TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

TP53Gene and Cancer Resistance in Elephants

(2016) Raymond P. Perez et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Quantitative PCR as a predictor of aligned ancient DNA read counts following targeted enrichment

(2016) Jacob Enk et al.   BIOTECHNIQUES

Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans

(2015) Lisa M. Abegglen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Comparative sequence analyses of genome and transcriptome reveal novel transcripts and variants in the Asian elephant Elephas maximus

(2015) Puli Chandramouli Reddy et al.   JOURNAL OF BIOSCIENCES

Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish

(2015) J S Chua et al.   ONCOGENE

Quantitative implications of the approximate irrelevance of mammalian body size and lifespan to lifelong cancer risk

(2015) Richard Peto   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis

(2015) Aleah F. Caulin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Ancient Whole Genome Enrichment Using Baits Built from Modern DNA

(2014) Jacob M. Enk et al.   MOLECULAR BIOLOGY AND EVOLUTION

Origins and functional evolution of Y chromosomes across mammals

(2014) Diego Cortez et al.   NATURE

DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach

(2014) D. E. V. Pires et al.   NUCLEIC ACIDS RESEARCH

p53  is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state

(2014) S. Senturk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ecology and mode-of-life explain lifespan variation in birds and mammals

(2014) K. Healy et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Larger Mammalian Body Size Leads to Lower Retroviral Activity

(2014) Aris Katzourakis et al.   PLoS Pathogens

Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidence

(2013) Irena Manov et al.   BMC BIOLOGY

Complete Genome Sequences of Elephant Endotheliotropic Herpesviruses 1A and 1B Determined Directly from Fatal Cases

(2013) G. S. Wilkie et al.   JOURNAL OF VIROLOGY

High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat

(2013) Xiao Tian et al.   NATURE

The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a

(2013) A Sparks et al.   ONCOGENE

A model based criterion for gene expression calls using RNA-seq data

(2013) Günter P. Wagner et al.   THEORY IN BIOSCIENCES

Biology, not environment, drives major patterns in maximum tetrapod body size through time

(2012) R. B. Sookias et al.   Biology Letters

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism

(2012) V. Gorbunova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The maximum rate of mammal evolution

(2012) A. R. Evans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Measurement of mRNA abundance using RNA-seq data: RPKM measure is inconsistent among samples

(2012) Günter P. Wagner et al.   THEORY IN BIOSCIENCES

Improving the Physical Realism and Structural Accuracy of Protein Models by a Two-Step Atomic-Level Energy Minimization

(2011) Dong Xu et al.   BIOPHYSICAL JOURNAL

p53 Requires an Intact C-Terminal Domain for DNA Binding and Transactivation

(2011) Hyunjung Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

Peto's Paradox: evolution's prescription for cancer prevention

(2011) Aleah F. Caulin et al.   TRENDS IN ECOLOGY & EVOLUTION

Birth-and-Death Long-Term Evolution Promotes Histone H2B Variant Diversification in the Male Germinal Cell Line

(2010) R. Gonzalez-Romero et al.   MOLECULAR BIOLOGY AND EVOLUTION

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

GUIDANCE: a web server for assessing alignment confidence scores

(2010) O. Penn et al.   NUCLEIC ACIDS RESEARCH

The Evolution of Maximum Body Size of Terrestrial Mammals

(2010) F. A. Smith et al.   SCIENCE

New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0

(2010) Stéphane Guindon et al.   SYSTEMATIC BIOLOGY

Genomic DNA Sequences from Mastodon and Woolly Mammoth Reveal Deep Speciation of Forest and Savanna Elephants

(2010) Nadin Rohland et al.   PLOS BIOLOGY

RNA-Seq gene expression estimation with read mapping uncertainty

(2009) Bo Li et al.   BIOINFORMATICS

Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat

(2009) A. Seluanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Isoforms of the p53 Protein

(2009) M. P. Khoury et al.   Cold Spring Harbor Perspectives in Biology

The Origins and Evolution of the p53 Family of Genes

(2009) V. A. Belyi et al.   Cold Spring Harbor Perspectives in Biology

Mouse Models of p53 Functions

(2009) G. Lozano   Cold Spring Harbor Perspectives in Biology

Trophoblastic p53 is stabilised by a cis–trans isomerisation necessary for the formation of high molecular weight complexes involving the N-terminus of p53

(2008) M. Cohen et al.   BIOCHIMIE

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS