Article
Microbiology
Yuvaneswary Veloo, Syahidiah S. A. Thahir, Sakshaleni Rajendiran, Lim K. Hock, Norazah Ahmad, Vickneshwaran Muthu, Rafiza Shaharudin
Summary: The indiscriminate use of antibiotics in poultry farming has led to the emergence of antibiotic-resistant bacteria in poultry products and the surrounding environment. This study found high rates of multidrug-resistant Gram-negative bacteria in the environment of poultry farms, with some strains exhibiting resistance to multiple antibiotics. The presence of these bacteria poses a significant threat to the effectiveness of available antibiotics in treating infectious diseases. Efforts to regulate antibiotic use and conduct research on One Health issues are necessary to combat and prevent the spread of antibiotic-resistant bacteria.
MICROBIOLOGY SPECTRUM
(2022)
Review
Environmental Sciences
Mei Zhuang, Yigal Achmon, Yuping Cao, Xiaomin Liang, Liang Chen, Hui Wang, Bupe A. Siame, Ka Yin Leung
Summary: The presence of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in the microbiome poses a significant global public health concern. Different habitats are at risk due to excessive antibiotic use and evolutionary changes in the resistome. China leads in the number of papers related to ARGs compared to other countries, with varied distributions of ARG subtypes across different environments.
ENVIRONMENTAL POLLUTION
(2021)
Article
Immunology
J. W. Timoteus Deelen, Wouter C. Rottier, Jose A. Giron Ortega, Jesus Rodriguez-Bano, Stephan Harbarth, Evelina Tacconelli, Gunnar Jacobsson, Jean-Ralph Zahar, Cornelis H. van Werkhoven, Marc J. M. Bonten
Summary: This study validated a prediction rule for community-onset 3GC-R infections in an international cohort, showing improvement in empirical antibiotic use. However, the validation of the hospital-onset rule yielded suboptimal performance.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Engineering, Environmental
Yifan Zhao, Jingfeng Gao, Zhiqi Wang, Huihui Dai, Yuwei Wang
Summary: The study investigated the effects of antibiotics and heavy metals on microbial communities and resistance genes on PVC microplastics and surrounding sewage. Results showed that PVC microplastics enriched pathogenic bacteria from sewage, with the highest abundance of the resistance gene tnpA. Zinc, tetracycline, and ampicillin inhibited microbial enrichments for a short period, while copper and the co-existence of antibiotics and heavy metals inhibited enrichments for a longer period, leading to lower microbial diversities and resistance gene abundances.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Infectious Diseases
Roman Kozlov, Alexey Kuzmenkov
Summary: The study in Russia found an increasing trend in antimicrobial resistance among Enterobacteriaceae, with the lowest susceptibility to colistin, ampicillin, and ampicillin/sulbactam, and the best susceptibility to combinations containing avibactam.
Review
Biotechnology & Applied Microbiology
Christopher Mutuku, Zoltan Gazdag, Szilvia Melegh
Summary: Antimicrobial pharmaceuticals are considered as emergent micropollutants that can have significant eco-toxicological effects even at low concentrations. The lack of standardized regulations for monitoring antibiotic content in environmental water quality standards leads to the indiscriminate discharge of antimicrobials into urban wastewater treatment facilities. This can result in the development of antibiotic resistance in bacteria and potential health consequences. The emergence of multiple antibiotic-resistant bacteria in untreated hospital effluents and wastewater treatment plants is linked to continuous exposure to antimicrobials. Understanding the correlation between environmental exposure to antibiotics and the evolution and spread of resistant bacteria is crucial for formulating mitigation measures.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2022)
Article
Infectious Diseases
Clair L. Firth, Annemarie Kaesbohrer, Peter Pless, Sandra Koeberl-Jelovcan, Walter Obritzhauser
Summary: The assumed link between high levels of antimicrobial use on farms and the presence of antimicrobial-resistant (AMR) bacteria was not statistically proven in this study of 50 dairy farms in Austria. While 26% of the farms had ESBL-producing E. coli, there was no significant difference between high and low antimicrobial users. Only one farm was confirmed to have MRSA.
