Review
Medicine, General & Internal
Keiko Tamaki, Hidekazu Mera, Sho Takeshita, Shinsuke Fujioka, Maki Goto, Taichi Matsumoto, Yoshihisa Yamano, Yasushi Takamatsu, Yoshio Tsuboi
Summary: This case is a rare presentation of rapidly progressive HAM/TSP with lymphoma-type ATL, where the patient did not respond to steroids and chemotherapy. Abnormal lymphocytes in the cerebrospinal fluid suggested possible infiltration of ATL cells into the brain and spinal cord.
Article
Pathology
Kyohei Yamada, Hiroaki Miyoshi, Noriaki Yoshida, Joji Shimono, Kensaku Sato, Kazutaka Nakashima, Mai Takeuchi, Fumiko Arakawa, Naoko Asano, Eriko Yanagida, Masao Seto, Koichi Ohshima
Summary: The mRNA expression levels of HBZ and tax in patients with ATLL are associated with clinicopathological characteristics, with different levels of expression impacting disease severity and overall survival time. Patients with high levels of tax expression are at a higher risk of poor prognosis and reduced survival time. Further studies are needed to fully understand the clinical significance of HBZ and tax mRNA expressions in ATLL.
Review
Pharmacology & Pharmacy
Junji Yamauchi, Natsumi Araya, Naoko Yagishita, Tomoo Sato, Yoshihisa Yamano
Summary: HAM/TSP is a rare inflammatory disease that causes unremitting and progressive neurological disorders. Immune-modulating agents are used to slow disease progression, but the lack of surrogate biomarkers hampers clinical trials and the assessment of treatment efficacy. The identification of biomarkers associated with viral components or inflammatory mediators is crucial for improving patient care and developing therapies for HAM/TSP.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Biology
Mohadeseh Zarei-Ghobadi, Mohsen Sheikhi, Majid Teymoori-Rad, Sahar Yaslianifard, Mehdi Norouzi, Somayeh Yaslianifard, Reza Faraji, Mohammad Farahmand, Shiva Bayat, Mohieddin Jafari, Sayed-Hamidreza Mozhgani
Summary: This study identified important signaling pathways related to positive regulation of transcription and histone modification in the interaction network of HAM/TSP and ATLL. Several hub genes were found to be commonly upregulated or downregulated in both diseases according to ontology-based enrichment analysis. The results provide insights into the interactions between HTLV-1 and host cells in HAM/TSP and ATLL.
BMC RESEARCH NOTES
(2021)
Article
Genetics & Heredity
Naoki Iijima, Junji Yamauchi, Naoko Yagishita, Natsumi Araya, Satoko Aratani, Kenichiro Tanabe, Tomoo Sato, Ayako Takata, Yoshihisa Yamano
Summary: In patients with HAM/TSP, 92% suffer from urinary dysfunction which worsens over time. Urinary symptoms are more severe in patients with poorer gait function. Urinary catheterization and mirabegron are effective in relieving symptoms.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Review
Medical Laboratory Technology
Sanaz Ahmadi Ghezeldasht, David J. Blackbourn, Arman Mosavat, Seyed Abdolrahim Rezaee
Summary: Adult T-cell leukemia/lymphoma (ATLL) is a malignancy caused by HTLV-1 infection, and this review discusses the complex signaling networks in ATLL pathogenesis as well as the main candidates involved. HTLV-1 trans-activator protein (TAX) and HTLV-1 basic leucine zipper factor (HBZ) play a role in ATLL manifestation by interacting with host responses and deregulating cell signaling. These viral factors could potentially be used as biomarkers or therapeutic targets for ATLL. The challenging aspects of HTLV-1 oncogenesis introduced in this review could also open new avenues for understanding acute leukemia pathogenesis.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2023)
Article
Hematology
Lucy B. Cook, Adrienne A. Phillips
Summary: ATL is an aggressive T-cell malignancy with limited survival outcomes with chemotherapy, but novel therapies like mogamulizumab show promise for different ATL subtypes. The implementation of molecular methods may guide diagnosis and treatment, but universal availability remains a challenge worldwide.
Article
Biochemistry & Molecular Biology
Tomohiro Kozako, Naho Kato, Takeo Ohsugi, Yu-ichiro Uchida, Makoto Yoshimitsu, Kenji Ishitsuka, Yasuki Higaki, Haruna Sato, Akiyoshi Aikawa, Shin-ichiro Honda
Summary: In this study, researchers found that SRT1720 can induce cell death in adult T-cell leukemia/lymphoma (ATL) cells through apoptosis and autophagy, and it exhibits anti-tumor activity.
