Article
Chemistry, Applied
Yong Liu, Jian Hu, Zhenhua Xiao, Xiaolin Jin, Chuanxia Jiang, Panchao Yin, Liqun Tang, Taolin Sun
Summary: In this work, the dynamics of hydrogels from the polyelectrolyte complexation of sodium hyaluronate and chitosan under different temperature and salt concentration were investigated. The study found that increasing temperature and adding salt significantly reduce the mechanical behavior of hydrogels. The stress relaxation of semi-flexible chain segments is accelerated at high temperature and salt concentration, which is controlled by a thermally activated bond dissociation process. The study also revealed that the chain aggregations in hydrogels are physically crosslinked by surrounded semi-flexible chains, and their diffusion is hindered by topological entanglements and ionic associations.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Jian-Feng Zhou, Guo-Dong Zheng, Wen-Jun Wang, Zhong-Ping Yin, Ji-Guang Chen, Jing-En Li, Qing-Feng Zhang
Summary: In this study, two quercetin loading zein nanoparticles with shell of caseinate (SC-ZNP) and caseinate-chitosan double layer (CHC-ZNP) were prepared, and their physicochemical properties as well as bioavailability enhancement effects were compared. The results showed that SC-ZNP had better redispersibility and smaller size change after freeze-drying compared to CHC-ZNP. Both nanoparticles significantly improved the solubility and passive diffusion velocity of quercetin. Moreover, the bioavailability of quercetin in SC-ZNP and CHC-ZNP groups were enhanced by 2.34 and 1.89 times, respectively.
FOOD HYDROCOLLOIDS
(2021)
Article
Polymer Science
Olimpia Daniela Frent, Narcis Duteanu, Alin Cristian Teusdea, Stefania Ciocan, Laura Vicas, Tunde Jurca, Mariana Muresan, Annamaria Pallag, Paula Ianasi, Eleonora Marian
Summary: The aim of this study was to prepare microspheres based on biodegradable polymers and load them with a water-insoluble and environmentally sensitive active drug. The experimental results showed that the prepared microspheres had a high drug entrapment rate and could achieve controlled release of the active drug at the intestinal level. Furthermore, the microspheres exhibited good thermal stability, making them suitable for drug delivery systems.
Article
Medicine, General & Internal
Ji Yeong Kim, Yoo Na Kim, Yu Jung Lee, Sung Eun Sim, Yu Ri Ko, Jin Woo Shim, Ku Sang Lee, Mina Joo, Hue Jung Park
Summary: This study aimed to compare the analgesic efficacy of different drugs in the treatment of knee osteoarthritis patients, and found that polynucleotide sodium effectively reduced weight-bearing pain compared to standard hyaluronic acid viscosupplementation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Applied
Fanfan Song, Jie Chen, Zhengquan Zhang, Shaojun Tian
Summary: The effect of layer-by-layer coating of liposomes with chitosan and pea protein isolate hydrolysates (PPIH) was evaluated. The potential of PPIH as a coating material was found, and the influence of chitosan and PPIH on vesicle size and zeta potential of liposomes was investigated. The chitosan layer of liposomes exhibited a loose structure, but after the second layer of coating with PPIH, a more compact and dense shell structure was formed. The stability of FL Lipo-C-P was favored by electrostatic interactions, hydrogen bonds, and hydrophobic interactions, resulting in higher oxidation stability and slower release of flaxseed oil.
Article
Food Science & Technology
Kalpani Y. Perera, Shubham Sharma, Brendan Duffy, Shivani Pathania, Amit K. Jaiswal, Swarna Jaiswal
Summary: This study aims to develop a biodegradable active chitosan-alginate layer-by-layer bio-nanocomposite film for food packaging applications. The developed films showed improved tensile strength, elongation at break, UV barrier properties, and antimicrobial activity.
FOOD PACKAGING AND SHELF LIFE
(2022)
Article
Biochemistry & Molecular Biology
Ozge Karabiyik Acar, Seden Bedir, A. Basak Kayitmazer, Gamze Torun Kose
Summary: This study introduces a novel three-dimensional coacervate scaffold encapsulating bone marrow mesenchymal stem cells, with an interconnected structure promoting cell-cell and cell-matrix interactions. The scaffold demonstrates remarkable cellular viability under chondrogenic induction, and shows elevated expression levels of chondrogenic markers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Martha Gabriela Chuc-Gamboa, Carolina Maria Camara Perera, Fernando Javier Aguilar Ayala, Rossana Faride Vargas-Coronado, Juan Valerio Cauich-Rodriguez, Diana Maria Escobar-Garcia, Luis Octavio Sanchez-Vargas, Neith Pacheco, Julio San Roman del Barrio
Summary: Chitosan films modified with sodium hyaluronate and crosslinked with PEGDE showed improved thermal stability and cytocompatibility for osteoblasts, but did not exhibit antimicrobial activity against several bacteria strains.
