Review
Chemistry, Multidisciplinary
Hongyu Bian, Yi Yiing Goh, Yuxia Liu, Haifeng Ling, Linghai Xie, Xiaogang Liu
Summary: The performance of neural synapse networks depends on the characteristics of synaptic learning, requiring the design of reliable multi-functional neural synaptic devices to achieve intelligent functions.
ADVANCED MATERIALS
(2021)
Article
Clinical Neurology
Anastasia Brodovskaya, Tamal Batabyal, Shinnosuke Shiono, Huayu Sun, Jaideep Kapur
Summary: This study investigates the role of the thalamus and corpus callosum in bilateral cortical synchronization. The findings suggest that the thalamus generates bilateral sleep spindles and primarily generalized absence seizures, while the corpus callosum mediates the spread of seizures bilaterally.
ANNALS OF NEUROLOGY
(2022)
Article
Cell Biology
Kunwei Wu, David Castellano, Qingjun Tian, Wei Lu
Summary: The study reveals distinct roles of GluN2A and GluN2B-NMDA receptors in regulating tonic inhibition in hippocampal neurons, with NMDAR subunit-specific mechanisms at play. Tonic inhibition is modulated by various factors in both physiological and pathological conditions.
Article
Cell Biology
Joshua B. Melander, Aran Nayebi, Bart C. Jongbloets, Dale A. Fortin, Maozhen Qin, Surya Ganguli, Tianyi Mao, Haining Zhong
Summary: Cortical function relies on balanced activation of excitatory and inhibitory neurons. The organization and dynamics of shaft excitatory synapses onto cortical inhibitory interneurons are not well understood. Studies show that synapses onto PV+ neurons are less variable and more stable.
Review
Cell Biology
Wing-Yu Fu, Nancy Y. Ip
Summary: Alzheimer's disease (AD) is a neurodegenerative disease characterized by the progressive deterioration of cognitive functions. Synaptic dysfunction is a major neuro-pathological change in AD, but the underlying mechanisms remain unclear. Recent genomic analyses have identified genetic risk factors associated with AD, and understanding their role in synaptic dysfunction could provide insights into AD pathogenesis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Article
Biology
Cecilia D. Velasco, Rachel Santarella-Mellwig, Martin Schorb, Li Gao, Oliver Thorn-Seshold, Artur Llobet
Summary: Microtubules in the presynaptic compartment of cholinergic autaptic synapses are dynamic. When the balance between microtubule growth and shrinkage is disrupted, there is an increase in spontaneous neurotransmitter release. Additionally, microtubules restrict spontaneous neurotransmitter release and promote the replenishment of the readily releasable pool of synaptic vesicles.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hang Xing, Xiong Han, Sihan Xu, Zhongyu Sun, Shijun Yang
Summary: This study demonstrates the therapeutic effects of Brivaracetam (BRV) in altering short-term synaptic activities and abnormal low-frequency brain activities during interictal periods of epileptic seizures. BRV slows down the mobilization of synaptic vesicles and reduces short-term synaptic potentiation (STP), contributing to the treatment of epileptic seizures. These findings advance our understanding of BRV's pharmacological role and optimization of treatment strategies.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Biology
Evdokia Menelaou, Sandeep Kishore, David L. McLean, Markus Meister
Summary: This study unravels the impact of mixed synapses within the spinal locomotor circuitry of larval zebrafish and finds that differences in mixed synapse density can contribute to excitability underestimations and connectivity overestimations, explaining the "violations" of the size principle.
Article
Biochemistry & Molecular Biology
Matteo Moschetta, Tiziana Ravasenga, Antonio De Fusco, Luca Maragliano, Davide Aprile, Marta Orlando, Silvio Sacchetti, Silvia Casagrande, Gabriele Lignani, Anna Fassio, Pietro Baldelli, Fabio Benfenati
Summary: The study reveals that Synapsin I acts as a novel Ca2+ buffer in excitatory terminals, and blocking its binding to Ca2+ leads to abnormal neurotransmitter release and short-term plasticity. This finding sheds light on the physiological role of Ca2+ binding to SynI in the regulation of SV clustering and trafficking in nerve terminals.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Julika Radecke, Raphaela Seeger, Anna Kadkova, Ulrike Laugks, Amin Khosrozadeh, Kenneth N. Goldie, Vladan Lucic, Jakob B. Sorensen, Benoit Zuber
Summary: This study used cryo-electron tomography to observe the intermediate steps following synaptic stimulation, and found that during the early fusion stage after stimulation, synaptic vesicles undergo morphological changes to establish contact with the plasma membrane. The subsequent late fusion stage results in fusion pore opening and collapse of the synaptic vesicles. These morphological observations likely correspond to the transition of synaptic vesicles from one functional pool to another.
