Article
Cell Biology
Giuseppe Balsamo, Eduardo Blanco-Hernandez, Feng Liang, Robert Konrad Naumann, Stefano Coletta, Andrea Burgalossi, Patricia Preston-Ferrer
Summary: Research on the mouse dorsal presubiculum demonstrates a modular patch-matrix organization that is conserved across species, including human. The restricted apical dendrites of HD cells within the matrix suggest a non-random sampling of patterned inputs and a precise structure-function architecture in the cortical representation of HD.
Article
Multidisciplinary Sciences
Yangfan Peng, Federico J. Barreda Tomas, Paul Pfeiffer, Moritz Drangmeister, Susanne Schreiber, Imre Vida, Joerg R. P. Geiger
Summary: This study reveals that inhibition by fast-spiking interneurons in the rat superficial presubiculum is organized in the form of a dominant super-reciprocal microcircuit motif. The unique connectivity arises from the asymmetric, polarized morphology of fast-spiking interneuron axons, improving head direction tuning of pyramidal cells. The structured inhibition based on asymmetrical axons is proposed as an overarching spatial connectivity principle for tailored computation across brain regions.
Article
Biochemical Research Methods
Elishai Ezra-Tsur, Oren Amsalem, Lea Ankri, Pritish Patil, Idan Segev, Michal Rivlin-Etzion
Summary: Retinal direction selectivity, mediated by starburst amacrine cells (SACs), originates from their centrifugal preference in response to stimuli. Utilizing the Retinal Stimulation Modeling Environment (RSME), detailed simulations revealed that precise organization of input kinetics along SAC processes and reciprocal inhibition between SACs contribute to this centrifugal preference. Additionally, the contribution of SAC-SAC inhibitory connections and SAC centrifugal preference to direction selectivity in direction selective ganglion cells (DSGCs) was explored, enhancing our understanding of SACs' role in visual processing.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Masashi Tanimoto, Ikuko Watakabe, Shin-Ichi Higashijima
Summary: Spatio-temporal information about head orientation and movement is crucial for balance and motion perception. In this study, we used in vivo Ca2+ imaging to investigate the response patterns of hair cells and ganglion neurons in larval zebrafish to static tilt and vibration. Our results suggest that different types of hair cells in the otolith organs respond selectively to head vibration and static tilt, while maintaining a spatially ordered direction preference that is preserved in ganglion neurons. This demonstrates the presence of topographically organized selectivity for the direction and dynamics of head orientation/movement in the vestibular periphery.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Mehdi Fallahnezhad, Julia Le Mero, Xhensjana Zenelaj, Jean Vincent, Christelle Rochefort, Laure Rondi-Reig
Summary: The head-direction (HD) system is a neural circuit crucial for navigation, consisting of anatomical structures with neurons selective to the animal's head direction. HD cells display temporal coordination across brain regions, independent of the animal's behavior or sensory inputs, which mediates a single, stable, and persistent HD signal necessary for intact orientation. By manipulating the cerebellum, researchers identify pairs of HD cells recorded from two brain structures that lose their temporal coordination, specifically during the removal of external sensory inputs. The cerebellum contributes to the preservation of a single and stable sense of direction through distinct mechanisms depending on sensory signals.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Yvette E. Fisher, Michael Marquis, Isabel D'Alessandro, Rachel Wilson
Summary: In neural networks, there is a tradeoff between sensitivity and stability. Dopamine neurons in the fruit fly's head direction network are specifically active when the fly turns to change its head direction, and their activity scales with rotational speed. Pairing dopamine release with a visual cue strengthens the cue's influence on head direction cells, while inhibiting these neurons decreases the influence of the cue. This mechanism allows for accelerated learning when rich head direction information is available, while protecting stored information at other times.
Article
Multidisciplinary Sciences
Zaki Ajabi, Alexandra T. Keinath, Xue-Xin Wei, Mark P. Brandon
Summary: The head direction (HD) system functions as the brain's internal compass, but its mechanisms of anchoring and drift remain unclear. In this study, population recordings of thalamic HD cells revealed a second dimension of activity, referred to as network gain, which predicted realignment and drift dynamics. Moreover, the network gain maintained a 'memory trace' of previously displayed landmarks and influenced the internal HD representation. These findings challenge the classical one-dimensional interpretations of the HD system.
Article
Multidisciplinary Sciences
Weipang Chang, Andrea Pedroni, Reinhard W. Koster, Stefania Giacomello, Konstantinos Ampatzis
Summary: This study demonstrates experimentally that Purkinje cells in the valvular part of the cerebellum in adult zebrafish exhibit variable firing patterns and functional responses, categorizing into three classes. Compared to Purkinje cells in the corpus cerebelli, valvular Purkinje cells receive weak and occasional input from the inferior olive and are inactive during locomotion. These findings expand the understanding of regional functional differences among Purkinje cells and highlight their non-locomotor functionalities.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Xiaoyang Long, Bin Deng, Calvin K. Young, Guo-Long Liu, Zeqi Zhong, Qian Chen, Hui Yang, Sheng-Qing Lv, Zhe Sage Chen, Sheng-jia Zhang
Summary: Head direction cells are an important component in the brain's spatial navigation system. FS HD cells in the somatosensory cortex display sharper head-directionality than RS HD cells and coexist with RS HD cells and AHV cells in a layer-specific manner. These findings challenge the concept that FS interneurons are weakly tuned to sensory stimuli and provide insights into the local circuit organization of HD signaling in the brain.
