Article
Geriatrics & Gerontology
Siyu Chen, Shiqi Chen, Zhijian Zhao, Xueqing Cao, Zhangling Chen, Jun Lin
Summary: Lower serum 25(OH)D concentration is associated with higher all-cause mortality in patients with rheumatoid arthritis, while the association between omega-3 % and mortality is not significant. Optimizing serum vitamin D levels may be an important factor in reducing mortality risk in this population.
Article
Rheumatology
Mahadevappa Hemshekhar, Vidyanand Anaparti, Hani El-Gabalawy, Neeloffer Mookherjee
Summary: The combination of highly bioavailable curcumin, vitamin D-3, and omega-3 fatty acids significantly delays and reduces the development of collagen-induced arthritis (CIA). This study suggests a rationale for systematically evaluating these widely available supplements in individuals at risk for developing rheumatoid arthritis.
ARTHRITIS RESEARCH & THERAPY
(2021)
Article
Nutrition & Dietetics
Melissa Rittenhouse, Jonathan Scott, Patricia Deuster
Summary: Soldiers in the study had slightly higher diet quality compared to the control group, but showed deficiencies in biochemical markers such as omega-3 index and vitamin D. Therefore, improvements in diet quality and nutritional status are necessary to enhance soldiers' health, performance, and readiness.
Article
Medicine, General & Internal
Jill Hahn, Nancy R. Cook, Erik K. Alexander, Sonia Friedman, Joseph Walter, Vadim Bubes, Gregory Kotler, I-Min Lee, JoAnn E. Manson, Karen H. Costenbader
Summary: Vitamin D supplementation for five years, with or without omega 3 fatty acids, reduced autoimmune disease by 22%, while omega 3 fatty acid supplementation with or without vitamin D reduced the autoimmune disease rate by 15% (not statistically significant). Both treatment arms showed larger effects than the reference arm (vitamin D placebo and omega 3 fatty acid placebo).
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Review
Nutrition & Dietetics
Yann Nguyen, Johanna Sigaux, Jean-Guillaume Letarouilly, Pauline Sanchez, Sebastien Czernichow, Rene-Marc Flipo, Martin Soubrier, Luca Semerano, Raphaele Seror, Jeremie Sellam, Claire Daien
Summary: Oral vitamin supplementation did not show significant reduction in RA activity, however, folic acid supplementation can prevent methotrexate-related side effects, and vitamin D can prevent musculo-skeletal complications in patients with vitamin D deficiency.
Review
Nutrition & Dietetics
Tala Raad, Anne Griffin, Elena S. George, Louise Larkin, Alexander Fraser, Norelee Kennedy, Audrey C. Tierney
Summary: Rheumatoid Arthritis is a chronic autoimmune condition that may be influenced by dietary interventions, though further studies are needed for confirmation. Current research suggests that dietary interventions with an anti-inflammatory basis could potentially improve symptoms of arthritis.
Review
Biochemistry & Molecular Biology
Lambros Athanassiou, Ifigenia Kostoglou-Athanassiou, Michael Koutsilieris, Yehuda Shoenfeld
Summary: Vitamin D is a steroid hormone that has potent immune-modulating properties. Research has shown that vitamin D deficiency may be related to the development of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. It may also play a role in the pathogenesis of these diseases.
Article
Nutrition & Dietetics
Akemi T. Wijayabahu, Angela M. Mickle, Volker Mai, Cynthia Garvan, Toni L. Glover, Robert L. Cook, Jinying Zhao, Marianna K. Baum, Roger B. Fillingim, Kimberly T. Sibille
Summary: The study found that shorter leukocyte telomere length (LTL), a measure of cellular aging, is associated with elevated inflammatory cytokines and chronic pain. Micronutrients such as vitamin D and omega 3, which have anti-inflammatory properties, are also found to be associated with LTL and chronic pain. The complex relationships between anti-inflammatory micronutrients, inflammation, cellular aging, and chronic pain are highlighted in this study.
Article
Cell Biology
Sneha Verma, Ved Chaturvedi, N. K. Ganguly, Shivani Arora Mittal
Summary: Vitamin D plays an important role in regulating the immune system and its deficiency is associated with immune-related diseases. Studies have found lower levels of Vitamin D to be associated with diseases like Rheumatoid Arthritis and COVID-19, although contrasting data exists.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Medicine, General & Internal
Pamela M. Rist, Julie E. Buring, Nancy R. Cook, JoAnn E. Manson, Tobias Kurth
Summary: The study concluded that supplementation of vitamin D and marine omega-3 fatty acids did not reduce the frequency or severity of migraines in middle-aged or older adults, compared to a placebo.
AMERICAN JOURNAL OF MEDICINE
(2021)
Review
Immunology
Maurizio Cutolo, Stefano Soldano, Alberto Sulli, Vanessa Smith, Emanuele Gotelli
Summary: Vitamin D, a steroid hormone, has complex influences on the immune system and may affect various clinical conditions. Its serum concentrations fluctuate seasonally due to UV-B exposure, and low levels of 25OHD are implicated in the pathogenesis and clinical manifestations of diseases like rheumatoid arthritis and systemic sclerosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Yuwei Zhan, Zhou Yang, Ying Liu, Feng Zhan, Shudian Lin
Summary: This study used the NHANES database to investigate the combined effect of rheumatoid arthritis (RA) and Mediterranean diet (MD) on the risk of cardiovascular diseases (CVD). The results showed that RA and low adherence to the MD were associated with an increased risk of CVD, and there may be an interaction between RA and low adherence to MD.
Article
Immunology
Tian-Ping Zhang, Hong-Miao Li, Qian Huang, Li Wang, Xiao-Mei Li
Summary: The study revealed that genetic variations in CYP2R1 and CYP27B1 were associated with the genetic background of rheumatoid arthritis (RA), while altered methylation levels of VDR and CYP27B1 were related to the risk of RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Giuseppina Augimeri, Francesca Ida Montalto, Cinzia Giordano, Ines Barone, Marilena Lanzino, Stefania Catalano, Sebastiano Ando, Francesca De Amicis, Daniela Bonofiglio
Summary: The traditional Mediterranean Diet, rich in bioactive compounds like polyphenols, retinoids, and PUFAs, has been shown to have beneficial effects against chronic illnesses. These compounds possess antioxidant, anti-inflammatory, and antitumoral properties, making them potential candidates for future anticancer therapeutics in breast cancer.
Article
Pharmacology & Pharmacy
Xiaoyu Xu, Hongyu Luo, Qian Chen, Zikang Wang, Xixuan Chen, Xiaping Li, Huan Chen, Miao Wang, Yingyue Xu, Min Dai, Jianwei Wang, Xuekuan Huang, Bin Wu, Yanping Li
Summary: This study used network pharmacology and molecular docking to explore the mechanism of vitamin D in rheumatoid arthritis (RA). The results showed that vitamin D plays a vital role in treating RA by regulating cell proliferation, immune response, apoptotic process, and the nuclear factor-kappa B (NF-κB) signalling pathway. ALB, TNF, CASP3, and TP53 may be important punctuation points or diagnostic markers for future RA treatment.
FRONTIERS IN PHARMACOLOGY
(2022)