Review
Biotechnology & Applied Microbiology
Yuanzheng Wu, Jishun Li, Hyun-Jae Shin
Summary: Viral nanoparticles are versatile building blocks and supra-molecular templates in nanotechnology, offering advantages such as biocompatibility, biodegradability, water solubility, and high uptake capability. They have been utilized for genetic and chemical manipulation, targeted drug delivery, and encapsulation of various payloads for diagnosis or therapeutic intervention.
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
(2021)
Article
Biophysics
Nazanin Amiryaghoubi, Elaheh Dalir Abdolahinia, Ailar Nakhlband, Shaghayegh Aslzad, Marziyeh Fathi, Jaleh Barar, Yadollah Omidi
Summary: Chitosan-based pH-sensitive nanocomposites were developed for targeted delivery of doxorubicin to osteosarcoma cells. The nanocomposites exhibited enhanced drug release under acidic conditions and showed high cellular uptake and cytotoxicity in folate receptor-expressing cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Laura Sanchez-Garcia, Eric Volta-Duran, Eloi Parlade, Elisa Mazzega, Alejandro Sanchez-Chardi, Naroa Serna, Hector Lopez-Laguna, Mara Mitstorfer, Ugutz Unzueta, Esther Vazquez, Antonio Villaverde, Ario de Marco
Summary: Nanobodies are valuable tools in advanced therapeutic strategies, but their small size and limited valence for interactions may pose restrictions for in vivo applications. Modular protein constructs have been designed to fuse nanobodies with protein domains, promoting self-assembly into stable nanoparticles with maintained specificity for targets.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Fangfang Jin, Qian Zeng, Husun Qian, Dian Zhang, Yu Wei, Yange Wang, Chengsen Chai, Wei Cheng, Shijia Ding, Tingmei Chen
Summary: A dual-targeted aptamer-decorated DNA hydrogel system (DTA-H) is reported for efficient, stable, and targeted delivery of drugs, showing significant potential for cancer therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Abhishesh Kumar Vikas, Abhishesh Kumar Mehata, Matte Kasi Viswanadh, Ankit Kumar Malik, Aseem Setia, Pooja Kumari, Sanjeev Kumar Mahto, Madaswamy S. Muthu
Summary: This research developed redox-sensitive dual-receptor-targeted nanoparticles loaded with cabazitaxel, showing significantly improved cellular uptake and anticancer activity against A549 lung cancer cells.
Article
Engineering, Biomedical
Eunkyeong Jung, Seung Won Jeong, Yeongjong Lee, Chanhee Jeon, Hyunbin Shin, Nanhee Song, Yujin Lee, Dongwon Lee
Summary: Stimulus-responsive self-assembling prodrug-based nanomedicine has emerged as a novel paradigm in controlled drug delivery, showing potential in cancer treatment by releasing multiple active substances and exerting cooperative anticancer effects.
Review
Polymer Science
Magdalena J. Bigaj-Jozefowska, Bartosz F. Grzeskowiak
Summary: Nanotechnology is a widely researched approach to improve cancer therapies, with polymeric nanocarriers playing a crucial role in delivering drugs and enhancing treatment outcomes. Biological membranes, such as those derived from red blood cells or cancer cells, have been extensively studied for their potential in improving biosafety and targeting properties. This review summarizes the development of biomimetic polymeric nanocarriers for efficient cancer treatment.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Multidisciplinary Sciences
Matilde Duran-Lobato, Josefa Alvarez-Fuentes, Mercedes Fernandez-Arevalo, Lucia Martin-Banderas
Summary: This study proposed and evaluated transferrin surface-modified Delta(9)-THC-loaded poly(lactide-co-glycolic) nanoparticles as a novel THC-based anticancer therapy. The nanoparticles showed lower cell viability and slower internalization compared to plain nanoparticles. The uptake studies indicated that the nanoparticles were internalized through cholesterol-associated and clathrin-mediated mechanisms.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Calrin Joseph, Aliscia Daniels, Sooboo Singh, Moganavelli Singh
Summary: This study successfully prepared functionalized gold nanoparticles for targeted gene delivery in breast cancer cells. The nanoparticles exhibited favorable size and negative charge, effectively protecting the gene from degradation and showing good cellular compatibility and enhanced transgene activity. Folate-targeted nanoparticles demonstrated better gene delivery efficiency in specific types of breast cancer cells.
