Review
Pharmacology & Pharmacy
Jovana Rajkovic, Radmila Novakovic, Jelica Grujic-Milanovic, Alibek Ydyrys, Nurzhanat Ablaikhanova, Daniela Calina, Javad Sharifi-Rad, Basem Al-Omari
Summary: This comprehensive review analyzes and discusses the specific mechanisms and molecular targets of calotropin in cancer treatment, providing new perspectives for adjuvant therapy in different types of cancer.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Di Liu, Yin-Hua Liang, Yun-Tao Yang, Miao He, Zi-Jun Cai, Wen-Feng Xiao, Yu-Sheng Li
Summary: OA is a common joint disease in elderly individuals, with unclear molecular mechanisms and limited treatment options. Studies have shown that circRNAs play a significant role in the pathogenesis and progression of OA.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Review
Reproductive Biology
Ahmad Saburi, Mohammad Saeed Kahrizi, Navid Naghsh, Hasti Etemadi, Ahmet Ilhan, Ali Adili, Shadi Ghoreishizadeh, Rozita Tamjidifar, Morteza Akbari, Gulinnaz Ercan
Summary: Ovarian cancer is a common malignant tumor in women and is one of the leading causes of cancer-related death in this group. Chemotherapy is the main treatment option, but drug resistance can worsen the outcome. Understanding the role of microRNAs in chemotherapy resistance can help develop new strategies for treatment.
JOURNAL OF OVARIAN RESEARCH
(2022)
Review
Medicine, Research & Experimental
Sheik Aliya, Munirah Alhammadi, Uichang Park, Jitendra N. Tiwari, Jeong-Hwan Lee, Young-Kyu Han, Yun Suk Huh
Summary: Formononetin, a natural product with phytoestrogenic properties, exhibits potent chemotherapeutic activity with less toxicity. It inhibits cell proliferation, invasion, and metastasis by targeting major signaling pathways. It induces apoptosis and cell cycle arrest and regulates the neoplastic microenvironment. Furthermore, it suppresses cell migration, invasion, and angiogenesis in human cancer cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, General & Internal
Meropi Karakioulaki, Eleni Papakonstantinou, Antonios Goulas, Daiana Stolz
Summary: IgE plays an important role in both COPD and asthma, being associated with respiratory symptoms, lung function, bacterial and viral infections, airway remodeling, and bronchial hyperreactivity. Asthma is related to allergic sensitization and Th2-mediated immune airway response, while COPD is mainly considered a Th1-mediated inflammatory process.
FRONTIERS IN MEDICINE
(2021)
Review
Oncology
Federica Rascio, Federica Spadaccino, Maria Teresa Rocchetti, Giuseppe Castellano, Giovanni Stallone, Giuseppe Stefano Netti, Elena Ranieri
Summary: The PI3K/Akt pathway plays a crucial role in drug resistance in cancer by impacting tumor cell growth and metastasis through different signaling pathways. Its multi-level deregulation contributes to resistance in various cancer types. Understanding the pathway is essential in developing potential inhibition strategies for overcoming drug resistance.
Article
Food Science & Technology
Pouya Mohammadnezhad, Alberto Valdes, Gerardo Alvarez-Rivera
Summary: The by-products generated by agri-food industries have potential health-promoting compounds. Studies are showing the importance of these bioactive compounds in preventing or improving diseases. Thus, efficient extraction procedures and comprehensive chemical and functional characterization with high-throughput bioanalytical and omics technologies are important for supporting health claims of new food-related bioactive molecules. This review summarizes advanced strategies for obtaining and evaluating the biological activity of functional ingredients from food by-products.
CURRENT OPINION IN FOOD SCIENCE
(2023)
Review
Medical Laboratory Technology
Sanjukta Dasgupta, Nilanjana Ghosh, Parthasarathi Bhattacharyya, Sushmita Roy Chowdhury, Koel Chaudhury
Summary: Asthma and chronic obstructive pulmonary disease (COPD) are common lung diseases that have a significant impact on morbidity and mortality worldwide. Asthma-COPD overlap (ACO) is a complex pulmonary disease that shares features of both asthma and COPD. This review examines the metabolic alterations in patients with asthma, COPD, and ACO, and discusses the use of metabolomics techniques for biomarker discovery and understanding the pathogenesis of these diseases. The review also highlights the challenges in metabolite identification and quality assessment, and envisions bridging the gap between phenotype and metabotype in the future.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2023)
Article
Microbiology
Jose Antonio Ramirez, Maria del Rocio Reyes-Montes, Gabriela Rodriguez-Arellanes, Armando Perez-Torres, Maria Lucia Taylor
Summary: Histoplasmosis is a systemic mycosis caused by the Histoplasma capsulatum complex, which can invade the Central Nervous System (CNS). It leads to life-threatening injuries, including meningitis, abscesses, histoplasmomas, and spinal cord injuries. This review provides updated information on the epidemiology, clinical forms, pathogenesis, diagnosis, and therapy of this mycosis, with a focus on the CNS.
