Article
Dermatology
Alina D. Schmidt, Cristina de Guzman Strong
Summary: Atopic dermatitis is a common inflammatory skin disorder affecting up to 20% of children worldwide, with patients commonly experiencing dry skin and itchiness and an increased risk for asthma and allergic rhinitis. The prevalence of AD has tripled in industrial countries over the past 30 years, prompting further investigation into the pathogenesis mechanisms amidst environmental exposures. Studies have identified a role for epigenetic regulation associated with AD and potential drivers for AD pathogenesis.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Acoustics
T. Nau, C. Schoenmann, B. Hindelang, L. Riobo, A. Doll, S. Schneider, L. Englert, H. He, T. Biedermann, U. Darsow, F. Lauffer, V. Ntziachristos, J. Aguirre
Summary: Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Current severity assessments rely on visual observation and subjective symptoms. However, optoacoustic mesoscopy has been shown to provide precise biomarkers of inflammation, potentially enabling more accurate evaluations of AD severity.
Review
Health Care Sciences & Services
Hou-Ren Tsai, Jing-Wun Lu, Li-Yu Chen, Tai-Li Chen
Summary: JAK inhibitors show promising efficacy in treating AD, but with a higher risk of treatment-emergent adverse events. Long-term follow-up is needed to assess the safety profile.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Medicine, General & Internal
Robert Bissonnette, Jasmina Jankicevic, Etienne Saint-Cyr Proulx, Catherine Maari
Summary: The number of clinical trials in atopic dermatitis patients is increasing globally and involves patients of diverse skin colors and ethnicities. This diversity presents challenges such as assessing disease severity in patients with different skin colors, understanding the impact of ethnicity on quality of life and patient-reported outcomes, including underrepresented ethnicities, and reporting drug safety in diverse populations. There is a need for physician training and improved reporting of ethnicity, race, and skin color in clinical trial publications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Chunying Xiao, Zhongbin Sun, Jixin Gao, Yaxing Bai, Chen Zhang, Bingyu Pang, Hongjiang Qiao, Meng Fu, Erle Dang, Gang Wang
Summary: This study demonstrated the critical role of skin barrier protein FLG in the pathogenesis of atopic dermatitis, with CPT-induced dermatitis being more severe in Flg(-/-) mice compared to wild-type mice. Additionally, emollients MPS and ceramide partially restored epidermal function and alleviated skin inflammation in the Flg(-/-) mouse model of AD induced by CPT.
Article
Microbiology
Eric Climent, Juan Francisco Martinez-Blanch, Laura Llobregat, Beatriz Ruzafa-Costas, Miguel Angel Carrion-Gutierrez, Ana Ramirez-Bosca, David Prieto-Merino, Salvador Genoves, Francisco M. Codoner, Daniel Ramon, Empar Chenoll, Vicente Navarro-Lopez
Summary: This study investigated the effects of a probiotic formulation on improving symptoms of atopic dermatitis (AD) in children, showing changes in gut microbiome and levels of specific bacterial genera. The results suggest that the probiotic modulates the gut microbiome with significant changes in certain bacterial genera, leading to improvement in AD symptoms.
Article
Biochemistry & Molecular Biology
Ana B. Arroyo, Martin Bernal-Carrion, Joaquin Canton-Sandoval, Isabel Cabas, Raul Corbalan-Velez, Teresa Martinez-Menchon, Belen Ferri, Maria L. Cayuela, Diana Garcia-Moreno, Victoriano Mulero
Summary: Atopic dermatitis (AD) is a highly prevalent chronic inflammatory skin disease with no specific treatment. Recent research has shown the critical role of NAD(+) and PAR metabolism in oxidative stress and skin inflammation. Alterations in NAMPT and PARP expression were observed in AD patients, indicating their potential as therapeutic targets for skin inflammatory disorders. Pharmacological inhibition of NAMPT and PARP reduced AD-associated biomarkers in a human 3D organotypic skin model, suggesting new potential treatments for AD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Rinkesh K. Gupta, Jacqueline Miller, Michael Croft
Summary: This study found that the TNF family cytokine TWEAK plays an important role in keratinocyte dysregulation and the pathogenesis of AD. Blocking TWEAK and IL-13 had similar therapeutic effects in treating AD. Therefore, neutralizing TWEAK could be a potential therapeutic option for treating AD.
