The structure of the core NuRD repression complex provides insights into its interaction with chromatin

Histone deacetylases: structural determinants of inhibitor selectivity

(2015) Carmina Micelli et al.   DRUG DISCOVERY TODAY

Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting

(2015) Toshimasa Itoh et al.   NUCLEIC ACIDS RESEARCH

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

(2015) Mahmood M. Alam et al.   Nature Communications

Towards an understanding of the structure and function of MTA1

(2014) Christopher J. Millard et al.   CANCER AND METASTASIS REVIEWS

Role of MTA1 in cancer progression and metastasis

(2014) Nirmalya Sen et al.   CANCER AND METASTASIS REVIEWS

Towards elucidating the stability, dynamics and architecture of the nucleosome remodeling and deacetylase complex by using quantitative interaction proteomics

(2014) Susan L. Kloet et al.   FEBS Journal

Insight into the Architecture of the NuRD Complex

(2014) Saad S. M. Alqarni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond

(2014) Eric Verdin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recombinant Protein Expression for Structural Biology in HEK 293F Suspension Cells: A Novel and Accessible Approach

(2014) Nicola Portolano et al.   Jove-Journal of Visualized Experiments

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts

(2013) Richard D.W. Kelly et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The NuRD architecture

(2013) Hillary F. Allen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Core Chromatin Remodeling Factor Instructs Global Chromatin Signaling through Multivalent Reading of Nucleosome Codes

(2013) Sujit S. Nair et al.   MOLECULAR CELL

Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates

(2013) Christopher J. Millard et al.   MOLECULAR CELL

Lysine-specific chemical cross-linking of protein complexes and identification of cross-linking sites using LC-MS/MS and the xQuest/xProphet software pipeline

(2013) Alexander Leitner et al.   Nature Protocols

MBD3 Localizes at Promoters, Gene Bodies and Enhancers of Active Genes

(2013) Takashi Shimbo et al.   PLoS Genetics

Metastasis-Associated Protein 1/Nucleosome Remodeling and Histone Deacetylase Complex in Cancer

(2012) D.-Q. Li et al.   CANCER RESEARCH

New developments in theATSASprogram package for small-angle scattering data analysis

(2012) Maxim V. Petoukhov et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Structure of HDAC3 bound to co-repressor and inositol tetraphosphate

(2012) Peter J. Watson et al.   NATURE

A cross-platform toolkit for mass spectrometry and proteomics

(2012) Matthew C Chambers et al.   NATURE BIOTECHNOLOGY

Structural plasticity of histones H3–H4 facilitates their allosteric exchange between RbAp48 and ASF1

(2012) Wei Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stoichiometry of chromatin-associated protein complexes revealed by label-free quantitative mass spectrometry-based proteomics

(2012) Arne H. Smits et al.   NUCLEIC ACIDS RESEARCH

Molecular architecture of human polycomb repressive complex 2

(2012) Claudio Ciferri et al.   eLife

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression

(2011) Nicola Reynolds et al.   EMBO JOURNAL

Chromatin-modifying Complex Component Nurf55/p55 Associates with Histones H3 and H4 and Polycomb Repressive Complex 2 Subunit Su(z)12 through Partially Overlapping Binding Sites

(2011) Agnieszka J. Nowak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

(2011) Frank W. Schmitges et al.   MOLECULAR CELL

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery

(2011) Jasmeen Oberoi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and function of WD40 domain proteins

(2011) Chao Xu et al.   Protein & Cell

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

An Isotopically Coded CID-cleavable Biotinylated Cross-linker for Structural Proteomics

(2010) Evgeniy V. Petrotchenko et al.   MOLECULAR & CELLULAR PROTEOMICS

FoXS: a web server for rapid computation and fitting of SAXS profiles

(2010) D. Schneidman-Duhovny et al.   NUCLEIC ACIDS RESEARCH

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

DAMMIF, a program for rapidab-initioshape determination in small-angle scattering

(2009) Daniel Franke et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Histone deacetylase inhibitors: Potential in cancer therapy

(2009) P.A. Marks et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Structural basis of histone H4 recognition by p55

(2008) J.-J. Song et al.   GENES & DEVELOPMENT

Structural Basis for the Recognition of Histone H4 by the Histone-Chaperone RbAp46

(2008) Natalia V. Murzina et al.   STRUCTURE

The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex

(2007) Andrea E. Roche et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY