Article
Pharmacology & Pharmacy
Federica Galimberti, Manuela Casula, Elena Olmastroni
Summary: The retention of apoB-containing lipoproteins in the subendothelial layer is crucial for the development of atherosclerotic processes. Recent evidence suggests that the number of atherogenic particles trapped in the arterial lumen, rather than their lipid content, plays a key role in this process. Hence, apoB level is proposed as a better indicator than LDL-cholesterol for assessing cardiovascular disease risk, particularly in specific patient subgroups. Routine measurement of both LDL-cholesterol and apoB is essential for estimating overall cardiovascular risk, evaluating residual risk, and monitoring therapeutic effectiveness.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Environmental Sciences
Hao Zhao, Wei Gui, Xin Tan, Ying Chen, Yao Ning, Xin Wang
Summary: This study investigated the relationship between neonicotinoid insecticides (NNIs) and their metabolites in urine with serum lipid profiles in adults. The results showed a significant positive correlation between N-desmethyl-acetamiprid and total cholesterol (TC) levels, especially in participants aged over 46 years. Body mass index (BMI) also modified the association between N-desmethyl-acetamiprid and LDL-C and Apo-B levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Cardiac & Cardiovascular Systems
Kyung An Kim, Na Jin Kim, Eun-Ho Choo
Summary: This meta-analysis aimed to evaluate the effect of fibrate treatment on cardiovascular risk. It found that fibrate therapy was associated with decreased risk of major adverse cardiovascular outcomes (MACE), primarily through the reduction of low-density lipoprotein cholesterol (LDL-C) rather than triglyceride levels.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Liu Shi, Dongmei Zhang, Jianqing Ju, Anlu Wang, Tianyi Du, Xuanye Chen, Yewen Song, Zhuye Gao, Hao Xu
Summary: In the general US adult population, remnant cholesterol (RC) is associated with hypertension beyond LDL-C levels. Elevated RC levels are linked to a higher prevalence of hypertension, independent of BMI, LDL-C, HDL-C, or triglycerides.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
C. J. MacDonald, A. L. Madika, G. Severi, A. Fournier, M. C. Boutron-Ruault
Summary: The study found that non-O blood groups, particularly the A group, are associated with an increased risk of dyslipidaemia. Current smokers have a 30% higher risk of dyslipidaemia compared to never-smokers. These results could be useful for personalized approaches to preventing cardiovascular risk factors.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Mehran Nouri, Mohammad Ali Mohsenpour, Niki Katsiki, Saeed Ghobadi, Alireza Jafari, Shiva Faghih, Maciej Banach, Mohsen Mazidi
Summary: In this meta-analysis, the relationship between serum lipid profile and breast cancer risk was investigated. The results showed a negative association between high-density lipoprotein cholesterol (HDL-C) level and breast cancer risk, while other indicators such as TG, TC, ApoA and LDL-C were not associated with breast cancer development.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Hematology
Gissette Reyes-Soffer, Henry N. Ginsberg, Lars Berglund, P. Barton Duell, Sean P. Heffron, Pia R. Kamstrup, Donald M. Lloyd-Jones, Santica M. Marcovina, Calvin Yeang, Marlys L. Koschinsky
Summary: High levels of Lp(a) are an independent and causal risk factor for atherosclerotic cardiovascular diseases. Genetic factors determine 70% to 90% of interindividual heterogeneity in Lp(a) levels. There is a lack of standardized assays, diagnostic guidelines, and targeted treatments for lowering Lp(a). Understanding the genetic and biological basis for variation in Lp(a) levels in different populations is crucial.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Urology & Nephrology
Chuanfei Zeng, Qing Zhan, Linghai Lv, Yanbing Chen, Xiaojiang Zhan
Summary: This study investigated the association between the LDL-C/apo B ratio (LAR) and all-cause mortality and cardiovascular events in peritoneal dialysis (PD) patients. The results showed that a low LAR was significantly associated with an increased risk of all-cause mortality and cardiovascular events.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Hae Won Jung, Moni Ra, Han Joon Bae, Seung-Pyo Hong
Summary: The association between Apo B, Apo B/A1 ratio, lipoprotein (a), and LDL-C/Apo B ratio with coronary artery disease (CAD) in non-diabetic patients without high LDL-C levels was unclear. A study was conducted on 487 non-diabetic patients with LDL-C < 130.0 mg/dL to evaluate the most strongly associated parameter with CAD. The LDL-C/Apo B ratio was found to be the most predictive parameter for coronary atherosclerosis in non-diabetic patients without high LDL-C levels.
