期刊
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
卷 45, 期 4, 页码 694-700出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2016.1228665
关键词
Polymerized porcine hemoglobin; acute anemia; normovolemic hemodilution; oxygen delivery
资金
- National Natural Science Foundation of China [81102367]
- Science and Technology Research and Development Project of Shaanxi Province [2016SF-243, 2011K12-03-10]
- National High-Tech R&D Program (863 Program) [2012AA021902]
- China Scholarship Council of the Ministry of Education [2011KTCL03-23]
- National Major Scientific and Technological Special Project for 'Significant New Drugs Development' [2014ZX09102043-004]
The objective of this study was to investigate the recovery ability of polymerized porcine hemoglobin (pPolyHb) in a rat model of acute anemia caused by normovolemic hemodilution (ANH). After the ANH procedure, rats were infused with either pPolyHb or red blood cells. The results showed pPolyHb could carry a sufficient amount of oxygen to the tissues to maintain normal aerobic metabolism and hemodynamic stability, without any significant toxic effects on renal and liver function according to pathological, and biochemical analysis. The data suggest pPolyHb may be a good candidate for the treatment of acute anemia in future clinical trials.
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