期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 65, 期 13, 页码 683-694出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2016.1157800
关键词
Doxorubicin; dual-responsive nanocarrier; magnetic nanoparticles; targeted delivery
资金
- University of Tabriz
The aim of study was to develop a novel drug nanocarrier via facile coating of a folate-conjugated dual-responsive copolymer with carboxylic functional groups on the surface of magnetic nanoparticles for the efficient loading and cell-specific targeting of a positively charged anticancer agent. The nanocarrier exhibited many favorable capabilities such as narrow distributed nano-ranged size (similar to 30nm), high drug loading capacity (similar to 65%), and stimuli-responsive drug release. The results of various cell cytotoxicity studies such as MTT assay, DAPI staining, and flow cytometry concluded that the developed smart nanocarrier paves a way for efficient cancer therapy by the multiple targeting strategies. [GRAPHICS] .
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