Article
Biochemistry & Molecular Biology
Yanlin He, Xing Cai, Hailan Liu, Krisitine M. Conde, Pingwen Xu, Yongxiang Li, Chunmei Wang, Meng Yu, Yang He, Hesong Liu, Chen Liang, Tingting Yang, Yongjie Yang, Kaifan Yu, Julia Wang, Rong Zheng, Feng Liu, Zheng Sun, Lora Heisler, Qi Wu, Qingchun Tong, Canjun Zhu, Gang Shu, Yong Xu
Summary: The translation discusses how obesity is primarily caused by consuming excessive calories beyond energetic requirements, while the underlying drivers have not been fully defined. The study found that activating specific neural pathways can regulate different types of feeding behavior, driven by either hunger or non-hunger cues.
MOLECULAR PSYCHIATRY
(2021)
Article
Biology
Soohong Min, Yangkyun Oh, Pushpa Verma, Samuel C. Whitehead, Nilay Yapici, David Van Vactor, Greg S. B. Suh, Stephen Liberles
Summary: The study reveals the essential role of Drosophila Piezo in volume-based control of meal size, with neurons expressing Piezo responding to food reservoir organ distension. Activating Piezo neurons decreases appetite, while knockout and silencing of Piezo lead to gut bloating and increased food consumption and body weight.
Article
Neurosciences
Qingqing Liu, Xing Yang, Moxuan Luo, Junying Su, Jinling Zhong, Xiaofen Li, Rosa H. M. Chan, Liping Wang
Summary: Using a machine-learning-assisted behavior tracking system, researchers discovered that feeding in mice is fragmented and involves competing motivations for food consumption and environment exploration. Activation of specific neural populations orchestrates the preparation, initiation, and maintenance of feeding segments, resolving motivational conflicts. This iterative neural processing sequence provides insights into optimizing goal-directed behaviors.
Article
Biochemistry & Molecular Biology
Benjamin M. Seitz, Ivy B. Hoang, Lauren E. DiFazio, Aaron P. Blaisdell, Melissa J. Sharpe
Summary: For the past two decades, phasic activity in midbrain dopamine neurons has been thought to be associated with the prediction error in temporal-difference reinforcement learning. Recent studies have challenged this view and our research provides further evidence to support these challenges, suggesting that midbrain dopamine activity plays a crucial role in the association between events.
Article
Biology
Catarina Catela, Yihan Chen, Yifei Weng, Kailong Wen, Paschalis Kratsios
Summary: This study identified the transcriptome of spinal motor neurons (MNs) in mice during embryonic and postnatal stages and discovered novel genes and transcription factors related to terminal differentiation. It was found that homeodomain transcription factors, including Hoxc8, played a crucial role in maintaining the expression of terminal differentiation markers in MNs. These findings provide insights into the evolutionary role of Hox in neuronal terminal differentiation.
Article
Multidisciplinary Sciences
Nicolas A. Morgenstern, Ana Filipa Isidro, Inbal Israely, Rui M. Costa
Summary: This study reveals a previously unknown excitatory circuit in the brain, which conveys a delayed second phase of excitation to the striatum through a polysynaptic pathway involving PT neurons, cholinergic interneurons, and glutamate-releasing axons. This circuit mechanism may have important implications for behavior, plasticity, and learning.
Article
Multidisciplinary Sciences
Shuangshuang Ma, Min Chen, Yihao Jiang, Xinkuan Xiang, Shiqi Wang, Zuohang Wu, Shuo Li, Yihui Cui, Junying Wang, Yanqing Zhu, Yan Yang, Huan Ma, Shumin Duan, Haohong Li, Yan Yang, Christopher J. Lingle, Hailan Hu
Summary: Ketamine, a potent antidepressant, continues to suppress neuronal firing and block NMDARs in the brain for up to 24 hours after a single injection. This sustained effect is not due to endocytosis, but rather the trapping of ketamine in NMDARs. By modulating the activity of NMDARs, the duration of ketamine action can be controlled, providing new opportunities for therapeutic use of ketamine.