Article
Veterinary Sciences
Thomas Werner, Annemarie Kaesbohrer, Barbara Wasner, Sandra Koeberl-Jelovcan, Sebastian G. Vetter, Christa Egger-Danner, Klemens Fuchs, Walter Obritzhauser, Clair L. Firth
Summary: The aim of this study was to investigate the prevalence of ESBL/AmpC-producing E. coli and antibiotic resistance among commensal E. coli on Austrian dairy farms. The study collected AMU data from 51 farms in 2020, and fecal samples from cows and calves in 2020 and 2022. The results showed a significant association between antibiotic use and resistance in E. coli, with cephalosporins and penicillins being the most commonly used antibiotics and tetracyclines, sulfonamides, and penicillins being the most frequently resistant antibiotics.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Infectious Diseases
Navaneeth Narayanan, Tiffany Lin, David Vinarov, Thomas Bucek, Liya Johnson, Cheryl Mathew, Saira Chaudhry, Luigi Brunetti
Summary: This study found that obesity was independently associated with the presence of multidrug-resistant (MDR) bacteria among Enterobacterales.Obesity was independently associated with gram-negative MDR bacteria in a culture.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Environmental Sciences
Zhangjie Peng, Yujie Mao, Na Zhang, Lu Zhang, Zhi Wang, Maozhen Han
Summary: Antibiotic resistance genes (ARGs) are a global public health concern due to extensive use and abuse of antibiotics, and metagenomic sequencing has been utilized to study their distribution and sources. However, understanding the transmission mechanism of ARGs is still limited, highlighting the importance of utilizing metagenomic data for in-depth research. This review assesses the use of metagenomic data in ARG studies and summarizes bioinformatic tools and databases for profiling and tracking ARGs, emphasizing the need for comprehensive approaches to analyzing ARG profiles in different environments. Future studies should focus on utilizing metagenomic data and bioinformatic tools to better understand and manage ARG pollution.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Gang Shu, Jianyu Qiu, Yilei Zheng, Lijen Chang, Haohuan Li, Funeng Xu, Wei Zhang, Lizi Yin, Hualin Fu, Qigui Yan, Ting Gan, Juchun Lin
Summary: Salmonella is an important pathogen causing various animal and human infections. The abuse of antimicrobials has led to the emergence of resistant Salmonella, especially ESBL-producing strains, posing challenges to animal industries and public health. This study collected 117 Salmonella isolates from diseased chickens and investigated their antimicrobial resistance patterns, prevalence and co-occurrence of ESBL and virulence genes, and sequence types. The isolates showed different frequencies of resistance to antibiotics, with 41.03% being ESBL-producers. ESBL genes, such as bla(CTX-M-55), bla(OXA-31), bla(CTX-M-65), and bla(TEM-1), were detected. The isolates also carried multiple virulence genes. There were associations between cephalosporin resistance and ESBL genes, as well as between the presence of most virulence genes and ESBL genes. Horizontal transfer of ESBL and virulence genes was observed. The study highlights that Salmonella isolates from chickens are common carriers of ESBLs and multiple virulence genes, and their interaction reinforces the pathogenic potential of Salmonella.
Article
Infectious Diseases
Mario Galindo-Mendez, Humberto Navarrete-Salazar, Francisco Baltazar-Jimenez, Eduardo Munoz-de La Paz, Maria Fernanda Sanchez-Mawcinitt, Alexis Gomez-Pardo, Elvira Garza-Gonzalez, Luis Alfredo Ponce-de-Leon-Garduno, Rafael Franco-Cendejas, Rayo Morfin-Otero, Fabian Rojas-Larios, Juan Pablo Mena-Ramirez, Cecilia Teresita Morales-de-la-Pena, Lourdes Garcia-Mendoza, Elena Victoria Choy-Chang, Laura Karina Aviles-Benitez, Eduardo Lopez-Gutierrez, Jorge Luis Canizales-Oviedo, Nicolas Eric Barlandas-Rendon, Joyarib Yanelli Maldonado-Anicacio, Alina Aracely Rosales-Garcia, Heidy Leticia Ostos-Cantu
Summary: This study investigated the resistance mechanisms of ESBL-producing E. coli strains against fosfomycin. The results showed that fosA3 and fosA1 genes played important roles in fosfomycin resistance, and there was a strong association between fos and bla(CTX-M) genes and ST131 clones in uropathogenic E. coli.
