Article
Chemistry, Medicinal
Ting Shen, Zijian Yang
Summary: The study demonstrated that the pemirolast potassium ocular in situ gels have good stability and sustained release ability, effectively suppressing inflammatory symptoms and improving drug bioavailability in the therapy of allergic conjunctivitis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Gerard Esteruelas, Lyda Halbaut, Victor Garcia-Torra, Marta Espina, Amanda Cano, Miren Ettcheto, Antoni Camins, Eliana B. Souto, Maria Luisa Garcia, Elena Sanchez-Lopez
Summary: A novel in situ gelling system dispersing RLZ-loaded nanoparticles has been successfully developed as an innovative neuroprotective strategy for potential topical treatment of glaucoma, achieving a more delayed distribution in the posterior eye segment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Applied
Yi-Nan Du, Jia-Nan Yan, Shi-Qi Xu, Yu-Qiao Wang, Xue-Chen Wang, Hai-Tao Wu
Summary: The aim of this study was to investigate the effect of gellan gum (GG) on the cold gelation of large yellow croaker roe protein isolate (pcRPI). The water-holding ability and storage modulus of the pcRPI-GG binary gels increased with the GG concentration, where the storage modulus of the pcRPI-0.2% GG gel was approximately 30.7 times that of the pure pcRPI gel. Compare to the other binary gels, pcRPI-0.2% GG gels exhibited a lower lacunarity and higher junction density, with a denser, more aggregated microstructure. Consequently, curcumin was embedded in pcRPI-0.2% GG gels, and simulated gastrointestinal digestion test results showed that GG addition effectively protected and slowed curcumin release in the gastrointestinal environment. These findings may contribute to elucidating the interaction of pcRPI with GG and demonstrate the potential of binary gels for the embedding and delivery of active substances.
Article
Pharmacology & Pharmacy
Guiting Huang, Jin Xie, Shuyuan Shuai, Shaofeng Wei, Yingchong Chen, Zhiyu Guan, Qin Zheng, Pengfei Yue, Changhong Wang
Summary: This study successfully utilized a carbohydrate polymer deacetylated gellan gum (DGG) as matrix to design nanocrystals-based intranasal in situ gel (IG) for nose-to-brain drug delivery, showing excellent therapeutic efficacy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Applied
Tian-Qi Zhou, Xue-Chen Wang, Ling-Yi Gao, Jia-Nan Yan, Hai-Tao Wu
Summary: This study investigated the synergetic gelation of curdlan gum (CG) and gellan gum (GG) at different ratios. The optimal gelation was achieved at a mass ratio of 1:1 and a total concentration of 0.6%. The gel properties were influenced by the CG/GG ratio, with the strongest gel observed at a ratio of 5:5. The improved gel properties were attributed to hydrogen bonds between CG and GG. The CG/GG binary composite gel exhibited increased water holding capacity as the CG/GG ratio decreased. Furthermore, the microstructure of the CG/GG gel was denser and more homogeneous, supporting its stronger gel rigidity and water holding capacity.
FOOD HYDROCOLLOIDS
(2024)
Article
Polymer Science
Shuwen Zhou, Xinmeng Zheng, Ke Yi, Xuancheng Du, Cheng Wang, Pengfei Cui, Pengju Jiang, Xinye Ni, Lin Qiu, Jianhao Wang
Summary: This study synthesized a glutathione-gellan gum conjugate (GSH-GG) as a responsive gelling material for delivering doxorubicin hydrochloride (DOX) for cancer therapy. DOX-loaded GSH-GG showed temperature-ion dual responsive gelling property and lower drug release under acidic conditions, with selective action on cancer cells and potential for complete inhibition of tumor progression.
Article
Chemistry, Applied
Yulin Li, Xin Qi, Liyuan Rong, Jinwang Li, Mingyue Shen, Jianhua Xie
Summary: This study investigated the improvement of heat-induced pea protein isolate (PPI) gel using gellan gum (GG). The addition of GG significantly enhanced the gel strength, water holding capacity, and rheological properties of GG-PPI gels. Scanning electron microscopy revealed the promotion of a dense and homogeneous gel network structure by GG.
FOOD HYDROCOLLOIDS
(2024)
Article
Food Science & Technology
Juanjuan Wang, Xue Zhao, Changyu Zhou, Chong Wang, Yanyan Zheng, Keping Ye, Chunbao Li, Guanghong Zhou
Summary: The study aimed to investigate the properties and interaction mechanisms of the mixed-gel system containing gelatin (GL), gellan gum (GG), and inulin (IL). Results showed that addition of GG-IL improved the hardness, chewiness, and cohesiveness of the mixed-gel, while maintaining appropriate springiness. Water mobility of the mixed-gel decreased, viscoelasticity increased, and the melting temperature of the gel significantly increased at GG:IL = 2:8.
FOOD SCIENCE & NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Yanglin Wu, Yuan Gao, Chunwei Li
Summary: In this study, intelligent packaging films with improved stability were developed by modifying black rice anthocyanins and cocoloring with curcumin. The modified anthocyanins showed enhanced thermal, photostability, and pH stability. The films exhibited improved optical characteristics, mechanical properties, water vapor barrier, oxidation resistance, and color stability compared to other films.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Kaoru Kohyama, Sayaka Ishihara, Makoto Nakauma, Takahiro Funami
Summary: This study aimed to investigate the effects of mechanical properties of soft food gels on breakability with the human tongue. The results suggest that fracture deformation of food gels alone is a more important factor for gel fracture during compression between the tongue and hard palate.
FOOD HYDROCOLLOIDS
(2021)
Article
Pharmacology & Pharmacy
Somayeh Taymouri, Shabnam Shahnamnia, Azadeh Mesripour, Jaleh Varshosaz
Summary: In this study, a composite in-situ gel formulation containing APZ loaded TFS was developed and optimized for the intranasal brain targeting of APZ, showing promising therapeutic effects for schizophrenia treatment. The optimized formulation demonstrated excellent targeting and efficacy in vivo, with significant behavioral improvements observed.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Instruments & Instrumentation
Purva Khare, Manasi M. Chogale, Pratik Kakade, Vandana B. Patravale
Summary: This article proposes a transmucosal ocular delivery system of Posaconazole using a gellan gum-based in situ gelling nano-suspension. The nanosuspension demonstrated enhanced antibacterial properties and drug release compared to a marketed itraconazole nanosuspension. The developed nanosuspension showed good mucoadhesion and minimal irritancy.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Agricultural Engineering
Manoj J. Dev, Rahul G. Warke, Gangadhar M. Warke, Girish B. Mahajan, Tanuja A. Patil, Rekha S. Singhal
Summary: This review provides a comprehensive analysis of the upstream and downstream processes of gellan gum production from an industrial perspective. It covers topics such as biosynthesis, strain and media engineering, bioreactor design, and scale-up considerations. The review also explores modifications to downstream operations to improve cost-effectiveness and environmental sustainability. Additionally, it discusses regulatory criteria and analytical tools for validating gellan gum as a food ingredient, as well as highlights the applications of gellan gum derivatives in various industrial sectors.
BIORESOURCE TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria A. Bonifacio, Stefania Cometa, Andrea Cochis, Annachiara Scalzone, Piergiorgio Gentile, Alessandro C. Scalia, Lia Rimondini, Piero Mastrorilli, Elvira De Giglio
Summary: In this study, a hydrogel containing a blend of two gellan gums and lignin crosslinked with magnesium ions was developed for cartilage regeneration. The presence of lignin improved the chondrogenesis of hMSCs and had bacteriostatic properties. The hydrogel was also shown to be processable as a bioink for 3D bioprinting and created a physiological environment for cell growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Environmental Sciences
Nandakumar Selvasudha, Joseph PushpaSweety, Thekkila-Veedu Saranya, Kandasamy Ruckmani, Loganathan Gayathri
Summary: This study aimed to adapt a simple protein estimation method for detecting nisin and to formulate and evaluate site-specific nanoformulation for therapeutic applications. Among the three nanoformulations prepared and characterized, the one with gellan gum showed the best characteristics. Interaction and stability patterns were confirmed using FT-IR and DSC, and CD demonstrated the stability of nisin in an alkaline environment. The formulated gellan gum-nisin colloidal nanoparticles showed significant effectiveness against colon cancer cells and antimicrobial activity against Staphylococcus aureus.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)