Article
Cell Biology
Xiaojia Zhu, Haotian Yan, Yafeng Zhan, Furui Feng, Chuanyao Wei, Yong-Gang Yao, Cirong Liu
Summary: This study presents a comprehensive atlas of the marmoset cerebellum, revealing detailed anatomical structures, functional connectivity, and structural connectivity patterns. The atlas is publicly available and provides valuable insights into the interaction between the cerebellum and the cerebral cortex.
Article
Multidisciplinary Sciences
Susumu Takahashi, Takumi Hombe, Sakiko Matsumoto, Kaoru Ide, Ken Yoda
Summary: Animals demonstrate remarkable navigation abilities, possibly due to the presence of head direction cells that encode the animal's heading information. In the study of shearwater chicks, it was found that their head direction cells exhibited a preference for the north direction, indicating the existence of an internally generated magnetic compass in animals.
Editorial Material
Biochemistry & Molecular Biology
Aylin Apostel, Jonas Rose
Summary: The study found head-direction cells, but not place cells, in the hippocampal formation of quails, shedding light on the poorly understood avian hippocampus.
Article
Optics
Shuang Gao, Shui Ying Xiang, Zi Wei Song, Ya Nan Han, Yu Na Zhang, Yue Hao
Summary: This study proposes a photonic spiking neural network (SNN) approach for motion detection and direction recognition tasks, mimicking the visual nervous system. Simulation results validate the effectiveness and robustness of the proposed method, providing theoretical support for the future large-scale application of hardware photonic SNN.
Article
Biology
Pantelis Vafidis, David Owald, Tiziano D'Albis, Richard Kempter, Srdjan Ostojic
Summary: The ring attractor models play a crucial role in angular path integration, requiring precisely tuned connectivity in head direction circuits. By using a local, biologically plausible learning rule guided by supervisory allothetic cues, accurate path integration can be achieved.
Article
Multidisciplinary Sciences
Lema Massi, Kenta M. Hagihara, Julien Courtin, Julian Hinz, Christian Mueller, Maria Sol Fustinana, Chun Xu, Nikolaos Karalis, Andreas Luthi
Summary: Memory encoding and retrieval rely on specific interactions across multiple brain areas, but the anatomical and functional specificity of neuronal circuit organization underlying information transfer across these areas is still unclear.
Article
Neurosciences
Qiusong Tang, Christian Laut Ebbesen, Juan Ignacio Sanguinetti-Scheck, Patricia Preston-Ferrer, Anja Gundlfinger, Jochen Winterer, Prateep Beed, Saikat Ray, Robert Naumann, Dietmar Schmitz, Michael Brecht, Andrea Burgalossi
JOURNAL OF NEUROSCIENCE
(2015)
Article
Biochemistry & Molecular Biology
Maria Diamantaki, Markus Frey, Patricia Preston-Ferrer, Andrea Burgalossi
Article
Neurosciences
Qiusong Tang, Andrea Burgalossi, Christian Laut Ebbesen, Juan Ignacio Sanguinetti-Scheck, Helene Schmidt, John J. Tukker, Robert Naumann, Saikat Ray, Patricia Preston-Ferrer, Dietmar Schmitz, Michael Brecht
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Edith Chorev, Patricia Preston-Ferrer, Michael Brecht
NATURE NEUROSCIENCE
(2016)
Article
Biology
Maria Diamantaki, Markus Frey, Philipp Berens, Patricia Preston-Ferrer, Andrea Burgalossi
Review
Neurosciences
Robert K. Naumann, Patricia Preston-Ferrer, Michael Brecht, Andrea Burgalossi
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Article
Neurosciences
Stefano Coletta, Roxana Zeraati, Khaled Nasr, Patricia Preston-Ferrer, Andrea Burgalossi
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Article
Neurosciences
Stefano Coletta, Markus Frey, Khaled Nasr, Patricia Preston-Ferrer, Andrea Burgalossi
JOURNAL OF NEUROSCIENCE
(2018)
Article
Cell Biology
Maria Diamantaki, Stefano Coletta, Khaled Nasr, Roxana Zeraati, Sophie Laturnus, Philipp Berens, Patricia Preston-Ferrer, Andrea Burgalossi
Article
Biochemistry & Molecular Biology
Patricia Preston, Lena Wartosch, Dorothee Guenzel, Michael Fromm, Patthara Kongsuphol, Jiraporn Ousingsawat, Karl Kunzelmann, Jacques Barhanin, Richard Warth, Thomas J. Jentsch
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Article
Neurosciences
Lingjun Ding, Hongbiao Chen, Maria Diamantaki, Stefano Coletta, Patricia Preston-Ferrer, Andrea Burgalossi
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Joseph Clerke, Patricia Preston-Ferrer, Ioannis S. Zouridis, Audrey Tissot, Laura Batti, Fabian F. Voigt, Stephane Pages, Andrea Burgalossi, Manuel Mameli
Summary: The study found that cocaine withdrawal induces discrete and opposing synaptic adaptations from the lateral habenula (LHb) onto ventral tegmental area (VTA) neurons in mice. Different subsets of VTA neurons receive varied synaptic changes in response to LHb input during cocaine withdrawal.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2021)
Review
Cell Biology
Patricia Preston-Ferrer, Andrea Burgalossi
CELL AND TISSUE RESEARCH
(2018)