Article
Immunology
Ramon Cortez, Luana N. Moreira, Marina Padilha, Mariana D. Bibas, Ricardo K. Toma, Gilda Porta, Carla R. Taddei
Summary: Studies have shown that the composition of intestinal microbiome in pediatric patients with primary sclerosing cholangitis (PSC) is influenced by disease, age, and disease activity status, highlighting significant differences in microbiome between PSC patients. Specific genera Veillonella and Megasphaera have increased relative abundance depending on age at diagnosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Anlly Fresno Rueda, Ryan Samuel, Benoit St-Pierre
Summary: Phytobiotics show positive impacts on gut health of weaned pigs by influencing the balance of lactate-producing and lactate-utilizing bacteria, as well as the composition of microbial communities in the gut. Plant-derived bioactive products may help maintain a favorable metabolic equilibrium in gut environments, highlighting their potential as a solution for gut health challenges during the weaning period.
Article
Nutrition & Dietetics
Adelaide Teofani, Irene Marafini, Federica Laudisi, Daniele Pietrucci, Silvia Salvatori, Valeria Unida, Silvia Biocca, Giovanni Monteleone, Alessandro Desideri
Summary: This study investigated the impact of lifestyle and dietary habits on the intestinal microbiota diversity and relative abundance in patients with IBD, identifying specific confounders and covariates that influence the association between certain bacterial taxa and disease status. The results suggest that variables related to an IBD-associated lifestyle and dietary habits play a role in modulating the gut microbiota in IBD patients compared to healthy controls.
Article
Pharmacology & Pharmacy
Liang Dai, Yingjue Tang, Wenjun Zhou, Yanqi Dang, Qiaoli Sun, Zhipeng Tang, Mingzhe Zhu, Guang Ji
Summary: Mesalamine treatment partially restored the disrupted gut microbiota diversity and community composition in ulcerative colitis (UC) patients. Many genera and metabolites were significantly altered in UC group and reversed by mesalamine, indicating its beneficial role in modulating gut microbiota signature with correlated metabolites in different pathways as potential therapeutic targets and biomarkers for UC.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Yali Liu, Mingyue Zhou, Ming Yang, Chen Jin, Yonggui Song, Jingbin Chen, Meng Gao, Zhifu Ai, Dan Su
Summary: Pulsatilla chinensis saponins contribute to the anti-inflammatory effects in ulcerative colitis by regulating intestinal flora, specifically increasing beneficial bacteria like norank_F_Muribaculaceae and norank_F_norank_O_Clostridia_UCG-014 while decreasing harmful bacteria like Bacteroides.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Wenchao Gu, Liangkun Zhang, Tao Han, Hailiang Huang, Jian Chen
Summary: In the DSS-induced UC model, the dysbiosis of gut microbiome is closely related to inflammatory factors, and the relative abundance of gut microbiome changes dynamically in the occurrence and development of ulcerative colitis.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Microbiology
Jian Wan, Yujie Zhang, Wenfang He, Zuhong Tian, Junchao Lin, Zhenzhen Liu, Yani Li, Min Chen, Shuang Han, Jie Liang, Yongquan Shi, Xuan Wang, Lei Zhou, Ying Cao, Jiayun Liu, Kaichun Wu
Summary: Patients with ulcerative colitis (UC) are at a higher risk of developing Clostridioides difficile infection (CDI), but the gut microbial structure and metabolites in UC and CDI patients have been poorly studied. This study identifies significant differences in gut microbiota and metabolites between UC and CDI patients compared to those with UC alone.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Marie Vibeke Vestergaard, Kristine H. Allin, Carsten Eriksen, Oliwia Zakerska-Banaszak, Ramesh P. Arasaradnam, Mohammad T. Alam, Karsten Kristiansen, Susanne Brix, Tine Jess
Summary: This study re-analyzed fecal microbiota data from 45 cohorts of inflammatory bowel disease (IBD) patients. The analysis identified a large number of genera associated with IBD, providing potential new treatment targets.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Medicine, Research & Experimental
Chang Gao, Bin Ni, Xiaolu Lu, Chunyu Guo, Guilin Wei
Summary: Corydalis bungeana Turcz. (CBT) has been found to effectively treat UC through improving pathological injury, reducing inflammation, and regulating gut microbiota. Proteomics investigation revealed that CBT exerted its effects mainly through detoxification processes. The integrated multi-omics network identified potential targets for CBT treatment of UC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Gastroenterology & Hepatology
Heather J. Galipeau, Alberto Caminero, Williams Turpin, Miriam Bermudez-Brito, Alba Santiago, Josie Libertucci, Marco Constante, Juan Antonio Raygoza Garay, Gaston Rueda, Sarah Armstrong, Alex Clarizio, Michelle Smith, Michael G. Surette, Premysl Bercik, Kenneth Croitoru, Elena F. Verdu
Summary: Increased fecal proteolytic activity was found before the clinical diagnosis of UC, which may serve as a noninvasive biomarker of inflammation associated with changes in gut microbiota. The study suggests potential therapeutic targets for at-risk populations based on antiprotease treatments.