Article
Environmental Sciences
Yifan Zhao, Jingfeng Gao, Zhiqi Wang, Yingchao Cui, Yi Zhang, Huihui Dai, Dingchang Li
Summary: This study investigated the formation of biofilms on contaminated microplastics in sewage polluted with antibiotics and/or heavy metals. The results showed that triclocarban (TCC), a common pollutant, did not hinder bacterial adhesion and biofilm formation on polyethylene microplastics (PE MPs). In fact, TCC-contaminated PE MPs were more likely to attract potential pathogenic and resistant bacteria compared to clean PE MPs. The presence of TCC, antibiotics, and copper in the sewage exerted a stronger selective pressure on bacterial communities and promoted the co-selection of resistance genes. Additionally, TCC-contaminated PE MPs increased the abundance of certain mobile genetic elements in sewage, which could facilitate the transmission of resistance genes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Infectious Diseases
Jia Du, Qinghua Liu, Ying Pan, Shaodan Xu, Huanxuan Li, Junhong Tang
Summary: This paper summarizes the occurrence, fate, and ecotoxicity of fluoroquinolone antibiotics in various environmental media. It reviews the toxicity effect on various organisms and compares the toxicology mechanisms. Gaps in toxicological investigations and the knowledge of natural transformation toward drug-resistant bacteria are identified.
Article
Infectious Diseases
Candace Guzman-Cole, Fabian Santiago, Sona Garsevanyan, Suzanne Sindi, Miriam Barlow
Summary: This study revealed that local selective pressures have a greater influence on the population structure of resistance genes in bacterial populations than migration, indicating the potential for antibiotic resistance to be controlled at a regional level.
Article
Materials Science, Textiles
Mohd Shabbir, Luqman Jameel Rather, Mudsser Azam, Qazi Mohd Rizwanul Haque, Mohd Ali Khan, Faqeer Mohammad
JOURNAL OF NATURAL FIBERS
(2020)
Review
Biochemistry & Molecular Biology
Mujtaba Aamir Bhat, Khurshid Ahmad, Mohd Sajjad Ahmad Khan, Mudasir Ahmad Bhat, Ahmad Almatroudi, Safikur Rahman, Arif Tasleem Jan
Article
Materials Science, Biomaterials
Shaheen Husain, Suresh K. Verma, Hemlata, Mudsser Azam, Meryam Sardar, Q. M. R. Haq, Tasneem Fatma
Summary: This study demonstrates the biological synthesis of silver nanoparticles (AgNPs) using Nostoc muscorum NCCU 442 aqueous extract as the reducing and capping agent, with the nanoparticles characterized by various methods. The synthesized AgNPs showed polycrystalline nature and significant antibacterial activity against Staphylococcus aureus MTCC 902.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Plant Sciences
Mujtaba Aamir Bhat, Rakeeb Ahmad Mir, Vijay Kumar, Ali Asghar Shah, Sajad Majeed Zargar, Safikur Rahman, Arif Tasleem Jan
Summary: Plants develop internal defense mechanisms to combat abiotic stressors, but it is essential to equip them with a system that enhances sustainable agricultural productivity and multi-stress tolerance. Breeding tolerant cultivars and genomic engineering approaches are key to sustainably addressing abiotic stresses. The CRISPR/Cas genome editing tool offers highly accurate and precise editing capabilities, providing a new avenue for developing high-yielding and climate-resilient crop varieties.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Microbiology
Mudsser Azam, Rajni Gaind, Gulshan Yadav, Amit Sharma, Kirti Upmanyu, Manisha Jain, Ruchi Singh
Summary: The study investigated colistin resistance in Klebsiella pneumoniae, finding genetically distinct strains with various mechanisms of resistance indicating spontaneous emergence within this bacterial species.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Oncology
Arif Tasleem Jan, Safikur Rahman, Raied Badierah, Eun Ju Lee, Ehab H. Mattar, Elrashdy M. Redwan, Inho Choi
Summary: Exosomes are membrane-enclosed cellular entities of endocytic origin that shuttle proteins and RNA molecules between cells for communication. They hold promise for drug delivery, but challenges remain in understanding their formation and function under physiological conditions, as well as the lack of methods to illuminate intraluminal vesicle release at target sites. Nonetheless, exosomes offer potential for developing systems that enable the specific delivery of therapeutics in diseases like cancer.
