Article
Plant Sciences
Consolacion Alvarez, Manuel Brenes-Alvarez, Fernando P. Molina-Heredia, Vicente Mariscal
Summary: This study analyzed the protein changes in rice and nostoc during the early stages of symbiosis using mass spectrometry, and identified differentially expressed proteins related to signal transduction, adhesion, defense, and cell wall modification. The study also revealed new proteins activated during the early stages of the nostoc-rice symbiosis. These findings provide important insights into the symbiotic interaction between nostoc and land plants.
PLANT AND CELL PHYSIOLOGY
(2022)
Review
Environmental Sciences
Sylwia Sliwinska-Wilczewska, Kinga Wisniewska, Zofia Konarzewska, Agata Cieszynska, Aldo Barreiro Felpeto, Anita U. Lewandowska, Adam Latala
Summary: Allelopathy, the phenomenon of one plant species affecting the growth of another, is common in marine, brackish, and freshwater habitats. It can provide a competitive advantage for some phytoplankton species and may influence species succession and bloom development. Understanding the interactions of allelopathy with other factors is crucial for future research in this field.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Food Science & Technology
Gracjana Budzalek, Sylwia Sliwinska-Wilczewska, Marek Klin, Kinga Wisniewska, Adam Latala, Jozef Maria Wiktor
Summary: This study demonstrated the allelopathic activity of Ulva intestinalis on bloom-forming cyanobacteria, showing both negative and positive effects on different species. The addition of filtrate inhibited growth and decreased pigment content for some cyanobacteria, while stimulating growth for others. Additionally, the extract caused changes in microcystin and phenol content within the cyanobacterial cells. The allelopathic effect of U. intestinalis was found to depend on the target species and the method used.
Review
Environmental Sciences
Martina Kolackova, Anna Janova, Marketa Dobesova, Monika Zvalova, Pavel Chaloupsky, Olga Krystofova, Vojtech Adam, Dalibor Huska
Summary: Proficient photosynthetic microalgae/cyanobacteria produce a remarkable amount of various biomolecules. Secondary metabolites (SM) represent high value products for global biotrend application. Production improvement can be achieved by nutritional, environmental, and physiological stress as a first line tools for their stimulation. However, deep understanding and connection of specific stress elucidator are missing. Hence, the present review summarizes recent evidence with an emphasis on the carotenoids, phenolic, and lessdiscussed compounds (glycerol, proline, mycosporins-like amino acids), highlighting the need to expand knowledge in this area using genome-editing tools and omics approaches.
ENVIRONMENTAL RESEARCH
(2023)
Review
Environmental Sciences
Aditya Abha Singh, Annesha Ghosh, Madhoolika Agrawal, Shashi Bhushan Agrawal
Summary: Tropospheric ozone (O-3) is a secondary pollutant that induces oxidative stress in plants. They respond to O-3 exposure by activating phenylpropanoid, isoprenoid, and alkaloid pathways, resulting in the synthesis of secondary defense metabolites. Chronic exposure to O-3 shifts carbon flows towards secondary metabolism, enabling plants to cope with stress and achieve homeostasis. This review discusses the impact of O-3 on plant species, including crops, trees, and medicinal plants, focusing on their secondary metabolic pathways, ROS scavenging abilities, and defense mechanisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Medicinal
Jingqiu Dai, Casey S. Philbin, Clay Wakano, Wesley Y. Yoshida, Philip G. Williams
Summary: Six new nostocyclophanes and four known compounds have been isolated from Nostoc linckia (Nostocaceae) cyanobacterial strain UTEX B1932. The new compounds were characterized by NMR and MS techniques. These compounds demonstrated moderate to weak growth inhibition against MDA-MB-231 breast cancer cells.
Article
Environmental Sciences
Maria Christodoulou, Jouni Jokela, Matti Wahlsten, Lyudmila Saari, Athena Economou-Amilli, Marli de Fatima Fiore, Kaarina Sivonen
Summary: This study investigated the taxonomy of three Nostoc-like cyanobacterial strains isolated from a shallow lake in Brazil and evaluated their bioactive potential. It identified a new species of cyanobacteria called Aliinostoc alkaliphilum, which exhibited antibacterial and antifungal activities and contained a previously unreported bioactive metabolite, nocuolin A. The phylogenetic studies also revealed that many strains currently classified as Nostoc and known to produce bioactive metabolites actually belong to different evolutionary lineages. These findings emphasize the importance of using a polyphasic approach in cyanobacterial taxonomy and natural product discovery programs.
Review
Biotechnology & Applied Microbiology
Shaloo Verma, Shobit Thapa, Nahid Siddiqui, Hillol Chakdar
Summary: Cyanobacteria, as ubiquitous photosynthetic prokaryotes, produce diverse bioactive secondary metabolites with complex chemical structures and robust biological activities. These metabolites have various medicinal and therapeutic applications, and research on cyanobacteria has shown promising progress in improving the production of secondary metabolites through synthetic biology tools and metabolomic approaches.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2022)
Article
Environmental Sciences
Zofia Konarzewska, Sylwia Sliwinska-Wilczewska, Aldo Barreiro Felpeto, Adam Latala
Summary: This study investigated the impact of temperature, irradiance, and salinity on the allelopathic interactions between different phenotypes of Synechococcus sp. cyanobacteria. It was found that temperature had the most significant effect on allelopathy, with different phenotypes showing differential responses to environmental factors.
MARINE ENVIRONMENTAL RESEARCH
(2022)
Article
Forestry
Hong Jiang, Shanchun Yan, Zhaojun Meng, Shen Zhao, Dun Jiang, Peng Li
Summary: This study investigated the insect resistance mechanism of L. olgensis in a mixed forest by planting larch and ashtree seedlings in different proportions. It was found that the allelopathic effect of ashtrees on larches increased the content of secondary metabolites in larch needles. The banding forests with a proportion of 3:3 and 5:5 showed a more significant effect in increasing the content of secondary metabolites in larch needles.
Review
Biology
Thomas J. Travers-Cook, Jukka Jokela, Claudia C. Buser
Summary: Ecological interactions influence evolutionary dynamics by selecting upon fitness variation within species. Antagonistic interactions often promote genetic and species diversity, despite the inherently suppressive effect they can have on the species experiencing them. In this review, the authors discuss how certain single-celled and dimorphic fungi have evolved allelopathic killer phenotypes that engage in antagonistic interactions, and explore the evolutionary pathways, functions, and consequences of killer phenotypes. They highlight that killer phenotypes are powerful models for studying allelopathic antagonism, but their evolutionary ecology remains largely unknown. The authors discuss what is known and what remains to be ascertained about killer phenotype ecology and evolution.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Chemistry, Medicinal
Robert Konkel, Marta Ceglowska, Karolina Szubert, Ewa Wieczerzak, Sofia Iliakopoulou, Triantafyllos Kaloudis, Hanna Mazur-Marzec
Summary: This study investigated the structural diversity of cyanopeptolins produced by Nostoc edaphicum and identified the highest number of cyanopeptides found in one strain. The biological assays confirmed the significance of certain cyanopeptides on the activity against protease and cancer cells.
Review
Biochemistry & Molecular Biology
Rupanshee Srivastava, Rajesh Prajapati, Tripti Kanda, Sadhana Yadav, Nidhi Singh, Shivam Yadav, Rajeev Mishra, Neelam Atri
Summary: Microbes, particularly cyanobacteria, produce a variety of secondary metabolites with therapeutic potential. These metabolites could be potential options for COVID-19 treatment due to their demonstrated pharmacological actions against various pathogens. Numerous cyanobacterial metabolites have shown activity against bacteria, fungi, viruses, and tumor cells, making them valuable candidates for the development of medicinal molecules.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Agriculture, Multidisciplinary
Sakineh Rashidi, Ali Reza Yousefi, Majid Pouryousef, Nieves Goicoechea
Summary: This study found that arbuscular mycorrhizal fungi (AMF) have a significant impact on the photosynthetic pigments and secondary metabolites content in the roots and reproductive organs of problematic weed species such as Ipomoea purpurea, Digitaria sanguinalis, and Solanum nigrum. Colonization with AMF increased the levels of phenols, flavonoids, and terpenoids in these weeds, as well as improved total phenolics in D. sanguinalis seeds. Additionally, the activity of phenylalanine ammonia lyase enzyme was enhanced in D. sanguinalis leaves colonized by specific AMF species.
CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE
(2022)
Article
Forestry
Dalila Pasquini, Luana Beatriz dos Santos Nascimento, Cecilia Brunetti, Francesco Ferrini, Roslyn M. Gleadow
Summary: Climate change favors invasive species like Pittosporum undulatum, which contributes to biodiversity loss in Eucalyptus forests in south-eastern Australia. Our study investigated the invasiveness of P. undulatum by examining the release of allelopathic compounds and the content of antioxidant secondary metabolites. We found that P. undulatum's invasiveness is likely due to the high content of secondary metabolites that provide protection against abiotic stresses, rather than the release of allelopathic compounds.
Article
Chemistry, Multidisciplinary
Emmanuel Reyna-Gonzalez, Bianca Schmid, Daniel Petras, Roderich D. Suessmuth, Elke Dittmann
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2016)
Review
Marine & Freshwater Biology
Leanne A. Pearson, Elke Dittmann, Rabia Mazmouz, Sarah E. Ongley, Paul M. D'Agostino, Brett A. Neilan
Article
Biochemistry & Molecular Biology
Claire Pancrace, Keishi Ishida, Enora Briand, Douglas Gatte Pichi, Annika R. Weiz, Arthur Guljarnow, Thibault Scalvenzi, Nathalie Sassoon, Christian Hertweck, Elke Dittmann, Muriel Gugger
ACS CHEMICAL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Daniel Dehm, Julia Krumbholz, Martin Baunach, Vincent Wiebach, Katrin Hinrichs, Arthur Guljamow, Takeshi Tabuchi, Holger Jenke-Kodama, Roderich D. Sussmuth, Elke Dittmann
ACS CHEMICAL BIOLOGY
(2019)
Article
Microbiology
Tino Barchewitz, Arthur Guljamow, Sven Meissner, Stefan Timm, Manja Henneberg, Otto Baumann, Martin Hagemann, Elke Dittmann
ENVIRONMENTAL MICROBIOLOGY
(2019)
Article
Food Science & Technology
Maxime Georges des Aulnois, Damien Reveillon, Elise Robert, Amandine Caruana, Enora Briand, Arthur Guljamow, Elke Dittmann, Zouher Amzil, Myriam Bormans
Article
Pharmacology & Pharmacy
Latife Koeker, Reyhan Akcaalan, Elke Dittmann, Meric Albay
Summary: The study found that high light intensity is the most important factor affecting protein-bound microcystin in surface water of Kucukcekmece Lagoon. Higher concentrations of microcystins, both free and protein-bound forms, were found in summer due to favorable environmental conditions such as temperature, light, and physicochemical parameters.
Article
Microbiology
Arthur Guljamow, Tino Barchewitz, Rebecca Grosse, Stefan Timm, Martin Hagemann, Elke Dittmann
Summary: The freshwater cyanobacterium Microcystis is highly successful and tolerant to environmental fluctuations. Externally added microcystin can interact with intracellular proteins, particularly with RubisCO, leading to its relocation in response to high light and low carbon conditions, contributing to the metabolic flexibility and success of Microcystis in the field.
Article
Biochemistry & Molecular Biology
Angela H. Soeriyadi, Sarah E. Ongley, Jan-Christoph Kehr, Russel Pickford, Elke Dittmann, Brett A. Neilan
Summary: The study found that the marine cyanobacterial nonribosomal peptide synthetase (NRPS) pathway is amenable for the biosynthesis of indolactam variants, with relaxed specificity observed in the native lyngbyatoxin pathway NRPS. Site-directed mutagenesis of the substrate-binding pocket resulted in altered substrate preference, showing relative congruence between in vitro substrate activation and in vivo product formation. Further research with alternative tailoring domains may reveal the true in vivo effects of the mutations introduced.
Article
Chemistry, Multidisciplinary
Julia Krumbholz, Keishi Ishida, Martin Baunach, Jonna E. Teikari, Magdalena M. Rose, Severin Sasso, Christian Hertweck, Elke Dittmann
Summary: In this study, two cell density-dependent chemical mediators in the symbiotic model strain Nostoc punctiforme were discovered and their pronounced impact on the regulation of specialized metabolism was demonstrated. Through transcriptional, bioinformatic, and labeling studies, two adjacent biosynthetic gene clusters were assigned to the biosynthesis of these two polyketide mediators. These findings provide insight into the orchestration of specialized metabolite production and offer lessons for the genomic mining and high-titer production of cyanobacterial bioactive compounds.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Sabine Meyer, Andi Mainz, Jan-Christoph Kehr, Roderich D. Suessmuth, Elke Dittmann
Article
Biochemistry & Molecular Biology
Muhammad N. Ahmed, Emmanuel Reyna-Gonzalez, Bianca Schmid, Vincent Wiebach, Roderich D. Suessmuth, Elke Dittmann, David P. Fewer
ACS CHEMICAL BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Sabine Meyer, Jan-Christoph Kehr, Andi Mainz, Daniel Dehm, Daniel Petras, Roderich D. Suessmuth, Elke Dittmann
CELL CHEMICAL BIOLOGY
(2016)
Review
Biochemistry & Molecular Biology
Manuel Montalban-Lopez, Thomas A. Scott, Sangeetha Ramesh, Imran R. Rahman, Auke J. van Heel, Jakob H. Viel, Vahe Bandarian, Elke Dittmann, Olga Genilloud, Yuki Goto, Maria Jose Grande Burgos, Colin Hill, Seokhee Kim, Jesko Koehnke, John A. Latham, A. James Link, Beatriz Martinez, Satish K. Nair, Yvain Nicolet, Sylvie Rebuffat, Hans-Georg Sahl, Dipti Sareen, Eric W. Schmidt, Lutz Schmitt, Konstantin Severinov, Roderich D. Suessmuth, Andrew W. Truman, Huan Wang, Jing-Ke Weng, Gilles P. van Wezel, Qi Zhang, Jin Zhong, Joern Piel, Douglas A. Mitchell, Oscar P. Kuipers, Wilfred A. van der Donk
Summary: This article reviews the research progress of ribosomally-synthesized and post-translationally modified peptides (RiPPs) as of June 2020, including the discovery of new RiPP classes, deeper understanding of the mechanisms for the installation of post-translational modifications, and the mechanisms by which enzymes recognize leader peptides. Additionally, genome mining tools and strategies for RiPP engineering are also discussed in the review.
NATURAL PRODUCT REPORTS
(2021)