期刊
ELIFE
卷 5, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.16088
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资金
- University Of Oxford Clarendon Fund Scholarship
- Medical Research Council [1531859, MC_UU_12020/5, MC_UU_12024/2, MC_UU_12024/1]
- Wellcome Trust [109030/Z/15/Z, 101821]
- Human Frontier Science Program [LT000396/2009-L]
- European Research Council SNAP-PD
- National Institutes of Health [P51 OD011132]
- Medical Research Council [MC_UU_12024/1, 1531859, MC_UU_12020/5, 1310799, MC_UU_12024/2] Funding Source: researchfish
- Parkinson's UK [J-1403, J-0901] Funding Source: researchfish
- Wellcome Trust [101821/Z/13/Z] Funding Source: researchfish
- MRC [MC_UU_12024/1, MC_UU_12020/5, MC_UU_12024/2] Funding Source: UKRI
- Wellcome Trust [101821/Z/13/Z] Funding Source: Wellcome Trust
Corticostriatal afferents can engage parvalbumin-expressing (PV+) interneurons to rapidly curtail the activity of striatal projection neurons (SPNs), thus shaping striatal output. Schemes of basal ganglia circuit dynamics generally consider striatal PV+ interneurons to be homogenous, despite considerable heterogeneity in both form and function. We demonstrate that the selective co-expression of another calcium-binding protein, secretagogin (Scgn), separates PV+ interneurons in rat and primate striatum into two topographically-, physiologically- and structurally distinct cell populations. In rats, these two interneuron populations differed in their firing rates, patterns and relationships with cortical oscillations in vivo. Moreover, the axons of identified PV+/Scgn+ interneurons preferentially targeted the somata of SPNs of the so-called 'direct pathway', whereas PV+/Scgn- interneurons preferentially targeted 'indirect pathway' SPNs. These two populations of interneurons could therefore provide a substrate through which either of the striatal output pathways can be rapidly and selectively inhibited to subsequently mediate the expression of behavioral routines.
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