Article
Multidisciplinary Sciences
Shuangshuang Ma, Min Chen, Yihao Jiang, Xinkuan Xiang, Shiqi Wang, Zuohang Wu, Shuo Li, Yihui Cui, Junying Wang, Yanqing Zhu, Yan Zhang, Huan Ma, Shumin Duan, Haohong Li, Yan Yang, Christopher J. Lingle, Hailan Hu
Summary: By manipulating the interactions between the lateral habenula (LHb) and NMDARs, we are able to adjust the duration of ketamine's antidepressant effects in vivo. This study reveals the causal mechanisms behind the sustained antidepressant effects of ketamine and opens up new possibilities for therapeutic use.
Article
Neurosciences
Kevin M. Manz, Benjamin C. Coleman, Alexis N. Jameson, Dipanwita G. Ghose, Sachin Patel, Brad A. Grueter
Summary: The study showed that cocaine decreases thalamocortical glutamatergic drive onto PV-INs through a monoamine-independent mechanism, involving sigma-1 activity and retrograde endocannabinoid signaling at presynaptic CB1R. Cocaine-induced CB1R activity blocks the expression of CB1R-dependent long-term depression at this synaptic locus.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Cell Biology
Ping Lu, Yonghui Zhao, Zili Xie, Huan Zhou, Xinzhong Dong, Gregory F. Wu, Brian S. Kim, Jing Feng, Hongzhen Hu
Summary: Although touch and itch are coded by different neuronal populations, light touch can provoke itch in the presence of pruritogens, resulting in a phenomenon called alloknesis. This study reveals the cellular and molecular mechanisms involved in pruritogen-induced mechanical itch sensitization, showing that histamine and chloroquine activate specific prurioceptors and sensitize Piezo2 channel function through the PLC and PKC8 signaling pathways. Understanding this signaling axis could provide insights into treating pruritus.
Article
Multidisciplinary Sciences
Nao Horio, Stephen D. Liberles
Summary: This study reveals a neuronal mechanism by which hunger selectively enhances attraction to food odors over other olfactory cues. Specifically, activation of hypothalamic AGRP neurons promotes food odor preference, which is mediated by neuropeptide Y release in the thalamus.
Article
Biochemistry & Molecular Biology
Sherry J. Cheriyamkunnel, Saloni Rose, Pedro F. Jacob, Lauren A. Blackburn, Shaleen Glasgow, Jacob Moorse, Mike Winstanley, Patrick J. Moynihan, Scott Waddell, Carolina Rezaval
Summary: This study describes how fruit flies make decisions between feeding and courtship behaviors, with nutritional status playing a key role in prioritizing these actions. The tyramine signaling pathway is identified as essential for mediating this decision-making process, with tyramine levels modulating the activity of neurons controlling food-seeking and courtship behaviors.
Review
Plant Sciences
M. Boix-Castejon, E. Roche, M. Olivares-Vicente, F. J. Alvarez-Martinez, M. Herranz-Lopez, V. Micol
Summary: Food intake behavior is influenced by physiological and psychological processes, and the neuroendocrine regulation of food intake involves signals that modulate appetite, satiety, and hunger. Natural plant compounds are being studied for their potential in appetite control, but the research lacks conclusive physiological data, such as anthropometric evaluations and hormone analysis. More systematic clinical studies are needed to decode the hormone patterns regulating hunger and satiety and to correlate brain connectivity with appetite and satiety.
Article
Engineering, Electrical & Electronic
Azzedine Boukerche, Dunhao Zhong, Peng Sun
Summary: This paper investigates the application of reinforcement learning techniques for collaborative traffic signal control in a traffic road network, while considering the issue of data transmission delay. By designing new RL agents and proposing a traffic state prediction method, the performance of the proposed method surpasses previous methods and addresses the data transmission delay issue.
IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY
(2022)
Article
Cell Biology
Benoit Drouillas, Cecile Brocard, Sebastien Zanella, Remi Bos, Frederic Brocard
Summary: The persistent sodium current (INaP) in the spinal locomotor network plays a significant role in both self-sustained spiking and bursting oscillations, and is mediated by the Nav1.6 and Nav1.1 channels.
Article
Neurosciences
Manasi Iyer, Rachel A. Essner, Bernhard Klingenberg, Matthew E. Carter
JOURNAL OF COMPARATIVE NEUROLOGY
(2018)
Editorial Material
Neurosciences
Lisa R. Beutler, Zachary A. Knight
Review
Neurosciences
Chan Lek Tan, Zachary A. Knight
Article
Multidisciplinary Sciences
Christopher A. Zimmerman, Erica L. Huey, Jamie S. Ahn, Lisa R. Beutler, Chan Lek Tan, Seher Kosar, Ling Bai, Yiming Chen, Timothy V. Corpuz, Linda Madisen, Hongkui Zeng, Zachary A. Knight
Article
Biology
Yiming Chen, Rachel A. Essner, Seher Kosar, Oliver H. Miller, Yen-Chu Lin, Sheyda Mesgarzadeh, Zachary A. Knight
Article
Neurosciences
Yoav Livneh, Arthur U. Sugden, Joseph C. Madara, Rachel A. Essner, Vanessa Flores, Lauren A. Sugden, Jon M. Resch, Bradford B. Lowell, Mark L. Andermann
Article
Neurosciences
Yiming Chen, Heeun Jang, Perry W. E. Spratt, Seher Kosar, David E. Taylor, Rachel A. Essner, Ling Bai, David E. Leib, Tzu-Wei Kuo, Yen-Chu Lin, Mili Patel, Aygul Subkhangulova, Saul Kato, Evan H. Feinberg, Kevin J. Bender, Zachary A. Knight, Jennifer L. Garrison
Article
Biology
Lisa R. Beutler, Timothy Corpuz, Jamie S. Ahn, Seher Kosar, Weimin Song, Yiming Chen, Zachary A. Knight
Article
Neurosciences
Christopher A. Zimmerman, Zachary A. Knight
CURRENT OPINION IN NEUROBIOLOGY
(2020)
Editorial Material
Multidisciplinary Sciences
Christopher A. Zimmerman
Article
Multidisciplinary Sciences
James C. R. Grove, Lindsay A. Gray, Naymalis La Santa Medina, Nilla Sivakumar, Jamie S. Ahn, Timothy Corpuz, Joshua D. Berke, Anatol C. Kreitzer, Zachary A. Knight
Summary: The study reveals that dopaminergic neurons in the VTA respond differently to nutrients and water intake, tracking gastrointestinal nutrients and hydration levels to facilitate learning about the consequences of ingestion.
Article
Biology
Ling Bai, Nilla Sivakumar, Shenliang Yu, Sheyda Mesgarzadeh, Tom Ding, Truong Ly, Timothy Corpuz, James C. R. Grove, Brooke C. Jarvie, Zachary A. Knight
Summary: Animals learn about the nutritional value and toxicity of food through experience, with enteroendocrine cells playing a crucial role in this process. The study discovered that different EEC subtypes have inhibitory effects on food intake and influence learning differently.
Editorial Material
Biochemistry & Molecular Biology
Christopher A. Zimmerman
Summary: The peptide hormone secretin influences drinking behavior by adjusting the excitability of neurons in the brain's thirst circuit.
Article
Neurosciences
Julia Cox, Adelaide R. Minerva, Weston T. Fleming, Christopher A. Zimmerman, Cameron Hayes, Samuel Zorowitz, Akhil Bandi, Sharon Ornelas, Brenna McMannon, Nathan F. Parker, Ilana B. Witten
Summary: Emerging evidence suggests that there are sex differences in decision-making behavior, but the neural substrates underlying these differences are not well understood. This study demonstrates that in mice, the motivation to engage in a value-based decision-making task is modulated more strongly by action value in females than in males. The anterior cingulate cortex neurons projecting to the dorsomedial striatum contribute to this sex difference.
NATURE NEUROSCIENCE
(2023)