Article
Microbiology
Wenke Zhang, Xiaoquan Fan, Haobo Shi, Jian Li, Mingqian Zhang, Jin Zhao, Xiaoquan Su
Summary: In this study, a comprehensive method called Qscore was proposed to evaluate the performance of 16S rRNA amplicons in microbial profiling. The method integrated factors such as amplification rate, taxonomic annotation, sequence type, and length. Evaluation of a wide range of microbe species and microbiomes showed that the Qscore-suggested parameters resulted in high precision in microbiome profiling. This study has significant implications for guiding future microbiome studies and enabling the reuse of massive sequence data.
MICROBIOLOGY SPECTRUM
(2023)
Review
Medicine, Research & Experimental
Parul Singh, Duaa Ahmed Idris Elhaj, Ibrahim Ibrahim, Hala Abdullahi, Souhaila Al Khodor
Summary: Gestational diabetes mellitus (GDM) is a common complication of pregnancy that increases the risk of obesity and diabetes in the offspring. The maternal microbiome plays a significant role in both maternal and infant health, as microbial metabolites can influence the host's health. This review explores the impact of the microbiota and microbial metabolites on the development of GDM and discusses interventions to improve metabolic health using microbiota-based approaches.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Microbiology
Jason A. Rothman, Jenna L. Riis, Katrina R. Hamilton, Clancy Blair, Douglas A. Granger, Katrine L. Whiteson
Summary: Human oral microbial communities have significant implications for oral and systemic health due to their diversity. Understanding the differences between healthy and dysbiotic oral microbiomes is important, especially within and between families. This study investigates the changes in oral microbiome composition within individuals and the impact of factors such as environmental tobacco smoke exposure, metabolic regulation, inflammation, and antioxidant potential. The findings reveal differences in oral microbiomes between children and caregivers, with shared diversity but distinct differences, and highlight the associations between the oral microbiome and various salivary markers.
Article
Food Science & Technology
Marek Aljewicz, Beata Nalepa, Slawomir Ciesielski
Summary: This study investigated the impact of different β-glucans on the gut microbiome in rats and found that oat β-glucan and curdlan increased the abundance of specific bacterial genera, while a positive correlation was observed between Streptococcus bacteria and the growth rate of rats. Consuming β-glucans at the recommended dose by EFSA did not significantly alter the structure of the gut microbiome in rats.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Endocrinology & Metabolism
Qing Wang, Qi Wang, Lanbo Zhao, Yadi Bin, Li Wang, Lei Wang, Kailu Zhang, Qiling Li
Summary: The blood microbiome of PCOS patients showed significantly lower alpha diversity, different beta diversity, and significant taxonomic variations compared to healthy controls.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Seyed Mohsen Hosseini, Mohsen Danesh Mesgaran, Ali Reza Vakili, Abbas Ali Naserian, Ehsan Khafipour
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
(2019)
Article
Microbiology
Shirin Moossavi, Shadi Sepehri, Bianca Robertson, Lars Bode, Sue Goruk, Catherine J. Field, Lisa M. Lix, Russell J. de Souza, Allan B. Becker, Piushkumar J. Mandhane, Stuart E. Turvey, Padmaja Subbarao, Theo J. Moraes, Diana L. Lefebvre, Malcolm R. Sears, Ehsan Khafipour, Meghan B. Azad
