期刊
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
卷 45, 期 5, 页码 897-906出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2016.1188396
关键词
Adjuvant; foot-and-mouth disease vaccine; polyglycerol polyricinoleate; stability; w/o nano-emulsion
资金
- National Natural Science Foundation of China [21336010]
- National High Technology Research and Development Program of China (863 Program) [2014AA021005, 2014AA021006]
- National Science and Technology Major Project [2013ZX10004606]
A stable and bio-compatible w/o nano-emulsion was developed as adjuvant for foot and mouth disease (FMD) vaccine with isopropyl myristate as oil phase, polyglycerol polyricinoleate, and Tween 80 as surfactants. Dissolving Tween 80 in aqueous phase decreased the droplet size and improved stability of the emulsion through narrowing size distribution, increasing viscosity, and reducing the interfacial tension between oil and water. The nano-emulsion was then formulated with inactivated FMD virus and ovalbumin to investigate its potential application as an adjuvant. Compared with commercial ISA-206 adjuvant, the novel w/o nano-emulsion was able to induce both humoral- and cell-mediated immune response.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据