Article
Zoology
Lu-Chao Lv, Yao-Yao Lu, Xun Gao, Wan-Yun He, Ming-Yi Gao, Kai-Bin Mo, Jian-Hua Liu
Summary: This study characterized NDM-5-producing Enterobacteriaceae from aquatic products in Guangzhou, China, identifying bla(NDM-5) in Citrobacter freundii and Escherichia coli strains on various plasmids. The transfer of bla(NDM-5) between different plasmids was likely facilitated by the Tn7051 transposon, expanding the transmission vectors of this carbapenemase gene.
ZOOLOGICAL RESEARCH
(2022)
Article
Infectious Diseases
Linjing Wang, Haijun Chen, Wanting Liu, Ling Yang, Zhenbo Xu, Dingqiang Chen
Summary: This study characterized the genome sequence of a drug-resistant Klebsiella michiganensis strain and identified novel plasmids carrying resistance genes. The findings provide insights into the genetic mechanisms of drug resistance in this emerging pathogen and highlight the importance of surveillance and control measures.
Review
Environmental Sciences
Nawel Zaatout, Samia Bouras, Nouria Slimani
Summary: Wastewater is a hotspot niche for multi-drug resistant and pathogenic bacteria, particularly Enterobacteriaceae-producing ESBL-E. This meta-analysis showed an increasing prevalence of ESBL-E in wastewater over time, with hospital wastewater being a significant reservoir. There is a need for developing new sewage treatment systems to reduce the introduction of resistant bacteria and antibiotic residues.
JOURNAL OF WATER AND HEALTH
(2021)
Article
Infectious Diseases
Tushar Kumar Dey, Johanna Frida Lindahl, Ake Lundkvist, Delia Grace, Ram Pratim Deka, Rajeswari Shome, Samiran Bandyopadhyay, Naresh Kumar Goyal, Garima Sharma, Bibek Ranjan Shome
Summary: This study investigated the prevalence of beta-lactamase-producing Enterobacteriaceae in milk samples from two Indian states, revealing the presence of various prevalent beta-lactamase genes. The findings underscore the potential risk of antimicrobial-resistant bacteria in dairy products and the need for comprehensive approaches to accurately assess antibiotic resistance.
Article
Microbiology
Sun Hee Moon, En Huang
Summary: Understanding cefiderocol resistance mechanisms is crucial for developing solutions against infections and resistance development. Cefiderocol resistance in Klebsiella pneumoniae AR 0047 is associated with SHV beta-lactamase activities and loss of the outer membrane porin. The combination of cefiderocol and avibactam presents an opportunity to enhance effectiveness against cefiderocol-resistant pathogens.
MICROBIOLOGY SPECTRUM
(2023)
Article
Ecology
Md Saiful Islam, Md Abdus Sobur, Saifur Rahman, Fatimah Mohammed Ballah, Samina Ievy, Mahbubul Pratik Siddique, Marzia Rahman, Md Abdul Kafi, Md Tanvir Rahman
Summary: Migratory birds may carry ESBL-producing E. coli and other antibiotic resistance genes, posing potential threats to human health.
Article
Microbiology
Mohamed A. Nossair, Fatma A. Abd El Baqy, Mohammad S. Y. Rizk, Haitham Elaadli, Alaa M. Mansour, Ayman H. Abd El-Aziz, Adil Alkhedaide, Mohamed Mohamed Soliman, Hazem Ramadan, Mustafa Shukry, Sabah Shaaban
Summary: A cross-sectional study was conducted in dairy cattle farms and poultry farms in northern Egypt to assess the prevalence of ESBL-producing Enterobacteriaceae in humans, cattle, and poultry. The study found that the prevalence of ESBL-producing Enterobacteriaceae was 30.0%, 20.0%, and 25.0% in humans, cattle, and poultry, respectively. The majority of the ESBL-producing Enterobacteriaceae showed a multi-drug resistant phenotype.
Article
Microbiology
Alireza Barani, Akram Sadat Tabatabaee Bafroee, Leila Jabalameli
Summary: This study in Ahvaz, Iran found a high prevalence of ESBL genes among intestinal E. coli isolates from drug users, with bla-TEM gene being the most prevalent. The multidrug resistance (MDR) patterns, especially simultaneous resistance to seven antimicrobials, highlight the risk of transferring resistance genes between nonpathogenic and pathogenic bacteria.