CELL HOST & MICROBE
(2019)
Article
Microbiology
Ruidong Mi, Rakesh Patidar, Annemieke Farenhorst, Zhangbin Cai, Shadi Sepehri, Ehsan Khafipour, Ayush Kumar
FEMS MICROBIOLOGY LETTERS
(2019)
Article
Biochemistry & Molecular Biology
Ruozhi Zhao, Ehsan Khafipour, Shadi Sepehri, Fei Huang, Trust Beta, Garry X. Shen
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2019)
Article
Pharmacology & Pharmacy
Nour Eissa, Hayam Hussein, Abdoulaye Diarra, Omar Elgazzar, Abdelilah S. Gounni, Charles N. Bernstein, Jean-Eric Ghia
BIOCHEMICAL PHARMACOLOGY
(2019)
Article
Microbiology
Elnaz Azad, Kelsey B. Fehr, Hooman Derakhshani, Robert Forster, Surya Acharya, Ehsan Khafipour, Emma McGeough, Tim A. McAllister
Article
Microbiology
J. C. Plaizier, P. Azevedo, B. L. Schurmann, P. Gorka, G. B. Penner, E. Khafipour
Article
Agriculture, Dairy & Animal Science
Jan C. Plaizier, Anne-Mette Danscher, Paula A. Azevedo, Hooman Derakhshani, Pia H. Andersen, Ehsan Khafipour
Summary: High-yielding dairy cows require high-grain diets to meet their energy demands, but excessive grain feeding can lead to subacute ruminal acidosis (SARA) and disrupt the taxonomic composition and functionality of the microbial populations in the digestive tract. Our study found that SARA altered the populations of various bacterial taxa attached to the epithelia in the digestive tract, potentially reducing the beneficial effects of these bacteria and increasing the risk of pathogenic invasion. The effects of SARA were most pronounced in the rumen and large intestine, with differing impacts on the small intestine, highlighting the need for further research on the consequences of dysbiosis caused by SARA.
Article
Agriculture, Dairy & Animal Science
J. Guo, L. Xu, H. Khalouei, K. Fehr, V. Senaratne, J. E. Ghia, I. Yoon, E. Khafipour, J. C. Plaizier
Summary: Subacute ruminal acidosis (SARA) is a metabolic disorder in dairy cows that is associated with dysbiosis of rumen and hindgut microbiomes, translocation of immunogenic compounds from the gut lumen into blood circulation, and systemic inflammatory response. This study found that Saccharomyces cerevisiae fermentation products (SCFP) can attenuate the inflammation resulting from SARA episodes by stabilizing the rumen environment and reducing proinflammatory status.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Infectious Diseases
Jean-Eric Ghia, Sophie Gaulin, Laure Ghia, Laure Garancher, Claude Flamand
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Nutrition & Dietetics
Shirin Moossavi, Faisal Atakora, Kozeta Miliku, Shadi Sepehri, Bianca Robertson, Qing Ling Duan, Allan B. Becker, Piushkumar J. Mandhane, Stuart E. Turvey, Theo J. Moraes, Diana L. Lefebvre, Malcolm R. Sears, Padmaja Subbarao, Catherine J. Field, Lars Bode, Ehsan Khafipour, Meghan B. Azad
FRONTIERS IN NUTRITION
(2019)
Article
Gastroenterology & Hepatology
Yun Han Kwon, Huaqing Wang, Emmanuel Denou, Jean-Eric Ghia, Laura Rossi, Michelle E. Fontes, Steve P. Bernier, Md. Sharif Shajib, Suhrid Banskota, Stephen M. Collins, Michael G. Surette, Waliul I. Khan
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Multidisciplinary Sciences
E. Azad, H. Derakhshani, R. J. Forster, R. J. Gruninger, S. Acharya, T. A. McAllister, E. Khafipour
SCIENTIFIC REPORTS
(2019)
Article
Immunology
Jasmine Grover, Parveen Chhuneja, Vandana Midha, Jean Eric Ghia, Dipak Deka, Chandra Shekhar Mukhopadhyay, Neena Sood, Ramit Mahajan, Arshdeep Singh, Ramneek Verma, Ekta Bansal, Ajit Sood
FRONTIERS IN IMMUNOLOGY
(2019)