期刊
FRONTIERS IN MICROBIOLOGY
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2016.00011
关键词
Bacillus anthracis; restriction enzymes; DNA methyltransferase; R-M; selfish genes; type IV restriction enzymes; methylation-dependent restriction enzyme; orphan DNA methyltransferase
类别
资金
- Frontiers
Restrictionmodification (RM) systems are widespread among prokaryotes and, depending on their type, may be viewed as selfish genetic elements that persist as toxinantitoxin modules, or as cellular defense systems against phage infection that confer a selective advantage to the host bacterium. Studies in the last decade have made it amply clear that these two options do not exhaust the list of possible biological roles for RM systems. Their presence in a cell may also have a bearing on other processes such as horizontal gene transfer and gene regulation. From genome sequencing and experimental data, we know that Bacillus anthracis encodes at least three methylation-dependent (typeIV) restriction endonucleases (RE), and an orphan DNA methyltransferase. In this article, we first present an outline of our current knowledge of RM systems in B. anthracis. Based on available DNA sequence data, and on our current understanding of the functions of similar genes in other systems, we conclude with hypotheses on the possible roles of the three REs and the orphan DNA methyltransferase.
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