ARCHIVES OF MICROBIOLOGY
(2021)
Article
Infectious Diseases
Samanta Freire, Teresa Grilo, Laurent Poirel, Marta Aires-de-Sousa
Summary: This study investigated the potential role of urban pigeons in the dissemination of multidrug-resistant bacteria. The results showed that these pigeons can carry ESBL-producing Escherichia coli strains, which may contribute to the spread of antimicrobial resistance in the environment.
Article
Environmental Sciences
Lukas Bock, Lisandra Aguilar-Bultet, Adrian Egli, Manuel Battegay, Andreas Kronenberg, Roland Vogt, Carole Kaufmann, Sarah Tschudin-Sutter
Summary: Higher outdoor temperature may be associated with an increase in the incidence of ESBL-PE, independent of other potential confounding factors, such as antimicrobial consumption.
ENVIRONMENTAL RESEARCH
(2022)
Article
Infectious Diseases
Candace Guzman-Cole, Fabian Santiago, Sona Garsevanyan, Suzanne Sindi, Miriam Barlow
Summary: This study revealed that local selective pressures have a greater influence on the population structure of resistance genes in bacterial populations than migration, indicating the potential for antibiotic resistance to be controlled at a regional level.
Article
Infectious Diseases
Ermioni Avgere, Christos Zafeiridis, Kassandra A. Procter, Apostolos Beloukas, Panagiota Giakkoupi
Summary: The first prospective surveillance of ESBL and colistin-resistant Escherichia coli recovered from sick pigs in Central Greece was conducted to investigate the spread of relevant genetic elements. The study found a 40% prevalence of ESBLs and an 80% prevalence of MCR-1, with a co-occurrence rate of 32%. The identified ESBL types were CTX-M-3 and SHV-12. Resistance to colistin, chloramphenicol, cotrimoxazole, and ciprofloxacin was detected in varying degrees among the isolates. The presence of diverse E. coli isolates carrying resistance genes on stable plasmids suggests that horizontal plasmid transfer may facilitate the dissemination of resistance genes.
Article
Infectious Diseases
Jana Makhlouf, Georgi Merhi, Tamara Salloum, Edmond Abboud, Sima Tokajian
Summary: This study provides a comprehensive molecular characterization of a carbapenem-resistant E. hormaechei ssp. xiangfangensis strain, identifying multiple resistance genes integrated within phages and plasmids. The findings highlight the emergence of multi-drug resistant Enterobacter cloacae complex members in clinical settings, emphasizing the importance of monitoring their dissemination.
INFECTION GENETICS AND EVOLUTION
(2021)
Review
Biotechnology & Applied Microbiology
Sohyun Cho, Charlene R. Jackson, Jonathan G. Frye
Summary: Surface water is a favorable environment for the accumulation and spread of antibiotic resistant bacteria, including ESBL-producing Enterobacteriaceae. The prevalence of ESBL-producing Enterobacteriaceae, particularly E. coli and K. pneumoniae, in aquatic environments worldwide poses a growing threat to public health. This review aims to explore the contamination of ESBL-producing Enterobacteriaceae in freshwater environments and understand their sources and transmission routes, as well as the factors driving their presence.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Microbiology
Gaelle Gruel, David Couvin, Stephanie Guyomard-Rabenirina, Guillaume Arlet, Jean-Christophe Bambou, Matthieu Pot, Xavier Roy, Antoine Talarmin, Benoit Tressieres, Severine Ferdinand, Sebastien Breurec
Summary: This study determines the prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in feces of household and shelter pets in Guadeloupe. The study finds that the only risk factor associated with a higher prevalence of ESBL-E rectal carriage is a stay in a shelter. The study also identifies ESBL-E as mainly Escherichia coli, with certain plasmids carrying antimicrobial resistance genes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Daniela Ceccarelli, Arie Kant, Alieda van Essen-Zandbergen, Cindy Dierikx, Joost Hordijk, Ben Wit, Dik J. Mevius, Kees T. Veldman
FRONTIERS IN MICROBIOLOGY
(2019)
Letter
Infectious Diseases
Muhd Haziq F. Abdul Momin, Apostolos Liakopoulos, David C. Bean, Lynette M. Phee, David W. Wareham
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2019)
Article
Multidisciplinary Sciences
Zheren Zhang, Chao Du, Frederique de Barsy, Michael Liem, Apostolos Liakopoulos, Gilles P. van Wezel, Young H. Choi, Dennis Claessen, Daniel E. Rozen
Article
Microbiology