Article
Hematology
Yuma Sakamoto, Takashi Ishida, Ayako Masaki, Takayuki Murase, Morishige Takeshita, Reiji Muto, Hiromi Iwasaki, Asahi Ito, Shigeru Kusumoto, Nobuaki Nakano, Masahito Tokunaga, Kentaro Yonekura, Yukie Tashiro, Shinsuke Iida, Atae Utsunomiya, Ryuzo Ueda, Hiroshi Inagaki
Summary: TP53 mutations are associated with unfavorable prognosis of ATL, regardless of treatment strategy. The establishment of alternative modalities to overcome the adverse impact of TP53 mutations in patients with ATL is required.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Virology
Takuro Kameda, Kotaro Shide, Yuki Tahira, Masaaki Sekine, Seiichi Sato, Junzo Ishizaki, Masanori Takeuchi, Keiichi Akizuki, Ayako Kamiunten, Haruko Shimoda, Takanori Toyama, Kouichi Maeda, Kiyoshi Yamashita, Noriaki Kawano, Hiroshi Kawano, Tomonori Hidaka, Hideki Yamaguchi, Yoko Kubuki, Akira Kitanaka, Hitoshi Matsuoka, Kazuya Shimoda
Summary: A chart survey was conducted in Miyazaki Prefecture, Japan to study the clinical features of indolent adult T-cell leukemia/lymphoma (ATL). The study found that the prognosis of smoldering-type and favorable chronic-type ATL was better compared to unfavorable chronic-type ATL. In addition to conventional factors, the level of soluble interleukin-2 receptor (sIL2-R) may serve as an indicator for guiding treatment.
Article
Chemistry, Multidisciplinary
Daniel A. Rauch, John C. Harding, Lee Ratner, Samuel A. Wickline, Hua Pan
Summary: Adult T-cell leukemia/lymphoma (ATLL) is a rare but highly malignant tumor caused by human T-cell leukemia virus type 1. A nano-delivery system was developed to inhibit NF-kappa B signaling pathways in tumors by delivering siRNA, resulting in significant tumor growth inhibition and enhanced sensitivity to chemotherapy in late-stage ATLL tumors.
Article
Medicine, General & Internal
Atsuko Nasu, Yuka Gion, Yoshito Nishimura, Asami Nishikori, Misa Sakamoto, Yuria Egusa, Azusa Fujita, Tadashi Yoshino, Yasuharu Sato
Summary: The study suggests that the expression of SOX4 and p16 may help differentiate between ATLL and PTCL-NOS, with significantly higher expression of SOX4 in ATLL patients. It is recommended to perform immunohistochemical staining of SOX4 when pathologists face challenges discriminating between the two diseases.
Article
Virology
Carmen de Mendoza, Ariadna Rando, Elisenda Miro, Maria Jose Pena, Iciar Rodriguez-Avial, Diego Ortega, Alejandro Gonzalez-Praetorius, Gabriel Reina, Ilduara Pintos, Maria Jose Pozuelo, Vicente Soriano
Summary: The rate of ATLL is very low in Spain and mostly associated with migrants from HTLV-1 endemic regions. ATLL patients have a poor clinical outcome, with most of them dying within one year. In Spain, HTLV-1 testing should be performed on migrants from HTLV-1 endemic countries and natives who have lived in or had sex partners from such regions.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shingo Nakahata, Daniel Enriquez-Vera, M. Ishrat Jahan, Kenji Sugata, Yorifumi Satou
Summary: This comprehensive review summarizes the immunopathogenesis of HTLV-1 infection in ATL and discusses clinical findings for developing treatment strategies.
Review
Virology
Takeharu Kato, Yoshitaka Imaizumi, Yasushi Miyazaki
Summary: Nationwide surveys have played an important role in understanding the pathophysiology and prognosis of adult T-cell leukemia/lymphoma (ATL) in Japan. Different surveys have provided information on the classification and prognosis of ATL. Recent surveys have shown an increase in age at onset and a slight improvement in survival rates for certain types of ATL, while little improvement has been observed for others.
Article
Virology
Francisco Murilo Zerbini, Stuart G. Siddell, Arcady R. Mushegian, Peter J. Walker, Elliot J. Lefkowitz, Evelien M. Adriaenssens, Poliane Alfenas-Zerbini, Bas E. Dutilh, Maria Laura Garcia, Sandra Junglen, Mart Krupovic, Jens H. Kuhn, Amy J. Lambert, Malgorzata Lobocka, Hanna M. Oksanen, David L. Robertson, Luisa Rubino, Sead Sabanadzovic, Peter Simmonds, Nobuhiro Suzuki, Koenraad Van Doorslaer, Anne-Mieke Vandamme, Arvind Varsani
Summary: Following the ICTV Ratification Vote in March 2021, a standard two-part binomial nomenclature is now the standard for naming virus species. The adoption of this new nomenclature is still in its early stages, making it timely to clarify the distinction between viruses and virus species and provide guidelines for their correct naming and writing.