Article
Plant Sciences
Se Hoon Lee, Jeesuk Yu, Sang Hyun Cho
Summary: The study indicated that a combination of Panax ginseng extract and probiotics has a preventive effect on AD-like skin lesions in mice, reducing transepidermal water loss, serum IgE level, and expression of inflammatory cytokines in the skin.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Caterina Anania, Giulia Brindisi, Ivana Martinelli, Edoardo Bonucci, Miriam D'Orsi, Sara Ialongo, Anna Nyffenegger, Tonia Raso, Mattia Spatuzzo, Giovanna De Castro, Anna Maria Zicari, Carlo Carraro, Maria Grazia Piccioni, Francesca Olivero
Summary: Atopic dermatitis is a chronic inflammatory skin disorder with increasing prevalence in children and adults. The potential role of probiotics in preventing atopic dermatitis has generated considerable interest, as they can modulate systemic inflammation and immune responses. However, the molecular mechanisms and efficacy of probiotics in anti-allergic effects are still unclear and controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ana Claudia Paiva-Santos, Melissa Gama, Diana Peixoto, Ines Sousa-Oliveira, Ines Ferreira-Faria, Mahdi Zeinali, Soheil Abbaspour-Ravasjani, Filipa Mascarenhas-Melo, Hamed Hamishehkar, Francisco Veiga
Summary: Atopic dermatitis is a chronic skin disease with a challenging treatment, and nanotechnology shows great potential for improved therapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Xiangmei Hua, Conrad Dean Blosch, Hannah Dorsey, Maria K. Ficaro, Nicole L. Wallace, Richard P. Hsung, Jun Dai
Summary: The study found that the expression of epidermal RORα is highly expressed in normal skin and positively regulates the expression of differentiation markers and skin barrier-related genes in keratinocytes. However, in inflammatory skin diseases including atopic dermatitis (AD), the expression of RORα is downregulated. By using a mouse model with epidermis-specific Rora deficiency, it was found that the deficiency intensified AD-like symptoms and impaired the skin barrier function. These results demonstrate the importance of epidermal RORα in suppressing AD development by maintaining normal keratinocyte differentiation and skin barrier function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Pei-Yun Shih, Chia-Jung Li, Su-Boon Yong
Summary: Atopic dermatitis is a chronic inflammatory skin disease characterized by immune function imbalance and impaired epidermal barrier function. The JAK/STAT signaling pathway plays a critical role in its pathogenesis, and JAK inhibitors offer a novel therapeutic approach.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Mingyu Jang, Bo Mi Kang, Huisuk Yang, Jungyoon Ohn, Ohsang Kwon, Hyungil Jung
Summary: Dissolving microneedles (DMN) with therapeutic molecules have been developed to enhance transdermal drug delivery efficiency, particularly for treating skin inflammatory diseases like atopic dermatitis (AD). High-dose TA-DMN is presented as a potential candidate for the treatment of skin inflammatory diseases.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Medicine, Research & Experimental
Camila Stofella Sodre, Mayra Stambovsky Vieira, Juliany Lima Estefan, Cristiane Moraes, Fernanda Sampaio Cavalcante, Katia Regina Netto dos Santos, Dennis de Carvalho Ferreira
Summary: A literature review found that probiotics have the potential to improve symptoms of atopic dermatitis in adult patients, reducing itchiness and severity as measured by SCORAD. However, there is still controversy and divergence regarding the actual benefits of probiotics in this context.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Computer Science, Cybernetics
Krishna Kumar Gupta, Sanjay Kumar
Summary: In this study, a novel high-order weighted fuzzy time series (FTS) forecasting method is proposed. The method utilizes k-mean clustering, weighted fuzzy logical relations, and probabilistic fuzzy set (PFS) to handle the occurrence of recurrence of fuzzy logical relations and uncertainties in assigning membership grades. The proposed method uses Gaussian probability distribution function to assign probabilities to membership grades and demonstrates its superiority in forecasting SBI share price and University of Alabama enrollments.