Daniela Ceccarelli, Ayla Hesp, Jeanet van der Goot, Philip Joosten, Steven Sarrazin, Jaap A. Wagenaar, Jeroen Dewulf, Dik J. Mevius
JOURNAL OF MEDICAL MICROBIOLOGY
(2020)
Article
Agriculture, Dairy & Animal Science
Anita Dame-Korevaar, Egil A. J. Fischer, Jeanet van der Goot, Francisca Velkers, Daniela Ceccarelli, Dik Mevius, Arjan Stegeman
Article
Infectious Diseases
Apostolos Liakopoulos, Roberto M. La Ragione, Christoph Nagel, Ulrich Schatzschneider, Daniel E. Rozen, Jonathan W. Betts
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2020)
Article
Fisheries
Sandrine Baron, Daniela Ceccarelli, Inger Dalsgaard, Sophie A. Granier, Olga Haenen, Eva Jansson, Lone Madsen, Eric Jouy, Isabelle Kempf, Emeline Larvor, Thierry Morin, Joop Testerink, Kees Veldman, Kari Karbech Mouritsen, Betty Van Gelderen, Michal Voorbergen-Laarman, Eva Saker, Eva Blomkvist, Peter Smith
Article
Microbiology
Ana Sofia Ribeiro Duarte, Timo Roder, Liese Van Gompel, Thomas Nordahl Petersen, Rasmus Borup Hansen, Inge Marianne Hansen, Alex Bossers, Frank M. Aarestrup, Jaap A. Wagenaar, Tine Hald
Summary: Metagenomics can reveal the genetic content of microbiota in different environments, with great potential for investigating the transmission of foodborne hazards. This study demonstrates the application of metagenomics in attributing antimicrobial resistance sources, showing a potential relationship between fecal resistome components and specific reservoirs.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Linda B. S. Aulin, Apostolos Liakopoulos, Piet H. van der Graaf, Daniel E. Rozen, J. G. Coen van Hasselt
Summary: Collateral sensitivity-based antibiotic treatments have the potential to limit the emergence of antimicrobial resistance, the efficacy of which depends critically on the design of treatment schedules.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Apostolos Liakopoulos, Linda B. S. Aulin, Matteo Buffoni, Efthymian Fragkiskou, J. G. Coen van Hasselt, Daniel E. Rozen
Summary: Collateral sensitivity (CS) is a phenomenon where resistance to one antibiotic increases sensitivity to other antibiotics, providing treatment opportunities to combat antibiotic resistance. This study investigates the generality of CS effects for different resistance mutations in Streptococcus pneumoniae, a gram-positive pathogen. By measuring the collateral and fitness effects of relevant resistance alleles, the researchers identify common CS effects, but also unique effects for each allele or allelic pair. Mathematical modeling demonstrates that both collateral and fitness effects impact the population dynamics of resistance evolution. The findings highlight the importance of considering allelic identity and interactions in CS-based therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Microbiology
Wietske Dohmen, Apostolos Liakopoulos, Marc J. M. Bonten, Dik J. Mevius, Dick J. J. Heederik
Summary: A long-term study in 39 Dutch pig farms revealed the presence of ESBL-producing Enterobacterales in both pigs and pig farmers, suggesting the possibility of genetic and horizontal transmission. These findings are crucial for developing targeted intervention strategies to reduce the risk of human exposure to ESBL-producing Enterobacterales.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Laura B. Zwep, Yob Haakman, Kevin L. W. Duisters, Jacqueline J. Meulman, Apostolos Liakopoulos, J. G. Coen van Hasselt
Summary: This study developed a methodology to quantify collateral effect directionality and effect size from large-scale antimicrobial resistance population surveillance data, which was evaluated using MIC data for 419 Escherichia coli strains. The proposed approach identified several antibiotic combinations showing symmetrical or non-symmetrical CR and CS, providing guidance for future combination therapy and prescribing.
JAC-ANTIMICROBIAL RESISTANCE
(2021)
Letter
Infectious Diseases
L. B. S. Aulin, C. I. M. Koumans, Y. Haakman, W. van Os, M. E. M. Kraakman, J. Gooskens, W. K. Smits, A. Liakopoulos, J. G. C. van Hasselt
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Microbiology
Anita Dame-Korevaar, Jannigje G. Kers, Jeanet van der Goot, Francisca C. Velkers, Daniela Ceccarelli, Dik J. Mevius, Arjan Stegeman, Egil A. J. Fischer
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Infectious Diseases
Philip Joosten, Daniela Ceccarelli, Evelien Odent, Steven Sarrazin, Haitske Graveland, Liese Van Gompel, Antonio Battisti, Andrea Caprioli, Alessia Franco, Jaap A. Wagenaar, Dik Mevius, Jeroen Dewulf