Review
Biochemistry & Molecular Biology
Mengchen Wang, Qiaoyu Li, Meiqi Jin, Zhen Wang, Xuelian Zhang, Xiaobo Sun, Yun Luo
Summary: This study reviews the different sources of three ncRNAs (microRNAs, long noncoding RNAs, and circular RNAs) involved in the pathogenesis of diabetic retinopathy (DR) and the related drug development progress, providing a better understanding of the role of ncRNAs in various retinal cells and offering therapeutic directions and targets for DR treatment.
Review
Biochemistry & Molecular Biology
Malgorzata Guz, Witold Jeleniewicz, Marek Cybulski
Summary: In recent years, the roles of non-coding RNAs (ncRNAs), particularly miRNAs, in cancer have been widely recognized. Aberrant expression of miRNAs is associated with various stages of cancer development, making them potential biomarkers and therapeutic targets. MiRNAs show promising applications in cancer diagnosis, prediction, and response to therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Chuan Xing Li, Jing Gao, C. Magnus Skold, Asa M. Wheelock
Summary: A dysregulated network of miRNA-mRNA-protein related to female COPD was constructed in this study, identifying novel biomarkers and disease pathways, and providing new hypotheses about COPD pathology.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Weihao Zhao, Shang Zhang, Yumin Zhu, Xiaochen Xi, Pengfei Bao, Ziyuan Ma, Thomas H. Kapral, Shuyuan Chen, Bojan Zagrovic, Yucheng T. Yang, Zhi John Lu
Summary: RNA-binding proteins play crucial roles in post-transcriptional regulation, and accurately identifying their binding sites in multiple cell lines and tissue types is essential for understanding their regulatory mechanisms in physiological and pathological conditions. The updated POSTAR3 database includes comprehensive improvements in data collection, annotation infrastructure, and analysis, supporting annotation of post-transcriptional regulation in multiple species.
NUCLEIC ACIDS RESEARCH
(2022)
Review
Genetics & Heredity
Alessia Bernini Di Michele, Valerio Onofri, Mauro Pesaresi, Chiara Turchi
Summary: Sudden cardiac death (SCD) is a significant cause of death globally and has attracted the attention of researchers in legal medicine. The expression level of miRNAs, a class of non-coding RNA, has the potential to serve as biomarkers for identifying different causes of SCD.
Article
Medicine, General & Internal
Henryka Hometowska, Jakub Klekowski, Natalia Swiatoniowska-Lonc, Beata Jankowska-Polanska, Mariusz Chabowski
Summary: This study aimed to assess the prevalence of fatigue, anxiety, and depression in patients with asthma, COPD, and ACO and to consider their mutual correlations. The results showed that patients with COPD, asthma, and ACO generally suffered from an increased level of fatigue and depression. Anxiety was high in all groups, but it was at a similar level for patients suffering from each of the three diseases under consideration. It is important to treat the physical symptoms as well as the psychological disorders since they greatly impact patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Joanna Wieczfinska, Przemyslaw Sitarek, Tomasz Kowalczyk, Piotr Rieske, Rafal Pawliczak
Summary: Bronchial epithelial cells and fibroblasts are crucial in airway remodelling, with human rhinovirus infection playing a role in this process. Curcumin has been shown to reduce gene expression related to airway remodelling and may potentially limit or prevent this process, dependent on NF-kappa B, c-Myc, and STAT3 pathways. Further research is needed to fully understand the effects of curcumin on airway remodelling.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Tomasz Kowalczyk, Anna Merecz-Sadowska, Laurent Picot, Irena Brcic Karaconji, Joanna Wieczfinska, Tomasz Sliwinski, Przemyslaw Sitarek
Summary: In recent years, there has been growing interest in using transgenic plants as biofactories for the production of valuable secondary metabolites and recombinant proteins. Advances in genetic engineering technology have allowed for direct modification of genes involved in the biosynthesis of these compounds. Research has resulted in efficient plant systems that can produce specific metabolites and proteins, and the use of bioreactors enables industrial-scale production. This review paper provides an overview of the key research in the past decade, highlighting the use of transgenic plants as small, green biofactories and discussing the current state of patents in this field.
Review
Cell Biology
Joanna Wieczfinska, Paulina Kleniewska, Rafal Pawliczak
Summary: The COVID-19 pandemic has resulted in high mortality, particularly in patients with comorbidities such as diabetes, hypertension, and COPD. Oxidative stress is believed to play a significant role in the pathogenesis of these comorbidities. Although the exact mechanism of death in critically ill COVID-19 patients is still unclear, lung vasculature injury and loss of lung function are considered crucial. Medications used in COVID-19 treatment that influence reactive oxygen and nitrogen species production may be beneficial. However, oxidative stress is also involved in antiviral immune response, and understanding the redox mechanisms in severe COVID-19 could impact its treatment.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Toxicology
Paulina Natalia Kopa-Stojak, Rafal Pawliczak
Summary: This study aims to summarize the current knowledge on the effects of cigarettes, electronic nicotine delivery systems, and tobacco heating products on miRNA-mediated gene expression regulation and their potential impact on smoking-related respiratory disease development. A literature search was conducted from October 2021 to February 2022, including relevant literature such as clinical trials, cellular and animal-based studies. The results showed that cigarette smoke significantly altered the transcriptome and miRNA expression profile. Although the effects of electronic cigarettes and tobacco heating products on miRNA profile were reduced compared to cigarette smoke, there were still significant differences in miRNA expression compared to air-control, which may be harmful to never-smokers.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
Article
Microbiology
Marharyta Sobczak, Rafal Pawliczak
Summary: This study compared the efficacy of COVID-19 vaccines and found that full vaccination can decrease the risk of infection and death. The vaccines are also effective against variants of SARS-CoV-2. The efficacy of vaccination is similar in different age groups.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2022)
Article
Biochemistry & Molecular Biology
Marharyta Sobczak, Rafal Pawliczak
Summary: Vitamin D may not only inhibit airway remodeling but also have a synergistic effect with anti-asthmatic drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Marharyta Sobczak, Rafal Pawliczak
Summary: This study compares the factors contributing to the increasing number of COVID-19 cases in five selected European Union countries in 2021 and 2022. The research findings indicate that despite high vaccination rates, these countries experienced a sharp increase in daily cases during the summer of 2022, potentially due to the presence of the Omicron variant.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Marcin Kosmalski, Jozef Drzewoski, Izabela Szymczak-Pajor, Andrzej Zieleniak, Melania Mikolajczyk-Solinska, Jacek Kasznicki, Agnieszka Sliwinska
Summary: The study aimed to evaluate the association between Irisin and non-alcoholic fatty liver disease (NAFLD). The results showed that Irisin concentration was correlated with anthropometric and biochemical parameters, suggesting its potential as a diagnostic biomarker for NAFLD.
Article
Public, Environmental & Occupational Health
Marharyta Sobczak, Rafal Pawliczak
Summary: This study aimed to investigate the common factors responsible for the increased COVID-19 mortality in Eastern European countries. The findings showed that COVID-19 mortality is associated with the number of cases, hospitalizations, and patients in intensive care. Stringency index and vaccination also have an impact on COVID-19 mortality. Moreover, the presence of new variants increased the death rates.
Article
Chemistry, Medicinal
Izabela Szymczak-Pajor, Jozef Drzewoski, Ewa Swiderska, Justyna Strycharz, Anna Gabryanczyk, Jacek Kasznicki, Marta Bogdanska, Agnieszka Sliwinska
Summary: Accumulating evidence suggests that metformin has anticancer properties by inducing apoptosis and inhibiting the growth and proliferation of cancer cells. However, its effect on histone acetylation status remains unclear. Therefore, this study aimed to evaluate the impact of metformin on HATs and HDACs in human pancreatic cancer cell lines.
Article
Respiratory System
Marharyta Sobczak, Rafal Pawliczak
Summary: This meta-analysis investigates the impact of vitamin D supplementation on asthma. The study found that supplementation during pregnancy can decrease the risk of wheezing in infants, but has no effect on asthma in infants. Additionally, vitamin D has varying effects on forced expiratory volume in children and asthma control test scores in adults.
BMC PULMONARY MEDICINE
(2023)
Article
Immunology
Monika Marko, Rafal Pawliczak
Summary: This study assessed the risk of skin infections related to dupilumab monotherapy in moderate-to-severe atopic dermatitis. The results showed a significant decrease in overall skin infections and nonherpetic skin infections in the dupilumab group compared to placebo. However, there were more herpetic infections in the dupilumab group in 2b phase studies.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Article
Respiratory System
Monika Marko, Rafal Pawliczak
Summary: This study aimed to evaluate the efficacy and safety of oral antihistamines, intranasal antihistamines, intranasal glucocorticosteroids, subcutaneous immunotherapy, and sublingual immunotherapy in the treatment of allergic rhinitis. The results showed that these treatment methods were effective and safe in reducing the symptoms of seasonal and perennial allergic rhinitis.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Marharyta Sobczak, Rafal Pawliczak
Summary: The number of COVID-19 cases was higher in early autumn 2022 compared to autumn 2021. Hence, this study aimed to investigate the factors contributing to the differences in COVID-19 cases between the time periods of 2021/2022 and 2022/2023, taking into account the occurrence of influenza. Multiple factor analysis was conducted using publicly available databases for Austria, Germany, Greece, Italy, and Slovenia. The factors correlated with the increase in COVID-19 cases in the 2021/2022 season were the presence of dominant SARS-CoV-2 variants and the relaxation of restrictions and strict health system policies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Monika Marko, Rafal Pawliczak
Summary: Atopic dermatitis (AD) and psoriasis are inflammatory skin diseases with increasing prevalence worldwide, causing decreased quality of life and socioeconomic burden. Resveratrol and its derivatives, based on natural compounds, show potential therapeutic effects through anti-inflammatory and antioxidant pathways.