CYBERNETICS AND SYSTEMS
(2023)
Review
Immunology
Ahmad Firoz, Hani Mohammed Ali, Suriya Rehman, Irfan A. Rather
Summary: Gastric cancer is a global health concern with a significant number of cases. Early diagnosis and treatment improve survival rates, but advanced stage tumors have lower survival rates. Oncolytic viruses show promise as more efficient diagnostic and treatment strategies. Oncogenic viruses play a significant role in gastric cancer progression.
Article
Immunology
Irfan A. Rather, Majid Rasool Kamli, Jamal S. M. Sabir, Bilal Ahmad Paray
Summary: The development of antiviral resistance has led to an increasing demand for unconventional antivirals. This study isolated lactiplantibacillus plantarum from raw camel milk and found it exhibited high antiviral activity against the H1N1 influenza virus. The findings highlight the potential of camel milk as a source of beneficial lactiplantibacillus with antagonistic properties against H1N1.
Article
Biochemistry & Molecular Biology
Suza Mohammad Nur, Mohammed Razeeth Shait Mohammed, Mazin A. Zamzami, Hani Choudhry, Aamir Ahmad, Bushra Ateeq, Irfan A. Rather, Mohammad Imran Khan
Summary: In this study, it was found that tumor cells undergo metabolic reprogramming, including methylation regulation and changes in 1C metabolism, after detachment from the extracellular matrix, promoting cancer cell survival and metastasis.
Article
Biochemistry & Molecular Biology
Baljinder Kaur, Rajan Rolta, Deeksha Salaria, Balvir Kumar, Olatomide A. Fadare, Renato Araujo da Costa, Ajaz Ahmad, Mahmood Basil A. Al-Rawi, Mohammad Raish, Irfan A. Rather
Summary: The study investigates the potential of phytoconstituents from Foeniculum vulgare in binding to breast cancer target protein. Molecular docking and MD simulations reveal that alpha-pinene and D-limonene show promising binding energies and stability. These compounds could serve as potential therapeutic agents for breast cancer.
Article
Biochemistry & Molecular Biology
Meenakshi Gupta, Shaikh Maryam Ghufran, Tasneem Kausar, Rafat Ali, Subhrajit Biswas, Shahid M. Nayeem, Romana Ishrat, Sher Ali, Ajaz Ahmad, Irfan A. Rather, Maryam Sarwat
Summary: The study suggests that Z-guggulsterone, a compound found in an ancient saffron-based polyherbal formulation, Dawa-ul-Kurkum, may be the main active constituent responsible for its potential anticancer effects against hepatocellular carcinoma (HCC). The research utilized molecular docking, in vitro screenings, and molecular dynamics simulation studies to identify the binding interactions and evaluate the therapeutic potential of Z-guggulsterone. These findings highlight the importance of considering Z-guggulsterone as a promising phytoconstituent in the treatment of HCC.
Article
Microbiology
Irfan A. Rather, Jamal S. M. Sabir, Amer H. Asseri, Mohmmad Younus Wani, Aijaz Ahmad
Summary: Candida albicans is a common cause of fungal infections in humans and azoles are commonly used for treatment. However, their overuse has led to drug resistance. In this study, new triazole-based molecules were developed and tested against Candida albicans. In vitro and in silico results showed that these derivatives have the potential to be effective antifungal drugs, as they effectively bind to the target enzyme, inhibit ergosterol production, and prevent biofilm formation.
Article
Immunology
Othman R. Alzahrani, Yousef M. Hawsawi, Abdullah D. Alanazi, Hanan E. Alatwi, Irfan A. Rather
Summary: This study is a preliminary investigation of the antiviral properties of postbiotic metabolites derived from Leuconostoc mesenteroides GBUT-21, focusing on their potential biological role in inactivating SARS-CoV-2 and reducing related inflammatory pathways.
Article
Microbiology
Irfan A. Rather, Majid Rasool Kamli, Jamal S. M. Sabir, Sajad Ali
Summary: The study systematically investigated the antiviral potential of lactic acid bacteria against H9N2 avian influenza virus, with a specific strain showing potent antiviral activity and antioxidant properties. This suggests that lactic acid bacteria, particularly Lactiplantibacillus plantarum KAU007, could be considered as a potential probiotic targeting H9N2.