ARCHIVES OF VIROLOGY
(2022)
Article
Medicine, General & Internal
Emmanuel Bottieau, Lukas Van Duffel, Sayda El Safi, Kanika Deshpande Koirala, Basudha Khanal, Suman Rijal, Narayan Raj Bhattarai, Thong Phe, Kruy Lim, Deby Mukendi, Jean-Roger Lilo Kalo, Pascal Lutumba, Barbara Barbe, Jan Jacobs, Marjan Van Esbroeck, Nikki Foque, Achilleas Tsoumanis, Philippe Parola, Cedric P. Yansouni, Marleen Boelaert, Kristien Verdonck, Francois Chappuis
Summary: This study investigated the frequencies and diagnostic predictors of the ubiquitous priority infections causing persistent fever in the tropics. The results showed that leptospirosis, rickettsiosis, and enteric fever accounted for a substantial proportion of the persistent fever cases across all tropical areas, in addition to malaria, tuberculosis, and HIV. However, very few discriminative features were identified, and rapid diagnostic tests for leptospirosis and Salmonella Typhi infection performed poorly.
Article
Public, Environmental & Occupational Health
Anneleen Kiekens, Bernadette Dierckx de Casterle, Giampietro Pellizzer, Idda H. Mosha, Fausta Mosha, Tobias F. Rinke de Wit, Raphael Z. Sangeda, Alessio Surian, Nico Vandaele, Liesbet Vranken, Japhet Killewo, Michael Jordan, Anne-Mieke Vandamme
Summary: HIV drug resistance is a complex issue influenced by multiple factors. Studying the interconnectedness of these factors can provide a better understanding of the complexity of the system and guide interventions.
Article
Multidisciplinary Sciences
Anneleen Kiekens, Bernadette Dierckx de Casterle, Anne-Mieke Vandamme
Summary: Systems mapping methods are increasingly used in the study of complex public health issues, providing a holistic and multi-perspective overview and understanding of the dynamic nature of a system. This article presents a practical guideline on how to apply systems mapping to analyze public health problems using a concrete case study.
Article
Infectious Diseases
Wendemagegn Enbiale, Almut Boeer-Auer, Bereket Amare, Kristien Verdonck, Gail Davey, Johan van Griensven, Henry J. C. de Vries
Summary: This study provides a detailed description of the clinical and histopathologic spectrum of podoconiosis at different stages of the disease. The observations can serve as a guide for classifying patients with podoconiosis for prognostic assessment and treatment decision.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Virology
Peter J. Walker, Stuart G. Siddell, Elliot J. Lefkowitz, Arcady R. Mushegian, Evelien M. Adriaenssens, Poliane Alfenas-Zerbini, Donald M. Dempsey, Bas E. Dutilh, Maria Laura Garcia, R. Curtis Hendrickson, Sandra Junglen, Mart Krupovic, Jens H. Kuhn, Amy J. Lambert, Malgorzata Lobocka, Hanna M. Oksanen, Richard J. Orton, David L. Robertson, Luisa Rubino, Sead Sabanadzovic, Peter Simmonds, Donald B. Smith, Nobuhiro Suzuki, Koenraad Van Doorslaer, Anne-Mieke Vandamme, Arvind Varsani, Francisco Murilo Zerbini
Summary: This article discusses the changes in virus taxonomy approved by the International Committee on Taxonomy of Viruses (ICTV) in March 2022. The ICTV members voted on 174 taxonomic proposals, all of which were ratified by an absolute majority. The implementation of a new naming rule for virus species has resulted in over 60% of virus species being named in the 'Genus_name species_epithet' format.
ARCHIVES OF VIROLOGY
(2022)
Article
Virology
Kasper T. Christensen, Florian Pierard, Kurt Beuselinck, David Bonsall, Rory Bowden, Katrien Lagrou, Frederik Nevens, Yoeri Schrooten, Peter Simmonds, Anne-Mieke Vandamme, Eric Van Wijngaerden, Tim Dierckx, Lize Cuypers, Kristel Van Laethem
Summary: The utility of full-genome next-generation sequencing (FG-NGS) for HCV genotyping was assessed in this study. FG-NGS showed improved specificity for subtypes, identified mixed infections and recombinant strains, and detected resistance-associated substitutions (RASs). However, the predictive value of FG-NGS for treatment outcome in DAA-naive patients remains uncertain. With further refinements, FG-NGS may be the future of HCV genotyping.
