease risk evaluation.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jordan M. Kraaijenhof, Tycho R. Tromp, Nick S. Nurmohamed, Laurens F. Reeskamp, Marije Langenkamp, Johannes H. M. Levels, S. Matthijs Boekholdt, Nicholas J. Wareham, Menno Hoekstra, Erik S. G. Stroes, G. Kees Hovingh, Aldo Grefhorst
Summary: The study found that while ANGPTL3 predominantly resides on HDL, its activity is highest when bound to LDL particles.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Geriatrics & Gerontology
Yuntao Chen, Marzieh Araghi, Piotr Bandosz, Martin J. Shipley, Sara Ahmadi-Abhari, Sophia Lobanov-Rostovsky, Tishya Venkatraman, Mika Kivimaki, Martin O'Flaherty, Eric J. Brunner
Summary: This study examines the impact of changes in hypertension prevalence on mortality, dementia, and disability. Three scenarios were modeled based on observed trends, and the results show a potential influence on life expectancy and risk of dementia and disability.
LANCET HEALTHY LONGEVITY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Adrianus J. Bakermans, Merel Kouwenhoven, Judith De Vos, Dylan K. De Vries, Yolan J. Reckman, Emile S. Farag, David R. Koolbergen, Jolanda Kluin, Aart J. Nederveen, Gustav J. Strijkers, S. Matthijs Boekholdt
Summary: This study aimed to validate MRI measurements of extracellular volume fraction (ECV) against ex vivo histology of myocardial tissue samples. The results showed a strong correlation between ECV and myocardial collagen content. However, there was no correlation between native T-1 values of the myocardium and ECV or myocardial collagen content.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
Article
Sport Sciences
Juliette C. van Hattum, Sjoerd M. Verwijs, S. Matthijs Boekholdt, Maarten Groenink, R. Nils Planken, Adrienne van Randen, Aart J. Nederveen, Maarten H. Moen, Cornelis A. C. M. Wijne, Joelle J. N. Daems, Birgitta K. Velthuis, Danny A. J. van de Sande, Ruud Spee, Suzanna T. de Vries, Maurits J. van der Veen, Yigal M. Pinto, Arthur A. M. Wilde, Harald T. Jorstad, ELITE Consortium
Summary: This article introduces the ELITE study, which aims to investigate the cardiovascular effects of elite sports and exercise. The study collects data from elite athletes in the Netherlands and conducts long-term observations and diagnostics to determine the impact of elite sports and exercise on the heart. The study also includes research on cardiac sequelae following infections with myocardial involvement. This is a prospective observational study.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Conall Green, Thomas Beaney, David Salman, Catherine Robb, Celeste A. de Jager Loots, Parthenia Giannakopoulou, Chi Udeh-Momoh, Sara Ahmadi-Abhari, Azeem Majeed, Lefkos T. Middleton, Alison H. Mcgregor
Summary: Those who were shielding or lonely at the onset of the pandemic had lower levels of physical activity during the pandemic. These associations are influenced by co-morbidities and health status.