Article
Mechanics
Philip R. Barnett, Lorenzo Vigna, Jose L. Martinez-Collado, Andrea Calzolari, Dayakar Penumadu
Summary: This study investigated the performance of recycled carbon fiber composites in terms of energy absorption, crush efficiency, and crush stress at different temperatures. The results showed that recycled fiber composites can achieve high energy absorption levels, making them a promising alternative to expensive and environmentally unfriendly continuous fiber laminates.
COMPOSITE STRUCTURES
(2023)
Article
Cell Biology
Dominic Bingham, Channa Elise Jakobs, Florian Wernert, Fanny Boroni-Rueda, Nicolas Jullien, Eva-Maria Schentarra, Karoline Friedl, Julie Da Costa Moura, Danique Michelle van Bommel, Ghislaine Caillol, Yuki Ogawa, Marie-Jeanne Papandreou, Christophe Leterrier
Summary: We measure and visualize the presynaptic actin cytoskeleton and identify a major population of actin-enriched presynapses that have more presynaptic components and higher synaptic vesicle cycling. Pharmacological perturbations suggest an optimal amount of actin and the presence of distinct actin structures within presynapses. We directly visualize these nanostructures using Single Molecule Localization Microscopy (SMLM) and validate our results in natural synapses between cultured neurons.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Cell Biology
Katherine E. Odegaard, Gabriel Gallegos, Sneh Koul, Victoria L. Schaal, Neetha N. Vellichirammal, Chittibabu Guda, Andrea P. Dutoit, Steven J. Lisco, Sowmya Yelamanchili, Gurudutt Pendyala
Summary: This study aims to identify distinct synaptic vesicle (SV) proteins as signatures for offspring exposed to oxycodone (oxy) during and after pregnancy. The research found that MEGF8, associated with carpenter syndrome, was downregulated in the IUO offspring, while LAMTOR4, associated with the regulator complex involved in lysosomal signaling and trafficking, was upregulated in the PNO groups. These findings provide insights into the impact of oxy exposure on the SV proteome in exposed offspring and could potentially lead to the development of new therapeutic targets.
Review
Chemistry, Multidisciplinary
Xuhai Liu, Fengyun Wang, Jie Su, Ye Zhou, Seeram Ramakrishna
Summary: Neuromorphic circuits have made significant progress in simulating brain functionality, but are still far behind biological neural circuits. The lack of comprehensive understanding of the brain's operating mechanism and the use of 3D neuromorphic hardware with compatible software algorithms can help overcome the limitations of current 2D artificial circuits.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Clinical Neurology
Jorge Arriagada-Diaz, Lorena Prado-Vega, Ana M. Cardenas Diaz, Alvaro O. Ardiles, Arlek M. Gonzalez-Jamett
Summary: Dynamin superfamily proteins play important roles in synaptic transmission and plasticity by regulating synaptic vesicle recycling and neurotransmitter release. Mutations and dysfunction of these proteins are associated with various neurological disorders.
Review
Neurosciences
Owen P. Gross, Edward N. Pugh, Marie E. Burns
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2015)
Article
Physiology
Gabriel Peinado Allina, Christopher Fortenbach, Franklin Naarendorp, Owen P. Gross, Edward N. Pugh, Marie E. Burns
JOURNAL OF GENERAL PHYSIOLOGY
(2017)
Article
Biophysics
Owen P. Gross, Edward N. Pugh, Marie E. Burns
BIOPHYSICAL JOURNAL
(2012)
Correction
Biochemistry & Molecular Biology
Xiufeng Song, Sergey A. Vishnivetskly, Owen P. Gross, Katrina Emelianoff, Ana Mendez, Jeannie Chen, Eugenia V. Gurevich, Marie E. Burns, Vsevolod V. Gurevich
Article
Biochemistry & Molecular Biology
Xiufeng Song, Sergey A. Vishnivetskiy, Owen P. Gross, Katrina Emelianoff, Ana Mendez, Jeannie Chen, Eugenia V. Gurevich, Marie E. Burns, Vsevolod V. Gurevich
Article
Neurosciences
Owen P. Gross, Marie E. Burns
JOURNAL OF NEUROSCIENCE
(2010)
Article
Neurosciences
Frank Naarendorp, Tricia M. Esdaille, Serenity M. Banden, John Andrews-Labenski, Owen P. Gross, Edward N. Pugh
JOURNAL OF NEUROSCIENCE
(2010)
Article
Neurosciences
Owen P. Gross, Edward N. Pugh, Marie E. Burns
Correction
Neurosciences
Owen P. Gross, Edward N. Pugh, Marie E. Burns