Article
Medicine, General & Internal
Vivencio Barrios, Xavier Pinto, Carlos Escobar, Jose F. F. Varona, Jose M. Gamez
Summary: Despite improvements in CVD prevention, a small proportion of patients achieve recommended LDL-C goals under high-intensity LLT. This study aimed to assess LDL-C target attainment and associated factors in a real-world setting in Spain. Of the 1570 patients included, the LDL-C goal attainment rate was 31.1%, with established CVD and familial hypercholesterolemia being significant factors for non-achievement.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaojing Jia, Yan Qi, Ruizhi Zheng, Lin Lin, Chunyan Hu, Yuanyue Zhu, Qiuyu Cao, Xueyan Wu, Hongyan Qi, Ran Wei, Yi Zhang, Min Xu, Yu Xu, Tiange Wang, Zhiyun Zhao, Yuhong Chen, Mian Li, Weiqing Wang, Yufang Bi, Jieli Lu
Summary: This study aimed to investigate the association between the discordance of LDL-C with apoB or non-HDL-C and arterial stiffness and elevated CIMT in middle-aged and elderly adults. The results showed that elevated apoB or non-HDL-C was a better predictor of arterial stiffness, while LDL-C was a better predictor of elevated CIMT.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Endocrinology & Metabolism
Chunyan Zhao, Yueqi Wang, Liu Xiao, Lin Li
Summary: The results of this meta-analysis suggest that levothyroxine treatment may reduce total cholesterol, triglycerides, low-density lipoprotein cholesterol, and apolipoprotein B levels in older patients with subclinical hypothyroidism (SCH). However, it does not significantly affect bone mineral density, fatigue, hypothyroidism symptoms, quality of life, body mass index, cognitive function, depression, blood pressure, or increase the incidence of adverse events in older SCH patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Aliza Hussain, Caroline Sun, Elizabeth Selvin, Vijay Nambi, Josef Coresh, Xiaoming Jia, Christie M. Ballantyne, Ron C. Hoogeveen
Summary: Despite statin and antihypertensive therapies, older Americans continue to have high ASCVD risk. Novel measures of triglyceride-rich lipoproteins are associated with ASCVD, and genetic polymorphisms related to triglyceride catabolism are potential therapeutic targets. In older adults, LDL-TG and ANGPTL3 are independent predictors of ASCVD events after adjustment for traditional risk factors.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Bagherniya, Thomas P. Johnston, Amirhossein Sahebkar
Summary: This paper reviewed the effect of bioactive natural compounds on plasma Apo B concentrations, concluding that medicinal plants and nutraceuticals can generally be used as complementary medicine to reduce plasma Apo B levels in a safe, accessible, and inexpensive manner in an attempt to prevent and treat cardiovascular disease.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Geyue Qu, Zhongying Zhang, Hong Zhu
Summary: This study found discordance between LDL-C and non-HDL-C or apoB in middle-aged and elderly Chinese individuals, which was associated with a higher risk of arterial stiffness. Non-HDL-C or apoB levels could be used to identify individuals who may benefit from more comprehensive lipid modification.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Urology & Nephrology
K. Scott Brimble, Javier Ganame, Peter Margetts, Arsh Jain, Jeffrey Perl, Michael Walsh, Jackie Bosch, Salim Yusuf, Samy Beshay, Winnie Su, Deborah Zimmerman, Shun Fu Lee, Azim S. Gangji
Summary: BIA-guided volume management and vitamin D supplementation showed no effect on left ventricular hypertrophy in patients receiving peritoneal dialysis.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Emily J. Rugel, Clara K. Chow, Daniel J. Corsi, Perry Hystad, Sumathy Rangarajan, Salim Yusuf, Scott A. Lear
Summary: This study examines the availability of age-friendly urban environments indicators in rural areas and low- and middle-income countries. The results show that there is less access to environmental supports for healthy aging in these settings, and calls for tailoring the World Health Organization's indicators to a broader range of communities.
Article
Cardiac & Cardiovascular Systems
Michael Boehm, Helmut Schumacher, Christian Werner, Koon K. Teo, Eva M. Lonn, Felix Mahfoud, Thimoteus Speer, Giuseppe Mancia, Josep Redon, Roland E. Schmieder, Karen Sliwa, Nikolaus Marx, Michael A. Weber, Ulrich Laufs, Bryan Williams, Salim Yusuf, Johannes F. E. Mann
Summary: This study analyzed the association between physical activity and renal and cardiovascular outcomes in high-risk patients aged >= 55 years. The results showed that moderate physical activity was associated with improved kidney outcomes, with a threshold of at least two sessions per week. The association between physical activity and renal outcomes did not differ significantly between those with and without diabetes, but the absolute benefit of activity was greater in people with diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Environmental Sciences
Matthew Shupler, Perry Hystad, Aaron Birch, Yen Li Chu, Matthew Jeronimo, Daniel Miller-Lionberg, Paul Gustafson, Sumathy Rangarajan, Maha Mustaha, Laura Heenan, Pamela Seron, Fernando Lanas, Fairuz Cazor, Maria Jose Oliveros, Patricio Lopez-Jaramillo, Paul A. Camacho, Johnna Otero, Maritza Perez, Karen Yeates, Nicola West, Tatenda Ncube, Brian Ncube, Jephat Chifamba, Rita Yusuf, Afreen Khan, Zhiguang Liu, Shutong Wu, Li Wei, Lap Ah Tse, Deepa Mohan, Parthiban Kumar, Rajeev Gupta, Indu Mohan, K. G. Jayachitra, Prem K. Mony, Kamala Rammohan, Sanjeev Nair, P. V. M. Lakshmi, Vivek Sagar, Rehman Khawaja, Romaina Iqbal, Khawar Kazmi, Salim Yusuf, Michael Brauer
Summary: A multinational measurement campaign was conducted to develop household and personal PM2.5 exposure models, which can be used to quantify levels of household air pollution (HAP). The models found that primary cooking fuel type, heating fuel type, country, and season were highly predictive of PM2.5 concentrations.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew Smyth, Martin O'Donnell, Graeme J. Hankey, Sumathy Rangarajan, Patricio Lopez-Jaramillo, Denis Xavier, Hongye Zhang, Michelle Canavan, Albertino Damasceno, Peter Langhorne, Alvaro Avezum, Nana Pogosova, Aytekin Oguz, Salim Yusuf
Summary: The INTERSTROKE study found that acute stroke is associated with anger or emotional upset and heavy physical exertion. Anger or emotional upset is associated with all stroke, ischemic stroke, and intracerebral hemorrhage, while heavy physical exertion is only associated with intracerebral hemorrhage.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Jaffar Al-Sheikhli, Ian Patchett, Ven Gee Lim, Leeann Marshall, Will Foster, Michael Kuehl, Shamil Yusuf, Sandeep Panikker, Kiran Patel, Faizel Osman, Prithwish Banerjee, Nicolas Lellouche, Tarvinder Dhanjal
Summary: The feasibility study of using the DiamondTemp ablation (DTA) catheter system for ventricular tachycardia (VT) ablation in ischaemic cardiomyopathy (ICM) patients showed significant improvements in patient condition and clinical outcomes.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Sonia S. Anand, Matthias G. Friedrich, Douglas S. Lee, Phillip Awadalla, J. P. Despres, Dipika Desai, Russell J. de Souza, Trevor Dummer, Grace Parraga, Eric Larose, Scott A. Lear, Koon K. Teo, Paul Poirier, Karleen M. Schulze, Dorota Szczesniak, Jean-Claude Tardif, Jennifer Vena, Katarzyna Zatonska, Salim Yusuf, Eric E. Smith
Summary: This study investigated the association of adiposity on vascular brain injury and cognitive scores. The results showed that generalized and visceral adiposity were associated with reduced cognitive scores, even after adjusting for cardiovascular risk factors, educational level, and vascular brain injury.
Article
Urology & Nephrology
Suceena Alexander, Santosh Varughese, Rajanbabu Franklin, Grace Rebekah, Sanjeet Roy, Sabina Yusuf, Athul Thomas, Jeethu Joseph Eapen, Elenjickal Elias John, Anna T. Valson, Vinoi George David, Mohamed R. Daha, John Feehally, Jonathan Barratt, George T. John
Summary: Introduction: Glomerular Research And Clinical Experiments-IgA Nephropathy in Indians (GRACE-IgANI) is the first prospective South Asian IgA nephropathy cohort with pre-specified objectives, protocolized longitudinal follow-up, and extensive biosample collection. The study identified important predictors for composite outcome, including specific clinical variables and annual decline in estimated glomerular filtration rate (eGFR).
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Andre Lamy, Wesley Tong, Philip Joseph, Peggy Gao, Prem Pais, Patricio Lopez-Jaramillo, Marjan Walli-Attaei, Tony Dans, Denis Xavier, Shamim Talukder, Anwar Santoso, Habib Gamra, Salim Yusuf
Summary: The International Polycap Study 3 (TIPS-3) trial showed that a polypill containing multiple drugs can effectively reduce the occurrence of cardiovascular events in people without cardiovascular disease. There are regional variations in the costs and affordability of this polypill. Based on the economic classification by the World Bank, the polypill is affordable in countries at different economic levels.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2022)
Article
Multidisciplinary Sciences
Yunita Sari, Saldy Yusuf, Haryanto, Lita Heni Kusumawardani, Annas Sumeru, Eman Sutrisna, Saryono
Summary: This study explores the cultural beliefs and practices of Javanese diabetic patients and their impact on self-management of the disease. The findings highlight the diverse influences of Javanese culture on the health status of diabetic patients.
Article
Peripheral Vascular Disease
Jose P. Lopez-Lopez, Daniel D. Cohen, Natalia Alarcon-Ariza, Margarita Mogollon-Zehr, Daniela Ney-Salazar, Maria A. Chacon-Manosalva, Daniel Martinez-Bello, Johanna Otero, Gabriela Castillo-Lopez, Maritza Perez-Mayorga, Sumathy Rangarajan, Salim Yusuf, Patricio Lopez-Jaramillo
Summary: This study aimed to investigate the prevalence of hypertension and its associations with anthropometric, socioeconomic, and behavioral factors among different ethnic groups in Colombia. The results showed a higher prevalence of hypertension in Afro-descendants compared to other ethnic groups, with low education level being the strongest factor associated with hypertension.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Biology
Marie Loh, Weihua Zhang, Hong Kiat Ng, Katharina Schmid, Amel Lamri, Lin Tong, Meraj Ahmad, Jung-Jin Lee, Maggie C. Y. Ng, Lauren E. Petty, Cassandra N. Spracklen, Fumihiko Takeuchi, Md Tariqul Islam, Farzana Jasmine, Anuradhani Kasturiratne, Muhammad Kibriya, Karen L. Mohlke, Guillaume Pare, Gauri Prasad, Mohammad Shahriar, Miao Ling Chee, H. Janaka de Silva, James C. Engert, Hertzel C. Gerstein, K. Radha Mani, Charumathi Sabanayagam, Marijana Vujkovic, Ananda R. Wickremasinghe, Tien Yin Wong, Chittaranjan S. Yajnik, Salim Yusuf, Habibul Ahsan, Dwaipayan Bharadwaj, Sonia S. Anand, Jennifer E. Below, Michael Boehnke, Donald W. Bowden, Giriraj R. Chandak, Ching-Yu Cheng, Norihiro Kato, Anubha Mahajan, Xueling Sim, Mark McCarthy, Andrew P. Morris, Jaspal S. Kooner, Danish Saleheen, John C. Chambers
Summary: South Asians have a higher risk of developing type 2 diabetes (T2D). Through a genomewide association meta-analysis, researchers identified 21 novel genetic loci associated with T2D, which are linked to adiposity and glucose metabolism. A polygenic risk score based on South Asian-derived summary statistics can predict T2D risk.
COMMUNICATIONS BIOLOGY
(2022)
Correction
Biology
Marie Loh, Weihua Zhang, Hong Kiat Ng, Katharina Schmid, Amel Lamri, Lin Tong, Meraj Ahmad, Jung-Jin Lee, Maggie C. Y. Ng, Lauren E. Petty, Cassandra N. Spracklen, Fumihiko Takeuchi, Md. Tariqul Islam, Farzana Jasmine, Anuradhani Kasturiratne, Muhammad Kibriya, Karen L. Mohlke, Guillaume Pare, Gauri Prasad, Mohammad Shahriar, Miao Ling Chee, H. Janaka de Silva, James C. Engert, Hertzel C. Gerstein, K. Radha Mani, Charumathi Sabanayagam, Marijana Vujkovic, Ananda R. Wickremasinghe, Tien Yin Wong, Chittaranjan S. Yajnik, Salim Yusuf, Habibul Ahsan, Dwaipayan Bharadwaj, Sonia S. Anand, Jennifer E. Below, Michael Boehnke, Donald W. Bowden, Giriraj R. Chandak, Ching-Yu Cheng, Norihiro Kato, Anubha Mahajan, Xueling Sim, Mark I. McCarthy, Andrew P. Morris, Jaspal S. Kooner, Danish Saleheen, John C. Chambers
COMMUNICATIONS BIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Nana Pogosova, Jacqueline Bosch, Deepak L. Bhatt, Keith A. A. Fox, Stuart J. Connolly, Marco Alings, Peter Verhamme, Eva Muehlhofer, Olga Shestakovska, Salim Yusuf, John W. Eikelboom
Article
Cardiac & Cardiovascular Systems
Sidong Li, Zhiguang Liu, Philip Joseph, Bo Hu, Lu Yin, Lap Ah Tse, Sumathy Rangarajan, Chuangshi Wang, Yang Wang, Shofiqul Islam, Weida Liu, Fanghong Lu, Yindong Li, Yan Hou, Deren Qiang, Qian Zhao, Ning Li, Rensheng Lei, Di Chen, Aiying Han, Guoqin Liu, Peng Zhang, Yahong Zhi, Chunmei Liu, Jinkui Yang, Aobulikasimu Resalaiti, Haibin Ma, Yuanting Ma, Yu Liu, Xiaojie Xing, Quanyong Xiang, Zhengrong Liu, Yundong Sheng, Jinghua Tang, Lisheng Liu, Salim Yusuf, Wei Li
Summary: China shows gender and regional disparities in cardiovascular disease and mortality rates. Significant reductions in cardiovascular disease incidence can be achieved by controlling metabolic risk factors and improving education.
EUROPEAN HEART JOURNAL
(2022)