期刊
BIOMED RESEARCH INTERNATIONAL
卷 2016, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2016/5276271
关键词
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资金
- Sichuan Sci & Tech Support Program [2013NZ0041, 2013NZ0056]
- Chinese National Sci & Tech Support Program [2013BAD20B07, 2015BAD03B01-11]
- National Biological Breeding Capacity Building and Industrialization Projects [2014-2573]
- National Development and Reform Commission
MicroRNAs are a class of 18-22-nucleotide noncoding RNAs that posttranscriptionally regulate gene expression and have been shown to play an important role during myoblast differentiation. In this study, we found that the expression of miR-145a-5p was gradually increased during C2C12 myoblast differentiation, and miR-145a-5p inhibitors or mimics significantly suppressed or promoted the relative expression of specific myogenesis related marker genes. Moreover, overexpression or inhibition of miR-145a-5p enhanced or repressed the expression of some special genes involved in the endogenous Wnt signaling pathway during C2C12 myoblast differentiation, including Wnt5a, LRP5, Axin2, and beta-catenin. These results indicated that miR-145a-5p might be considered as a newmyogenic differentiation-associated microRNA that can promote C2C12 myoblast differentiation by enhancing genes related to myoblasts differentiation.
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