APPLIED SCIENCES-BASEL
(2021)
Article
Food Science & Technology
Wenqi Yan, Haochen Sun, Wenxin Liu, Hao Chen
Summary: In this study, a walnut peptide-chitosan-sodium alginate composite film was prepared using layer-by-layer assembly. The addition of genipin improved the mechanical, oil absorption, and water vapor barrier properties of the composite film. The proportion of chitosan and walnut peptide had significant effects on the color, transmittance, mechanical properties, barrier properties, and antioxidant properties of the composite film. The composite film with 1% (w/v) chitosan, 1% (w/v) walnut peptide, and 0.01% (w/v) genipin showed the best performance in terms of tensile strength, water vapor permeability, oil absorption, and antioxidant properties.
Article
Chemistry, Applied
Qian Luan, Hao Zhang, Jiahui Wang, Yan Li, Miaoyu Gan, Qianchun Deng, Luyun Cai, Hu Tang, Fenghong Huang
Summary: The study suggests that the electrostatically reinforced and sealed nanocellulose-based macrospheres can protect probiotics from the harsh conditions of the stomach and gradually release them in the intestines.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Ruonan Sun, Junxiang Zhu, Hao Wu, Shiqing Wang, Wenxiang Li, Qingjie Sun
Summary: By adjusting the surface charge density of TOCNs, the properties and stability of the film can be improved. The TOCNs in sodium alginate/chitosan multilayer film form a compact and uniform interlayer structure through strong electrostatic interactions and hydrogen bonding. The addition of TOCNs can also enhance the mechanical properties, thermal stability, hydrophobicity, and barrier properties of the multilayer film.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Doudou Jing, Wei Wu, Xuanzuo Chen, Hongwei Xiao, Zhenhao Zhang, Fengxia Chen, Zhicai Zhang, Jianxiang Liu, Zengwu Shao, Feifei Pu
Summary: In this study, it was found that quercetin inhibits OS proliferation and immune escape by non-covalently inhibiting JAK2 through the JH2 domain, and the use of folic acid-modified liposomes can overcome the limitations of quercetin.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Doudou Jing, Wei Wu, Xuanzuo Chen, Hongwei Xiao, Zhenhao Zhang, Fengxia Chen, Zhicai Zhang, Jianxiang Liu, Zengwu Shao, Feifei Pu
Summary: Osteosarcoma is a malignant solid tumor that is difficult to cure and prone to lung metastasis, making it a challenge to find new treatments. Quercetin may inhibit JAK2 and affect the JAK2-STAT3-PD-L1 signaling pathway, potentially serving as an effective strategy for treating osteosarcoma. Encapsulating quercetin with folic acid-modified liposomes could improve its solubility and oral availability.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Chemistry, Applied
Lukas Muenster, Zdenka Capakova, Petr Humpolicek, Ivo Kuritka, Bjorn E. Christensen, Jan Vicha
Summary: The sequential periodate-chlorite oxidation process for the synthesis of 2,3-dicarboxylated hyaluronate (DCH) from sodium hyaluronate is investigated, and the impact of reaction parameters on the properties of DCH is studied. The fully and partially oxidized DCH derivatives are compared to untreated sodium hyaluronate in terms of drug loading efficiency, release rates, and cytotoxicity towards healthy and cancerous cells, and DCH derivatives are found to outperform sodium hyaluronate in all aspects.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Biomedical
Xiaotao Xing, Qi Tang, Jiaojiao Zou, Haisen Huang, Jian Yang, Xin Gao, Xun Xu, Shixing Ma, Maojiao Li, Cheng Liang, Lin Tan, Li Liao, Weidong Tian
Summary: The systemic elimination of senescent cells using senolytic drugs has therapeutic effects on age-related diseases, including senile osteoporosis. However, low bioavailability and potential side effects limit their clinical application. In this study, a bone-targeted delivery system for senolytics was developed to effectively treat senile osteoporosis.
ACTA BIOMATERIALIA
(2023)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)