Review
Chemistry, Physical
Jiahao Shi, Bin Ma, Yuhe Zhang, Haiyang Yong, Zhili Li, A. Sigen, Xiaobei Huang, Dezhong Zhou
Summary: Cancer therapy is a global challenge, but a variety of promising anticancer therapeutics have been developed. However, their direct administration often fails to achieve the desired efficacy due to low bioavailability and poor tissue selectivity. Polymers offer advantages for drug delivery, yet are generally poorly targeted to the tumor microenvironment (TME). The relatively lower acidity of the TME provides a specific trigger for the development of polymers for targeted delivery, and this article summarizes the strategies, mechanisms, and applications of acidity-sensitive polymers for delivering various anticancer therapeutics.
CHEMISTRY OF MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Kuikun Yang, Shaoyi Zhang, Jie He, Zhihong Nie
Summary: The combination of inorganic nanoparticles and organic polymers in nanosized assemblies creates synergistically enhanced properties that hold great potential for cancer imaging and therapy.
Article
Chemistry, Multidisciplinary
Raul Cosialls, Cristina Simo, Salvador Borros, Vanessa Gomez-Vallejo, Claudia Schmidt, Jordi Llop, Ana B. Cuenca, Angela Casini
Summary: In this study, the synthesis of F-18-labelled[Pd2L4](4+) metallacages was reported for the advancement of self-assembled metallosupramolecular architectures as new generation theranostic agents. Various spectroscopic and bio-analytical methods supported the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, either alone or encapsulating cisplatin, were studied using PET/CT imaging in healthy mice in vivo, in combination with ICP-MS ex vivo.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Xiangshi Sun, Kongtong Yu, Yulin Zhou, Shiyan Dong, Wenji Hu, Yating Sun, Yuhuan Li, Jing Xie, Robert J. Lee, Fengying Sun, Yifan Ma, Shengnian Wang, Betty Y. S. Kim, Yifan Wang, Zhaogang Yang, Wen Jiang, Youxin Li, Lesheng Teng
Summary: The newly synthesized amphiphilic polymers can self-assemble into micellar nanoparticles with favorable hydrolysis kinetics, biocompatibility, and long circulation time. These materials not only exhibit better inflammation-targeting effects, but also do not induce an acidic microenvironment during degradation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Oncology
Rajeswari Raguraman, Dhaval Bhavsar, Dongin Kim, Xiaoyu Ren, Vassilios Sikavitsas, Anupama Munshi, Rajagopal Ramesh
Summary: Exosomes are small vesicles that can be used as drug delivery vehicles for cancer treatment due to their unique characteristics. Preclinical studies have shown that exosomes can effectively deliver chemotherapeutics, biologicals, and natural products with potent anticancer activity. However, challenges in large-scale production, storage, and stability have limited the number of exosome-based clinical trials.
Article
Chemistry, Multidisciplinary
Naroa Serna, Victor Pallares, Ugutz Unzueta, Annabel Garcia-Leon, Eric Volta-Duran, Alejandro Sanchez-Chardi, Eloi Parlade, Ariana Rueda, Isolda Casanova, Aida Falgas, Lorena Alba-Castellon, Jorge Sierra, Antonio Villaverde, Esther Vazquez, Ramon Mangues
Summary: Self-assembling non-immunoglobulin scaffold proteins show promise as nanoscale drug carriers and alternatives to antibody-based carriers. This research demonstrates the engineering of human scaffold proteins to target a specific cytokine receptor, CXCR4, and effectively deliver an anti-mitotic drug in a mouse model of acute myeloid leukemia. The protein nanoconjugates showed high efficiency and selectivity in drug delivery, highlighting their potential as alternatives to antibodies in targeted drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)