Insights into the Binding of Cyclic RGD Peptidomimetics to α5β1Integrin by using Live-Cell NMR And Computational Studies

αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating

(2016) Carlos Mas-Moruno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Integrin-based therapeutics: biological basis, clinical use and new drugs

(2016) Klaus Ley et al.   NATURE REVIEWS DRUG DISCOVERY

Live Cell NMR

(2014) Darón I. Freedberg et al.   Annual Review of Biophysics

Strategies To Inhibit Tumor Associated Integrin Receptors: Rationale for Dual and Multi-Antagonists

(2014) Helen M. Sheldrake et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

(2014) Roger Stupp et al.   LANCET ONCOLOGY

Metal ion and ligand binding of integrin α5β1

(2014) Wei Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determination of the binding epitope of RGD-peptidomimetics to αvβ3 and αIIbβ3 integrin-rich intact cells by NMR and computational studies

(2013) Ileana Guzzetti et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Tumor Targeting via Integrin Ligands

(2013) Udaya Kiran Marelli et al.   Frontiers in Oncology

Cyclic RGD Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds as New Potent Integrin Ligands

(2012) Mattia Marchini et al.   CHEMISTRY-A EUROPEAN JOURNAL

Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor

(2012) Masamichi Nagae et al.   JOURNAL OF CELL BIOLOGY

Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation

(2011) Carlos Mas-Moruno et al.   Anti-Cancer Agents in Medicinal Chemistry

STD and trNOESY NMR Study of Receptor-Ligand Interactions in Living Cancer Cells

(2011) Donatella Potenza et al.   CHEMBIOCHEM

Applications of saturation transfer difference NMR in biological systems

(2011) Anirban Bhunia et al.   DRUG DISCOVERY TODAY

Cilengitide in patients with recurrent glioblastoma: the results of NABTC 03-02, a phase II trial with measures of treatment delivery

(2011) Mark R. Gilbert et al.   JOURNAL OF NEURO-ONCOLOGY

Targeting αvβ3 Integrin: Design and Applications of Mono- and Multifunctional RGD-Based Peptides and Semipeptides

(2010) L. Auzzas et al.   CURRENT MEDICINAL CHEMISTRY

Integrins as therapeutic targets: lessons and opportunities

(2010) Dermot Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Cyclic RGD-Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds as New Potent Integrin Ligands

(2009) Ana Sofia M. da Ressurreição et al.   CHEMISTRY-A EUROPEAN JOURNAL

Small Molecule Integrin Antagonists in Cancer Therapy

(2009) Mayra Paolillo et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Synthesis and Conformational Studies of Peptidomimetics Containing a New Bifunctional Diketopiperazine Scaffold Acting as a β-Hairpin Inducer

(2007) Ana Sofia M. Ressurreição et al.   JOURNAL OF ORGANIC CHEMISTRY

Transferred-NOE NMR experiments on intact human platelets: receptor-bound conformation of RGD-peptide mimics

(2007) Donatella Potenza et al.   ORGANIC & BIOMOLECULAR CHEMISTRY