JOURNAL OF CLINICAL VIROLOGY
(2022)
Article
Immunology
Lukas Van Duffel, Cedric P. Yansouni, Jan Jacobs, Marjan Van Esbroeck, Kadrie Ramadan, Jozefien Buyze, Achilleas Tsoumanis, Barbara Barbe, Marleen Boelaert, Kristien Verdonck, Francois Chappuis, Emmanuel Bottieau
Summary: In patients with persistent fever, C-reactive protein (CRP) and procalcitonin (PCT) showed higher sensitivity for bacterial infections than white blood cell (WBC) count. The use of inflammatory biomarkers can help identify patients who do not require antibiotics in low-resource settings.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Virology
Martin Pirkl, Joachim Buech, Carole Devaux, Michael Boehm, Anders Sonnerborg, Francesca Incardona, Ana Abecasis, Anne-Mieke Vandamme, Maurizio Zazzi, Rolf Kaiser, Thomas Lengauer
Summary: Human immunodeficiency virus (HIV) can develop resistance to all antiretroviral drugs, but multidrug resistance is rare. The accumulation of resistance mutations follows a predetermined order rather than being acquired randomly and simultaneously. Understanding this order can help elucidate the mechanisms of multidrug resistance.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Kristien Verdonck, Stefan Morreel, Jef Vanhamel, Bea Vuylsteke, Christiana Nostlinger, Marie Laga, Josefien van Olmen
Summary: In Antwerp, Belgium's second largest city, a local initiative was established to support contact tracing and self-isolation in ethnically diverse neighborhoods following a COVID-19 surge in July 2020. The initiative involved volunteer COVID coaches who assisted with contact tracing, provided support during self-isolation, and referred cases to healthcare professionals when necessary. Although the initiative was successful, it was later incorporated into the local health system as part of the government's efforts to combat the outbreak.
FRONTIERS IN PUBLIC HEALTH
(2023)
Editorial Material
Public, Environmental & Occupational Health
Bruno Marchal, Joris Michielsen, Sara Simon, Kristien Verdonck, Kirsten Accoe, Calvin Tonga, Katja Polman, Orawan Tawaytibhongs, Tom Cornu, Stefanie Dens, Houssynatou Sy, Claudia Nieto-Sanchez, Sara Van Belle
Article
Public, Environmental & Occupational Health
Geovanna Amancha, Yamile Celis, Jorge Irazabal, Mercy Falconi, Karla Villacis, Pruthu Thekkur, Divya Nair, Freddy Perez, Kristien Verdonck
Summary: This study describes the antimicrobial resistance profiles of Escherichia coli and Salmonella spp. in chicken carcasses and the antimicrobials commonly used in animals in Ecuador. The prevalence of antimicrobial resistance in poultry calls for the development of guidelines and regulations on antimicrobial use and engagement with livestock producers.
REVISTA PANAMERICANA DE SALUD PUBLICA-PAN AMERICAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Monica Lopez, Adriana Martinez, Yamile Celis Bustos, Pruthu Thekkur, Divya Nair, Kristien Verdonck, Freddy Perez
Summary: This study assessed the compliance of secondary and tertiary level hospitals in Colombia with monthly reporting of antibiotic consumption to the national public health surveillance system. The results showed gaps in consistency and frequency of reporting, with a decline in compliance in 2020, possibly due to the COVID-19 pandemic. Efforts are needed to improve compliance and address data quality issues for valid interpretation of antibiotic consumption trends.
REVISTA PANAMERICANA DE SALUD PUBLICA-PAN AMERICAN JOURNAL OF PUBLIC HEALTH
(2023)
Letter
Health Care Sciences & Services
Leonardo W. Heyerdahl, Stef Dielen, ToTran Nguyen, Carla Van Riet, Tarun Kattumana, Clarissa Simas, Nico Vandaele, Anne-Mieke Vandamme, Corinne Vandermeulen, Tamara Giles-Vernick, Heidi Larson, Koen Peeters Grietens, Charlotte Gryseels
LANCET REGIONAL HEALTH-EUROPE
(2022)
Article
Virology
Sofia G. Seabra, Pieter J. K. Libin, Kristof Theys, Anna Zhukova, Barney Potter, Hanna Nebenzahl-Guimaraes, Alexander E. Gorbalenya, Igor A. Sidorov, Victor Pimentel, Marta Pingarilho, Ana T. R. de Vasconcelos, Simon Dellicour, Ricardo Khouri, Olivier Gascuel, Anne-Mieke Vandamme, Guy Baele, Lize Cuypers, Ana B. Abecasis
Summary: This study characterized the genetic diversity and phylodynamics of the Zika virus and proposed a dynamic classification system that reflects its divergence levels. Through comprehensive analyses of the full-length coding region of the virus, the study identified genetic groups and differentiation patterns.