Review
Pharmacology & Pharmacy
Mudasir Ahmad Bhat, Awdhesh Kumar Mishra, Mujtaba Aamir Bhat, Mohammad Iqbal Banday, Ommer Bashir, Irfan A. Rather, Safikur Rahman, Ali Asghar Shah, Arif Tasleem Jan
Summary: Myxobacteria are unicellular, Gram-negative, soil-dwelling, gliding bacteria that can form fruiting bodies containing myxospores under unfavorable conditions. They have a rich potential for producing bioactive compounds and are being explored as sources of new antibiotics against antibiotic-resistant pathogens.
Article
Medicine, General & Internal
Mudsser Azam, Kirti Upmanyu, Ratan Gupta, Karugatharayil Sasi Sruthy, Monika Matlani, Deepali Savargaonkar, Ruchi Singh
Summary: Loop-mediated isothermal amplification (LAMP) based malaria diagnostic assays are crucial for strengthened surveillance in low-resource settings. The developed two-tube LAMP assay demonstrated high sensitivity and specificity for detecting P. vivax and P. falciparum infections, with comparable results to commercial kits and superior performance in detecting co-infections.
Review
Biochemistry & Molecular Biology
Safikur Rahman, Vijay Kumar, Anuj Kumar, Tasduq S. Abdullah, Irfan A. Rather, Arif Tasleem Jan
Summary: Breast cancer, the second leading cause of death in women, is a complex and heterogeneous type of cancer with limited treatment effectiveness. Nanomedicine, as a drug delivery module, can enhance drug targeting and stability, potentially improving clinical outcomes of breast cancer treatment.
Review
Forestry
Abdul Rehaman, Awdhesh Kumar Mishra, Asma Ferdose, Tasir S. Per, Mohd Hanief, Arif Tasleem Jan, Mohd Asgher
Summary: Melatonin plays a crucial role in plants by serving as a defense mechanism against oxidative stress and enhancing plant productivity. Its multifunctional properties make it an important component in overcoming abiotic stresses in plants.
Review
Plant Sciences
Mudasir Ahmad Bhat, Awdhesh Kumar Mishra, Saima Jan, Mujtaba Aamir Bhat, Mohammad Azhar Kamal, Safikur Rahman, Ali Asghar Shah, Arif Tasleem Jan
Summary: Plants are affected by various environmental stresses, which can disrupt their functioning and impact their growth and productivity. Plant growth-promoting rhizobacteria (PGPR), through their association with plant roots, help plants adapt and survive under changing environmental conditions and become more resilient to stress. They aid in nutrient acquisition, regulation of water content, osmotic balance, and ion homeostasis, contributing to stress alleviation and promoting plant growth and development. This review examines the use of PGPR in increasing plant tolerance to different stresses and their effects on crop yield and food security.
Review
Biology
Mujtaba Aamir Bhat, Awdhesh Kumar Mishra, Javeed Ahmad Tantray, Hanan Ali Alatawi, Mohd Saeed, Safikur Rahman, Arif Tasleem Jan
Summary: The gut microbiota plays a crucial role in regulating physiology and maintaining health, with an imbalance potentially leading to diseases such as cardiovascular disease. Research has highlighted the relationship between gut microbiota and risk factors for CVD, offering potential for preventive measures.
Review
Microbiology
Priya Yadav, Mudsser Azam, V Ramesh, Ruchi Singh
Summary: The diagnosis of leishmaniasis is influenced by the clinical features and infective species, but the rise in atypical presentations poses challenges in patient treatment. Understanding these unusual presentations can help broaden the perspective and prevent misdiagnosis.
Review
Environmental Sciences
Saima Jan, Awdhesh Kumar Mishra, Mujtaba Aamir Bhat, Mudasir Ahmad Bhat, Arif Tasleem Jan
Summary: Water is a vital resource for life on earth, but it is being polluted at an alarming rate due to human activities, leading to concerns about water shortage worldwide. Toxic contaminants negatively impact aquatic and terrestrial organisms and cause serious diseases in humans. Therefore, water treatments that can eliminate toxins are crucial. However, traditional wastewater treatment technologies are expensive and inefficient, highlighting the need for advanced sustainable approaches.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Virology
Seon-Ju Yeo, Vui Thi Hoang, Tuan Bao Duong, Ngoc Minh Nguyen, Hien Thi Tuong, Mudsser Azam, Haan Woo Sung, Hyun Park
Summary: This study identified a novel reassortment low-pathogenic avian influenza H5N3 subtype virus that emerged in South Korea in 2018, showing differences from old Korean H5N3 strains. Phylogenetic and molecular analyses indicated that this virus had multiple reassortments with Eurasian viruses.