Article
Pharmacology & Pharmacy
Irfan A. Rather, Mohammad Younus Wani, Majid Rasool Kamli, Jamal S. M. Sabir, Khalid Rehman Hakeem, Ahmad Firoz, Yong-Ha Park, Yan-Yan Hor
Summary: This study demonstrates the anti-biofilm and anti-virulence properties of Lactiplantibacillus plantarum KAU007 against Streptococcus pyogenes. The results show that Lactiplantibacillus plantarum KAU007 inhibits the growth and survival of S. pyogenes, as well as the formation of biofilm and the production of virulence-associated factors. This research provides a basis for further investigation into the use of Lactiplantibacillus plantarum KAU007 as an antibacterial agent to combat streptococcal infections.
Article
Pharmacology & Pharmacy
Irfan A. Rather, Mohmmad Younus Wani, Majid Rasool Kamli, Jamal S. M. Sabir, Khalid Rehman Hakeem, Ahmad Firoz, Yong Ha Park, Yan Yan Hor
Summary: In this study, the antimicrobial potential of Lactobacillus metabolite extracts (LMEs) purified from four Lactobacillus strains was investigated against mono- and polymicrobial biofilms formed by C. albicans and S. aureus. The results showed that LMEKAU0021 effectively inhibited biofilm formation and affected the cell membrane integrity in both pathogens.
Article
Biochemistry & Molecular Biology
Mohammad Imran Khan, Hani Choudhry, Sadaf Jahan, Irfan A. A. Rather
Summary: With the increasing prevalence of multi-drug-resistant fungal infections, especially in developing countries, the development of new strategies and drugs to overcome drug resistance in fungal pathogens is crucial. This study investigated the potential of human neutrophil peptide (HNP) as a treatment for Candida infections. Results showed that HNP alone and in combination with fluconazole (FLC) exhibited antifungal activity against both susceptible and resistant C. albicans isolates. Furthermore, HNP inhibited biofilm formation and the activity of drug efflux pumps and their genes. These findings suggest that HNP could be used as a monotherapy or in combination with FLC to treat azole-resistant C. albicans.
Article
Chemistry, Physical
Kajol Bhati, Divya Bajpai Tripathy, Ashutosh Kumar Dixit, Vignesh Kumaravel, Jamal S. M. Sabir, Irfan A. Rather, Shruti Shukla
Summary: In recent years, there has been increasing interest in the application of biocompatible and non-toxic nanomaterials, such as graphene nano-sheets (GNSs), for fingerprint detection in forensic science and crime investigation. This study synthesized GNSs using waste chickpea seeds and characterized their properties. The GNSs exhibited high fluorescence, excitation-independent emission, and biocompatibility. They were also found to have antimicrobial properties and can be used to detect latent fingerprints on non-porous surfaces.
Article
Plant Sciences
Venkatadri Babu, J. Irshad Ahamed, Agastian Paul, Sajad Ali, Irfan A. Rather, Jamal S. M. Sabir
Summary: This study evaluated the in vitro antibacterial, antioxidant, and anti-breast cancer properties of vegetable seed extracts using different solvents. The ethyl acetate extract exhibited strong inhibitory effects against bacteria and showed notable scavenging activity against DPPH and hydrogen peroxide. In addition, it demonstrated potential anticancer properties against human breast cancer cells. Molecular docking experiments identified a compound with promising binding energy, suggesting further investigation into its anticancer potential and pharmacological characteristics.
Article
Chemistry, Medicinal
Suriya Rehman, Balasamy Rabindran Jermy, Irfan A. Rather, Jamal S. M. Sabir, Suhailah S. Aljameel, Munirah A. Almessiere, Yassine Slimani, Firdos A. Khan, Abdulhadi Baykal
Summary: This study investigates the synthesis of praseodymium ion-substituted nano-spinel ferrites and their potential applications in cancer treatment and antifungal activities. The results show that the synthesized nanomaterial has a significant effect on cancer cell viability and exhibits antifungal properties. The findings suggest that these nanotherapeutics have promising prospects in the pharmaceutical field.
