Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

Clarifying the morphology of the ostium primum defect

(2015) Robert H. Anderson et al.   JOURNAL OF ANATOMY

Opposite Phenotypes of Muscle Strength and Locomotor Function in Mouse Models of Partial Trisomy and Monosomy 21 for the Proximal Hspa13-App Region

(2015) Véronique Brault et al.   PLoS Genetics

Tbx1 Coordinates Addition of Posterior Second Heart Field Progenitor Cells to the Arterial and Venous Poles of the Heart

(2014) M. Sameer Rana et al.   CIRCULATION RESEARCH

Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation

(2014) Chaitali Misra et al.   HUMAN MOLECULAR GENETICS

Expression of the BMP Receptor Alk3 in the Second Heart Field Is Essential for Development of the Dorsal Mesenchymal Protrusion and Atrioventricular Septation

(2013) Laura E. Briggs et al.   CIRCULATION RESEARCH

Genetics of Congenital Heart Disease

(2013) Akl C. Fahed et al.   CIRCULATION RESEARCH

Engineered chromosome-based genetic mapping establishes a 3.7 Mb critical genomic region for Down syndrome-associated heart defects in mice

(2013) Chunhong Liu et al.   HUMAN GENETICS

Massively Parallel Sequencing Reveals the Complex Structure of an Irradiated Human Chromosome on a Mouse Background in the Tc1 Model of Down Syndrome

(2013) Susan M. Gribble et al.   PLoS One

Genetic Modifiers Predisposing to Congenital Heart Disease in the Sensitized Down Syndrome Population

(2012) Huiqing Li et al.   Circulation-Cardiovascular Genetics

Tbx5-Hedgehog Molecular Networks Are Essential in the Second Heart Field for Atrial Septation

(2012) Linglin Xie et al.   DEVELOPMENTAL CELL

The pathogenesis of atrial and atrioventricular septal defects with special emphasis on the role of the dorsal mesenchymal protrusion

(2012) Laura E. Briggs et al.   DIFFERENTIATION

Imaging heart development using high-resolution episcopic microscopy

(2011) Timothy J Mohun et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Down syndrome: searching for the genetic culprits

(2011) E. Lana-Elola et al.   Disease Models & Mechanisms

Genetic analysis of Down syndrome-associated heart defects in mice

(2011) Chunhong Liu et al.   HUMAN GENETICS

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome

(2011) Arnaud Duchon et al.   MAMMALIAN GENOME

Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse

(2010) Louisa Dunlevy et al.   CARDIOVASCULAR RESEARCH

Characterization and In Vivo Pharmacological Rescue of a Wnt2-Gata6 Pathway Required for Cardiac Inflow Tract Development

(2010) Ying Tian et al.   DEVELOPMENTAL CELL

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions

(2010) Tao Yu et al.   HUMAN MOLECULAR GENETICS

Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome

(2010) Lina Chakrabarti et al.   NATURE NEUROSCIENCE

Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project

(2009) Sallie B Freeman et al.   GENETICS IN MEDICINE

A new mouse model for the trisomy of the Abcg1–U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome

(2009) Patricia Lopes Pereira et al.   HUMAN MOLECULAR GENETICS

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

(2009) Kwan-Hyuck Baek et al.   NATURE

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

(2009) J. O. Korbel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart

(2008) M. M. Goddeeris et al.   DEVELOPMENT

Genotype–phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

(2008) Robert Lyle et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Trisomy represses Apc Min -mediated tumours in mouse models of Down’s syndrome

(2008) Thomas E. Sussan et al.   NATURE

A myocardial lineage derives from Tbx18 epicardial cells

(2008) Chen-Leng Cai et al.   NATURE